Cited by 599Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, Bert, Rentzsch, Fabian, Kuhn, Kerstin, Happel, Christoph M., von Laue, Christoph Cramer, Snyder, Petra, Rothbächer, Ute, Holstein, Thomas W.·2000·Nature

DOI 10.1038/35025063

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Abstract

Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues. Wnt signalling pathways are conserved in nematodes, insects and vertebrates. Despite its developmental significance, the evolutionary origin of Wnt signalling is unclear. Here we describe the molecular characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria. Wnt and Tcf are expressed in the putative Hydra head organizer, the upper part of the hypostome. Wnt, beta-Catenin and Tcf are transcriptionally upregulated when head organizers are established early in bud formation and head regeneration. Wnt and Tcf expression domains also define head organizers created by de novo pattern formation in aggregates. Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals.

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Authors: Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W.
Affiliations: Technische Universität Darmstadt (DE)
Institut de Biologie du Développement Marseille (FR)
Corresponding author: Hobmayer, Bert
ORCID: Hobmayer, Bert
Rentzsch, Fabian
Happel, Christoph M.
Rothbächer, Ute
Holstein, Thomas W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-09
Volume: 407
Issue: 6801
Pages: 186-189
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35025063
OpenAlex: W1784854092
Cited by: 599
References: 36
Citations by year: 2026: 14 · 2025: 25 · 2024: 20 · 2023: 19 · 2022: 32 · 2021: 37 · 2020: 27 · 2019: 24 · 2018: 15 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 15 · 2012: 30
FWCI: 31.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
TUbilio (Technical University of Darmstadt) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: Wnt signaling, axis formation, Hydra, head organizer, hypostome, Dishevelled, glycogen synthase kinase-3, β-catenin, TCF/LEF, head regeneration, bud formation, Cnidaria
MeSH terms: Dishevelled Proteins, Animals, Cytoskeletal Proteins, Hydra, Molecular Sequence Data, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Polymerase Chain Reaction, Body Patterning, Organizers, Embryonic, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

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