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Cited by 5,111

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Mammalian MAP kinase signalling cascades

Chang, Lufen, Karin, Michael·2001·Nature
DOI 10.1038/35065000
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Citations

Cites

Research works printed but not linked: 50

  1. English, J. et al. New insights into the control of MAP kinase pathways. Exp. Cell Res. 253, 255–270 (1999). · DOI · Paper page
  2. Gutkind, S. J. Regulation of mitogen-activated protein kinase signalling networks by G-protein coupled receptors [online] http://www.stke.org/cgi/content/full/OC_sigtrans;2000/40/re1 (2000). · DOI · Paper page
  3. Herskowitz, I. MAP kinase pathways in yeast: for mating and more. Cell 80, 187–197 (1995). · DOI · Paper page
  4. Xia, Y. et al. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc. Natl Acad. Sci. USA 97, 5243–5248 (2000). · DOI · Paper page
  5. Yujiri, T., Sather, S., Fanger, C. R. & Johnson, G. L. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282, 1911–1914 (1998). · DOI · Paper page
  6. Schaeffer, H. J. et al. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281, 1668–1671 (1998). · DOI · Paper page
  7. Xia, Y., Wu, Z., Su, B., Murray, B. & Karin, M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12, 3369–3381 (1998). · DOI
  8. Wasserman, J. D. & Matthew, F. An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95, 355–364 (1998). · DOI
  9. Kallunki, T., Deng, T., Hibi, M. & Karin, M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87, 929-939 (1996). · DOI · Paper page
  10. Treisman, R. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8, 205–215 (1996). · DOI · Paper page
  11. Han, J., Jiang, Y., Li, Z., Kravchenko, V. V. & Ulevitch, R. J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386, 296–299 (1997). · DOI · Paper page
  12. Chen, C. Y. et al. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 14, 1236–1248 (2000). · DOI · Paper page
  13. Winzen, R. et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 19, 6742–6753 (1999).
  14. Lasa, M. et al. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol. Cell. Biol. 20, 4265–4274 (2000). · DOI · Paper page
  15. Kotlyarov, A. et al. MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis. Nature Cell Biol. 1, 94–97 (1999). · DOI · Paper page
  16. Pyronnet, S. et al. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18, 270–279 (1999). · DOI · Paper page
  17. Graves, L. M. et al. Regulation of carbamoyl phosphate synthetase by MAP kinase. Nature 403, 328–332 (2000). · DOI
  18. Palmer, A., Gavin, A. C. & Nebreda, A. R. A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. EMBO J. 17, 5037–5047 (1998). · DOI · Paper page
  19. Bhatt, R. R. & Ferrell, J. E. J. The protein kinase p90 rsk as an essential mediator of cytostatic factor activity. Science 286, 1362–1365 (1999). · DOI
  20. Gross, S. D., Schwab, M. S., Lewellyn, A. L. & Maller, J. L. Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk. Science 286, 1365–1367 (1999). · DOI
  21. Treinies, I., Paterson, H. F., Hooper, S., Wilson, R. & Marshall, C. J. Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis. Mol. Cell. Biol. 19, 321–329 (1999). · DOI
  22. Minden, A. et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719–1723 (1994). · DOI · Paper page
  23. Sabapathy, K. et al. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr. Biol. 9, 116–125 (1999). · DOI · Paper page
  24. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. & Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326–1331 (1995). · DOI · Paper page
  25. Le-Niculescu, H. et al. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19, 751–763 (1999). · DOI · Paper page
  26. Yang, D. et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865–870 (1997). · DOI · Paper page
  27. Behrens, A., Sibilia, M. & Wagner, E. F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet. 21, 326–329 (1999). · DOI · Paper page
  28. Xu, X., Raber, J., Yang, D., Su, B. & Mucke, L. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc. Natl Acad. Sci. USA 94, 12655–12660 (1997). · DOI
  29. Tournier, C. et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870–874 (2000). · DOI · Paper page
  30. Shaulian, E. et al. The mammalian UV response: c-Jun induction is required for exit from the p53-imposed checkpoint. Cell 103, 897–907 (2000). · DOI · Paper page
  31. Kauffmann-Zeh, A. et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI (3)K and PKB. Nature 385, 544–548 (1997). · DOI · Paper page
  32. Bonni, A. et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358–1362 (1999). · DOI · Paper page
  33. Pagès, G. et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374–1377 (1999). · DOI · Paper page
  34. Alberola-Ila, J., Forbush, K. A., Seger, R., Krebs, E. G. & Perlmutter, R. M. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373, 620–623 (1995). · DOI · Paper page
  35. Giroux, S. et al. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9, 369–372 (1999). · DOI · Paper page
  36. Kuan, C. Y. et al. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22, 667–676 (1999). · DOI · Paper page
  37. Sabapathy, K. et al. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89, 115–124 (1999). · DOI · Paper page
  38. Ganiatsas, S. et al. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc. Natl Acad. Sci. USA 95, 6881–6886 (1998). · DOI
  39. Hilberg, F., Aguzzi, A., Howells, N. & Wagner, E. F. c-Jun is essential for normal mouse development and hepatogenesis. Nature 365, 179–181 (1993). · DOI · Paper page
  40. Su, B. et al. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727–736 (1994). · DOI · Paper page
  41. Li, W., Whaley, C. D., Mondino, A. & Mueller, D. L. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Science 271, 1272–1276 (1996). · DOI · Paper page
  42. Sabapathy, K. et al. JNK1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J. Exp. Med. 193, 317–318 (2001). · DOI
  43. Nishina, H. et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J. Exp. Med. 186, 941–953 (1997). · DOI
  44. Dong, C. et al. Defective T cell differentiation in the absence of Jnk1. Science 282, 2092–2095 (1998). · DOI · Paper page
  45. Yang, D. D. et al. Differentiation of CD4(+) T cells to Th1 cells requires MAP kinase JNK2. Immunity 9, 575–585 (1998). · DOI · Paper page
  46. Dong, C. et al. JNK is required for effector T-cell function but not for T-cell activation. Nature 405, 91–94 (2000). · DOI · Paper page
  47. Swat, W. et al. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity 8, 625–634 (1998). · DOI
  48. Tamura, K. et al. Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis. Cell 102, 221–231 (2000). · DOI · Paper page
  49. Adams, R. H. et al. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol. Cell 6, 109–116 (2000). · DOI · Paper page
  50. Lu, H. T. et al. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845–1857 (1999). · DOI · Paper page

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Metadata

Authors
Chang, L., & Karin, M.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2001-03
Volume
410
Issue
6824
Pages
37-40
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/35065000
OpenAlex
W1996405087
Cited by
5,111
References
2
FWCI
86.53
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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