Lipid metabolism in Alzheimer’s disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

CYCLOOXYGENASES 1 AND 2

Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,737 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works

Statins and the risk of dementia

Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00164-2 · Cited by 1,347 · see citing works

The emerging field of lipidomics

Wenk, M. R. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1776 · Cited by 1,325 · see citing works

The human ATP-binding cassette (ABC) transporter superfamily

Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302 · see citing works

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works

Brain Cholesterol: Long Secret Life Behind a Barrier

Björkhem, I., & Meaney, S. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000120374.59826.1b · Cited by 1,044 · see citing works

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works

Linking lipids to Alzheimer's disease: cholesterol and beyond

Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912 · see citing works

Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions

Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081880 · Cited by 908 · see citing works

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

Kennedy, M. A., Barrera, G. C., Nakamura, K., Baldán, Á., Tarr, P. T., Fishbein, M. C., Frank, J. S., Francone, O. L., & Edwards, P. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.002 · Cited by 885 · see citing works

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works

Alzheimer's disease: the cholesterol connection

Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 864 · see citing works

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works

Lipidomics: coming to grips with lipid diversity

Shevchenko, A., & Simons, K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2934 · Cited by 828 · see citing works

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

Human apolipoprotein E. The complete amino acid sequence

Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741 · see citing works

APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE

Roses, M. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.387 · Cited by 707 · see citing works

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

Söderberg, M., Edlund, C., Kristensson, K., & Dallner, G. (1991) · Lipids · doi:10.1007/bf02536067 · Cited by 667 · see citing works

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

Han, X., M. Holtzman, D., W. McKeel, D., Kelley, J., & Morris, J. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00997.x · Cited by 626 · see citing works

Cellular lipidomics

Gerrit van, M. E. E. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600798 · Cited by 563 · see citing works

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

Han, X., Holtzman, D. M., & McKeel, D. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00332.x · Cited by 562 · see citing works

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Refolo, L. M., Pappolla, M. A., LaFrancois, J. J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M. H., Petanceska, S. S., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0422 · Cited by 521 · see citing works

Use of Lipid-Lowering Agents, Indication Bias, and the Risk of Dementia in Community-Dwelling Elderly People

Rockwood, K. J., Kirkland, S., Hogan, D. B., MacKnight, C., Merry, H. R., Verreault, R., Wolfson, C. M., & McDowell, I. (2002) · Archives of Neurology · doi:10.1001/archneur.59.2.223 · Cited by 517 · see citing works

Deregulation of sphingolipid metabolism in Alzheimer’s disease

He, X., Huang, Y., Li, B., Gong, C.-X., & Schuchman, E. H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.010 · Cited by 516 · see citing works

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., Dong, L. M., Jakes, R., Huang, D. Y., Pericak-Vance, M., Schmechel, D., & Roses, A. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11183 · Cited by 474 · see citing works

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

Puglielli, L., Konopka, G., Pack-Chung, E., Ingano, L. A. M., Berezovska, O., Hyman, B. T., Chang, T., Tanzi, R. E., & Kovacs, D. M. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-905 · Cited by 470 · see citing works

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.

Pasinetti, G., & Aisen, P. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00218-8 · Cited by 457 · see citing works

Lipoprotein receptors in the nervous system

Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135342 · Cited by 457 · see citing works

Cholesterol homeostasis and function in neurons of the central nervous system

Pfrieger, F. W. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3018-7 · Cited by 453 · see citing works

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., et al. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38094-9 · Cited by 436 · see citing works

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

West, X. Z., Malinin, N. L., Merkulova, A. A., Tischenko, M., Kerr, B. A., Borden, E. C., Podrez, E. A., Salomon, R. G., & Byzova, T. V. (2010) · Nature · doi:10.1038/nature09421 · Cited by 431 · see citing works

ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

Gelissen, I. C., Harris, M., Rye, K., Quinn, C. M., Brown, A. J., Kockx, M., Cartland, S. P., Packianathan, M., Kritharides, L., & Jessup, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000200082.58536.e1 · Cited by 430 · see citing works

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

Schindler, S. E., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0470 · Cited by 426 · see citing works

Lipids in membrane protein structures

Pálsdóttir, H., & Hunte, C. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.06.012 · Cited by 424 · see citing works

Cholesterol-dependent Formation of GM1 Ganglioside-bound Amyloid β-Protein, an Endogenous Seed for Alzheimer Amyloid

Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., & Matsuzaki, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100252200 · Cited by 406 · see citing works

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

Haag, M. D. M., Hofman, A., Koudstaal, P. J., Stricker, B. H. C., & Breteler, M. M. B. (2009) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.150433 · Cited by 393 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 381 · see citing works

A neuroscientist's guide to lipidomics

Piomelli, D., Astarita, G., & Rapaka, R. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2233 · Cited by 380 · see citing works

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

Gomez‐Isla, T., West, H. L., Rebeck, G. W., Harr, S. D., Growdon, J. H., Locascio, J. J., Perls, T. T., Lipsitz, L. A., & Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410390110 · Cited by 378 · see citing works

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

Lütjohann, D., Papassotiropoulos, A., Björkhem, I., Locatelli, S., Bagli, M., Oehring, R. D., Schlegel, U. S., Jessen, F., Rao, M. L., von Bergmann, K., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32052-6 · Cited by 378 · see citing works

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Sanchez-Mejia, R. O., Newman, J. W. I., Toh, S., Yu, G.-Q., Zhou, Y., Halabisky, B., Cissé, M., Scearce-Levie, K. A., Cheng, I. H.-J., Gan, L., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2213 · Cited by 369 · see citing works

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H.-S., Wang, B., Cole, S. L., Herz, J., Muglia, L., & Bu, G. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.008 · Cited by 364 · see citing works

Lipid rafts, cholesterol, and the brain

Korade, Z., & Kenworthy, A. K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.019 · Cited by 342 · see citing works

Cholesterol in Alzheimer's disease

Shobab, L. A., Hsiung, G. R., & Feldman, H. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70248-9 · Cited by 332 · see citing works

Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron

Goritz, C., Mauch, D. H., & Pfrieger, F. W. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.02.006 · Cited by 330 · see citing works

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

Poirier, J., Baccichet, A., Dea, D., & Gauthier, S. G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90456-p · Cited by 329 · see citing works

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

Svennerholm, L. T., & Gottfries, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031039.x · Cited by 327 · see citing works

Role of Phosphatidylinositol(4,5)bisphosphate Organization in Membrane Transport by the Unc104 Kinesin Motor

Klopfenstein, D. R., Tomishige, M., Stuurman, N., & Vale, R. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00708-0 · Cited by 327 · see citing works

Oxysterols and neurodegenerative diseases

Björkhem, I., Cedazo-Mı́nguez, Á., Leoni, V., & Meaney, S. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.001 · Cited by 302 · see citing works

Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years

Svennerholm, L. T., Boström, K. B., Jungbjer, B., & Olsson, L. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63051802.x · Cited by 294 · see citing works

Brain Membrane Phospholipid Alterations in Alzheimer's Disease

Pettegrew, J. W., Panchalingam, K., Hamilton, R. L., & McClure, R. J. (2001) · Neurochemical Research · doi:10.1023/a:1011603916962 · Cited by 292 · see citing works

Complete Characterization of the Human ABC Gene Family

Dean, M. C., & Allikmets, R. L. (2001) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1012823120935 · Cited by 290 · see citing works

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Vaughan, A. M., & Oram, J. F. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600218-jlr200 · Cited by 283 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · cited 1× · see citing works

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

Haughey, N. J., Bandaru, V. V. R., Bae, M. H., & Mattson, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.003 · Cited by 271 · see citing works

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

Martín, M. V., Fabelo, N., Santpere, G., Puig, B., Marín, R., Ferrer, I., & Díaz, M. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1242 · Cited by 269 · see citing works

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Liu, Q., Trotter, J., Zhang, J., Peters, M. M., Cheng, H., Bao, J., Han, X., Weeber, E. J., & Bu, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4067-10.2010 · Cited by 268 · see citing works

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Hutter‐Paier, B., Huttunen, H. J., Puglielli, L., Eckman, C. B., Kim, D. Y., Hofmeister, A., Moir, R. D., Domnitz, S. B., Frosch, M. P., Windisch, M., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.043 · Cited by 268 · see citing works

Role of ABCG1 and other ABCG family members in lipid metabolism

Schmitz, G., Langmann, T., & Heimerl, S. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32205-7 · Cited by 265 · see citing works

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256 · see citing works

The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

Riddell, D. R., Zhou, H., Comery, T. A., Kouranova, E., Lo, C. F., Warwick, H. K., Ring, R. H., Kirksey, Y., Aschmies, S., Xu, J., et al. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.011 · Cited by 244 · see citing works

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works

Untitled work

Lalazar (1989) · doi:10.1016/s0021-9258(18)81806-3 · Cited by 238 · see citing works

Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

Guan, Z., Wang, Y., Cairns, N. J., Lantos, P. L., Dallner, G., & Sindelar, P. J. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199907000-00008 · Cited by 236 · see citing works

Lipid Signaling in Neural Plasticity, Brain Repair, and Neuroprotection

Bazan, N. G. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:1:089 · Cited by 235 · see citing works

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease

Hirsch-Reinshagen, V., Maia, L. F., Burgess, B. L., Blain, J.-F., Naus, K. E., McIsaac, S. A., Parkinson, P. F., Chan, J. Y., Tansley, G. H., Hayden, M. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508781200 · Cited by 233 · see citing works

Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer’s disease pathology

Frisardi, V., Panza, F., Seripa, D., Farooqui, T., & Farooqui, A. A. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.001 · Cited by 230 · see citing works

APOE genotype, cholesterol level, lipid-lowering treatment, and dementia

Dufouil, C., Richard, F., Fiévet, N., Dartigues, J., Ritchie, K. A., Tzourio, C., Amouyel, P., & Alpérovitch, A. (2005) · Neurology · doi:10.1212/01.wnl.0000160114.42643.31 · Cited by 229 · see citing works

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.

Fagan, A. M., Bu, G., Sun, Y., Daugherty, A., & Holtzman, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30121 · Cited by 226 · see citing works

Informatics and computational strategies for the study of lipids

Yetukuri, L., Ekroos, K., Vidal‐Puig, A., & Orešič, M. (2007) · Molecular BioSystems · doi:10.1039/b715468b · Cited by 220 · see citing works

Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Malaplate, C., Florent‐Béchard, S., Youssef, I., Koziel, V., Sponne, I., Kriem, B., Leininger‐Muller, B., Olivier, J. L., Oster, T., & Pillot, T. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.010 · Cited by 213 · see citing works

Neurofibrillary tangles in Niemann—Pick disease type C

Love, S., Bridges, L., & Case, C. P. (1995) · Brain · doi:10.1093/brain/118.1.119 · Cited by 211 · see citing works

Inflammation in the early stages of neurodegenerative pathology

Khandelwal, P. J., Herman, A. M., & Moussa, C. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.07.002 · Cited by 211 · see citing works

Role of Lipoproteins in the Delivery of Lipids to Axons during Axonal Regeneration

de Chaves, E. I. P., Rusiñol, A. E., Vance, D. E., Campenot, R. B., & Vance, J. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30766 · Cited by 209 · see citing works

Cholesterol reduction impairs exocytosis of synaptic vesicles

Linetti, A., Fratangeli, A., Taverna, E., Valnegri, P., Francolini, M., Cappello, V., Matteoli, M., Passafaro, M., & Rosa, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.060681 · Cited by 209 · see citing works

Alzheimer’s Disease And Inflammation: A Review Of Cellular And Therapeutic Mechanisms

Halliday, G. M., Robinson, S. R., Shepherd, C. E., & Kril, J. J. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03200.x · Cited by 206 · see citing works

Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains

Stokes, C. E., & Hawthorne, J. N. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05619.x · Cited by 206 · see citing works

Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex

Igarashi, M., Ma, K., Gao, F., Kim, H., Rapoport, S. I., & Rao, J. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101608 · Cited by 200 · see citing works

Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease

Fraser, T., Tayler, H. M., & Love, S. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0087-5 · Cited by 198 · see citing works

Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis

Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.056 · Cited by 195 · see citing works

The Impact of the Use of Statins on the Prevalence of Dementia and the Progression of Cognitive Impairment

Hajjar, I. M., Schumpert, J., Hirth, V., Wieland, D. M., & Eleazer, G. P. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.7.m414 · Cited by 188 · see citing works

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

Esposito, G., Giovacchini, G., Liow, J., Bhattacharjee, A. K., Greenstein, D. K., Schapiro, M. B., Hallett, M., Herscovitch, P., Eckelman, W. C., Carson, R. E., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.049619 · Cited by 182 · see citing works

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

Sun, Y., Yao, J., Kim, T.-W., & Tall, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300760200 · Cited by 179 · see citing works

Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model

Bu, B., Li, J., Davies, P., & Vincent, I. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06515.2002 · Cited by 178 · see citing works

Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer?s disease

Mulder, C., Wahlund, L., Teerlink, T., Blomberg, M. I., Veerhuis, R., van Kamp, G. J., Scheltens, P., & Scheffer, P. G. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0007-9 · Cited by 174 · see citing works

The Neurite Retraction Induced by Lysophosphatidic Acid Increases Alzheimer's Disease-like Tau Phosphorylation

Sayas, C. L., Moreno-Flores, M. T., Ávila, J., & Wandosell, F. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37046 · Cited by 172 · see citing works

Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection

Bazan, N. G. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.024 · Cited by 171 · see citing works

Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens

Farooqui, A. A., Rapoport, S. I., & Horrocks, L. A. (1997) · Neurochemical Research · doi:10.1023/a:1027380331807 · Cited by 163 · see citing works

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

Chen, H.-K., Liu, Z., Meyer-Franke, A., Brodbeck, J., Miranda, R. D., McGuire, J. G., Pleiss, M. A., Ji, Z.-S., Balestra, M. E., Walker, D. W., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276162 · Cited by 163 · see citing works

Intramembrane proteolysis by presenilins

Steiner, H., & Haass, C. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043065 · Cited by 161 · see citing works

Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases

Wang, Q., Yan, J., Chen, X., Li, J., Yang, Y., Weng, J., Deng, C., & Yenari, M. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.04.006 · Cited by 157 · see citing works

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., van Vark-van der Zee, L. C., Kuipers, F., Kiliaan, A., Blokland, A., Sijbrands, E. J. G., Steinbusch, H., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.07.005 · Cited by 154 · see citing works

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

Stephenson, D. T., Rash, K. S., Smalstig, B., Roberts, E. F., Johnstone, E., Sharp, J., Panetta, J., Little, S. P., Kramer, R. M., & Clemens, J. A. (1999) · Glia · doi:10.1002/(sici)1098-1136(199908)27:2 · Cited by 152 · see citing works

Altered cholesterol and fatty acid metabolism in Huntington disease

Block, R. C., Dorsey, E. R., Beck, C. A., Brenna, J. T., & Shoulson, I. (2010) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2009.11.003 · Cited by 152 · see citing works

Cytosolic phospholipase A 2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid‐β peptide

Kriem, B., Sponne, I., Fifre, A., Malaplate, C., Lozac'h‐Pillot, K., Koziel, V., Yen, F. T., Bihain, B. E., Oster, T., Olivier, J. L., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-1807fje · Cited by 152 · see citing works

Alzheimer Disease in 2020Preprint

Holtzman, D. M., Mandelkow, E., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011585 · Cited by 151 · see citing works

Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging

Gupta, V. B., Laws, S. M., Villemagne, V. L., Ames, D., Bush, A. I., Ellis, K. A., Lui, J. K., Masters, C., Rowe, C. C., Szoeke, C., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318211c352 · Cited by 149 · see citing works

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

Ikonomović, M. D., Abrahamson, E. E., Uz, T., Manev, H., & DeKosky, S. T. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2008.951855 · Cited by 147 · see citing works

Organellar lipidomics — background and perspectives

Klose, C. D., Surma, M. A., & Simons, K. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.03.005 · Cited by 146 · see citing works

Plasma 24S-hydroxycholesterol

Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Rao, M. L., Maier, W., Björkhem, I., von Bergmann, K., & Heun, R. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00030 · Cited by 145 · see citing works

Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease

Amtul, Z., Westaway, D. A., Cechetto, D. F., & Rozmahel, R. F. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00449.x · Cited by 140 · see citing works

Neural membrane phospholipids in alzheimer disease

Wells, K., Farooqui, A., Liss, L., & Horrocks, L. (1995) · Neurochemical Research · doi:10.1007/bf00992508 · Cited by 139 · see citing works

The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139 · see citing works

Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain

Grehan, S., Tse, E., & Taylor, J. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00812.2001 · Cited by 138 · see citing works

ABC transporters in cellular lipid trafficking

Schmitz, G., Kaminski, W. E., & Orsó, E. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200010000-00007 · Cited by 136 · see citing works

Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia

Karten, B., Campenot, R. B., Vance, D. E., & Vance, J. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508915200 · Cited by 136 · see citing works

Cholesterol‐dependent modulation of tau phosphorylation in cultured neurons

Fan, Q., Yu, W., Senda, T., Yanagisawa, K., & Michikawa, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00063.x · Cited by 135 · see citing works

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M., & Bu, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305803101 · Cited by 133 · see citing works

Fibrillar Amyloid-β-Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

Jana, A., & Pahan, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1243-10.2010 · Cited by 129 · see citing works

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

Rapp, A., Gmeiner, B. M. K., & Hüttinger, M. (2005) · Biochimie · doi:10.1016/j.biochi.2005.10.007 · Cited by 127 · see citing works

Involvement of astroglial ceramide in palmitic acid‐induced Alzheimer‐like changes in primary neurons

Patil, S. P., Melrose, J., & Chan, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05797.x · Cited by 126 · see citing works

Novel Role for Apolipoprotein E in the Central Nervous System

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M., & Holtzman, D. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212340200 · Cited by 126 · see citing works

Cortical distribution of gangliosides in Alzheimer's disease

Kraĉun, I., Bognar, S. K., Talan-Hranilović, J., & Ćosović, Č. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90058-y · Cited by 125 · see citing works

Cholesterol‐promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

Fester, L., Zhou, L., Bütow, A., Huber, C., von Lossow, R., Prange‐Kiel, J., Jarry, H., & Rune, G. M. (2009) · Hippocampus · doi:10.1002/hipo.20548 · Cited by 123 · see citing works

Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients

Kölsch, H., Heun, R., Kerksiek, A., von Bergmann, K., Maier, W., & Lütjohann, D. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.031 · Cited by 123 · see citing works

Interactions between neural membrane glycerophospholipid and sphingolipid mediators: A recipe for neural cell survival or suicide

Farooqui, A., Horrocks, L., & Farooqui, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21268 · Cited by 121 · see citing works

Sphingolipid metabolites in neural signalling and function

Colombaioni, L., & Garcia‐Gil, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.014 · Cited by 119 · see citing works

Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse–glia affair

Göritz, C., Mauch, D. H., Nägler, K., & Pfrieger, F. W. (2002) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(02)00014-1 · Cited by 118 · see citing works

Therapeutic potential of statins in Alzheimer's disease

Kandiah, N., & Feldman, H. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.352 · Cited by 114 · see citing works

Cholesterol and statins in Alzheimer's disease: Current controversies

Fonseca, A. C. R. G., Resende, R., Oliveira, C. R., & Pereira, C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.013 · Cited by 112 · see citing works

Deletion of the Transmembrane Transporter ABCG1 Results in Progressive Pulmonary Lipidosis

Baldán, Á., Tarr, P. T., Vales, C., Frank, J. S., Shimotake, T. K., Hawgood, S., & Edwards, P. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606597200 · Cited by 111 · see citing works

Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

Qin, W., Ho, L., Pompl, P. N., Peng, Y., Zhao, Z., Xiang, Z., Robakis, N. K. R. K., Shioi, J., Suh, J., & Pasinetti, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307699200 · Cited by 110 · see citing works

Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice

Cao, D., Fukuchi, K.-I., Wan, H., Kim, H., & Li, L. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.011 · Cited by 106 · see citing works

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Cam (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-8 · Cited by 106 · see citing works

GM1 ganglioside regulates the proteolysis of amyloid precursor protein

Zha, Q., Ruan, Y., Hartmann, T., Beyreuther, K. T., & Zhang, D. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001509 · Cited by 100 · see citing works

Statins — a cure-all for the brain?

Menge, T., Hartung, H.-P., & Stüve, O. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1652 · Cited by 98 · see citing works

Fatting the brain: a brief of recent research

Hussain, G., Schmitt, F., Loeffler, J., & de Aguilar, J. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00144 · Cited by 97 · see citing works

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight

Amtul, Z., Uhrig, M., Wang, L., Rozmahel, R. F., & Beyreuther, K. T. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.014 · Cited by 96 · see citing works

Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study.

Cheng, H., Xu, J., McKeel, D. W., & Han, X. (2003) · PubMed · Cited by 90 · see citing works

Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10

Ochoa, J. J., Pamplona, R., Ramírez-Tortosa, M. C., Granados-Principal, S. M., Pérez-López, P., Naudí, A., Portero‐Otín, M., López‐Frías, M., Battino, M. A., & Quiles, J. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.02.004 · Cited by 90 · see citing works

Use of Lipid‐Lowering Drugs in Older Adults With and Without Dementia: A Community‐Based Epidemiological Study

Rodríguez, E., Dodge, H. H., Birzescu, M., Stoehr, G. P., & Ganguli, M. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50515.x · Cited by 90 · see citing works

Measurement of Apolipoprotein E (apoE) in Cerebrospinal Fluid

Hesse, C., Larsson, H. E., Fredman, P., Minthon, L., Andreasen, N., Davidsson, P., & Blennow, K. (2000) · Neurochemical Research · doi:10.1023/a:1007516210548 · Cited by 89 · see citing works

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

Hagen, N., Hans, M., Hartmann, D., Swandulla, D., & van Echten‐Deckert, G. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.7 · Cited by 81 · see citing works

Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3

Sayas, C. L. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00149-x · Cited by 81 · see citing works

Long‐term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

Yu, H., Bi, Y., Ma, W., He, L., Yuan, L., Feng, J., & Xiao, R. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.12.001 · Cited by 80 · see citing works

Amyloid-β 42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism

Ryan, S. D., Whitehead, S. N., Swayne, L. A., Moffat, T. C., Hou, W., Ethier, M., Bourgeois, A. J. G., Rashidian, J., Blanchard, A. P., Fraser, P. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905654106 · Cited by 76 · see citing works

Endogenous Conversion of Omega-6 into Omega-3 Fatty Acids Improves Neuropathology in an Animal Model of Alzheimer's Disease

Lebbadi, M., Julien, C., Phivilay, A., Tremblay, C., Émond, V., Kang, J. X., & Calon, F. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111010 · Cited by 74 · see citing works

Studies on Plasmalogen-Selective Phospholipase A2 in Brain

Farooqui, A. A. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8091-y · Cited by 72 · see citing works

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Hirsch‐Reinshagen, V., Donkin, J. J., Stukas, S. K., Chan, J., Wilkinson, A., Fan, J., Parks, J. S., Kuivenhoven, J. A., ̈tjohann, D. L., Pritchard, H., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800584-jlr200 · Cited by 72 · see citing works

Brain Gangliosides in Dementia of the Alzheimer Type

Crino, P. B., Ullman, M. D., Vogt, B. A., Bird, E. D., & Volicer, L. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520400054019 · Cited by 71 · see citing works

Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex

Yuki, D., Sugiura, Y., Zaima, N., Akatsu, H., Hashizume, Y., Yamamoto, T., Fujiwara, M., Sugiyama, K., & Setou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.045 · Cited by 61 · see citing works

Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer’s disease

Zou, F., Gopalraj, R. K., Lok, J., Zhu, H., Ling, I.-F., Simpson, J. F., Tucker, H. M., Kelly, J. F., Younkin, S. G., Dickson, D. W., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm365 · Cited by 58 · see citing works

Plasmalogens, Docosahexaenoic Acid and Neurological Disorders

Farooqui, A. A., Ong, W., & Horrocks, L. A. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_45 · Cited by 57 · see citing works

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease

Geekiyanage, H., Upadhye, A., & Chan, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.001 · Cited by 51 · see citing works

Alterations of Phospholipid Metabolites in Postmortem Brain from Patients with Alzheimer's Diseasea

Nitsch, R. M., Pittas, A. G., Blusztajn, J. K., et al. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00200.x · Cited by 51 · see citing works

Structural Insight into the Differential Effects of Omega-3 and Omega-6 Fatty Acids on the Production of Aβ Peptides and Amyloid Plaques

Amtul, Z., Uhrig, M., Rozmahel, R. F., & Beyreuther, K. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183608 · Cited by 49 · see citing works

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains

Hejazi, L., Wong, J. W. H., Cheng, D., Proschogo, N. W., Ebrahimi, D., Garner, B., & Don, A. S. (2011) · Biochemical Journal · doi:10.1042/bj20110566 · Cited by 49 · see citing works

Niemann–Pick type C pathogenesis and treatment: from statins to sugars

Madra, M., & Sturley, S. L. (2010) · Clinical Lipidology · doi:10.2217/clp.10.19 · Cited by 48 · see citing works

Sialylated Human Apolipoprotein E (apoEs) Is Preferentially Associated with Neuron-Enriched Cultures from APOE Transgenic Mice

Xu, P., Schmechel, D. E., Qiu, H.-L., Herbstreith, M. H., Rothrock‐Christian, T., Eyster, M. V., Roses, A. D., & Gilbert, J. R. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0213 · Cited by 46 · see citing works

Phospholipases as mediators of amyloid beta peptide neurotoxicity: an early event contributing to neurodegeneration characteristic of Alzheimer's disease

Kanfer, J. N., Sorrentino, G., & SITAR, D. S. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00806-4 · Cited by 44 · see citing works

Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent‐insoluble membrane fraction in Niemann–Pick C1‐deficient cells

Sawamura, N., Gong, J., Chang, T.-Y., Yanagisawa, K., & Michikawa, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01596.x · Cited by 38 · see citing works

Genetic study evaluating LDLR polymorphisms and Alzheimer's disease

Lämsä, R., Helisalmi, S., Herukka, S., Tapiola, T., Pirttilä, T., Vepsäläinen, S., Hiltunen, M. O., & Soininen, H. S. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.009 · Cited by 36 · see citing works

Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

Glöckner, F., Meske, V., Lütjohann, D., & Ohm, T. G. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318212f185 · Cited by 35 · cited 1× · see citing works

Role of cholesterol in amyloid cascade: cholesterol-dependent modulation of tau phosphorylation and mitochondrial function

Michikawa, M. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00681.x · Cited by 29 · see citing works

Cholesterol and Amyloid β Fibrillogenesis

Yanagisawa, K. (2006) · Springer eBooks · doi:10.1007/0-387-23226-5_9 · Cited by 24 · see citing works

Cholesterol, Statins, and Alzheimer Disease

Koudinov, A. R., & Berezov, T. T. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020081 · Cited by 10 · see citing works

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Li, H., Evin, G. M., Hill, A. F., Hung, Y. H., Bush, A. I., & Garner, B. (2011) · Clinical Science · doi:10.1042/cs20110257 · Cited by 8 · see citing works

Phospholipid Metabolism in Brain

Brossard, M. (2006) · Springer eBooks · doi:10.1007/978-0-387-49931-4_1 · Cited by 3 · see citing works

Genetic architecture of Alzheimer's disease

Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation

Loving, B. A., Tang, M., Neal, M. C., Gorkhali, S., Murphy, R., Eckel, R. H., & Bruce, K. D. (2021) · Cells · doi:10.3390/cells10020198 · Cited by 105 · see citing works

Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy

Lee, J. Y., Jin, H. K., & Bae, J.-S. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.278 · Cited by 80 · see citing works

Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery

Ullah, R., Park, T. J., Huang, X., & Kim, M. O. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101451 · Cited by 78 · see citing works

Discussion on pathogenesis levels of hypertension

Wang, Q. (2007) · Zhongyi-yao xuebao

Exploration on relationship of basic pathogenesis and disease symptom

Zhang, Y. (2010) · Journal of Tianjin University of Traditional Chinese Medicine

Analysis of Pathogenesis and Correlative Factors of Acute Upper Gastrointestinal Hemorrhage

Qu, J. (2013) · Xiandai shengwu yixue jinzhan

Update on pathogenesis in idiopathic inflammatory myopathies

Wen-tao, W. (2005) · Yixue yanjiusheng xuebao

[Research progress of heterotopic ossification pathogenesis].

Rong, X., & Kong, Q. (2011) · PubMed