Cited by 1,879Angiogenesis and VEGF in CancerPancreatic function and diabetesPancreatic and Hepatic Oncology Research

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Induction of angiogenesis during the transition from hyperplasia to neoplasia

Folkman, Judah, Watson, Karol, Ingber, Donald, Hanahan, Douglas·1989·Nature

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Abstract

It is now well established that unrestricted growth of tumours is dependent upon angiogenesis. Previous studies on tumour growth, however, have not revealed when or how the transition to an angiogenic state occurs during early tumour development. The advent of transgenic mice carrying oncogenes that reproducibly elicit tumours of specific cell types is providing a new format for studying multi-step tumorigenesis. In one of these models, transgenic mice expressing an oncogene in the beta-cells of the pancreatic islets heritably recapitulate a progression from normality to hyperplasia to neoplasia. We report here that angiogenic activity first appears in a subset of hyperplastic islets before the onset of tumour formation. A novel in vitro assay confirms that hyperplasia per se does not obligate angiogenesis. Rather, a few hyperplastic islets become angiogenic in vitro at a time when such islets are neovascularized in vivo and at a frequency that correlates closely with subsequent tumour incidence. These findings suggest that induction of angiogenesis is an important step in carcinogenesis.

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Authors: Folkman, J., Watson, K., Ingber, D., & Hanahan, D.
Affiliations: Boston Children's Hospital (US)
Harvard University (US)
Brigham and Women's Hospital (US)
University of California, San Francisco (US)
ORCID: Ingber, Donald
Hanahan, Douglas
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1989-05
Volume: 339
Issue: 6219
Pages: 58-61
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/339058a0
OpenAlex: W1985528986
Cited by: 1,879
References: 27
Citations by year: 2026: 5 · 2025: 16 · 2024: 16 · 2023: 28 · 2022: 24 · 2021: 35 · 2020: 27 · 2019: 31 · 2018: 29 · 2017: 43 · 2016: 43 · 2015: 38 · 2014: 50 · 2013: 61 · 2012: 49
FWCI: 12.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Keywords: angiogenesis, pancreatic islets, beta-cell hyperplasia, transgenic mice, oncogenes, neovascularization, carcinogenesis
MeSH terms: Animals, Endothelium, Vascular, Hyperplasia, Islets of Langerhans, Adenoma, Islet Cell, Mice, Transgenic, Neovascularization, Pathologic, Oncogenes, Pancreatic Neoplasms, Precancerous Conditions, Mice

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Induction of angiogenesis during the transition from hyperplasia to neoplasia

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