Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

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Physical morbidity in elderly psychiatric inpatients: prevalence and possible relations between the major mental disorders and physical illness

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Thyroid epithelial cells produce large amounts of the Alzheimer beta- amyloid precursor protein (APP) and generate potentially amyloidogenic APP fragments

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Absence of Association of α1-Antichymotrypsin Polymorphisms with Alzheimer's Disease: A Report on Autopsy-Confirmed Cases

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Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope

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Evidence that glypican is a receptor mediating β-amyloid neurotoxicity in PC12 cells

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An investigation into the mechanisms mediating plasma lipoprotein‐potentiated β‐amyloid fibrillogenesis

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Apolipoprotein E and Amyloidogenesis

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Differential metabolism of ApoE isoforms in plasma and CSF

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Ferulic Acid Suppresses AmyloidβProduction in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide

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No effect of the alpha 1-antichymotrypsin A allele in Alzheimer's disease

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α1-Antichymotrypsin interaction with Aβ(1–42) does not inhibit fibril formation but attenuates the peptide toxicity

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Cladistic Approaches to Identifying Determinants of Variability in Multifactorial Phenotypes and the Evolutionary Significance of Variation in the Human Genome

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Endogenous Human Proteins Interfering with Amyloid Formation

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1-Antichymotrypsin Polymorphism: A Risk Factor for Hemorrhagic Stroke in Normotensive Subjects

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Lipid metabolism in Alzheimer’s and Parkinson’s disease

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Pharmacological Mechanisms in Alzheimer's Therapeutics

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The APP and PS1/2 Mutations Linked to Early Onset Familial Alzheimer’s Disease Increase the Extracellular Concentration of Aβ1–42(43)

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Induction of the α1-Antichymotrypsin Gene in the Brain Associated with TGF-β1 Deficiency or Systemic Administration of Endotoxin

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TGFβ1 enhances formation of cellular Aβ/apoE deposits in vascular myocytes

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Effects of apoE Deficiency and Occlusal Disharmony on Amyloid-Beta Production and Spatial Memory in Rats

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The Degenerative Dementias

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Distribution of plasma α1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls

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Gender-specific nonrandom association between the α1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease

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Muscarinic M1-Receptor Agonists

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Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice

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Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype

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Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

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Biophysical Properties of Apolipoprotein E4 Variants: Implications in Molecular Mechanisms of Correction of Hypertriglyceridemia

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The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tönz Syndrome

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Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic

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Prediction of Transmembrane Regions, Cholesterol, and Ganglioside Binding Sites in Amyloid-Forming Proteins Indicate Potential for Amyloid Pore Formation

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Novel Mutations in β-MYH7 Gene in Indian Patients With Dilated Cardiomyopathy

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From Small Peptides to Large Proteins against Alzheimer’sDisease

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Association between α1-antichymotrypsin signal peptide −15A/T polymorphism and the risk of Alzheimer’s disease: a meta-analysis

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Pharmacologic Management of Alzheimer Disease Part I: Hormonal and Emerging Investigational Drug Therapies

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Immunohistochemical Presence of Apolipoprotein D in Senile Plaques

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Astrocyte‐ and hepatocyte‐specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue‐specific chromatin structures

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Effect of cerebrospinal fluid from normal and Alzheimer's patients with different apolipoprotein E phenotypes on in vitro aggregation of amyloid beta-protein

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A Cell-Based Method for the Detection of Nanomolar Concentrations of Bioactive Amyloid

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Is the binding of β-amyloid protein to antichymotrypsin in Alzheimer plaques mediated by a β-strand insertion?

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The AMY Antigen Co-Occurs with Aβ and Follows Its Deposition in the Amyloid Plaques of Alzheimer's Disease and Down Syndrome

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Polygenic Determinants of Alzheimer's Disease: Modulation of the Risk by α‐1‐Antichymotrypsina

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Do Nonsteroidal Anti-Inflammatory Drugs Have a Protective Effect Against Dementia?

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APOE ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum

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Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases

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Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42

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Alpha-1-Antichymotrypsin Gene Polymorphism and Risk for Sporadic Alzheimer’s Disease in a German Population

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Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology

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Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study

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Role of A β Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease

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Apolipoprotein E and Alpha-1-Antichymotrypsin Polymorphisms in Sporadic Inclusion Body Myositis

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A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD

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Increased frequency of the α‐1‐antichymotrypsin T allele in cerebral amyloid angiopathy

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Isoform-specific binding of human apolipoprotein E to the non-amyloid β component of Alzheimer's disease amyloid

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Inflammatory Mechanisms of Alzheimer’s Disease

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Biological Markers for Alzheimer's Disease

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APOE Genotype in Relation to Sporadic and Alzheimer-Related CAA

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Differential Regulation of APP Secretion by Apolipoprotein E3 and E4a

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Vaccines for conformational disorders

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The Role of Aβ-Peptide on Spatial Memory, EEG, Auditory Evoked Potentials And Nicotinic Cholinergic Receptors in A/P Transgenic Mice

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Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition

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USE OF FUSED CIRCULATIONS TO INVESTIGATE THE ROLE OF APOLIPOPROTEIN E AS AMYLOID CATALYST AND PERIPHERAL SINK IN ALZHEIMER'S DISEASE

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Expression of Human Apolipoprotein E Downregulates Amyloid Precursor Protein–Induced Ischemic Susceptibility

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Aggregation of amyloid β-protein as function of age and apolipoprotein E in normal and Alzheimer's serum

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Co-localization of amyloid-associated proteins with amyloid β in rat soleus muscle in chloroquine-induced myopathy: a possible model for amyloid β formation in Alzheimer's disease

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Apolipoprotein E, Aβ‐Amyloid, and the Molecular Pathology of Alzheimer's Disease Therapeutic Implicationsa

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Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease

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Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease

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Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model

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Protein Misfolding Disorders and Rational Design of Antimisfolding Agents

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α1-Antichymotrypsin polymorphism in Japanese cases of Alzheimer's disease

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Nonsteroidal Anti-Inflammatory Drugs and Alzheimer??s Disease

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Lack of Association between an Intronic Polymorphism in the Presenilin-1 Gene and Sporadic Late-Onset Alzheimer Disease in Polish Patients

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Genetics and the Central Nervous System: Apolipoprotein E and Brain Injury

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A novel serpin-like protein, B-43, exists in both neurons and astrocytes: an immunohistochemical study in the parietal region of the bovine brain

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Original article Size frequency distributions of β-amyloid (Aβ) deposits: a comparative study of four neurodegenerative disorders

Armstrong, R. A. (2012) · Folia Neuropathologica · doi:10.5114/fn.2012.30524 · Cited by 11

Lack of Genetic Associations of Alpha-1-Antichymotrypsin Polymorphism with Alzheimer-Type Neuropathological Changes or Sporadic Alzheimer’s Disease

Sodeyama, N., Yamada, M., Itoh, Y., Suematsu, N., Matsushita, M., Otomo, E., & Mizusawa, H. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017123 · Cited by 11

Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription

Strachan-Whaley, M. R., Reilly, K., Dobson, J., & Kalisch, B. E. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.032 · Cited by 12

Apolipoprotein E genotypes in AA and AL amyloidoses

Kindy, M. S., de Beer, F. C., Markesbery, W. R., Pras, M., Aksentijevich, I. A., Kastner, D., Kyle, R. A., Solomon, A., & Woo, P. M. (1995) · Amyloid · doi:10.3109/13506129509036919 · Cited by 11

Protease Inhibitors and their Involvement in Neurological Disorders

Tizón, B., & Levy, E. (2007) · Springer eBooks · doi:10.1007/978-0-387-30379-6_20 · Cited by 11

Molecular pathology of Alzheimer's disease

Yamazaki, T., & Ihara, Y. (1997) · Neuropathology · doi:10.1111/j.1440-1789.1997.tb00051.x · Cited by 11

Changes in expression of lymphocyte amyloid precursor protein mRNA isoforms in normal aging and Alzheimer's disease

Ebstein, R. P., Nemanov, L., Lubarski, G., Dano, M., Trevis, T., & Korczyn, A. D. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00227-j · Cited by 11

Gene-environment interplay in neurogenesis and neurodegeneration

Palomo, T., Archer, T., Beninger, R. J., & Kostrzewa, R. M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033279 · Cited by 11

Rat Microglia Exhibit Increased Density on Alzheimer's Plaquesin Vitro

Joshi, S. N., & Crutcher, K. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6678 · Cited by 11

Apolipoprotein E receptor pathways in Alzheimer disease

Schmidt, V., Carlo, A.-S., & Willnow, T. E. (2014) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1262 · Cited by 10

The Complexity of the Genotype-Phenotype Relationship and the Limitations of Using Genetic “Markers” at the Individual Level

Templeton, A. R. (1998) · Science in Context · doi:10.1017/s0269889700003082 · Cited by 10

Normal Tension Glaucoma is not Associated With the Interleukin -1α (−889) Genetic Polymorphism

Wang, C.-Y., Shen, Y.-C., Lo, F.-Y., Su, C.-H., Lee, S.-H., Tsai, H.-Y., & Fan, S.-S. (2007) · Journal of Glaucoma · doi:10.1097/ijg.0b013e3180300818 · Cited by 10

Size frequency distribution of the β-amyloid (aβ) deposits in dementia with Lewy bodies with associated Alzheimer’s disease pathology

Armstrong, R. A., & Cairns, N. J. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0135-6 · Cited by 10

Chronic thrombin exposure results in an increase in apolipoprotein-E levels

Mhatre, M., Hensley, K., Nguyen, A., & Grammas, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20887 · Cited by 10

A study of apolipoproteins E and A-I in cutaneous amyloids

Chang, Y.-T., Tsai, S., Wang, W. J., Hong, C., Huang, C., & Wong, C. K. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04402.x · Cited by 12

No Association between Alpha-1-Antichymotrypsin Polymorphism and Alzheimer’s Disease in Chinese

Wang, Y.-C., Liu, T., Liu, H.-C., Chi, C.-W., Sim, C., Tsai, S., & Hong, C. (1999) · Neuropsychobiology · doi:10.1159/000026599 · Cited by 11

Cell cycle and chromosome segregation defects in alzheimer's disease

Potter, H., Geller, L. N., Thomas, A. E., Conforto, D., & Chichkova, R. I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)83340-0 · Cited by 10

Do β-amyloid (Aβ) deposits in patients with Alzheimer's disease and Down's syndrome grow according to the log-normal model?

Armstrong, R. A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00009-9 · Cited by 10

Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease

Naidu, A., Catalano, R., Bales, K. R., Wu, S., Paul, S. M., & Cordell, B. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00042 · Cited by 10

Apolipoprotein E affects amyloid formation but not amyloid growthin vitro: Mechanistic implications for ApoE4 enhanced amyloid burden and risk for Alzheimer's disease

Esler, W. P., Marshall, J. R., Stimson, E. R., Ghilardi, J. R., Vinters, H. V., Mantyh, P. W., & Maggio, J. E. (2002) · Amyloid · doi:10.3109/13506120209072439 · Cited by 10

Oxidative Stress in Alzheimer’s Disease

Ceballos-Picot, I. (1997) · Neuroscience intelligence unit · doi:10.1007/978-3-662-22516-5_5 · Cited by 10

Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides

Ma, J., Brewer, H. B., & Potter, H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00112-1 · Cited by 108

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

Castano, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, R. A., Soto, C., & Frangione, B. (1995) · Biochemical Journal · doi:10.1042/bj3060599 · Cited by 267

Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Aβ deposition, in an AβPP/PS double transgenic mouse model of Alzheimer's disease

Costa, D. A., Nilsson, L. N. G., Bales, K. R., Paul, S. M., & Potter, H. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6508 · Cited by 14

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.763 · Cited by 333