Phagocytosis and clearance of apoptotic cells is mediated by MER

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321

Programmed Cell Death in Animal Development

Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491

Phagocyte recognition of cells undergoing apoptosis

Savill, J., Fadok, V. A., Henson, P. M., & Haslett, C. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90215-7 · Cited by 981

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

D'Cruz, P. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.645 · Cited by 884

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 818

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

O’Bryan, J. P., Frye, R. A., Cogswell, P. C., Neubauer, A., Kitch, B., Prokop, C. A., Espinosa, R., Beau, M. M. L., Earp, H. S., & Liu, E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5016 · Cited by 746

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724

Human CD14 mediates recognition and phagocytosis of apoptotic cells

Devitt, A., Moffatt, O., Raykundalia, C., Capra, J. D., Simmons, D. L., & Gregory, C. D. (1998) · Nature · doi:10.1038/33169 · Cited by 681

Oestrogen action and male fertility: experimental and clinical findings

Li, X., Li, H., Lina, J., Li, X., & Rahman, N. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1981-4 · Cited by 27

MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells

Zheng, G.-L., Li, L., Zhang, Y., Qu, L., Wang, W., Li, M., Yu, S., Zhou, M., Luo, Y., Sun, Y., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1738278 · Cited by 26

Preclinical Characterization of XL092, a Novel Receptor Tyrosine Kinase Inhibitor of MET, VEGFR2, AXL, and MER

Hsu, J., Chong, C., Serrill, J., Goon, L., Balayan, J., Johnson, E. N., Lorenzana, G., Wu, S. K., Leong, K. G., Yun, T. J., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0262 · Cited by 26

A Real-Time Image-Based Efferocytosis Assay for the Discovery of Functionally Inhibitory Anti-MerTK Antibodies

Bravo, D. D., Shi, Y., Sheu, A., Liang, W., Lin, W., Wu, Y., Yan, M., & Wang, J. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200597 · Cited by 25

TAM receptors and the regulation of erythropoiesis in mice

Tang, H. R., Chen, S., Wang, H., Wu, H. J., Lu, Q., & Han, D. (2009) · Haematologica · doi:10.3324/haematol.13635 · Cited by 27

Measurement of Phagocytic Engulfment of Apoptotic Cells by Macrophages Using pHrodo Succinimidyl Ester

Aziz, M., Yang, W., & Wang, P. (2013) · Current Protocols in Immunology · doi:10.1002/0471142735.im1431s100 · Cited by 25

Signals from Dying Cells: Tolerance Induction by the Dendritic Cell

Ferguson, T. A., & Kazama, H. (2005) · Immunologic Research · doi:10.1385/ir:32:1-3:099 · Cited by 25

Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: Response pathways initiated in nearby viable cells

Patel, V. A., Lee, D. J., Longacre, A., Feng, L., Lieberthal, W., Rauch, J., Ucker, D. S., & Levine, J. S. (2009) · Autoimmunity · doi:10.1080/08916930902832124 · Cited by 25

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis

Guttenberg, M. A., Vose, A. T., Birukova, A., Lewars, K., Cumming, R. I., Albright, M. C., Mark, J. I., Salazar, C. J., Swaminathan, S., Yu, Z., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0390oc · Cited by 26

In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions

Atkin‐Smith, G. K., Santavanond, J. P., Light, A., Rimes, J. S., Samson, A. L., Er, J. A. K., Liu, J. J., Johnson, D. N., Page, M. L., Rajasekhar, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52867-5 · Cited by 25

Tim-4 functions as a scavenger receptor for phagocytosis of exogenous particles

Min, C., Park, J., Kim, G., Moon, H., Lee, S.-A., Kim, D., Moon, B., Yang, S., Lee, J., Kim, K., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02773-7 · Cited by 31

MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles

Yéfimova, M., Ravel, C., Rolland, A. D., Bourmeyster, N., & Jégou, B. (2021) · Cells · doi:10.3390/cells10061443 · Cited by 24

Longitudinal and simultaneous profiling of 11 modes of cell death in mouse retina post-optic nerve injury

Yao, Y., Xu, Y., Liang, J., Zhuang, X., & Ng, T. K. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109159 · Cited by 24

Inherited Retinal Dystrophy in Mer Knockout Mice

Duncan, J. L., Yang, H., Vollrath, D., Yasumura, D., Matthes, M. T., Trautmann, N., Chappelow, A. V., Feng, W., Earp, H. S., Matsushima, G. K., et al. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0067-4_21 · Cited by 24

The affirmative response of the innate immune system to apoptotic cells

Patel, V. A., Longacre, A., Cvetanović, M., Lee, D. J., Feng, L., Fan, H., Rauch, J., Ucker, D. S., & Levine, J. S. (2007) · Autoimmunity · doi:10.1080/08916930701357463 · Cited by 24

MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients

Cheong, H. S., Lee, S. O., Choi, C., Sung, Y., Shin, H. D., & Bae, S. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel182 · Cited by 24

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition

Xue, G., Kohler, R. S., Tang, F., Hynx, D., Wang, Y., Orso, F., Prêtre, V., Ritschard, R., Hirschmann, P., Cron, P. D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18213 · Cited by 25

The Deadly Dance of B Cells with Trypanosomatids

Silva‐Barrios, S., Charpentier, T., & Stäger, S. (2017) · Trends in Parasitology · doi:10.1016/j.pt.2017.10.001 · Cited by 26

Immunoproteasome subunit β5i regulates diet‐induced atherosclerosis through altering MERTK‐mediated efferocytosis in Apoe knockout mice

Liao, J., Xie, Y., Lin, Q., Yang, X., An, X., Xia, Y., Du, J., Wang, F., & Li, H. (2019) · The Journal of Pathology · doi:10.1002/path.5368 · Cited by 24

Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis

Berg, C. P., Stein, G. M., Keppeler, H., Gregor, M., Wesselborg, S., & Lauber, K. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0157-6 · Cited by 24

Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis

Wang, H., Du, Y., Huang, S., Sun, X., Ye, Y., Sun, H., Chu, X., Shan, X., Yuan, Y., Shen, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48914-w · Cited by 25

Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K-Dependent Factor Protein S

Ginisty, A., Gély-Pernot, A., Abaamrane, L., Morel, F., Arnault, P., Coronas, V., & Benzakour, O. (2014) · Stem Cells · doi:10.1002/stem.1862 · Cited by 23

TAM kinases as regulators of cell death

Post, S. M., Andreeff, M., Dinardo, C. D., Khoury, J. D., & Ruvolo, P. P. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.118992 · Cited by 22

Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow‐derived macrophages under inflammatory stress

Wu, S., Romero‐Ramírez, L., & Mey, J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30619 · Cited by 23

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis

Neel, D. V., Basu, H., Gunner, G., & Chiu, I. M. (2022) · Immunological Reviews · doi:10.1111/imr.13083 · Cited by 22

Dead cell phagocytosis and innate immune checkpoint

Yoon, K. W. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.10.147 · Cited by 23

Gas6/TAM Axis in Sepsis: Time to Consider Its Potential Role as a Therapeutic Target

Salmi, L., Gavelli, F., Patrucco, F., Caputo, M., Avanzi, G. C., & Castello, L. M. (2019) · Disease Markers · doi:10.1155/2019/6156493 · Cited by 22

Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro

Gregory, C. D., Pound, J. D., Devitt, A., Wilson-Jones, M., Ray, P., & Murray, R. J. (2009) · mAbs · doi:10.4161/mabs.1.4.9124 · Cited by 24

Genetic architecture of human fibrotic diseases: disease risk and disease progression

Gardet, A., Zheng, T. S., & Viney, J. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00159 · Cited by 23

Apoptosis and immune responses to self

Navratil, J. S., Sabatine, J. M., & Ahearn, J. M. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(03)00110-8 · Cited by 23

MerTK Downregulates Lipopolysaccharide-Induced Inflammation Through SOCS1 Protein but Does Not Affect Phagocytosis of Escherichia coli in Macrophages

Zhang, B., Lu, H., Jiang, A.-G., Wu, H., Fang, L., & Lv, Y.-X. (2018) · Inflammation · doi:10.1007/s10753-018-0877-5 · Cited by 22

Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells

Zhang, X., Zheng, P., Prestwood, T. R., Zhang, H., Carmi, Y., Tolentino, L. L., Wu, N., Choi, O., Winer, D. A., Strober, S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01982 · Cited by 22

Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx

Yang, S., Min, C., Moon, H., Moon, B., Lee, J., Jeon, J., Kwon, H., Jang, D. S., & Park, D. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05925-7 · Cited by 24

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS

Nguyen, L. T., Aprico, A., Nwoke, E. C., Walsh, A. D., Blades, F., Avneri, R., Martin, E., Zalc, B., Kilpatrick, T. J., & Binder, M. D. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02921-8 · Cited by 27

Apoptotic membrane dynamics in health and disease

Olson, M. F., & Julian, L. (2015) · Cell Health and Cytoskeleton · doi:10.2147/chc.s57893 · Cited by 23

Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?

Janning, M., Batalla, I. B., & Loges, S. (2015) · Expert Review of Hematology · doi:10.1586/17474086.2015.997704 · Cited by 22

B cells in glomerulonephritis: focus on lupus nephritis

Clatworthy, M. R., & Smith, K. G. C. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0092-1 · Cited by 23

Chapter 1 Immune Regulation by B Cells and Antibodies

Hoehlig, K., Lampropoulou, V., Roch, T., Neves, P., Calderón‐Gómez, E., Anderton, S. M., Steinhoff, U., & Fillatreau, S. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00401-x · Cited by 23

Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity

Jordö, E. D., Wermeling, F., Chen, Y., & Karlsson, M. C. I. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.01.010 · Cited by 22

Macrophage-mediated clearance of cells undergoing caspase-3-independent death

Turner, C., Devitt, A., Parker, K. M. A., MacFarlane, M., Giuliano, M., Cohen, G. M., & Gregory, C. D. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401170 · Cited by 22

Genetic models for the clearance of apoptotic cells

Cohen, P. L., & Caricchio, R. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.04.003 · Cited by 22

The proximal cis‐acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells

Wong, C. C. S., & Lee, W. M. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03092.x · Cited by 22

The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF

Gohlke, P. R., Williams, J., Vilen, B. J., Dillon, S. R., Tisch, R., & Matsushima, G. K. (2009) · Autoimmunity · doi:10.1080/08916930802668586 · Cited by 22

Human Mesenchymal Stromal Cell Secretome Promotes the Immunoregulatory Phenotype and Phagocytosis Activity in Human Macrophages

Holopainen, M., Impola, U., Lehenkari, P. P., Laitinen, S., & Kerkelä, E. (2020) · Cells · doi:10.3390/cells9092142 · Cited by 21

Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications

Dutta, S., Mukherjee, A., & Nongthomba, U. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.01.002 · Cited by 21

Role of Growth Arrest–Specific Gene 6 in the Development of Fungal Allergic Airway Disease in Mice

Shibata, T., Ismailoglu, U. B., Kittan, N. A., Serezani, A. P. M., Coelho, A. L., Chupp, G. L., Kunkel, S. L., Lukacs, N. W., & Hogaboam, C. M. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0049oc · Cited by 21

Exogenous Gas6 attenuates silica-induced inflammation on differentiated THP-1 macrophages

Shen, Y., Cui, X., Rong, Y., Zhang, Z., Xiao, L., Zhou, T., & Chen, W. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.05.029 · Cited by 21

Splenic Phagocytes Promote Responses to Nucleosomes in (NZB × NZW) F1 Mice

Okamoto, A., Fujio, K., van Rooijen, N., Tsuno, N. H., Takahashi, K., Tsurui, H., Hirose, S., Elkon, K. B., & Yamamoto, K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5264 · Cited by 21

Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension

Batchu, S. N., Hughson, A., Wadosky, K. M., Morrell, C. N., Fowell, D. J., & Korshunov, V. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307848 · Cited by 21

Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammation

Zhen, Y., Finkelman, F. D., & Shao, W.-H. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0917-368r · Cited by 20

TAM receptors: A phosphatidylserine receptor family and its implications in viral infections

Roy, S. G. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.09.003 · Cited by 19

The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages

Jiménez-García, L., Mayer, C., Burrola, P., Huang, Y., Shokhirev, M. N., & Lemke, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.960401 · Cited by 21

The resolution of phagosomes

Mylvaganam, S., & Freeman, S. A. (2023) · Immunological Reviews · doi:10.1111/imr.13260 · Cited by 23

Nonessential Role of β3 and β5 Integrin Subunits for Efficient Clearance of Cellular Debris after Light-Induced Photoreceptor Degeneration

Joly, S., Samardzija, M., Wenzel, A., Thiersch, M., & Grimm, C. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2432 · Cited by 20

Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging

Santulli-Marotto, S., Gervais, A., Fisher, J., Strake, B., Ogden, C. A., Riveley, C., & Giles-Komar, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145078 · Cited by 20

Cell death recognition model for the immune system

Sun, E. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.05.049 · Cited by 20

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

Gao, J.-X., Liu, X., Wen, J., Caligiuri, M. A., Stroynowski, I., Zheng, P., & Liu, Y. (2003) · Blood · doi:10.1182/blood-2003-07-2480 · Cited by 20

Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer

Happonen, K. E., Burrola, P., & Lemke, G. (2023) · Communications Biology · doi:10.1038/s42003-023-05287-y · Cited by 19

From MASH to HCC: the role of Gas6/TAM receptors

Apostolo, D., Ferreira, L. L., Vincenzi, F., Vercellino, N., Minisini, R., Latini, F., Ferrari, B., Burlone, M. E., Pirisi, M., & Bellan, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1332818 · Cited by 19

Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway

Ruan, S., Jia, R., Hu, L., Liu, Y., Tian, Q., Jiang, K., Xia, X., Tao, X., Liu, W., Pan, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455771 · Cited by 26

DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis

Kayashima, Y., Makhanova, N., & Maeda, N. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309522 · Cited by 19

Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells

Clarke, J., Yaqubi, M., Futhey, N. C., Sedaghat, S., Baufeld, C., Blain, M., Baranzini, S. E., Butovsky, O., White, J. H., Antel, J. P., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000129 · Cited by 18

TAM Receptor Knockout Mice Are Susceptible to Retinal Autoimmune Induction

Ye, F., Li, Q., Yan, K., Lu, Q., Han, L., Kaplan, H. J., Shao, H., & Lu, Q. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6700 · Cited by 19

Apoptosis and Apoptosis-Related Molecules in the Submandibular Gland of the Nonobese Diabetic Mouse Model for Sjögren's Syndrome: Limited Role for Apoptosis in the Development of Sialoadenitis

van Blokland, S. C. A., van Helden-Meeuwsen, C. G., Wierenga‐Wolf, A. F., Tielemans, D., Drexhage, H. A., van de Merwe, J. P., Homo‐Delarche, F., & Versnel, M. A. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000048721.21475.d1 · Cited by 19

The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

Manderson, A. P., Carlucci, F., Lachmann, P., Lazarus, R., Festenstein, R., Cook, H., Walport, M., & Botto, M. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1936 · Cited by 22

Environmental adjuvants, apoptosis and the censorship over autoimmunity

Rovere, P. Q., Manfredi, A. A., & Sabbadini, M. G. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.04.013 · Cited by 19

MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy

Du, Y., Lu, Z., Yang, D.-B., Wang, D., Jiang, L., Shen, Y.-F., Du, Q., & Yu, W. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147525 · Cited by 18

MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites

Lindsay, R. S., Whitesell, J. C., Dew, K. E., Rodriguez, E., Sandor, A., Tracy, D., Yannacone, S. F., Basta, B. N., Jacobelli, J., & Friedman, R. S. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200464 · Cited by 20

Two-Front War on Cancer—Targeting TAM Receptors in Solid Tumour Therapy

Mikołajczyk, A., Mituła, F., Popiel, D., Kaminska, B., Wieczorek, M., & Pieczykolan, J. (2022) · Cancers · doi:10.3390/cancers14102488 · Cited by 20

GM-CSF protects rat photoreceptors from death by activating the SRC-dependent signalling and elevating anti-apoptotic factors and neurotrophins

Schallenberg, M., Charalambous, P., & Thanos, S. (2012) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-012-1932-9 · Cited by 18

Tumor-Induced Immune Suppression

Gabrilovich, D. I., & Hurwitz, A. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-69118-3 · Cited by 18

TAM receptors are dispensable in the phagocytosis and killing of bacteria

Williams, B. J. C., Craven, R. R., Earp, H. S., Kawula, T. H., & Matsushima, G. K. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.06.006 · Cited by 18

Urokinase-Type Plasminogen Activator Inhibits Efferocytosis of Neutrophils

Yang, Y., Friggeri, A., Banerjee, S., Bdeir, K. H., Cines, D. B., Liu, G., & Abraham, E. H. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0452oc · Cited by 18

Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion

Gilbert, M., Carnathan, D. G., Cogswell, P. C., Lin, L., Baldwin, A. S., & Vilen, B. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4803 · Cited by 18

Serum Axl predicts histology-based response to induction therapy and long-term renal outcome in lupus nephritis

Parodis, I., Ding, H., Zickert, A., Cosson, G., Fathima, M., Grönwall, C., Mohan, C., & Gunnarsson, I. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212068 · Cited by 20

Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing

Lahey, K. C., Varsanyi, C., Wang, Z., Aquib, A., Gadiyar, V., Rodrigues, A. A., Pulica, R., Desind, S. Z., Davra, V., Calianese, D. C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084404 · Cited by 19

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens

Bee, G. C. W., Lokken-Toyli, K. L., Yeung, S. T., Rodriguez, L., Zangari, T., Anderson, E. E., Ghosh, S., Rothlin, C. V., Brodin, P., Khanna, K. M., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.018 · Cited by 17

Comparison of the Kinetics of Maturation of Phagosomes Containing Apoptotic Cells and IgG-Opsonized Particles

Viegas, M. S., Estronca, L. M. B. B., & Vieira, O. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048391 · Cited by 18

Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs

Neeli, I., Richardson, M. M., Khan, S. N., Nicolo, D., Monestier, M., & Radic, M. Z. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.09.027 · Cited by 17

Is the TAM Receptor Axl a Receptor for Lymphocytic Choriomeningitis Virus?

Sullivan, B. M., Welch, M. J., Lemke, G., & Oldstone, M. B. A. (2013) · Journal of Virology · doi:10.1128/jvi.03268-12 · Cited by 18

Donor kidney injury molecule-1 promotes graft recovery by regulating systemic necroinflammation

Lee, J.-Y., Ismail, O. Z., Zhang, X., Haig, A. R., Lian, D., & Gunaratnam, L. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14745 · Cited by 16

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Manoharan, P., Song, T., Radzyukevich, T. L., Sadayappan, S., Lingrel, J. B., & Heiny, J. A. (2019) · iScience · doi:10.1016/j.isci.2019.07.009 · Cited by 17

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Barthlott, T., Handel, A. E., Teh, H. Y., Wirasinha, R. C., Hafen, K., Žuklys, S., Roch, B., Orkin, S. H., de Villartay, J., Daley, S. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24158-w · Cited by 16

Negative regulation of human mononuclear phagocyte function

Hedl, M., & Abraham, C. (2013) · Mucosal Immunology · doi:10.1038/mi.2012.139 · Cited by 17

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Perche, O., Doly, M., & Ranchon‐Cole, I. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2007.12.005 · Cited by 17

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Malmegrim, K. C. R., Pruijn, G. J. M., & VENROOIJ, W. J. V. (2002) · PubMed · Cited by 17

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Ban, M., Liao, W., Baker, A., Compston, A., Thorpe, J. W., Molyneux, P. D., Fraser, M., Khadake, J., Jones, J., Coles, A. J., et al. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-019-0569-0 · Cited by 16

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Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

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