Cited by 3,640Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Morris, R. G. M., Anderson, E., Lynch, G. S., Baudry, M.·1986·Nature

DOI 10.1038/319774a0

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Abstract

Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA) and that exhibit a peculiar dependency on membrane voltage in becoming active only on depolarization. Blockade of these sites with the drug aminophosphonovaleric acid (AP5) does not detectably affect synaptic transmission in the hippocampus, but prevents the induction of hippocampal long-term potentiation (LTP) following brief high-frequency stimulation. We now report that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning, which is not. The L-isomer of AP5 did not produce behavioural effects. AP5 treatment also suppressed LTP in vivo. These results suggest that NMDA receptors are involved in spatial learning, and add support to the hypothesis that LTP is involved in some, but not all, forms of learning.

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Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Self-citation
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Self-citation
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Neurobiology of the hippocampus
Rawlins, J. N. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90113-1 · Cited by 1,097
The Biochemistry of Memory: A New and Specific Hypothesis
LYNCH, G. S., & Baudry, M. (1984) · Science · doi:10.1126/science.6144182 · Cited by 1,041
Self-citation

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Show all 19 references

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Kolb, B., Pittman, K. & Sutherland, R. J. Behav. Brain Res. (in the press).
Kolb, B., Sutherland, R. J. & Whishaw, I. Q. Behav. Neurosci. 97, 13–27 (1983). · DOI
Hagan, J. J., Tweedie, F. M. & Morris, R. G. M. Behav. Neurosci. (in the press).

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Self-citation
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Zhang, Q., Tanaka, K., Sun, P., Nakata, M., Yamamoto, R., Sakimura, K., Matsui, M., & Kato, N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.019 · Cited by 110
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Yamada, K., Hiramatsu, M., Noda, Y., Mamiya, T., Murai, M., Kameyama, T., Komori, Y., Nikai, T., Sugihara, H., & Nabeshima, T. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00161-3 · Cited by 110
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Morán, J., & Patel, A. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)91272-9 · Cited by 110
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Self-citation
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Sanderson, D. J., & Bannerman, D. M. (2010) · Hippocampus · doi:10.1002/hipo.20896 · Cited by 108
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Goodlett, C. R., Hamre, K. M., & West, J. R. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80119-6 · Cited by 108
Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition
Higgins, G. A., Ballard, T. M., Huwyler, J., Kemp, J. A., & Gill, R. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00402-1 · Cited by 108
Impaired modulation of AMPA receptors by calcium-dependent processes in streptozotocin-induced diabetic rats
Chabot, C., Massicotte, G., Milot, M., Trudeau, F., & Gagné, J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00648-3 · Cited by 108
Regional changes in the hippocampal density of AMPA and NMDA receptors across the lifespan of the rat
Wenk, G. L., & Barnes, C. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02792-x · Cited by 108
Effects of lobeline, a nicotinic receptor agonist, on learning and memory
Decker, M. W., Majchrzak, M. J., & Arnerić, S. P. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90508-q · Cited by 108
d-cycloserine attenuates scopolamine-induced learning and memory deficits in rats
Fishkin, R. J., İnce, E., Carlezon, W. A., & Dunn, R. W. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90886-m · Cited by 108
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Kitamura, Y., Miyazaki, A., Yamanaka, Y., & Nomura, Y. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03542.x · Cited by 108
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Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B., Segal, M., & McKay, R. D. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04177.1998 · Cited by 108
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Pizzi, M., Fallacara, C., Arrighi, V., Memo, M., & Spano, P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb02173.x · Cited by 108
Reprint of “Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies”
Vorhees, C. V., & Williams, M. T. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.06.002 · Cited by 107
Neuropsychiatric Lupus
Hanly, J. G. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2005.01.007 · Cited by 107
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy
Namba, T., Morimoto, K., Sato, K., Yamada, N., & Kuroda, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)90630-0 · Cited by 107
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Kew, J. N. C., Köester, A., Moreau, J., Jenck, F., Ouagazzal, A., Mutel, V., Richards, J. G., Trube, G., Fischer, G., Montkowski, A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04037.2000 · Cited by 107
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del Cerro, S., Jung, M., & Lynch, G. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90071-9 · Cited by 106
Self-citation
Multiple cellular cascades participate in long-term potentiation and in hippocampus-dependent learning
Baudry, M., Zhu, G., Liu, Y., Wang, Y., Briz, V., & Bi, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.033 · Cited by 106
Self-citation
Modulation of Hippocampal Long-Term Potentiation by the Amygdala: A Synaptic Mechanism Linking Emotion and Memory
Abe, K. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.86.18 · Cited by 106
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Shors, T. J., Falduto, J., & Leuner, B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03065.x · Cited by 106
Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury
Dash, P. K., Moore, A., & Dixon, C. E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02030.1995 · Cited by 106
An alternative to the LTP orthodoxy: a plasticity-pathology continuum model
McEachern, J. C., & Shaw, C. (1996) · Brain Research Reviews · doi:10.1016/0165-0173(96)00006-9 · Cited by 106
N-methyl-D-aspartate mediated responses decrease with age in Fischer 344 rat brain
Gonzales, R. A., Brown, L. M., Jones, T. W. A., Trent, R. D., Westbrook, S. L., & Leslie, S. W. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90100-x · Cited by 106

Authors: Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M.
Affiliations: University of St Andrews (GB)
University of California, Irvine (US)
ORCID: Morris, R. G. M.
Lynch, G. S.
Baudry, M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1986-02
Volume: 319
Issue: 6056
Pages: 774-776
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/319774a0
OpenAlex: W2025801062
Cited by: 3,640
References: 19
Citations by year: 2026: 25 · 2025: 30 · 2024: 44 · 2023: 31 · 2022: 42 · 2021: 63 · 2020: 52 · 2019: 65 · 2018: 83 · 2017: 85 · 2016: 82 · 2015: 89 · 2014: 103 · 2013: 98 · 2012: 101
FWCI: 31.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: NMDA receptor, AP5, long-term potentiation, hippocampus, place learning, spatial learning, visual discrimination learning, glutamate receptors, intraventricular infusion, synaptic plasticity
MeSH terms: Animals, Electric Stimulation, Hippocampus, Isomerism, Learning, Valine, Visual Perception, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, Rats

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

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