Cited by 1,215Phagocytosis and Immune RegulationSystemic Lupus Erythematosus ResearchCell death mechanisms and regulation

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Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, Rona S., McMahon, Eileen J., Pop, Shannon M., Reap, Elizabeth A., Caricchio, Roberto, Cohen, Philip L., Earp, H. Shelton, Matsushima, Glenn K.·2001·Nature

DOI 10.1038/35075603

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Abstract

Apoptosis is fundamental to the development and maintenance of animal tissues and the immune system. Rapid clearance of apoptotic cells by macrophages is important to inhibit inflammation and autoimmune responses against intracellular antigens. Here we report a new function for Mer, a member of the Axl/Mer/Tyro3 receptor tyrosine kinase family. mer(kd) mice with a cytoplasmic truncation of Mer had macrophages deficient in the clearance of apoptotic thymocytes. This was corrected in chimaeric mice reconstituted with bone marrow from wild-type animals. Primary macrophages isolated from mer(kd) mice showed that the phagocytic deficiency was restricted to apoptotic cells and was independent of Fc receptor-mediated phagocytosis or ingestion of other particles. The inability to clear apoptotic cells adequately may be linked to an increased number of nuclear autoantibodies in mer(kd) mice. Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus.

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
Phagocyte recognition of cells undergoing apoptosis
Savill, J., Fadok, V. A., Henson, P. M., & Haslett, C. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90215-7 · Cited by 981
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
D'Cruz, P. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.645 · Cited by 884
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.
Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 818
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
O’Bryan, J. P., Frye, R. A., Cogswell, P. C., Neubauer, A., Kitch, B., Prokop, C. A., Espinosa, R., Beau, M. M. L., Earp, H. S., & Liu, E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5016 · Cited by 746
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo
Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724
Human CD14 mediates recognition and phagocytosis of apoptotic cells
Devitt, A., Moffatt, O., Raykundalia, C., Capra, J. D., Simmons, D. L., & Gregory, C. D. (1998) · Nature · doi:10.1038/33169 · Cited by 681

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Cook, R. S., Jacobsen, K. M., Wofford, A., DeRyckere, D., Stanford, J. C., Prieto, A. L., Redente, E. F., Sandahl, M. A., Hunter, D. M., Strunk, K. E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67655 · Cited by 191
Engulfment signals and the phagocytic machinery for apoptotic cell clearance
Park, S., & Kim, I. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.52 · Cited by 189
The Pathophysiologic Role of Monocytes and Macrophages in Systemic Lupus Erythematosus: A Reappraisal
Katsiari, C. G., Liossis, S. C., & Sfikakis, P. P. (2009) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.11.002 · Cited by 182
Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons.
Kurant, E., Axelrod, S., Leaman, D., & Gaul, U. (2008) · Cell · doi:10.1016/j.cell.2008.02.052 · Cited by 175
B-lymphocytes, innate immunity, and autoimmunity
Viau, M., & Zouali, M. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.08.019 · Cited by 183
Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes
Bliederhaeuser, C., Grozdanov, V., Speidel, A., Zondler, L., Ruf, W. P., Bayer, H., Kiechle, M., Feiler, M. S., Freischmidt, A., Brenner, D., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1504-2 · Cited by 181
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Chen, B., Huang, S., Su, Y., Wu, Y.-J., Hanna, A., Brickshawana, A., Graff, J. M., & Frangogiannis, N. G. (2019) · Circulation Research · doi:10.1161/circresaha.119.315069 · Cited by 184
CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
Grajchen, E., Wouters, E., van de Haterd, B., Haidar, M., Hardonnière, K., Dierckx, T., Broeckhoven, J. V., Erens, C., Hendrix, S., Kerdine‐Römer, S., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01899-x · Cited by 194
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation
Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 184
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Rőszer, T., Menéndez-Gutierrez, M. P., Lefterova, M. I., Alameda, D., Núñez, V., Lazar, M. A., Fischer, T., & Ricote, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002230 · Cited by 188
Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal
Kohno, H., Chen, Y., Kevany, B. M., Pearlman, E. M., Miyagi, M., Maeda, T., Palczewski, K., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.448712 · Cited by 180
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Patin, É., Kutalik, Z., Guergnon, J., Bibert, S., Nalpas, B., Jouanguy, E., Munteanu, M., Bousquet, L., Argiro, L., Halfon, P., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.097 · Cited by 182
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Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry
Mercer, J., Knébel, S., Schmidt, F. I., Crouse, J., Tait‐Burkard, C., & Helenius, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004618107 · Cited by 171
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Li, S., Sun, Y., Liang, C., Thorp, E. B., Han, S., Jehle, A. W., Saraswathi, V., Pridgen, B. C., Kanter, J. E., Li, R., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199570 · Cited by 173
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Roos, A., Xu, W., Castellano, G., Nauta, A. J., Garred, P., Daha, M. R., & van Kooten, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200424904 · Cited by 168
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Potter, P. K., Cortés-Hernández, J., Quartier, P., Botto, M., & Walport, M. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3223 · Cited by 167
The phagocytosis of apoptotic cells
Fadok, V. A., & Chimini, G. (2001) · Seminars in Immunology · doi:10.1006/smim.2001.0333 · Cited by 166
Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium
Sun, M., Finnemann, S. C., Febbraio, M., Shan, L., Annangudi, S. P., Podrez, E. A., Hoppe, G., Darrow, R., Organisciak, D. T., Salomon, R. G., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509769200 · Cited by 165
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HoWangYin, K.-Y., Zlatanova, I., Pinto, C., Ngkelo, A., Cochain, C., Rouanet, M., Vilar, J., Lemitre, M., Stockmann, C., Fleischmann, B. K., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.020857 · Cited by 173
Regulation of phagocytosis by Rho GTPases
Mao, Y., & Finnemann, S. C. (2015) · Small GTPases · doi:10.4161/21541248.2014.989785 · Cited by 170
Origins, Biology, and Diseases of Tissue Macrophages
Cox, N., Pokrovskii, M. V., Vicario, R., & Geissmann, F. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-111748 · Cited by 171
Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis
Burstyn-Cohen, T., Lew, E. D., Través, P. G., Burrola, P. G., Hash, J. C., & Lemke, G. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.015 · Cited by 163
IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo
Ogden, C. A., Kowalewski, R., Peng, Y., Montenegro, V., & Elkon, K. B. (2005) · Autoimmunity · doi:10.1080/08916930500124452 · Cited by 163
Ultraviolet B Radiation-Induced Cell Death: Critical Role of Ultraviolet Dose in Inflammation and Lupus Autoantigen Redistribution
Caricchio, R., McPhie, L., & Cohen, P. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5778 · Cited by 163
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
Tjwa, M., Bellido‐Martín, L., Lin, Y., Lutgens, E., Plaisance, S., Bono, F., Delesque-Touchard, N., Hervé, C., Moura, R., Billiau, A., et al. (2007) · Blood · doi:10.1182/blood-2007-05-089565 · Cited by 162

Authors: Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K.
Affiliations: University of North Carolina at Chapel Hill (US)
AlphaVax (United States) (US)
University of Pennsylvania (US)
UNC Lineberger Comprehensive Cancer Center (US)
Corresponding author: Matsushima, Glenn K.
ORCID: Scott, Rona S.
Caricchio, Roberto
Cohen, Philip L.
Earp, H. Shelton
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-05
Volume: 411
Issue: 6834
Pages: 207-211
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35075603
OpenAlex: W2011617127
Cited by: 1,215
References: 31
Citations by year: 2026: 27 · 2025: 32 · 2024: 61 · 2023: 44 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 50 · 2018: 40 · 2017: 50 · 2016: 39 · 2015: 44 · 2014: 60 · 2013: 51 · 2012: 45
FWCI: 21.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Research Councils UK
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Mer receptor tyrosine kinase, efferocytosis, phagocytosis, macrophages, systemic lupus erythematosus, autoimmunity, inflammation, thymocytes
MeSH terms: c-Mer Tyrosine Kinase, Animals, Antibodies, Antinuclear, Cell Adhesion, Cells, Cultured, Crosses, Genetic, Cytochalasin B, Dexamethasone, Female, Flow Cytometry, Immunohistochemistry, Listeria monocytogenes, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Electron, Scanning, Microspheres, Mutation, Phagocytosis, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Radiation Chimera, Receptors, Fc, Thymus Gland, Bone Marrow Transplantation, Apoptosis, Macrophages, Peritoneal, Receptor Protein-Tyrosine Kinases, Mice

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Phagocytosis and clearance of apoptotic cells is mediated by MER

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