Radiation-induced cell cycle arrest compromised by p21 deficiency

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2. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
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3. Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1
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4. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors
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5. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
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6. miR-17∼92 cooperates with RB pathway mutations to promote retinoblastoma
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7. p21/p53, Cellular Growth Control and Genomic Integrity
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8. A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis
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9. A Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase
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10. WAC, a Functional Partner of RNF20/40, Regulates Histone H2B Ubiquitination and Gene Transcription
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11. p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein
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12. Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage
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13. Complete Pathologic Response Following Preoperative Chemoradiation Therapy for Middle to Lower Rectal Cancer Is Not a Prognostic Factor for a Better Outcome
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14. Thymoquinone Triggers Inactivation of the Stress Response Pathway Sensor CHEK1 and Contributes to Apoptosis in Colorectal Cancer Cells
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15. Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice
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16. The tumour suppressor protein p53 can repress transcription of cyclin B
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17. Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse
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18. The role of retinoids and retinoic acid receptors in normal hematopoiesis
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19. p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures
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20. p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint
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21. Cyclins and CDKS in development and cancer: lessons from genetically modified mice
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22. The role of DNA damage responses in p53 biology
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23. Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest
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24. H2O2 Induces a Transient Multi-phase Cell Cycle Arrest in Mouse Fibroblasts through Modulating Cyclin D and p21Cip1 Expression
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25. p53-dependent ceramide response to genotoxic stress.
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26. Involvement of p53 in cell differentiation and development
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27. Tbx2 Directly Represses the Expression of the p21WAF1 Cyclin-Dependent Kinase Inhibitor
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28. Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells
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29. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
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30. The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma
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31. p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells.
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33. A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation
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34. Photoprotective effects of green tea polyphenols
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35. Inhibitors of the Cip/Kip Family
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36. Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts
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37. Protective Role of p21 Waf1/Cip1 against Prostaglandin A 2 -Mediated Apoptosis of Human Colorectal Carcinoma Cells
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38. Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice
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39. Positive effect of the induction of p21WAF1/CIP1 on the course of ischemic acute renal failure
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40. AP4 encodes a c-MYC-inducible repressor of p21
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41. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo
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42. p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
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43. Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines
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44. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.
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45. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal
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46. p 21WAF1 C ontrol of E pithelial C ell C ycle and C ell F ate
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48. p57KIP2: “Kip”ing the Cell under Control
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49. Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery
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50. p53 accumulates but is functionally impaired when DNA synthesis is blocked
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51. From the Cover: p53 accumulates but is functionally impaired when DNA synthesis is blocked
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52. Regulation of p21WAF1/CIP1 Stability by WISp39, a Hsp90 Binding TPR Protein
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53. Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1in Cell Cycle-Independent Neuroprotection
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54. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
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55. Loss of cyclin‐dependent kinase inhibitors produces adipocyte hyperplasia and obesity
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56. Control of E2F activity by p21Waf1/Cip1
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57. p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis
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58. Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin
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59. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.
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60. Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin
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61. Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage
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62. Introduction: p53 – the first twenty years
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63. The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation
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64. The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
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65. Genetic Alterations in Esophageal Cancer
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66. Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation
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67. Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression <i>In vivo</i>
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70. p53 induction of heparin‐binding EGF‐like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
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71. Tsg101 Is Essential for Cell Growth, Proliferation, and Cell Survival of Embryonic and Adult Tissues
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72. Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis
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73. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
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74. JAK/STAT Pathway Plays a Critical Role in the Proinflammatory Gene Expression and Apoptosis of RAW264.7 Cells Induced by Trichothecenes as DON and T-2 Toxin
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75. Combined-Modality Treatment of Solid Tumors Using Radiotherapy and Molecular Targeted Agents
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76. p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
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77. Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
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78. Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells
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79. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
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80. Tumor suppressor p53 and its gain-of-function mutants in cancer
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81. Phosphorylation of p21 in G2/M Promotes Cyclin B-Cdc2 Kinase Activity
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82. Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation
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83. A DNA Damage Checkpoint Meets the Cell Cycle Engine
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84. Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners
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85. Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
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86. Induction of p21 WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16 INK4a
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87. Identification of genes induced by BRCA1 in breast cancer cells
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88. Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal Cells
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89. Different impact of p53 and p21 on the radiation response of mouse tissues
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90. Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression
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91. Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy
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92. Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I
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93. p53 downstream targets and chemosensitivity
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94. Pituitary Hypoplasia inPttg−/−Mice Is Protective forRb+/−Pituitary Tumorigenesis
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95. Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389
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96. N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation
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97. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53‐regulated apoptosis
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98. Targeted clearance of <i>p21</i> ‐ but not <i>p16</i> ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
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99. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
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100. The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression
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