Intramembrane proteolysis by presenilins
Abstract
Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.
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Aβ40 is the predominant form of amyloid β produced.
“although A40 is the predominant form of amyloid  (A) produced”
From Aβ40 Inhibits Amyloid Deposition<i>In Vivo</i> (2007) · cites this paper as Steiner and Haass, 2000
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“Sequential amyloid precursor protein (APP) processing by -secretase and -secretase produces a major A species, A 1-40, and a number of minor species, including A 1-42 (Steiner and Haass, 2000).”
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- Authors
- Steiner, H., & Haass, C.
- Affiliations
- Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
- Corresponding author
- Haass, Christian
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2000-12
- Volume
- 1
- Issue
- 3
- Pages
- 217-224
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1522789528
- Cited by
- 161
- References
- 12
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- presenilin, intramembrane proteolysis, Alzheimer's disease, amyloid-beta, secretases, amyloid plaques, neurodegenerative diseases
- MeSH terms
- Alzheimer Disease, Animals, Humans, Membrane Proteins, Models, Biological, Mutation, Endopeptidases, Signal Transduction, Aspartic Acid Endopeptidases, Amyloid beta-Protein Precursor, Neurodegenerative Diseases, Presenilin-1, Presenilin-2, Amyloid Precursor Protein Secretases
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