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Apolipoprotein E and cognitive performance
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“Interestingly, there was no difference in soluble Aβ levels between apoE3/APP and apoE4/APP transgenic mice, suggesting that the differential effect of apoE isoform on cognition may be due to its ability to modulate functional neuronal deficits triggered by Aβ or APP.”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
In the citing paper
“In transgenic mouse models with neuronal apoE over-expression, apoE4 mice, primarily females, had impairments in learning a water maze test and in vertical exploratory activity, compared with apoE3 mice (Raber et al., 2000).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Raber et al., 2000
In the citing paper
“Male apoE4 mice had significant deficits in spatial memory, whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“whereas apoE3 prevented Aβ or APP-induced cognitive impairment (Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“and were more severely impaired in learning and memory (Hartman et al., 2001; Raber et al., 1998; Raber et al., 2000).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Raber et al., 2000
In the citing paper
“apoE isoform specific sex differences in behavior have been previously shown (Raber et al., 1998, Raber et al., 2000).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Raber et al., 2000
In the citing paper
“For example, both apoE4 transgenic and apoE4-KI mice show age- and sex-dependent learning and memory deficits in the absence of Aβ accumulation, as compared to apoE3 transgenic and apoE3-KI mice [68–71].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [69]
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“…enolases; GFAP, glial fibrillary acidic protein; KO, knock-out; KI, knock-in; TG, transgenic mouse; WM, water maze test; RAM, radial arm maze test; LTP, long term potentiation ments in learning a water maze test and in vertical exploratory activity, compared with apoE3 mice (Raber et al., 2000).”
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Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment
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Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
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Self-citationEffects of sex and APOE ε4 on object recognition and spatial navigation in the elderly
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Self-citationSex- and APOE Isoform-Dependent Effects of Radiation on Cognitive Function
Villasana, L., Acevedo, S. F., Poage, C. T., & Raber, J. (2006) · Radiation Research · doi:10.1667/rr0642.1 · Cited by 74
Self-citationDefective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function.
Teter, B., Xu, P., Gilbert, J. R., Roses, A. D., Galasko, D., & Cole, G. M. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10221 · Cited by 74
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Apolipoprotein E4 and Sex Affect Neurobehavioral Performance in Primary School Children
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Epigenetic signature and enhancer activity of the human APOE gene
Yu, C., Cudaback, E., Foraker, J. E., Thomson, Z., Leong, L., Lutz, F., Gill, J. A., Saxton, A. D., Kraemer, B. C., Navas, P. A., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt354 · Cited by 71
Buttini, M., Masliah, E., Yu, G.-Q., Palop, J. J., Chang, S., Bernardo, A., Lin, C., Wyss-Coray, T., Huang, Y., & Mucke, L. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090973 · Cited by 80
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The generation and function of soluble apoE receptors in the CNS
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AR, apoE, and cognitive function
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Metadata
- Authors
- Raber, J., Wong, D., Yu, G.-Q., Buttini, M., Mahley, R. W., Pitas, R. E., & Mucke, L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Raber, Jacob
- Venue
- Nature
- Published
- 2000-03
- Volume
- 404
- Issue
- 6776
- Pages
- 352-354
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2089690753
- Cited by
- 237
- References
- 14
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, APOE ε4, APOE3, Alzheimer's disease, amyloid-beta, spatial memory, cognitive impairment, transgenic mice, amyloid precursor protein, genetic risk
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Cognition, Crosses, Genetic, Female, Humans, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Sex Characteristics, Space Perception, Amyloid beta-Protein Precursor, Maze Learning, Protein Isoforms, Mice, Apolipoprotein E3, Apolipoprotein E4
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