The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Neurons derived from radial glial cells establish radial units in neocortex
Abstract
The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migration. Radial glia are mitotically active throughout neurogenesis, and disappear or become astrocytes when neuronal migration is complete. Although the lineage relationships of cortical neurons and glia have been explored, the clonal relationship of radial glia to other cortical cells remains unknown. It has been suggested that radial glia may be neuronal precursors, but this has not been demonstrated in vivo. We have used a retroviral vector encoding enhanced green fluorescent protein to label precursor cells in vivo and have examined clones 1-3 days later using morphological, immunohistochemical and electrophysiological techniques. Here we show that clones consist of mitotic radial glia and postmitotic neurons, and that neurons migrate along clonally related radial glia. Time-lapse images show that proliferative radial glia generate neurons. Our results support the concept that a lineage relationship between neurons and proliferative radial glia may underlie the radial organization of neocortex.
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“The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”
From Development of prefrontal cortex (2022) · cites this paper as [50]
In the citing paper
“After this period of symmetric divisions, these progenitor cells — also known as radial glia — divide asymmetrically, generating postmitotic excitatory neurons that will migrate to their final location in the cerebral cortex by using the basal process of the radial glial cell as a scaffold55–58.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [56]
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Metadata
- Authors
- Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Kriegstein, Arnold R.
- Venue
- Nature
- Published
- 2001-02
- Volume
- 409
- Issue
- 6821
- Pages
- 714-720
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1503727145
- Cited by
- 2,016
- References
- 30
- Citations by year
- 2026: 41 · 2025: 44 · 2024: 42 · 2023: 64 · 2022: 56 · 2021: 68 · 2020: 108 · 2019: 89 · 2018: 57 · 2017: 75 · 2016: 71 · 2015: 91 · 2014: 90 · 2013: 98 · 2012: 103
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- radial glia, neocortex, neuronal migration, neuronal lineage, clonal analysis, neurogenesis, retroviral labeling, time-lapse imaging
- MeSH terms
- Animals, Antigens, Differentiation, Cell Differentiation, Cell Movement, Clone Cells, Luminescent Proteins, Mitosis, Neuroglia, Neurons, Rats, Sprague-Dawley, Microscopy, Video, Neocortex, Green Fluorescent Proteins, Rats
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