Cited by 1,240Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCellular transport and secretion

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Molecular dissection of autophagy: two ubiquitin-like systems

Ohsumi, Yoshinori·2001·Nature Reviews Molecular Cell Biology

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Abstract

Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.

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Crossref · 10.1038/35056522

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THE UBIQUITIN SYSTEM
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Protective effect of L-carnitine in cyclophosphamide-induced germ cell apoptosis
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“…of LC3 by the protease ATG4, which produces the cytosolic form LC3-I, followed by the sequential action of the E1-like enzyme ATG7, the E2-like enzyme ATG3 and the E3-ligase complex ATG5-ATG12-ATG16L1, which catalyzes the covalent conjugation of PE to LC3-I(Noda et al., 2008, Ohsumi, 2001).”
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Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity
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Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells
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An improved method for high-throughput quantification of autophagy in mammalian cells
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Autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1
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Staphylococcus aureus induces autophagy in bovine mammary epithelial cells and the formation of autophagosomes facilitates intracellular replication of Staph. aureus
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Authors: Ohsumi, Y.
Affiliations: National Institute for Basic Biology (JP)
Corresponding author: Ohsumi, Yoshinori
ORCID: Ohsumi, Yoshinori
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2001-03
Volume: 2
Issue: 3
Pages: 211-216
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/35056522
OpenAlex: W2792139654
Cited by: 1,240
References: 45
Citations by year: 2026: 13 · 2025: 25 · 2024: 30 · 2023: 44 · 2022: 39 · 2021: 34 · 2020: 64 · 2019: 65 · 2018: 51 · 2017: 54 · 2016: 59 · 2015: 44 · 2014: 58 · 2013: 56 · 2012: 67
FWCI: 7.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: autophagy, ubiquitin-like proteins, membrane dynamics, yeast, autophagy-related genes
MeSH terms: Autophagy-Related Protein 8 Family, Autophagy-Related Protein 7, Autophagy, Lysosomes, Microscopy, Electron, Microtubule-Associated Proteins, Models, Biological, Proteins, Saccharomyces cerevisiae, Ubiquitins, Vacuoles, Saccharomyces cerevisiae Proteins

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Molecular dissection of autophagy: two ubiquitin-like systems

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