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Cited by 599Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, Bert, Rentzsch, Fabian, Kuhn, Kerstin, Happel, Christoph M., von Laue, Christoph Cramer, Snyder, Petra, Rothbächer, Ute, Holstein, Thomas W.·2000·Nature
DOI 10.1038/35025063
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Abstract

Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues. Wnt signalling pathways are conserved in nematodes, insects and vertebrates. Despite its developmental significance, the evolutionary origin of Wnt signalling is unclear. Here we describe the molecular characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria. Wnt and Tcf are expressed in the putative Hydra head organizer, the upper part of the hypostome. Wnt, beta-Catenin and Tcf are transcriptionally upregulated when head organizers are established early in bud formation and head regeneration. Wnt and Tcf expression domains also define head organizers created by de novo pattern formation in aggregates. Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals.

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Crossref · 10.1038/35025063

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Metadata

Authors
Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W.
Affiliations
  • Technische Universität Darmstadt (DE)
  • Institut de Biologie du Développement Marseille (FR)
Corresponding author
Hobmayer, Bert
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2000-09
Volume
407
Issue
6801
Pages
186-189
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/35025063
OpenAlex
W1784854092
Cited by
599
References
36
Citations by year
2026: 14 · 2025: 25 · 2024: 20 · 2023: 19 · 2022: 32 · 2021: 37 · 2020: 27 · 2019: 24 · 2018: 15 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 15 · 2012: 30
FWCI
31.97
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • TUbilio (Technical University of Darmstadt) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords
Wnt signaling, axis formation, Hydra, head organizer, hypostome, Dishevelled, glycogen synthase kinase-3, β-catenin, TCF/LEF, head regeneration, bud formation, Cnidaria
MeSH terms
Dishevelled Proteins, Animals, Cytoskeletal Proteins, Hydra, Molecular Sequence Data, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Polymerase Chain Reaction, Body Patterning, Organizers, Embryonic, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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