Cited by 1,835Neuroscience and Neuropharmacology ResearchIon channel regulation and functionAmino Acid Enzymes and Metabolism

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

MacDermott, Amy B., Mayer, Mark L., Westbrook, Gary L., Smith, Stephen J., Barker, Jeffery L.·1986·Nature

DOI 10.1038/321519a0

Open this paper in CoChat — free account

Abstract

Excitatory amino acids act via receptor subtypes in the mammalian central nervous system (CNS). The receptor selectively activated by N-methyl-D-aspartic acid (NMDA) has been best characterized using voltage-clamp and single-channel recording; the results suggest that NMDA receptors gate channels that are permeable to Na+, K+ and other monovalent cations. Various experiments suggest that Ca2+ flux is also associated with the activation of excitatory amino-acid receptors on vertebrate neurones. Whether Ca2+ enters through voltage-dependent Ca2+ channels or through excitatory amino-acid-activated channels of one or more subtype is unclear. Mg2+ can be used to distinguish NMDA-receptor-activated channels from voltage-dependent Ca2+ channels, because at micromolar concentrations Mg2+ has little effect on voltage-dependent Ca2+ channels while it enters and blocks NMDA receptor channels. Marked differences in the potency of other divalent cations acting as Ca2+ channel blockers compared with their action as NMDA antagonists also distinguish the NMDA channel from voltage-sensitive Ca2+ channels. However, we now directly demonstrate that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2+ influx through NMDA receptor channels. Kainic acid (KA), which acts at another subtype of excitatory amino-acid receptor, was much less effective in trigge…

Integrity signals

Registry

Crossref · 10.1038/321519a0

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Inositol Trisphosphate, a Novel Second Messenger in Cellular Signal Transduction
Berridge, M. J., & Irvine, R. F. (1984) · Nature · doi:10.1038/312315a0 · Cited by 6,086
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Self-citation
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Calcium Channel
Hagiwara, S., & Byerly, L. (1981) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.04.030181.000441 · Cited by 1,193
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116
Glutamate stimulates inositol phosphate formation in striatal neurones
Sladeczek, F. A. J., Pin, J., Récasens, M., Bockaert, J., & Weiss, S. (1985) · Nature · doi:10.1038/317717a0 · Cited by 752
CALCIUM‐INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM OF SKINNED CELLS FROM ADULT HUMAN, DOG, CAT, RABBIT, RAT, AND FROG HEARTS AND FROM FETAL AND NEW‐BORN RAT VENTRICLES*
Fabiato, A., & Fabiato, F. (1978) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1978.tb41979.x · Cited by 467

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 8

Lansman, J. B., Hess, P. & Tsien, R. W. J. gen. Physiol. (in the press).
Cull-Candy, S. G. & Ogden, D. C. Proc. R. Soc. B224, 367–373 (1985).
Evans, R. H. & Watkins, J. C. J. Physiol., Lond. 277, 57P (1977).
Nowak, L. M. & Ascher, P. Soc. Neurosci. Abstr. 10, 23 (1984).
Mayer, M. L. & Westbrook, G. L. Soc. Neurosci. Abstr. 11, 785 (1985).
Ascher, P. & Nowak, L. J. Physiol., Lond. Proc. (in the press).
Nowak, L. M. & Ascher, P. Soc. Neurosci. Abstr. 11, 953 (1985).
Miledi, R. Proc. R. Soc. B209, 447–452 (1980).

Sorted by citations

Items 401–500 of 1,002

Central sensitization as a result of surgical pain: investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat
Lascelles, B. D. X., Waterman, A. E., Cripps, P., Livingston, A., & Henderson, G. (1995) · Pain · doi:10.1016/0304-3959(94)00266-h · Cited by 108
Aspects of vertebrate neuronal voltage-activated calcium currents and their regulation
Scott, R. H., Pearson, H. A., & DOLPHIN, A. C. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90014-r · Cited by 108
[3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites
Reynolds, I. J., & Miller, R. J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90697-8 · Cited by 108
WHY DO NEUROPROTECTIVE DRUGS WORK IN ANIMALS BUT NOT HUMANS?
DeGraba, T. J., & Pettigrew, L. C. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70203-6 · Cited by 107
Molecular Biology and Ontogeny of Glutamate Receptors in the Mammalian Central Nervous System
Simeone, T. A., Sanchez, R. M., & Rho, J. M. (2004) · Journal of Child Neurology · doi:10.1177/088307380401900507 · Cited by 110
Calcium‐Mediated Mechanisms of Ischemic Injury and Protection
Morley, P., Hogan, M. J., & Hakim, A. M. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00809.x · Cited by 107
The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex
Aroniadou‐Anderjaska, V., & Teyler, T. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91197-9 · Cited by 107
Activation of spinal N-methyl-d-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentials in spinalized rats
Liu, X., & Sandkühler, J. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00107-9 · Cited by 105
Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
Lei, S. Z., Zhang, D., Abele, A. E., & Lipton, S. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)90183-a · Cited by 105
Systemic approaches to modifying quinolinic acid striatal lesions in rats
Beal, M. F., Kowall, N. W., Swartz, K., Ferrante, R. J., & Jb, M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03901.1988 · Cited by 105
Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation
Tölle, T. R., Castro‐Lopes, J. M., Coimbra, A., & Zieglgänsberger, W. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90342-7 · Cited by 105
MULTIPLE SYSTEMS OF PERCEPTUAL CATEGORY LEARNING: THEORY AND COGNITIVE TESTS
Ashby, F. G., & Valentin, V. V. (2005) · Elsevier eBooks · doi:10.1016/b978-008044612-7/50080-9 · Cited by 104
In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord
Jakowec, M. W., Yen, L., & Kalb, R. G. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00094-y · Cited by 104
Combinations of AMPA Receptor Subunit Expression in Individual Cortical Neurons Correlate with Expression of Specific Calcium-Binding Proteins
Kondo, M., Sumino, R., & Okado, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01570.1997 · Cited by 104
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by receptor activation
Palmer, E., Monaghan, D. T., & Cotman, C. W. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90008-3 · Cited by 104
N--methyl-d-aspartate receptors mediate activation of the c-fos proto-oncogene in a model of brain injury
Herrera, D. G., & Robertson, H. A. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90081-e · Cited by 104
Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons
Rajdev, S., & Reynolds, I. J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90582-6 · Cited by 103
Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-d-aspartate receptor antagonist
Wada, S., Yone, K., Ishidou, Y., Nagamine, T., Nakahara, S., Niiyama, T., & Sakou, T. (1999) · Journal of Neurosurgery Spine · doi:10.3171/spi.1999.91.1.0098 · Cited by 104
Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats
Yashpal, K., Fisher, K., Chabot, J., & Coderre, T. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00337-2 · Cited by 103
Mechanisms that may underlie the behavioural effects of ethanol
Little, H. J. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90029-z · Cited by 103
Geometry and Charge Determine Pharmacological Effects of Steroids on N-Methyl-d-aspartate Receptor-Induced Ca2+ Accumulation and Cell Death
Weaver, C. E., Land, M. B., Purdy, R. H., Richards, K. G., Gibbs, T. T., & Farb, D. H. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39294-8 · Cited by 101
Excitotoxicity and Neurological Disorders: Involvement of Membrane Phospholipids
Farooqui, A. A., & Horrocks, L. A. (1994) · International review of neurobiology · doi:10.1016/s0074-7742(08)60306-2 · Cited by 102
Involvement of cGMP in Nociceptive Processing by and Sensitization of Spinothalamic Neurons in Primates
Lin, Q., Peng, Y. B., Wu, J., & Willis, W. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03293.1997 · Cited by 101
Long-term potentiation and N-methyl-d-aspartate receptors: Foundations of memory and neurologic disease?
Rison, R. A., & Stanton, P. K. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00017-8 · Cited by 102
Glucose deprivation neuronal injury in cortical culture
Monyer, H., Goldberg, M. P., & Choi, D. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90179-0 · Cited by 101
Nitric Oxide Mediates the Central Sensitization of Primate Spinothalamic Tract Neurons
Lin, Q., Paleček, J., Palečková, V., Peng, Y. B., Wu, J., Cui, M., & Willis, W. D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.3.1075 · Cited by 100
Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons
Cheng, Y., & Sun, A. Y. (1994) · Neurochemical Research · doi:10.1007/bf00969006 · Cited by 100
Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems
Rocha, L., Briones, M., Ackermann, R. F., Anton, B., Maidment, N. T., Evans, C. J., & Engel, J. (1996) · Epilepsy Research · doi:10.1016/s0920-1211(96)00046-0 · Cited by 99
Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study
Mitani, A., Andou, Y., & Kataoka, K. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90492-k · Cited by 99
Dopaminergic regulation of protein phosphorylation in the striatum: DARPP-32
Hemmings, H. C., Walaas, S. I., Ouimet, C. C., & Greengard, P. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90075-0 · Cited by 99
Blockade of morphine-induced analgesia and tolerance in mice by MK-801
Lutfy, K., Hurlbut, D. E., & Weber, E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90195-s · Cited by 98
The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia
Möddel, G., Jacobson, B. E., Ying, Z., Janigro, D., Bingaman, W. E., Gonzalez-Martinez, J. A., Kellinghaus, C., Prayson, R. A., & Najm, I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.042 · Cited by 97
Excitotoxicity in the Enteric Nervous System
Kirchgessner, A. L., Liu, M., & Alcantara, F. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-22-08804.1997 · Cited by 98
Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures
Felipo, V., Miñana, M., & Grisolı́a, S. (1993) · Brain Research · doi:10.1016/0006-8993(93)90368-w · Cited by 97
Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain
Bustos, G. A., Abarca, J., Campusano, J. M., Bustos, V., Noriega, V., & Aliaga, E. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.002 · Cited by 96
NMDA Receptor Dependent Long-term Potentiation in Chronic Pain
Li, X., Miao, H., & Zhuo, M. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2614-8 · Cited by 96
l-Homocysteate is a potent neurotoxin on cultured cortical neurons
Kim, J. P., Koh, J., & Choi, D. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)91531-9 · Cited by 96
2,3‐Benzodiazepines (GYKI 52466 and Analogs): Negative Allosteric Modulators of AMPA Receptors
Vizi, E. S., Mike, Á., & Tarnawa, I. (1996) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1996.tb00292.x · Cited by 96
Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms
Maio, R. D., Mastroberardino, P. G., Hu, X., Montero, L. M., & Greenamyre, J. T. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.02.012 · Cited by 95
Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures
Kim, D. K., Rordorf, G. A., Nemenoff, R. A., Koroshetz, W. J., & Bonventre, J. V. (1995) · Biochemical Journal · doi:10.1042/bj3100083 · Cited by 95
Impairment of gabaa receptor function byn-methyl-d-aspartate-mediated calcium influx in isolated ca1 pyramidal cells
Stelzer, A., & Shi, H. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90479-0 · Cited by 95
Involvement of the C-terminus of the inositol 1,4,5-trisphosphate receptor in Ca2+ release analysed using region-specific monoclonal antibodies
Nakade, S., Maeda, N., & Mikoshiba, K. (1991) · Biochemical Journal · doi:10.1042/bj2770125 · Cited by 95
Cellular localization and laminar distribution of AMPA glutamate receptor subunits mRNAs and proteins in the rat cerebral cortex
Conti, F., Minelli, A., & Brecha, N. C. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500208 · Cited by 96
Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder
Frye, R. E., Casanova, M. F., Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Brown, G. L., Edelson, S. M., Slattery, J. C., & Adams, J. B. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00192 · Cited by 100
Permeant ion regulation of N -methyl- d -aspartate receptor channel block by Mg 2+
Antonov, S. M., & Johnson, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14571 · Cited by 94
Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses
Staubli, U. V., Larson, J., Thibault, O., Baudry, M., & LYNCH, G. S. (1988) · Brain Research · doi:10.1016/0006-8993(88)90922-5 · Cited by 94
Rectification Properties and Ca2+ Permeability of Glutamate Receptor Channels in Hippocampal Cells
Lerma, J., Morales, M., Ibarz, J. M., & Somohano, F. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00605.x · Cited by 94
Systemic administration of mk-801 protects against N-methyl-d-aspartate-and quisqualate-mediated neurotoxicity in perinatal rats
McDonald, J. W., Silverstein, F. S., Cardona, D. J., Hudson, C. J., Chen, R., & Johnston, M. V. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90002-l · Cited by 94
Ischemia-induced changes in the electrical activity of the hippocampus
Buzsáki, G., Freund, T. F., Bayardo, F., & Somogyi, P. (1989) · Experimental Brain Research · doi:10.1007/bf00228898 · Cited by 94
Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia
Sun, M., & Reis, D. J. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90038-8 · Cited by 93
Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death
Koh, J., & Choi, D. W. (1991) · Brain Research · doi:10.1016/0006-8993(91)91140-v · Cited by 93
Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs
Yaksh, T. L., Dirig, D. M., & Malmberg, A. B. (1998) · Cancer Investigation · doi:10.3109/07357909809011705 · Cited by 93
Long-Term Potentiation in Two Synaptic Systems of the Hippocampal Brain Slice
Brown, T. H., Ganong, A. H., Kairiss, E. W., Keenan, C. L., & Kelso, S. R. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-148955-7.50018-7 · Cited by 92
A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation
Roche, K. A., Cook, M., Wilcox, G. L., & Kajander, C. K. (1996) · Pain · doi:10.1016/0304-3959(96)03025-4 · Cited by 92
Glutamate receptor‐linked changes in membrane potential and intracellular Ca2+ in primary rat astrocytes
Enkvist, M. O. K., Holopainen, I. E., & Åkerman, K. E. O. (1989) · Glia · doi:10.1002/glia.440020602 · Cited by 92
Responses to N-methyl-D-aspartate are enhanced in rats with Petit Mal-like seizures
Pumain, R., Louvel, J., Gastard, M. C., Kurcewicz, I., & Vergnes, M. (1992) · Springer eBooks · doi:10.1007/978-3-7091-9206-1_7 · Cited by 92
Dendritic NMDA Receptors Activate Axonal Calcium Channels
Christie, J. M., & Jahr, C. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.028 · Cited by 91
Do NMDA Antagonists Prevent Neuronal Injury? Yes.
Albers, G. W., Goldberg, M. P., & Choi, D. W. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530280112031 · Cited by 91
cGMP synthesis in cultured cerebellar neurons is stimulated by glutamate via a Ca2+-mediated, differentiation-dependent mechanism
Novelli, A., & Henneberry, R. C. (1987) · Developmental Brain Research · doi:10.1016/0165-3806(87)90219-7 · Cited by 91
Excitatory amino acid neurotoxicity at the N-methyl-d-aspartate receptor in cultured neurons: role of the voltage-dependent magnesium block
Cox, J. A., Lysko, P. G., & Henneberry, R. C. (1989) · Brain Research · doi:10.1016/0006-8993(89)90774-9 · Cited by 90
Corticosterone Enhances Kainic Acid‐Induced Calcium Elevation in Cultured Hippocampal Neurons
Elliott, E. M., & Sapolsky, R. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08345.x · Cited by 91
N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum
Scherer, W. J., & Udin, S. B. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03837.1989 · Cited by 90
Hypoxia-induced modification of the receptor in the brain of the newborn piglet
Hoffman, D. J., McGowan, J. E., Marro, P. J., Mishra, O. P., & Delivoria‐Papadopoulos, M. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91051-0 · Cited by 90
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons
Martina, M., Krasteniakov, N. V., & Bergeron, R. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00411.x · Cited by 89
The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischemia model
Hatfield, R., Gill, R., & Brazell, C. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90201-e · Cited by 89
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors
Hansen, J. J., & Krogsgaard‐Larsen, P. (1990) · Medicinal Research Reviews · doi:10.1002/med.2610100103 · Cited by 89
Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo
Gean, P., Shinnick‐Gallagher, P., & Anderson, A. C. (1989) · Brain Research · doi:10.1016/0006-8993(89)90160-1 · Cited by 89
Ca2+ and synaptic plasticity
Cavazzini, M., Bliss, T., & Emptage, N. J. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.013 · Cited by 93
Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord
Wee, K. S.-L., Zhang, Y., Khanna, S., & Low, C. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21747 · Cited by 99
Visualizing hippocampal synaptic function by optical detection of Ca2+ entry through the N-methyl-D-aspartate channel.
Malinow, R., Otmakhov, N., Blum, K. I., & Lisman, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8170 · Cited by 88
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
Breyhan, H., Wirths, O., Duan, K., Marcello, A., Rettig, J., & Bayer, T. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0539-7 · Cited by 87
The contribution of thenon-N-methyl-d-aspartate group of excitatory amino acid receptors to retinogeniculate transmission in the cat
Sillito, A. M., Murphy, P., & Salt, T. E. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90137-s · Cited by 86
Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca2+‐dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria
Исаев, Н. К., Zorov, D. B., Stelmashook, E. V., Uzbekov, R. E., Kozhemyakin, M. B., & Victorov, I. V. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00804-6 · Cited by 86
N-Methyl-D-Aspartate Receptors in the Retina
Shen, Y., Liu, X., & Yang, X. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:163 · Cited by 85
Lanthanum actions on excitatory amino acid‐gated currents and voltage‐gated calcium currents in rat dorsal horn neurons.
Reichling, D. B., & MacDermott, A. B. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018746 · Cited by 85
Self-citation
Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence
Fundytus, M. E., & Coderre, T. J. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17127.x · Cited by 85
Neuroprotective effects of MK-801, TCP, PCP and CPP against N-methyl-d-aspartate induced neurotoxicity in an in vivo perinatal rat model
McDonald, J. W., Silverstein, F. S., & Johnston, M. V. (1989) · Brain Research · doi:10.1016/0006-8993(89)90427-7 · Cited by 84
Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization
Harms, C., Bösel, J., Lautenschlager, M. M., Harms, U., Braun, J., Hörtnagl, H., Dirnagl, U., Kwiatkowski, D. J., Fink, K., & Endres, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.09.012 · Cited by 83
Na+,K+-ATPase Functionally Interacts with the Plasma Membrane Na+,Ca2+ Exchanger to Prevent Ca2+ Overload and Neuronal Apoptosis in Excitotoxic Stress
Sibarov, D. A., Bolshakov, A. E., Abushik, P. A., Krivoi, I. I., & Antonov, S. M. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.198341 · Cited by 83
Regulation of MAPK/ERK phosphorylation via ionotropic glutamate receptors in cultured rat striatal neurons
Mao, L., Tang, Q., Samdani, S., Liu, Z., & Wang, J. Q. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03223.x · Cited by 83
Receptor-activated Calcium Signals in Tangentially Migrating Cortical Cells
Soria, J. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.8.831 · Cited by 85
Calpain-mediated regulation of NMDA receptor structure and function
Bi, X., Rong, Y., Chen, J., Dang, S., Wang, Z., & Baudry, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00067-5 · Cited by 84
Acute and conditioned hyperalgesic responses to illness
Wicrtelak, E. P., Smith, K. P., Furness, L. E., Mooney-Heiberger, K., Mayr, T., Maier, S. F., & Watkins, L. R. (1994) · Pain · doi:10.1016/0304-3959(94)90098-1 · Cited by 83
Restoration of the Plasticity of Binocular Maps by NMDA After the Critical Period in Xenopus
Udin, S. B., & Scherer, W. J. (1990) · Science · doi:10.1126/science.2166343 · Cited by 83
Ketamine in Cancer Pain: An Update
Mercadante, S. (1996) · Palliative Medicine · doi:10.1177/026921639601000301 · Cited by 83
Suppression of Cortical NMDA Receptor Function Prevents Development of Orientation Selectivity in the Primary Visual Cortex
Ramoa, A. S., Mower, A. F., Liao, D. S., & Jafri, S. I. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04299.2001 · Cited by 82
Hypoxia‐activated Ca2+ currents in pacemaker neurones of rat rostral ventrolateral medulla in vitro.
Sun, M., & Reis, D. J. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020115 · Cited by 82
Plateau potential‐dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons
Morisset, V., & Nagy, F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00188.x · Cited by 81
Calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmission, brain aging and schizophrenia: A unifying hypothesis
Etienne, P. E., & Baudry, M. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90081-9 · Cited by 81
Calcium‐dependent subthreshold oscillations determine bursting activity induced by N ‐methyl‐ d ‐aspartate in rat subthalamic neurons in vitro
Zhu, Z., Munhall, A. C., Shen, K., & Johnson, S. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03240.x · Cited by 80
Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells
Froissard, P., Monrocq, H., & Duval, D. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00155-6 · Cited by 80
Reduction of NMDA receptors with dithiothreitol increases [3H]‐MK‐801 binding and NMDA‐induced Ca2+ fluxes
Reynolds, I. J., Rush, E. A., & Aizenman, E. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12109.x · Cited by 80
Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury
Okiyama, K., Smith, D. H., Thomas, M. J., & McIntosh, T. K. (1992) · Journal of neurosurgery · doi:10.3171/jns.1992.77.4.0607 · Cited by 80
Platelet‐activating factor antagonists reduce excitotoxic damage in cultured neurons from embryonic chick telencephalon and protect the rat hippocampus and neocortex from ischemic injury in vivo
Prehn, J. H. M., & Krieglstein, J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340205 · Cited by 80
Applications of quantitative measurements for assessing glutamate neurotoxicity.
Finkbeiner, S. M., & Stevens, C. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4071 · Cited by 80
Excitatory Amino Acid Neurotoxicity
Gillessen, T., Budd, S. L., & Lipton, S. A. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0123-7_1 · Cited by 81
Lowering of extracellular pH suppresses low-Mg2+-induces seizures in combined entorhinal cortex-hippocampal slices
Velı́šek, L., Dreier, J. P., Stanton, P. K., Heinemann, U., & Moshé, S. L. (1994) · Experimental Brain Research · doi:10.1007/bf00243215 · Cited by 79
Activity‐dependent tuning and the NMDA receptor
Debski, E. A., Cline, H. T., & Constantine‐Paton, M. (1990) · Journal of Neurobiology · doi:10.1002/neu.480210103 · Cited by 79
HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons
Lo, T.-M., Fallert, C. J., Piser, T. M., & Thayer, S. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)91125-x · Cited by 79
Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system
Leung, J. C., Travis, B. R., Verlander, J. W., Sandhu, S., Yang, S.-G., Zea, A. H., Weiner, I. D., & Silverstein, D. M. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00629.2001 · Cited by 84

Authors: MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L.
Affiliations: National Institutes of Health (US)
Yale University (US)
ORCID: Mayer, Mark L.
Westbrook, Gary L.
Smith, Stephen J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1986-05
Volume: 321
Issue: 6069
Pages: 519-522
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/321519a0
OpenAlex: W2010926499
Cited by: 1,835
References: 30
Citations by year: 2026: 8 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 18 · 2019: 22 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 20 · 2014: 29 · 2013: 23 · 2012: 24
FWCI: 40.51
Type: journal article
Language: en
Update notices: correction (1986-06-26)
correction (1986-06-26)
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: NMDA receptor, glutamate receptors, intracellular calcium, calcium influx, spinal cord neurons, kainic acid, voltage-gated calcium channels, magnesium block, arsenazo III, excitatory amino acid antagonists
MeSH terms: Animals, Aspartic Acid, Calcium, Cells, Cultured, Cytoplasm, Embryo, Mammalian, Neurons, Spinal Cord, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Receptors, Neurotransmitter, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks