Cited by 1,215Phagocytosis and Immune RegulationSystemic Lupus Erythematosus ResearchCell death mechanisms and regulation

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Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, Rona S., McMahon, Eileen J., Pop, Shannon M., Reap, Elizabeth A., Caricchio, Roberto, Cohen, Philip L., Earp, H. Shelton, Matsushima, Glenn K.·2001·Nature

DOI 10.1038/35075603

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Abstract

Apoptosis is fundamental to the development and maintenance of animal tissues and the immune system. Rapid clearance of apoptotic cells by macrophages is important to inhibit inflammation and autoimmune responses against intracellular antigens. Here we report a new function for Mer, a member of the Axl/Mer/Tyro3 receptor tyrosine kinase family. mer(kd) mice with a cytoplasmic truncation of Mer had macrophages deficient in the clearance of apoptotic thymocytes. This was corrected in chimaeric mice reconstituted with bone marrow from wild-type animals. Primary macrophages isolated from mer(kd) mice showed that the phagocytic deficiency was restricted to apoptotic cells and was independent of Fc receptor-mediated phagocytosis or ingestion of other particles. The inability to clear apoptotic cells adequately may be linked to an increased number of nuclear autoantibodies in mer(kd) mice. Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus.

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
Phagocyte recognition of cells undergoing apoptosis
Savill, J., Fadok, V. A., Henson, P. M., & Haslett, C. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90215-7 · Cited by 981
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
D'Cruz, P. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.645 · Cited by 884
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.
Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 818
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
O’Bryan, J. P., Frye, R. A., Cogswell, P. C., Neubauer, A., Kitch, B., Prokop, C. A., Espinosa, R., Beau, M. M. L., Earp, H. S., & Liu, E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5016 · Cited by 746
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo
Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724
Human CD14 mediates recognition and phagocytosis of apoptotic cells
Devitt, A., Moffatt, O., Raykundalia, C., Capra, J. D., Simmons, D. L., & Gregory, C. D. (1998) · Nature · doi:10.1038/33169 · Cited by 681

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Hall, M. O., Obin, M. S., Prieto, A. L., Burgess, B. L., & Abrams, T. A. (2002) · PubMed · Cited by 59
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Roddy, G. W., Rosa, R. H., Oh, J. Y., Ylöstalo, J., Bartosh, T. J., Choi, H., Lee, R. H., Yasumura, D., Ahern, K., Nielsen, G., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2011.308 · Cited by 61
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Huang, X., Finerty, P. J., Walker, J. R., Butler-Cole, C., Vedadi, M., Schapira, M., Parker, S. A., Turk, B. E., Thompson, D. A., & Dhe‐Paganon, S. (2008) · Journal of Structural Biology · doi:10.1016/j.jsb.2008.10.003 · Cited by 58
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Authors: Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K.
Affiliations: University of North Carolina at Chapel Hill (US)
AlphaVax (United States) (US)
University of Pennsylvania (US)
UNC Lineberger Comprehensive Cancer Center (US)
Corresponding author: Matsushima, Glenn K.
ORCID: Scott, Rona S.
Caricchio, Roberto
Cohen, Philip L.
Earp, H. Shelton
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-05
Volume: 411
Issue: 6834
Pages: 207-211
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35075603
OpenAlex: W2011617127
Cited by: 1,215
References: 31
Citations by year: 2026: 27 · 2025: 32 · 2024: 61 · 2023: 44 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 50 · 2018: 40 · 2017: 50 · 2016: 39 · 2015: 44 · 2014: 60 · 2013: 51 · 2012: 45
FWCI: 21.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Research Councils UK
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Mer receptor tyrosine kinase, efferocytosis, phagocytosis, macrophages, systemic lupus erythematosus, autoimmunity, inflammation, thymocytes
MeSH terms: c-Mer Tyrosine Kinase, Animals, Antibodies, Antinuclear, Cell Adhesion, Cells, Cultured, Crosses, Genetic, Cytochalasin B, Dexamethasone, Female, Flow Cytometry, Immunohistochemistry, Listeria monocytogenes, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Electron, Scanning, Microspheres, Mutation, Phagocytosis, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Radiation Chimera, Receptors, Fc, Thymus Gland, Bone Marrow Transplantation, Apoptosis, Macrophages, Peritoneal, Receptor Protein-Tyrosine Kinases, Mice

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Phagocytosis and clearance of apoptotic cells is mediated by MER

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