Cited by 435Pharmacology and Obesity TreatmentRegulation of Appetite and ObesityBariatric Surgery and Outcomes

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Medicinal strategies in the treatment of obesity

Bray, George A., Tartaglia, Louis A.·2000·Nature

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Abstract

When prevention fails, medicinal treatment of obesity may become a necessity. Any strategic medicinal development must recognize that obesity is a chronic, stigmatized and costly disease that is increasing in prevalence. Because obesity can rarely be cured, treatment strategies are effective only as long as they are used, and combined therapy may be more effective than monotherapy. For a drug to have significant impact on body weight it must ultimately reduce energy intake, increase energy expenditure, or both. Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion.

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Obesity and the regulation of energy balance
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See all 435

Authors: Bray, G. A., & Tartaglia, L. A.
Affiliations: Pennington Biomedical Research Center (US)
Takeda Oncology (United States) (US)
ORCID: Bray, George A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-04
Volume: 404
Issue: 6778
Pages: 672-677
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35007544
OpenAlex: W1489925379
Cited by: 432
References: 93
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 19 · 2015: 11 · 2014: 25 · 2013: 12 · 2012: 23
FWCI: 4.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords: obesity, anti-obesity drugs, sibutramine, orlistat, energy expenditure, energy intake, combination therapy, chronic disease, obesity treatment strategies
MeSH terms: Adipose Tissue, Dietary Fats, Eating, Energy Metabolism, Humans, Intestinal Absorption, Neuropeptides, Obesity, Anti-Obesity Agents

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