The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Medicinal strategies in the treatment of obesity
Abstract
When prevention fails, medicinal treatment of obesity may become a necessity. Any strategic medicinal development must recognize that obesity is a chronic, stigmatized and costly disease that is increasing in prevalence. Because obesity can rarely be cured, treatment strategies are effective only as long as they are used, and combined therapy may be more effective than monotherapy. For a drug to have significant impact on body weight it must ultimately reduce energy intake, increase energy expenditure, or both. Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion.
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“inhibiting their reuptake is the strategy employed by drugs such as sibutramine, which have proven effective but have side effects such as increased blood pressure and heart rate [40].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [40]
In the citing paper
“orlistat promotes weight loss; however, side effects caused discontinuation of the medication in many patients [40].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [40]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity : Preventing and managing the global epidemic
Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214
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Research works printed but not linked: 4
- Bray, G. A. Current and Contemporary Management of Obesity (Handbooks in Health Care, Newtown, PA, 1998).
- Conavatchel, W. Long-term tolerability profile of orlistat, an intestinal lipase inhibitor . Diabetologia 40, A196 ( 1997).
- Smeets, M., Geiselman, P., Bray, G. A. & York, D. A. The effect of oral enterostatin on hunger and food intake in human volunteers . FASEB J. 13, A871 ( 1999).
- Palmiter, R. D. et al. in Pennington Center Nutrition Series: Nutrition, Genetics, and Obesity 269–286 (Louisiana State Univ. Press, Baton Rouge, 1999).
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Schäffler, A., & Palitzsch, K.-D. (2001) · Springer eBooks · doi:10.1007/978-3-642-59539-4_17
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Gul, T., Haq, E., Balkhi, H. M., Reddy, G., Sawant, S. D., & Hamid, A. (2017) · Research Journal of Life Sciences Bioinformatics Pharmaceutical and Chemical Sciences · doi:10.26479/2017.0304.05
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Nauck, M. A. (2003) · Springer eBooks · doi:10.1007/978-3-642-55896-2_47
Basdevant, A. (2001) · Revue Française des Laboratoires · doi:10.1016/s0338-9898(01)80193-1
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Almeida, M., Rodrigues, G. S., Pinto, L. A., Stoppa, E. G., Machado, M. P. R., Gama, L. A., Soares, G. A., Marquez, R. G., Américo, M. F., & Miranda, J. R. D. A. (2025) · Surgery Open Digestive Advance · doi:10.1016/j.soda.2025.100213
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BindingDB Entry 50014867: BMS-201620: a selective beta 3 agonist.
BindingDB (2009) · UC San Diego · doi:10.7270/q2mp52q7
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BindingDB (2012) · UC San Diego · doi:10.7270/q2ms3t97
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Metadata
- Authors
- Bray, G. A., & Tartaglia, L. A.
- Affiliations
- Pennington Biomedical Research Center (US)
- Takeda Oncology (United States) (US)
- ORCID
- Bray, George A.
- Venue
- Nature
- Published
- 2000-04
- Volume
- 404
- Issue
- 6778
- Pages
- 672-677
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1489925379
- Cited by
- 432
- References
- 93
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 19 · 2015: 11 · 2014: 25 · 2013: 12 · 2012: 23
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- obesity, anti-obesity drugs, sibutramine, orlistat, energy expenditure, energy intake, combination therapy, chronic disease, obesity treatment strategies
- MeSH terms
- Adipose Tissue, Dietary Fats, Eating, Energy Metabolism, Humans, Intestinal Absorption, Neuropeptides, Obesity, Anti-Obesity Agents
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