The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Frizzled-7 signalling controls tissue separation during Xenopus gastrulation
Abstract
Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, the canonical beta-catenin pathway contributes to the establishment of the dorsal-ventral axis. A different branch, referred to as the planar cell polarity pathway, is essential for cell polarization during elongation of the axial mesoderm by convergent extension. Here we demonstrate that a third branch of the cascade is independent of Dishevelled function and involves signalling through trimeric G proteins and protein kinase C (PKC). During gastrulation, Frizzled-7 (Fz7)-dependent PKC signalling controls cell-sorting behaviour in the mesoderm. Loss of zygotic Fz7 function results in the inability of involuted anterior mesoderm to separate from the ectoderm, which leads to severe gastrulation defects. This result provides a developmentally relevant in vivo function for the Fz/PKC pathway in vertebrates.
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“Ca2+ can also activate PKC which regulates the process of tissue separation during gastrulation via activation of the small GTPase CDC42.100”
From Wnt signal transduction pathways (2008) · cites this paper as [100]
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Cites
Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Dishevelled controls cell polarity during Xenopus gastrulation
Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
Miller, J. R., Hocking, A. M., Brown, J. D., & Moon, R. T. (1999) · Oncogene · doi:10.1038/sj.onc.1203245 · Cited by 689
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680
Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
He, X., Saint‐Jeannet, J., Woodgett, J. R., VARMUS, H. E., & Dawid, I. B. (1995) · Nature · doi:10.1038/374617a0 · Cited by 484
Sheldahl, L. C., Park, M., Malbon, C. C., & Moon, R. T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80310-8 · Cited by 475
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406
Hsu, S.-C., Galcerán, J., & Grosschedl, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4807 · Cited by 363
Djiane, A., Riou, J.-F., Umbhauer, M., Boucaut, J.-C., & Shi, D.-L. (2000) · Development · doi:10.1242/dev.127.14.3091 · Cited by 316
Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1010 · Cited by 299
Medina, A., Reintsch, W., & Steinbeißer, H. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00240-9 · Cited by 174
Self-citationFrizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis
Deardorff, M. A., Tan, C. L., Conrad, L. J., & Klein, P. S. (1998) · Development · doi:10.1242/dev.125.14.2687 · Cited by 160
Winklbauer, R., & Schürfeld, M. (1999) · Development · doi:10.1242/dev.126.16.3703 · Cited by 133
Self-citationProtein kinase C isozymes have distinct roles in neural induction and competence in Xenopus
Otte, A. P., & Moon, R. T. (1992) · Cell · doi:10.1016/0092-8674(92)90074-m · Cited by 107
Sumanas, S., Strege, P. R., Heasman, J., & Ekker, S. C. (2000) · Development · doi:10.1242/dev.127.9.1981 · Cited by 105
Development and Control of Tissue Separation at Gastrulation in Xenopus
Wacker, S., Grimm, K., Joos, T. O., & Winklbauer, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9794 · Cited by 98
Self-citationExpression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system
Shi, D., Goisset, C., & Boucaut, J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00166-4 · Cited by 66
The Xenopus Ets transcription factor XER81 is a target of the FGF signaling pathway
Münchberg, S. R., & Steinbeißer, H. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00193-2 · Cited by 54
Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27
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Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Proximal events in Wnt signal transduction
Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,135
Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., & Foord, S. M. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.233 · Cited by 804
“Perhaps a better precedent is the involvement of the low-density lipoprotein receptor-related proteins in the response of frizzled receptors to their ligands, the Wnts (Winklbauer et al., 2001).”
BackgroundShaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements
Keller, R. E. (2002) · Science · doi:10.1126/science.1079478 · Cited by 731
Metadata
- Authors
- Winklbauer, R., Medina, A., Swain, R. K., & Steinbeisser, H.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Venue
- Nature
- Published
- 2001-10
- Volume
- 413
- Issue
- 6858
- Pages
- 856-860
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1664587663
- Cited by
- 263
- References
- 21
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Frizzled-7, Wnt signaling, gastrulation, Xenopus laevis, protein kinase C, trimeric G proteins, cell sorting, mesoderm, ectoderm, planar cell polarity, convergent extension, dorsal-ventral axis, β-catenin signaling
- MeSH terms
- Animals, Cytoskeletal Proteins, Embryo, Nonmammalian, Fibroblast Growth Factors, Gastrula, Mesoderm, Morphogenesis, Protein Kinase C, Receptors, Cell Surface, Xenopus laevis, Signal Transduction, Trans-Activators, Gene Expression, Oligonucleotides, Antisense, Cell Polarity, GTP-Binding Proteins, Xenopus Proteins, Receptors, G-Protein-Coupled, beta Catenin
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