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Isoform-specific effects of apolipoprotein E on cognitive performance in targeted-replacement mice overexpressing human APP
Abstract
The ε4 allele of apolipoprotein E (apoE4) is the predominant genetic risk factor for late‐onset Alzheimer's disease (AD) and is also implicated in cognitive deficits associated with normal aging. The biological mechanisms by which APOE genotype affects cognitive processes or AD pathogenesis remain unclear, but interactions of apoE with amyloid β peptide (Aβ) are thought to play an important role in mediating apoE's isoform‐specific effects on brain function. Here, we investigated the potential isoform‐dependent effects of apoE on behavioral and cognitive performance in human apoE3 and apoE4 targeted‐replacement (TR) mice that also overexpress the human amyloid precursor protein (APP). Beginning at 6–7 months of age, female APP‐Yac/apoE3‐TR (‘poE3’) and APP‐Yac/apoE4‐TR (‘poE4’) mice were tested on a battery of tests to evaluate basic sensorimotor functioning, spatial working memory, spatial recognition, episodic‐like memory and attentional processing. Compared with apoE3 mice, a generalized reduction in locomotor activity was observed in apoE4 mice. Moderate, but significant, cognitive impairments were also detected in apoE4 mice in the novel object‐location preference task, the contextual fear conditioning test, and a two‐choice visual discrimination/detection test, however spontaneous alternation performance in the Y‐maze was spared. These results offer additional support for the negative impact of apoE4 on both memory and attention and further suggest that APP‐Yac/apoE‐TR mice provide a novel and useful model for investigating the role of apoE in mediating susceptibility to cognitive decline.
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APOE genotype has been shown to affect fear conditioning in mice.
“APOE genotype has been shown to affect fear conditioning in mice (Kornecook et al., 2010, Olsen et al., 2012).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Kornecook et al., 2010
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Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · cited 3×
“…increased in women (Farlow 1997; Farrer et al. 1997; Ghebremedhin et al. 2001; Mortensen and Høgh 2001; Bartrés-Faz et al. 2002), a finding supported by preclinical data indicating more pronounced effects of apoE4 in female mice (Grootendorst et al. 2005; Hartman et al. 2001; Raber et al. 1998).”
BackgroundResultHoltzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y., & Paul, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6179 · Cited by 349
Dineley, K. T., Xia, X., Bui, D., Sweatt, J. D., & Zheng, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200164200 · Cited by 212 · cited 1×
“…stimuli or increasing the length of the retention delay, all of which have been shown to affect the nature or appearance of contextual fear memory deficits in transgenic mouse models of AD (Corcoran et al. 2002; Dineley et al. 2002; Kimura and Ohno 2009), remains a topic for future investigation.”
BackgroundSadowski, M. J., Pankiewicz, J., Scholtzova, H., Mehta, P. D., Prelli, F., Quartermain, D., & Wisniewski, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604011103 · Cited by 167
Hartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L., & Holtzman, D. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7715 · Cited by 157
Clinical application of apolipoprotein E genotyping to Alzheimer's disease
Roses, A., Strittmatter, W., Pericak-Vance, M., Corder, E., Saunders, A., & Schmechel, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92960-2 · Cited by 125 · cited 2×
“…status has been reported to be predictive of neuropsychological test performance in both demented and non-demented populations (Reed et al. 1994; Roses et al. 1994; Craft et al. 1998), and apoE4 is associated with more rapid cognitive decline in healthy elderly individuals (Caselli et al. 1999;…”
BackgroundGender and age modify the association between APOE and AD-related neuropathology
Ghebremedhin, E., Schultz, C., Thal, D. R., Rüb, U., Ohm, T. G., Braak, E., & Braak, H. (2001) · Neurology · doi:10.1212/wnl.56.12.1696 · Cited by 108
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Research works printed but not linked: 41
- 10.1002/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7 · DOI
- Bartrés‐Faz D., 2002, Apolipoprotein E gender effects on cognitive performance in age‐associated memory impairment, J Neuropsychiatry Clin Neurosci, 14, 80, 10.1176/jnp.14.1.80 · DOI
- 10.1016/j.bbr.2008.05.008 · DOI · Paper page
- Brendza R.P. Bales K.R. Paul S.M.&Holtzman D.M.(2002).Role of apoE/Aβ interactions in Alzheimer's disease: insights from transgenic mouse models.Mol Psychiatry7 132–135. · DOI
- 10.1212/WNL.53.1.201 · DOI
- 10.1101/lm.51002 · DOI · Paper page
- 10.1126/science.8346443 · DOI · Paper page
- 10.1212/WNL.51.1.149 · DOI · Paper page
- 10.1016/S0006-8993(98)01258-X · DOI
- 10.1016/j.physbeh.2006.08.009 · DOI
- 10.1016/j.bbr.2009.04.036 · DOI
- 10.1006/nbdi.2002.0483 · DOI · Paper page
- 10.1212/WNL.48.5_Suppl_6.30S · DOI
- 10.1001/jama.1997.03550160069041 · DOI · Paper page
- 10.1002/1096-8628(20001204)96:6<707::AID-AJMG1>3.0.CO;2-V · DOI
- Gold C.A.&Budson A.E.(2008).Memory loss in Alzheimer's disease: implications for development of therapeutics.Expert Rev Neurother8 1879–1891. · DOI
- 10.1037/0894-4105.19.2.199 · DOI
- 10.1016/j.bbr.2004.09.019 · DOI · Paper page
- 10.1016/j.nbd.2008.10.006 · DOI · Paper page
- 10.1016/S0149-7634(01)00041-0 · DOI
- 10.1038/ng0993-22 · DOI · Paper page
- 10.1097/00002093-199501002-00008 · DOI
- 10.1126/science.3283935 · DOI · Paper page
- 10.1073/pnas.0600549103 · DOI · Paper page
- 10.1385/JMN:23:3:235 · DOI · Paper page
- 10.1212/WNL.57.1.89 · DOI
- 10.1002/(SICI)1096-9861(19980323)392:4<428::AID-CNE2>3.0.CO;2-2 · DOI
- 10.1016/0006-8993(91)91092-F · DOI · Paper page
- 10.1016/j.bbr.2006.02.019 · DOI
- 10.1016/0896-6273(93)90070-8 · DOI · Paper page
- 10.1001/archneur.1994.00540240033012 · DOI
- 10.1037/0735-7044.106.2.274 · DOI · Paper page
- 10.1016/0166-2236(94)90156-2 · DOI
- 10.1073/pnas.95.18.10914 · DOI · Paper page
- 10.1212/WNL.43.8.1467 · DOI · Paper page
- 10.1073/pnas.90.5.1977 · DOI · Paper page
- 10.1016/j.neuroscience.2003.10.011 · DOI · Paper page
- 10.1016/0166-4328(96)00016-2 · DOI
- 10.1016/j.bbr.2006.10.024 · DOI
- 10.1096/fasebj.10.13.8940294 · DOI
- Wisniewski T., 1994, Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro, Am J Pathol, 145, 1030
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Kim, J., Yoon, H., Basak, J., & Kim, J. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0248 · Cited by 141
“ATP-binding cassette transporter A1 (ABCA1) overexpression in APP transgenic mice also showed a similar phenotype (Wahrle et al., 2008).”
BackgroundInfluentialJohnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice
Salomon-Zimri, S., Boehm-Cagan, A., Liraz, O., & Michaelson, D. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354777 · Cited by 34
Metadata
- Authors
- Kornecook, T. J., McKinney, A. P., Ferguson, M. T., & Dodart, J. ‐.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 9
- Issue
- 2
- Pages
- 182-192
- ISSN
- 1601-1848
- 1601-183X
- Cited by
- 27
- References
- 8
- Language
- en
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