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Retention of the Arginine Allele in Codon 72 of the p53 Gene Correlates with Poor Apoptosis in Head and Neck Cancer

Schneider‐Stock, R., Mawrin, C., Motsch, C., Boltze, C., Peters, B., Hartig, R., Buhtz, P., Giers, A., Rohrbeck, A., Freigang, B., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63211-7 · Cited by 76 · see citing works

The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis‐inducing stimuli

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Effect of p53 Status and STAT1 on Chemotherapy-Induced, Fas-Mediated Apoptosis in Colorectal Cancer

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p53: 25 years of research and more questions to answer

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Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling

Dunkern, T. R., Wedemeyer, I., Baumgärtner, M., Fritz, G., & Kaina, B. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00185-4 · Cited by 64 · see citing works

Mad dogs, Englishmen and apoptosis: The role of cell death in UV-induced skin cancer

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Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds

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SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway

Rujkijyanont, P., Watanabe, K., Ambekar, C., Wang, H., Schimmer, A. D., Beyene, J., & Dror, Y. (2008) · Haematologica · doi:10.3324/haematol.11579 · Cited by 59 · see citing works

Testicular germ cell tumours: The paradigm of chemo-sensitive solid tumours

di Pietro, A., de Vries, E. G. E., Gietema, J. A., Spierings, D. C. J., & de Jong, S. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.06.014 · Cited by 57 · see citing works

Single-stranded RNA viruses inactivate the transcriptional activity of p53 but induce NOXA-dependent apoptosis via post-translational modifications of IRF-1, IRF-3 and CREB

Lallemand, C., Blanchard, B., Palmieri, M., Lebon, P., May, E., & Tovey, M. G. (2006) · Oncogene · doi:10.1038/sj.onc.1209795 · Cited by 57 · see citing works

Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer

Jung, S., Kim, D. H., Choi, Y. J., Kim, S. Y., Park, H., Lee, H., Choi, C., Sung, Y. H., Lee, J. C., & Rho, J. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-99267-z · Cited by 56 · see citing works

The Roles of Thymidylate Synthase and p53 in Regulating Fas-Mediated Apoptosis in Response to Antimetabolites

Longley, D. B., Allen, W. L., McDermott, U., Wilson, T. R., Latif, T., Boyer, J. D., Lynch, M., & Johnston, P. G. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0532 · Cited by 56 · see citing works

Targeting Death Receptors in Bladder, Prostate and Renal Cancer

O’Kane, H. F., Watson, C. J., Johnston, S. R., Peták, I., William, R., Watson, G. W., & Williamson, K. E. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)00160-6 · Cited by 51 · see citing works

Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents

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Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.

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A comprehensive study of p53 transcriptional activity in thymus and spleen of γ irradiated mouse: High sensitivity of genes involved in the two main apoptotic pathways

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TDAG51 Is Not Essential for Fas/CD95 Regulation and Apoptosis In Vivo

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Breathing new insights into the role of mutant p53 in lung cancer

Chen, T., Ashwood, L. M., Kondrashova, O., Strasser, A., Kelly, G. L., & Sutherland, K. D. (2024) · Oncogene · doi:10.1038/s41388-024-03219-6 · Cited by 44 · see citing works

Ionizing radiation as a response‐enhancing agent for CD95‐mediated apoptosis

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Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts

Itoh, K., Hase, H., Kojima, H., Saotome, K., Nishioka, K., & Kobata, T. (2003) · Lara D. Veeken · doi:10.1093/rheumatology/keh039 · Cited by 42 · see citing works

Exploration of resistance mechanisms for epidermal growth factor receptor‐tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next‐generation sequencing

Iwama, E., Sakai, K., Azuma, K., Harada, D., Nosaki, K., Hotta, K., Nishio, M., Kurata, T., Fukuhara, T., Akamatsu, H., et al. (2018) · Cancer Science · doi:10.1111/cas.13820 · Cited by 41 · see citing works

A cross talk between cellular signalling and cellular redox state during heat-induced apoptosis in a rat histiocytoma

Sreedhar, A. S., Pardhasaradhi, B. V. V., Khar, A., & Srinivas, U. K. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00796-1 · Cited by 38 · see citing works

Characterization of p53-mediated Up-regulation of CD95 Gene Expression upon Genotoxic Treatment in Human Breast Tumor Cells

Ruiz‐Ruiz, C., Robledo, G., Cano, E., Redondo, J. M., & López‐Rivas, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304397200 · Cited by 37 · see citing works

Influence of TRP53 Status on FAS Membrane Localization, CFLAR (c-FLIP) Ubiquitinylation, and Sensitivity of GC-2spd (ts) Cells to Undergo FAS-Mediated Apoptosis1

Chandrasekaran, Y., McKee, C. M., Ye, Y., & Richburg, J. H. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.045146 · Cited by 37 · see citing works

Involvement of p53 and Fas/CD95 in murine neural progenitor cell response to ionizing irradiation

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p53-dependent stimulation of redox-related genes in the lymphoid organs of -irradiated mice identification of Haeme-oxygenase 1 as a direct p53 target gene

Meiller, A., Alvarez, S., Drané, P., Lallemand, C., Blanchard, B., Tovey, M. G., & May, E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm824 · Cited by 36 · see citing works

CD95 Is Part of a Let-7/p53/miR-34 Regulatory Network

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Acid Sphingomyelinase Activation Requires Caspase-8 but Not P53 nor Reactive Oxygen Species during Fas-Induced Apoptosis in Human Glioma Cells

Sawada, M., Nakashima, S., Kiyono, T., Yamada, J., Hara, S., Nakagawa, M., Shinoda, J., & Sakai, N. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5437 · Cited by 32 · see citing works

Expression Level of c-FLIP versus Fas Determines Susceptibility to Fas Ligand-Induced Cell Death in Murine Thymoma EL-4 Cells

Kataoka, T., Ito, M., Budd, R. C., Tschopp, J., & Nagai, K. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5438 · Cited by 31 · see citing works

The p53 Protein Influences the Sensitivity of Testicular Germ Cells to Mono-(2-Ethylhexyl) Phthalate-Induced Apoptosis by Increasing the Membrane Levels of Fas and DR5 and Decreasing the Intracellular Amount of c-FLIP1

Chandrasekaran, Y., & Richburg, J. H. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.030858 · Cited by 30 · see citing works

Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation

Li, L., Yao, Y.-C., Fang, S., Ma, C.-Q., Cen, Y., Xu, Z.-M., Dai, Z., Li, C., Li, S., Zhang, T., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590000 · Cited by 28 · see citing works

Spatio‐temporal expression of immediate early genes in the central nervous system of SJL/J mice

Gerhauser, I., Alldinger, S., Ulrich, R., & Baumgärtner, W. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.06.004 · Cited by 27 · see citing works

A promoter that acquired p53 responsiveness during primate evolution.

Contente, A., Zischler, H., Einspanier, A., & Dobbelstein, M. (2003) · PubMed · Cited by 24 · see citing works

Two Functionally Divergent p53-responsive Elements in the Rat Bradykinin B2 Receptor Promoter

Marks, J. R., Saifudeen, Z. R., Dipp, S., & El-Dahr, S. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304543200 · Cited by 24 · see citing works

The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

Cheema, Z. F., Santillano, D. R., Wade, S. B., Newman, J. M., & Miranda, R. C. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-11 · Cited by 24 · see citing works

p21Waf1 expression is regulated by nuclear intermediate filament vimentin in neuroblastoma

Mergui, X., Puiffe, M., Valteau‐Couanet, D., Lipinski, M., Bénard, J., & Amor-Guéret, M. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-473 · Cited by 23 · see citing works

The prognostic impact of TP53 comutation in EGFR mutant lung cancer patients: a systematic review and meta-analysis

Zhang, R., Tian, P., Chen, B., Wang, T., & Li, W. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1585690 · Cited by 23 · see citing works

Targeting Hepatoma Using Nitric Oxide Donor Strategies

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Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer

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Regulating the genome surveillance system: miRNAs and the p53 super family

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Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent

Yamauchi, H., Katayama, K., Ueno, M., He, X. J., Mikami, T., Uetsuka, K., Doi, K., & Nakayama, H. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0099-z · Cited by 21 · see citing works

Fas/CD95-mediated apoptosis in human glioblastoma cells: a target for sensitisation to topoisomerase I inhibitors

Ciusani, E., Perego, P., Carenini, N., Corna, E., Facchinetti, F., Boiardi, A., Salmaggi, A., & Zunino, F. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00837-1 · Cited by 20 · see citing works

Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma1

Mahidhara, R. S., de Oliveira, P. E. Q., Kohout, J., Beer, D. G., Lin, J., Watkins, S. C., Robbins, P. D., & Hughes, S. J. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2004.08.016 · Cited by 19 · see citing works

Correlation between antioxidant status, tumorigenicity and radiosensitivity in sister rat cell lines

Bravard, A. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.705 · Cited by 19 · see citing works

Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation

Brune, M., Müller, M., Melino, G., Bierhaus, A., Schilling, T., & Nawroth, P. P. (2012) · Oncogene · doi:10.1038/onc.2012.150 · Cited by 18 · see citing works

The neurogene BTG2TIS21/PC3 is transactivated by ΔNp73α via p53 specifically in neuroblastoma cells

Goldschneider, D., Million, K., Meiller, A., Haddada, H., Puisieux, A., Bénard, J., May, E., & Douc‐Rasy, S. (2005) · Journal of Cell Science · doi:10.1242/jcs.01704 · Cited by 18 · see citing works

Replication of damaged DNA in vitro is blocked by p53

Zhou, J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg468 · Cited by 18 · see citing works

Accumulation of an inactive form of p53 protein in cells treated with TNFα

Drané, P., Leblanc, V., Miró‐Mur, F., Saffroy, R., Debuire, B., & May, E. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400983 · Cited by 18 · see citing works

A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions

Inga, A., Nahari, D., Velasco-Miguel, S., Friedberg, E. C., & Resnick, M. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205779 · Cited by 17 · see citing works

The Therapeutic Potential of the Restoration of the p53 Protein Family Members in the EGFR-Mutated Lung Cancer

Fregni, M., Ciribilli, Y., & Zawacka‐Pankau, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137213 · Cited by 16 · see citing works

The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos

Husseini, N. E., & Hales, B. F. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx270 · Cited by 13 · see citing works

CD95L/FasL and its receptor CD95 (APO-1/Fas)

Peter, M. E., Barnhart, B. C., & Algeciras-Schimnich, A. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50042-9 · Cited by 15 · see citing works

Tissue Microarray Analysis of Fas and FasL Expressions in Human Non-small Cell Lung Carcinomas; with Reference to the p53 and bcl-2 Overexpressions

Myong, N. (2005) · Journal of Korean Medical Science · doi:10.3346/jkms.2005.20.5.770 · Cited by 12 · see citing works

Mutations of Fas (APO-1/CD95) and p53 Genes in Nonmelanoma Skin Cancer

Boldrini, L., Loggini, B., Gisfredi, S., Zucconi, Y., Baldinotti, F., Fogli, A., Simi, P., Cervadoro, G., Barachini, P., Basolo, F., et al. (2003) · Journal of Cutaneous Medicine and Surgery · doi:10.1007/s10227-002-0105-6 · Cited by 12 · see citing works

Thyroid cancer harboring PTEN and TP53 mutations: A peculiar molecular and clinical case report

Colombo, C. M., Pogliaghi, G., Tosi, D., Muzza, M., Bulfamante, G., Persani, L., Fugazzola, L., & Cirello, V. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.949098 · Cited by 11 · see citing works

APOPTOTIC PROTEINS

McCarthy, N. J., Mercer, J. R., & Bennett, M. R. (2001) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70196-x · Cited by 8 · see citing works

Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration

Yi, Y., Pyun, S.-H., Kim, C., Yun, G., Kang, E., Heo, S., Ullah, I., & Lee, S. (2024) · Cells · doi:10.3390/cells13060548 · Cited by 7 · see citing works

Relationship of Fas, FasL, p53 and bcl-2 expression in human non-small cell lung carcinomas.

Li, Y., Xu, K., Jiang, D., Zhao, J., Ge, J.-F., & Zheng, S.-Y. (2015) · PubMed Central · Cited by 7 · see citing works

Inhibition of MAT2A Impairs Skeletal Muscle Repair Function

Xiao, W., Huang, T.-E., Zhou, J., Wang, B., Wang, X., Zeng, W., Wang, Q., Lan, X., & Xiang, Y. (2024) · Biomolecules · doi:10.3390/biom14091098 · Cited by 6 · see citing works

Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system

Okazaki, T., & Sakamuro, D. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0201-5 · Cited by 7 · see citing works

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

Owen‐Schaub, L. B., Zhang, W. K., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A., Zhang, W., Kruzel, E., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3032 · Cited by 731 · see citing works

The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

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Tissue-specific regulation of Fas/APO-1/CD95 expression by p53

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p53 promotes selection for Fas-mediated apoptotic resistance.

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