The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.
Apolipoprotein E and cognitive performance
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In the citing paper
“Interestingly, there was no difference in soluble Aβ levels between apoE3/APP and apoE4/APP transgenic mice, suggesting that the differential effect of apoE isoform on cognition may be due to its ability to modulate functional neuronal deficits triggered by Aβ or APP.”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
In the citing paper
“In transgenic mouse models with neuronal apoE over-expression, apoE4 mice, primarily females, had impairments in learning a water maze test and in vertical exploratory activity, compared with apoE3 mice (Raber et al., 2000).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
In the citing paper
“Male apoE4 mice had significant deficits in spatial memory, whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“and were more severely impaired in learning and memory (Hartman et al., 2001; Raber et al., 1998; Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“apoE isoform specific sex differences in behavior have been previously shown (Raber et al., 1998, Raber et al., 2000).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Raber et al., 2000
In the citing paper
“For example, both apoE4 transgenic and apoE4-KI mice show age- and sex-dependent learning and memory deficits in the absence of Aβ accumulation, as compared to apoE3 transgenic and apoE3-KI mice [68–71].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [69]
Citations
Cites
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Self-citationHartley, D. M., Walsh, D. M., Ye, C. P., Diehl, T., Vasquez, S., Vassilev, P. M., Teplow, D. B., & Selkoe, D. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08876.1999 · Cited by 817
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
Price, D. L., & Sisodia, S. S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.479 · Cited by 581
(1997) · doi:10.1073/pnas.94.4.1550 · Cited by 535
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364
Self-citationButtini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss‐Coray, T., Mucke, L., & Mahley, R. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04867.1999 · Cited by 363
Self-citationHolcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K., & Morgan, D. (1999) · Behavior Genetics · doi:10.1023/a:1021691918517 · Cited by 353
Intracellular APP Processing and Aβ Production in Alzheimer Disease
Wilson, C., Doms, R. W., & Lee, V. M. ‐. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00001 · Cited by 187
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1 of the 14 references couldn’t be matched to a known paper.
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Items 201–238 of 238
Apolipoprotein E genotype, vitamin E, and Alzheimer’s disease prevention
Huebbe, P., & Rimbach, G. H. (2012) · Angewandte Botanik · doi:10.5073/jabfq.2008.082.012 · Cited by 2
Loss of Endothelial APOE4 Dysregulates Neural Function In Vivo
Marottoli, F. M., Balu, D., Flores-Barrera, E., de la Villarmois, E. A., Zhang, H., Chaudhary, R., Talati, R., Tseng, K. Y., & Tai, L. M. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.035080 · Cited by 1
Age-related behavioural abnormalities in C57BL/6.KOR– Apoe shl mice
Ueno, H., Takahashi, Y., Mori, S., Kitano, E., Murakami, S., Wani, K., Miyazaki, T., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2025) · Translational Neuroscience · doi:10.1515/tnsci-2022-0363 · Cited by 1
Lee, E.-G., Leong, L., Chen, S., Tulloch, J., & Yu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010302 · Cited by 1
Regular exercise ameliorates cognitive function in APOE-/- mice via the VEGF/ERK signaling pathway
Wang, Z., Yang, Q., Tong, X., Liao, M., Hu, Z., Huang, S., Wang, P., Tong, Z., Chen, Y. Q., Wang, Y., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.116005 · Cited by 1
The effect of chicken extract on ERK/CREB signaling is ApoE isoform-dependent
Yong, S. M., Ong, Q.-R., Siew, B. E., & Wong, B. (2014) · Food & Function · doi:10.1039/c4fo00428k · Cited by 1
[Recent research progress in Alzheimer's disease: relationship with APOE genotype].
Mitsuda, N. (2006) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.43.610 · Cited by 1
Stephens, G. S., You, J. C., Fu, C.-H., & Chin, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21126-7 · Cited by 1
Apolipoprotein E: Structural and Functional Interactions with Amyloid β
Stine, W. B., & LaDu, M. J. (2005) · Wiley eBooks · doi:10.1002/9783527619344.ch10 · Cited by 1
Koutseff, A. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Apolipoproteins E and C1 in the brain: role in Alzheimer's disease
Abildayeva, K. (2006) · Research Publications (Maastricht University) · doi:10.26481/dis.20061220ka
Lipoproteinstoffwechsel und koronare Herzkrankheit
Utermann, G. (2011) · Medizinische Genetik · doi:10.1007/s11825-010-0259-3
Abad‐Rodríguez, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.12.002
Rodriguez, G. A. (2014) · DigitalGeorgetown (Georgetown University Library)
Bouwer, S. (2010) · UWA Profiles and Research Repository (University of Western Australia)
Albrecht, M. A., & Foster, J. K. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_7
Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_2
Lipoproteinstoffwechsel und koronare Herzkrankheit
Erkrankungen, M. F. K. (2011)
EVALUATING THE IMPACTS OF ANTIDEPRESSANT USE ON THE RISK OF DEMENTIA
Duan, R. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.123
Strattan, L. E. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.097
Lambert, J. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.30576.487883
Perspectives on Neuroscience and Behavior
(2001) · The Neuroscientist · doi:10.1177/107385840100700102
Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung
Sichler, M. E. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9445
Age- and ApoE Genotype-Dependent Transcriptomic Responses to O3 in the Hippocampus of Mice
Nakamya, M. F., Hu, K., Jiang, C., Chong, Z., & Liu, R.-M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062407
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543276
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543279
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543273
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543264
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543267
Williams, T., Bathe, T., Vo, Q., Sacilotto, P., McFarland, K. N., Ruiz, A. J., Hery, G. P., Sullivan, P. M., Borchelt, D. R., Prokop, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23543261
Mouse models elucidating the role of apolipoprotein E in neurological conditions
Torres, E. R. S., & Raber, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00001-5
Self-citationRaber, J., & Nielsen, H. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_41-1
Self-citationRaber, J., & Nielsen, H. M. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_41
Self-citationSaul, A. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3915
Die Alzheimer-Krankheit: Molekulare Grundlagen und Therapieansätze
Finckh, U., Höck, C., & Nitsch, R. M. (2004) · Springer eBooks · doi:10.1007/978-3-642-18741-4_6
Metadata
- Authors
- Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Raber, Jacob
- Venue
- Nature
- Published
- 2000-03
- Volume
- 404
- Issue
- 6776
- Pages
- 352-354
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2089690753
- Cited by
- 237
- References
- 14
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, APOE ε4, APOE3, Alzheimer's disease, amyloid-beta, spatial memory, cognitive impairment, transgenic mice, amyloid precursor protein, genetic risk
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Cognition, Crosses, Genetic, Female, Humans, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Sex Characteristics, Space Perception, Amyloid beta-Protein Precursor, Maze Learning, Protein Isoforms, Mice, Apolipoprotein E3, Apolipoprotein E4
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