Maternal Care Influences Hippocampal N-Methyl-D-Aspartate Receptor Function and Dynamic Regulation by Corticosterone in Adulthood
Abstract
Background Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR) regulate synaptic plasticity, and NMDAR function is modulated by stress and CORT. We hypothesized that altered NMDAR function underlies the interaction of maternal and stress effects on hippocampal synaptic plasticity. Methods We used electrophysiology and western blot to examine NMDAR synaptic function/expression and NMDAR-dependent long-term potentiation (LTP) in adult offspring of mothers that varied in the frequency of pup licking/grooming (LG) (i.e., High or Low LG). Results Basal NMDAR synaptic function was enhanced in the hippocampal dentate gyrus (DG) of adult Low LG offspring. Synaptic expression of NMDAR but not α-amino-3-hydroxy-methyl-4-isoxazole propionic acid receptors was also increased. Stress level CORT (100 nmol/L) rapidly ( Conclusions Low LG offspring exhibit basally elevated NMDAR function coupled with insensitivity to CORT modulation indicative of a chronic alteration of NMDAR function. Elevated NMDAR function in the hippocampus might underlie impaired LTP in Low LG offspring.
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Female Long-Evans rats differ significantly in how frequently they lick/groom their pups, which is a stable feature of the maternal phenotype.
“Female Long-Evans rats differ significantly in how frequently they lick/groom (LG) their pups, which is a stable feature of the maternal phenotype.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [73]
Variations in pup LG over the first week of postnatal life affect the development of behavioral and HPA responses to stress in adulthood.
“We and other labs find that variations in pup LG over the first week of postnatal life rat affect the development of behavioral and hypothalamic-pituitary-adrenal (HPA) responses to stress in adulthood.66-75”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [73]
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- Authors
- Bagot, R. C., Tse, Y. C., Nguyen, H.-B., Wong, A. S., Meaney, M. J., & Wong, T. P.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Wong, Tak Pan
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 72
- Issue
- 6
- Pages
- 491-498
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2069943337
- Cited by
- 65
- References
- 50
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 2 · 2015: 10 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada (38868-03)
- Canadian Institutes of Health Research (MOP-106649)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- maternal care, NMDA receptor, corticosterone, hippocampus, synaptic plasticity, long-term potentiation, dentate gyrus, stress response, glucocorticoid receptor, AMPA receptors, APV, offspring development
- MeSH terms
- Animals, Corticosterone, Electrophysiology, Female, Grooming, Male, Maternal Behavior, Neuronal Plasticity, Blotting, Western, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Dentate Gyrus, Rats, Long-Evans, Rats
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