Cited by 599Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, Bert, Rentzsch, Fabian, Kuhn, Kerstin, Happel, Christoph M., von Laue, Christoph Cramer, Snyder, Petra, Rothbächer, Ute, Holstein, Thomas W.·2000·Nature

DOI 10.1038/35025063

Open this paper in CoChat — free account

Abstract

Members of the Wnt/wingless family of secreted proteins act as short-range inducers and long-range organizers during axis formation, organogenesis and tumorigenesis in many developing tissues. Wnt signalling pathways are conserved in nematodes, insects and vertebrates. Despite its developmental significance, the evolutionary origin of Wnt signalling is unclear. Here we describe the molecular characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria. Wnt and Tcf are expressed in the putative Hydra head organizer, the upper part of the hypostome. Wnt, beta-Catenin and Tcf are transcriptionally upregulated when head organizers are established early in bud formation and head regeneration. Wnt and Tcf expression domains also define head organizers created by de novo pattern formation in aggregates. Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals.

Integrity signals

Registry

Crossref · 10.1038/35025063

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A theory of biological pattern formation
Gierer, A., & Meinhardt, H. (1972) · Kybernetik · doi:10.1007/bf00289234 · Cited by 3,158
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
Evidence for a clade of nematodes, arthropods and other moulting animals
Aguinaldo, A. M. A., Turbeville, J. M., Linford, L. S., Rivera, M. C., Garey, J. R., Raff, R. A., & Lake, J. A. (1997) · Nature · doi:10.1038/387489a0 · Cited by 1,609
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
Wetering, M. L. V. D., Cavallo, R. A., Dooijes, D., van Beest, M., van Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T. L., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,347
Animal evolution: interrelationships of the living phyla
(2012) · Choice Reviews Online · doi:10.5860/choice.50-1469 · Cited by 1,041
Principles of Development
Wolpert, L., Tickle, C. A., Arias, A. M., Lawrence, P. A., & Locke, J. C. W. (2019) · Oxford University Press eBooks · doi:10.1093/hesc/9780198800569.001.0001 · Cited by 991
Early animal evolution: emerging views from comparative biology and geology
Knoll, A. H., & Carroll, S. B. (1999) · Science · doi:10.1126/science.284.5423.2129 · Cited by 821
Principles of Development
Webster, S. (2018) · doi:10.1002/9781394322084.ch1 · Cited by 786
PCR primer: a laboratory manual.
Dieffenbach, C. W., & Dveksler, G. S. (2003) · Cited by 733

Flagged first, then by citations

Show all 36 references

Sorted by citations

The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537
The Hedgehog and Wnt signalling pathways in cancer
Taipale, J., & Beachy, P. A. (2001) · Nature · doi:10.1038/35077219 · Cited by 1,394
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,210
Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint
Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101
The dynamic genome of Hydra
Chapman, J. A., Kirkness, E. F., Simakov, O., Hampson, S. E., Mitros, T., Weinmaier, T., Rattei, T., Balasubramanian, P. G., Borman, J., Busam, D., et al. (2010) · Nature · doi:10.1038/nature08830 · Cited by 810
Unexpected complexity of the Wnt gene family in a sea anemone
Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599
New aspects of Wnt signaling pathways in higher vertebrates
Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 561
Wnt Signaling and the Polarity of the Primary Body Axis
Petersen, C. P., & Reddien, P. W. (2009) · Cell · doi:10.1016/j.cell.2009.11.035 · Cited by 544
Wnt Signaling Induces the Myogenic Specification of Resident CD45+ Adult Stem Cells during Muscle Regeneration
Polesskaya, A., Seale, P., & Rudnicki, M. A. (2003) · Cell · doi:10.1016/s0092-8674(03)00437-9 · Cited by 515
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Bridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators
Rim, E. Y., Clevers, H. C., & Nusse, R. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-103615 · Cited by 507
Slicing across Kingdoms: Regeneration in Plants and Animals
Birnbaum, K. D., & Alvarado, A. S. (2008) · Cell · doi:10.1016/j.cell.2008.01.040 · Cited by 432
Secreted Frizzled‐related proteins: searching for relationships and patterns
Jones, S. E., & Jomary, C. (2002) · BioEssays · doi:10.1002/bies.10136 · Cited by 427
Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration
Chera, S., Ghila, L., Dobretz, K., Wenger, Y., Bauer, C. R., Buzgariu, W., Martinou, J., & Galliot, B. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.014 · Cited by 424
Pattern formation during de novo assembly of the Arabidopsis shoot meristem
Gordon, S., Heisler, M. G., Reddy, G. V., Ohno, C. K., Das, P. K., & Meyerowitz, E. M. (2007) · Development · doi:10.1242/dev.010298 · Cited by 388
Stem cell differentiation trajectories in Hydra resolved at single-cell resolution
Siebert, S., Farrell, J. A., Cazet, J. F., Abeykoon, Y., Primack, A. S., Schnitzler, C. E., & Juliano, C. E. (2019) · Science · doi:10.1126/science.aav9314 · Cited by 360
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
Loh, K. M., van Amerongen, R., & Nusse, R. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.011 · Cited by 335
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface
Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 334
An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation
Wikramanayake, A. H., Hong, M., Lee, P. N., Pang, K., Byrum, C. A., Bince, J. M., Xu, R., & Martindale, M. Q. (2003) · Nature · doi:10.1038/nature02113 · Cited by 324
Multiple Wnts are involved in Hydra organizer formation and regeneration
Lengfeld, T., Watanabe, H., Simakov, O., Lindgens, D., Gee, L., Law, L. Y., Schmidt, H. A., Özbek, S., Bode, H. R., & Holstein, T. W. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.02.004 · Cited by 300
Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis
Wittlieb, J., Khalturin, K., Lohmann, J. U., Anton‐Erxleben, F., & Bosch, T. C. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510163103 · Cited by 298
On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
Niehrs, C. (2010) · Development · doi:10.1242/dev.039651 · Cited by 283
Formation of the head organizer in hydra involves the canonical Wnt pathway.
Broun, M., Gee, L., Reinhardt, B., & Bode, H. R. (2005) · Development · doi:10.1242/dev.01848 · Cited by 287
Evolutionary crossroads in developmental biology: Cnidaria
Technau, U., & Steele, R. E. (2011) · Development · doi:10.1242/dev.048959 · Cited by 274
Muscle cells provide instructions for planarian regeneration
Witchley, J. N., Mayer, M., Wagner, D. E., Owen, J. H., & Reddien, P. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.022 · Cited by 264
Cnidarians: An evolutionarily conserved model system for regeneration?
Holstein, T. W., Hobmayer, E., & Technau, U. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10227 · Cited by 225
Wnt signaling
Eisenmann, D. M. (2005) · WormBook · doi:10.1895/wormbook.1.7.1 · Cited by 297
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
Gurley, K. A., Elliott, S. A., Simakov, O., Schmidt, H. A., Holstein, T. W., & Alvarado, A. S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.007 · Cited by 212
Models of Biological Pattern Formation: From Elementary Steps to the Organization of Embryonic Axes
Meinhardt, H. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)81001-5 · Cited by 219
The Evolution of the Wnt PathwayPreprint
Holstein, T. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007922 · Cited by 222
Unifying principles of regeneration I: Epimorphosis versus morphallaxis
Agata, K., Saito, Y., & Nakajima, E. (2007) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2007.00919.x · Cited by 210
Origin and evolution of endoderm and mesoderm
Technau, U., & Scholz, C. B. (2003) · The International Journal of Developmental Biology · doi:10.1387/ijdb.14756329 · Cited by 208
T‐cell factors: turn‐ons and turn‐offs
Hurlstone, A. F. L., & Clevers, H. C. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2303 · Cited by 208
Involvement of Wingless/Armadillo signaling in the posterior sequential segmentation in the cricket, Gryllus bimaculatus (Orthoptera), as revealed by RNAi analysis
Miyawaki, K., Mito, T., Sarashina, I., Zhang, H., Shinmyo, Y., Ohuchi, H., & Noji, S. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.01.002 · Cited by 201
The Genomic and Cellular Foundations of Animal Origins
Richter, D. J., & King, N. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133456 · Cited by 196
Why polyps regenerate and we don't: Towards a cellular and molecular framework for Hydra regeneration
Bosch, T. C. G. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.012 · Cited by 186
A WNT of things to come: Evolution of Wnt signaling and polarity in cnidarians
LEE, P., PANG, K., Matus, D. Q., & Martindale, M. Q. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.05.002 · Cited by 180
Discovering the Molecular Components of Intercellular Junctions--A Historical ViewPreprint
Franke, W. W. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003061 · Cited by 191
The Wnt code: cnidarians signal the way
Guder, C., Philipp, I., Lengfeld, T., Watanabe, H., Hobmayer, B., & Holstein, T. W. (2006) · Oncogene · doi:10.1038/sj.onc.1210052 · Cited by 177
Hydra, a fruitful model system for 270 years
Galliot, B. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.120086bg · Cited by 178
Evolution of striated muscle: Jellyfish and the origin of triploblasty
Seipel, K., & Schmid, V. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.03.032 · Cited by 172
Origins of neurogenesis, a cnidarian view
Galliot, B., Quiquand, M., Ghila, L., de Rosa, R., Miljkovic-Licina, M., & Chera, S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.563 · Cited by 168
An ancient Wnt-Dickkopf antagonism inHydra
Guder, C., Pinho, S., Nacak, T. G., Schmidt, H. A., Hobmayer, B., Niehrs, C., & Holstein, T. W. (2006) · Development · doi:10.1242/dev.02265 · Cited by 168
A maternally localised Wnt ligand required for axial patterning in the cnidarian Clytia hemisphaerica
Momose, T., Derelle, R., & Houliston, E. (2008) · Development · doi:10.1242/dev.021543 · Cited by 170
Two Oppositely Localised Frizzled RNAs as Axis Determinants in a Cnidarian Embryo
Momose, T., & Houliston, E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050070 · Cited by 163
Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis
Fritzenwanker, J. H., Saina, M., & Technau, U. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.014 · Cited by 165
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition
Ros-Rocher, N., Pérez-Posada, A., Leger, M. M., & Ruiz‐Trillo, I. (2021) · Open Biology · doi:10.1098/rsob.200359 · Cited by 169
Wnt/β-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra
Philipp, I., Aufschnaiter, R., Özbek, S., Pontasch, S., Jenewein, M., Watanabe, H., Rentzsch, F., Holstein, T. W., & Hobmayer, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812847106 · Cited by 152
Parameters of self-organization in Hydra aggregates
Technau, U., von Laue, C. C., Rentzsch, F., Luft, S., Hobmayer, B., Bode, H. R., & Holstein, T. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12127 · Cited by 156
It takes guts: the Drosophila hindgut as a model system for organogenesis.
Lengyel, J., & Iwaki, D. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0577 · Cited by 157
Three Amphioxus Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates
Schubert, M., Holland, L. Z., Stokes, M. D., & Holland, N. D. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0460 · Cited by 150
Diversification of gene function: homologs of the floral regulatorFLO/LFYcontrol the first zygotic cell division in the mossPhyscomitrella patens
Tanahashi, T., Sumikawa, N., Kato, M., & Hasebe, M. (2005) · Development · doi:10.1242/dev.01709 · Cited by 149
Brachyury, the blastopore and the evolution of the mesoderm
Technau, U. (2001) · BioEssays · doi:10.1002/bies.1114 · Cited by 148
Cnidarians as a model system for understanding evolution and regeneration
Galliot, B., & Schmid, V. J. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11902686 · Cited by 143
Head regeneration in Hydra
Bode, H. R. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10225 · Cited by 146
The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)
Scholz, C. B., & Technau, U. (2003) · Development Genes and Evolution · doi:10.1007/s00427-002-0272-x · Cited by 142
How do they do Wnt they do?: regulation of transcription by the Wnt/β‐catenin pathway
Archbold, H. C., Yang, Y., Chen, L., & Cadigan, K. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02293.x · Cited by 149
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
Valkenburg, K. C., Graveel, C. R., Diegel, C. R., Zhong, Z. A., & Williams, B. O. (2011) · Cancers · doi:10.3390/cancers3022050 · Cited by 144
Hydra and the evolution of stem cells
Bosch, T. C. G. (2009) · BioEssays · doi:10.1002/bies.200800183 · Cited by 140
Vertebrate Proteins Related to Drosophila Naked Cuticle Bind Dishevelled and Antagonize Wnt Signaling
Wharton, K. A., Zimmermann, G., Rousset, R., & Scott, M. P. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0238 · Cited by 140
The Hydra polyp: Nothing but an active stem cell community
Bosch, T. C. G., Anton‐Erxleben, F., Hemmrich, G., & Khalturin, K. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01143.x · Cited by 137
Turing's theory of morphogenesis of 1952 and the subsequent discovery of the crucial role of local self-enhancement and long-range inhibition
Meinhardt, H. (2012) · Interface Focus · doi:10.1098/rsfs.2011.0097 · Cited by 136
Canonical and non‐canonical Wnt signaling pathways in Caenorhabditis elegans : variations on a common signaling theme
Korswagen, H. C. (2002) · BioEssays · doi:10.1002/bies.10145 · Cited by 135
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer
Nakamura, Y., Tsiairis, C. D., Özbek, S., & Holstein, T. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018109108 · Cited by 134
An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
Vogg, M. C., Beccari, L. L., Ollé, L. I., Rampon, C., Vriz, S., Perruchoud, C., Wenger, Y., & Galliot, B. (2019) · Nature Communications · doi:10.1038/s41467-018-08242-2 · Cited by 123
Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells
Holnthoner, W., Pillinger, M., Gröger, M., Wolff, K. S., Ashton, A. W., Albanese, C., Neumeister, P., Pestell, R. G., & Petzelbauer, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209354200 · Cited by 130
Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?
Steele, R. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0744 · Cited by 129
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Petersen, H. O., Höger, S. K., Looso, M., Lengfeld, T., Kuhn, A., Warnken, U. H., Nishimiya‐Fujisawa, C., Schnölzer, M., Krüger, M., Özbek, S., et al. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv079 · Cited by 128
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells
Valenta, T. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg346 · Cited by 131
Characterization of the head organizer in hydra
Broun, M., & Bode, H. R. (2002) · Development · doi:10.1242/dev.129.4.875 · Cited by 127
Model systems for regeneration: Hydra
Vogg, M. C., Galliot, B., & Tsiairis, C. D. (2019) · Development · doi:10.1242/dev.177212 · Cited by 126
Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation
Khalturin, K., Anton-Erxleben, F., Milde, S., Plötz, C., Wittlieb, J., Hemmrich, G., & Bosch, T. C. G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.06.013 · Cited by 125
A simple plan-Cnidarians and the origins of developmental mechanisms
Ball, E. E., Hayward, D. C., Saint, R., & Miller, D. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1402 · Cited by 123
Nodal signalling determines biradial asymmetry in Hydra
Watanabe, H., Schmidt, H. A., Kuhn, A., Höger, S. K., Kocagöz, Y., Laumann-Lipp, N., Özbek, S., & Holstein, T. W. (2014) · Nature · doi:10.1038/nature13666 · Cited by 119
Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115
Neuropeptides in cnidarians
Grimmelikhuijzen, C. J. P., Williamson, M., & Hansen, G. N. (2002) · Canadian Journal of Zoology · doi:10.1139/z02-137 · Cited by 119
Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval inductionPreprint
Gleason, J. E., Korswagen, H. C., & Eisenmann, D. M. (2002) · Genes & Development · doi:10.1101/gad.981602 · Cited by 119
Early evolution of symmetry and polarity in metazoan body plans
Manuel, M. (2008) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2008.07.009 · Cited by 123
The Dawn of Developmental Signaling in the MetazoaPreprint
Richards, G. S., & Degnan, B. M. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.028 · Cited by 117
Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development
Gleason, J. E., Szyleyko, E. A., & Eisenmann, D. M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.050 · Cited by 112
Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
Harterink, M., Kim, D. H., Middelkoop, T. C., Doan, T. D., van Oudenaarden, A., & Korswagen, H. C. (2011) · Development · doi:10.1242/dev.064733 · Cited by 112
Interstitial stem cells in Hydra: multipotency and decision-making
David, C. N. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113476cd · Cited by 104
HyBMP5-8b , a BMP5-8 orthologue, acts during axial patterning and tentacle formation in hydra
Reinhardt, B., Broun, M., Blitz, I. L., & Bode, H. R. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.031 · Cited by 101
β-Catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii
Darras, S., Gerhart, J. C., Terasaki, M. R., Kirschner, M. W., & Lowe, C. J. (2011) · Development · doi:10.1242/dev.059493 · Cited by 107
β-catenin plays a central role in setting up the head organizer in hydra
Gee, L., Hartig, J. V., Law, L. Y., Wittlieb, J., Khalturin, K., Bosch, T. C. G., & Bode, H. R. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.036 · Cited by 105
The origin and evolution of Wnt signalling
Holzem, M., Boutros, M., & Holstein, T. W. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00699-w · Cited by 110
Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra
Hartl, M., Mitterstiller, A., Valovka, T., Breuker, K., Hobmayer, B., & Bister, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911060107 · Cited by 105
Stemness in Hydra - a current perspective
Hobmayer, B., Jenewein, M., Eder, D., Eder, M.-K., Glasauer, S. M. K., Gufler, S., Hartl, M., & Salvenmoser, W. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113426bh · Cited by 105
Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration
Duffy, D. J., Plickert, G., Künzel, T., Tilmann, W., & Uri Frank, A. (2010) · Development · doi:10.1242/dev.046631 · Cited by 104
Transcriptome profiling of the dynamic life cycle of the scypohozoan jellyfish Aurelia aurita
Brekhman, V., Malik, A., Haas, B. J., Sher, N., & Lotan, T. (2015) · BMC Genomics · doi:10.1186/s12864-015-1320-z · Cited by 101
The Notch signaling pathway in the cnidarian Hydra
Käsbauer, T., Towb, P., Alexandrova, O., David, C. N., Dall'Armi, E., Staudigl, A., Stiening, B., & Böttger, A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.022 · Cited by 99
Wnt Signaling, Stem Cells, and the Cellular Origin of Breast Cancer
Lindvall, C. J., Bu, W., Williams, B. O., & Li, Y. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0025-3 · Cited by 103
Conservation of Hox/ParaHox-Related Genes in the Early Development of a Cnidarian
Yanze, N., Spring, J., Schmidli, C., & Schmid, V. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0299 · Cited by 99
Early embryonic expression of a LIM-homeobox geneCs-lhx3is downstream of β-catenin and responsible for the endoderm differentiation inCiona savignyiembryos
Satou, Y., Imai, K. S., & Satoh, N. (2001) · Development · doi:10.1242/dev.128.18.3559 · Cited by 100
Intercellular Communication: the Drosophila Innexin Multiprotein Family of Gap Junction Proteins
Bauer, R., Löer, B., Ostrowski, K., Martini, J., Weimbs, A., Lechner, H., & Hoch, M. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.02.013 · Cited by 99
Structural Inheritance of the Actin Cytoskeletal Organization Determines the Body Axis in Regenerating Hydra
Livshits, A., Shani-Zerbib, L., Maroudas-Sacks, Y., Braun, E., & Keren, K. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.036 · Cited by 98
Wnt signaling in hydroid development: Formation of the primary body axis in embryogenesis and its subsequent patterning
Plickert, G., Jacoby, V., Uri Frank, A., Müller, W. A., & Mokady, O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.043 · Cited by 97
Immortality and the base of multicellular life: Lessons from cnidarian stem cells
Watanabe, H., Hoang, V. T., Mättner, R. A., & Holstein, T. W. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.09.008 · Cited by 98

Authors: Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W.
Affiliations: Technische Universität Darmstadt (DE)
Institut de Biologie du Développement Marseille (FR)
Corresponding author: Hobmayer, Bert
ORCID: Hobmayer, Bert
Rentzsch, Fabian
Happel, Christoph M.
Rothbächer, Ute
Holstein, Thomas W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-09
Volume: 407
Issue: 6801
Pages: 186-189
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35025063
OpenAlex: W1784854092
Cited by: 599
References: 36
Citations by year: 2026: 14 · 2025: 25 · 2024: 20 · 2023: 19 · 2022: 32 · 2021: 37 · 2020: 27 · 2019: 24 · 2018: 15 · 2017: 20 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 15 · 2012: 30
FWCI: 31.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
TUbilio (Technical University of Darmstadt) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: Wnt signaling, axis formation, Hydra, head organizer, hypostome, Dishevelled, glycogen synthase kinase-3, β-catenin, TCF/LEF, head regeneration, bud formation, Cnidaria
MeSH terms: Dishevelled Proteins, Animals, Cytoskeletal Proteins, Hydra, Molecular Sequence Data, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Polymerase Chain Reaction, Body Patterning, Organizers, Embryonic, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks