Krebs and his trinity of cycles

Kornberg, Hans

doi:10.1038/35043073

Cited by 86History of Science and MedicineBiographical and Historical AnalysisMedical History and Innovations

Krebs and his trinity of cycles

Kornberg, Hans·2000·Nature Reviews Molecular Cell Biology

DOI 10.1038/35043073

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Abstract

Everyone who has ever taken biology at school has heard of the Krebs cycle, but few realize that Hans Krebs also discovered two other cycles. It is appropriate, at the centenary of his birth, to consider the circumstances and experiments that led Krebs to establish these metabolic pathways.

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In 1937, Hans Krebs showed that succinate could be synthesized by animal tissues in the presence of pyruvate.
“In 1937, Hans Krebs (1, 32) showed that succinate could be synthesized by animal tissues in the presence of pyruvate, leading him to speculate that succinate may arise from citrate oxidation downstream of pyruvate.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [32]
In 1935, Szent-Györgyi worked out the sequence of reactions from succinate to fumarate to malate to OAA and demonstrated rapid oxidation of these substances by pigeon muscle suspensions.
“In 1935, Szent-Györgyi worked out the sequence of reactions from succinate to fumarate to malate to OAA and demonstrated the rapid oxidation of these substances by pigeon muscle suspensions (31, 32).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [32]
Krebs and Johnson found that citrate did not disappear during this process, indicating it was being continuously reformed.
“Moreover, they found that citrate did not disappear during this process, indicating that it was being continuously reformed (2, 32).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [32]
By adding malonate, an inhibitor of succinate oxidation, Krebs and Johnson found that succinate accumulated when OAA was added to muscle, implying the series of reactions was cyclical.
“By adding malonate, an inhibitor of succinate oxidation, they found that succinate accumulated when OAA was added to muscle, implying that this series of reactions was cyclical in nature (2, 32).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [32]

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Authors: Kornberg, H.
Affiliations: Boston University (US)
Corresponding author: Kornberg, Hans
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 225-228
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/35043073
OpenAlex: W1598906599
Cited by: 86
References: 23
Citations by year: 2026: 7 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 12 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 6
FWCI: 0.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
Social Sciences › Arts and Humanities › History › Biographical and Historical Analysis
Social Sciences › Arts and Humanities › History › Medical History and Innovations
Keywords: Hans Krebs, TCA cycle, history of biochemistry, metabolic pathways, centenary of birth, scientific discovery
MeSH terms: Biochemistry, Citric Acid Cycle, Glyoxylates, Humans, Ornithine, History, 20th Century

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