The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Neurons derived from radial glial cells establish radial units in neocortex
Abstract
The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migration. Radial glia are mitotically active throughout neurogenesis, and disappear or become astrocytes when neuronal migration is complete. Although the lineage relationships of cortical neurons and glia have been explored, the clonal relationship of radial glia to other cortical cells remains unknown. It has been suggested that radial glia may be neuronal precursors, but this has not been demonstrated in vivo. We have used a retroviral vector encoding enhanced green fluorescent protein to label precursor cells in vivo and have examined clones 1-3 days later using morphological, immunohistochemical and electrophysiological techniques. Here we show that clones consist of mitotic radial glia and postmitotic neurons, and that neurons migrate along clonally related radial glia. Time-lapse images show that proliferative radial glia generate neurons. Our results support the concept that a lineage relationship between neurons and proliferative radial glia may underlie the radial organization of neocortex.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”
From Development of prefrontal cortex (2022) · cites this paper as [50]
In the citing paper
“After this period of symmetric divisions, these progenitor cells — also known as radial glia — divide asymmetrically, generating postmitotic excitatory neurons that will migrate to their final location in the cerebral cortex by using the basal process of the radial glial cell as a scaffold55–58.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [56]
Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127
The columnar organization of the neocortex
Mountcastle, V. B. (1997) · Brain · doi:10.1093/brain/120.4.701 · Cited by 2,314
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
Blanton, M. G., Turco, J. J. L., & Kriegstein, A. R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90131-3 · Cited by 945
Self-citationIdentification of major cell classes in the developing mammalian nervous system
Hockfield, S. J., & McKay, R. D. G. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-12-03310.1985 · Cited by 792
Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain
Gaiano, N., Nye, J. S., & Fishell, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81172-1 · Cited by 727
Embryonic vertebrate central nervous system: Revised terminology
Angevine, J. B., Bodian, D., Coulombre, A. J., Edds, M. V., Hamburger, V., Jacobson, M., Lyser, K. M., Prestige, M. C., Sidman, R. L., Varon, S. S., et al. (1970) · The Anatomical Record · doi:10.1002/ar.1091660214 · Cited by 727
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–102 of 102
Huang, C., Liu, T., Wang, Q., Hou, W., Zhou, C., Song, Z., Shi, Y. S., Gao, X., Chen, G., Yin, Z., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa042 · Cited by 14
Zhang, J., Argueta, D., Tong, X., Vinters, H. V., Mathern, G. W., & Cepeda, C. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1486315 · Cited by 3
Metadata
- Authors
- Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Kriegstein, Arnold R.
- Venue
- Nature
- Published
- 2001-02
- Volume
- 409
- Issue
- 6821
- Pages
- 714-720
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1503727145
- Cited by
- 2,016
- References
- 30
- Citations by year
- 2026: 41 · 2025: 44 · 2024: 42 · 2023: 64 · 2022: 56 · 2021: 68 · 2020: 108 · 2019: 89 · 2018: 57 · 2017: 75 · 2016: 71 · 2015: 91 · 2014: 90 · 2013: 98 · 2012: 103
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- radial glia, neocortex, neuronal migration, neuronal lineage, clonal analysis, neurogenesis, retroviral labeling, time-lapse imaging
- MeSH terms
- Animals, Antigens, Differentiation, Cell Differentiation, Cell Movement, Clone Cells, Luminescent Proteins, Mitosis, Neuroglia, Neurons, Rats, Sprague-Dawley, Microscopy, Video, Neocortex, Green Fluorescent Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
