The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Medicinal strategies in the treatment of obesity
Abstract
When prevention fails, medicinal treatment of obesity may become a necessity. Any strategic medicinal development must recognize that obesity is a chronic, stigmatized and costly disease that is increasing in prevalence. Because obesity can rarely be cured, treatment strategies are effective only as long as they are used, and combined therapy may be more effective than monotherapy. For a drug to have significant impact on body weight it must ultimately reduce energy intake, increase energy expenditure, or both. Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion.
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In the citing paper
“inhibiting their reuptake is the strategy employed by drugs such as sibutramine, which have proven effective but have side effects such as increased blood pressure and heart rate [40].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [40]
In the citing paper
“orlistat promotes weight loss; however, side effects caused discontinuation of the medication in many patients [40].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [40]
Citations
Cites
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Flagged first, then by citations
Research works printed but not linked: 4
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Cited by
Sorted by citations
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
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Metadata
- Authors
- Bray, G. A., & Tartaglia, L. A.
- Affiliations
- Pennington Biomedical Research Center (US)
- Takeda Oncology (United States) (US)
- ORCID
- Bray, George A.
- Venue
- Nature
- Published
- 2000-04
- Volume
- 404
- Issue
- 6778
- Pages
- 672-677
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1489925379
- Cited by
- 432
- References
- 93
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 19 · 2015: 11 · 2014: 25 · 2013: 12 · 2012: 23
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- obesity, anti-obesity drugs, sibutramine, orlistat, energy expenditure, energy intake, combination therapy, chronic disease, obesity treatment strategies
- MeSH terms
- Adipose Tissue, Dietary Fats, Eating, Energy Metabolism, Humans, Intestinal Absorption, Neuropeptides, Obesity, Anti-Obesity Agents
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