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The C-terminal SAM domain of p73 binds to the N terminus of MDM2

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RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

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S100A1 blocks the interaction between p53 and mdm2 and decreases cell proliferation activity

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The p53 Tumour Suppressor Protein

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GC-selective DNA-binding antibiotic, Mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis

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p53-Mediated regulation of hepatic lipid metabolism: Forging links between metabolism, atherogenesis, and cancer

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CopA3 peptide inhibits MDM2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery

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Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest

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Core Binding Factor β Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation

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Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function

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Embryonic stem cells shed new light on the developmental roles of p53

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An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis

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Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

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Considering the Role of Murine Double Minute 2 in the Cardiovascular System?

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MDM2 does not influence p53-mediated sensitivity to DNA-damaging drugs.

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Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance

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p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner

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Knockdown of p53 by RNAi in ES cells facilitates RA-induced differentiation into muscle cells

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Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland

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The Enigma of p53Preprint

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Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds

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Differential requirements for MDM2 E3 activity during embryogenesis and in adult micePreprint

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MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion

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PROTAC as a novel anti-cancer strategy by targeting aging-related signaling

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Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors

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Identification of a Structural Determinant for Selective Targeting of HDMX

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Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2

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RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling

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Non-invasive assessment of porcine oocyte quality by supravital staining of cumulus–oocyte complexes with lissamine green B

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The proto‐oncogene function of Mdm2 in bone

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The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

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Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation

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A site-directed mutagenesis study of the MdmX RING domain

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Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice

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NOVEL TARGETS IN THE CELL CYCLE AND CELL CYCLE CHECKPOINTS

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A novel genetic modifier of p53, mop1, results in embryonic lethality

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SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma

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p53 Regulation Goes Live--Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling

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Do p53 stress responses impact organismal aging?

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Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53

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Transgenic Mice as an In Vivo Model of Lymphomagenesis

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Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability

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Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo

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Ovca1, a candidate gene of the genetic modifier of Tp53, Mop2, affects mouse embryonic lethality

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Analysing p53 tumour suppressor functions in mice

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Transgenic Mouse Models for Tumor Suppressor Genes

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Immortalization and transformation of primary cells mediated by engineered ecDNAsPreprint

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The SWIB/MDM2 motif of UBE4B activates the p53 pathway

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New developments in small molecules targeting p53 pathways in anticancer therapy

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A feedback circuit of miR-34a/MDM4/p53 regulates apoptosis in chronic lymphocytic leukemia cells

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p53-mediated metabolic response to low doses of ionizing radiation

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Ubiquitin E3 ligases controlling p53 stability

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Pifithrin-α ameliorates resveratrol-induced two-cell block in mouse preimplantation embryos in vitro

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Identification of two serine residues important for p53 DNA binding and protein stability

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A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene

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A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors

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Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms

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The p53 network and its control via MDM2 inhibitors: insights from a dynamic model

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Characterization of cancer-associated missense mutations in MDM2

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The induction of tumour suppressor protein P53 limits the entry of cells into the pluripotent inner cell mass lineage in the mouse embryo

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A closer view of an oncoprotein-tumor suppressor interaction

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Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX

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A metabolic crosstalk between liposarcoma and muscle sustains tumor growth

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Dependence on Mdm2 for Mdm4 inhibition of p53 activity

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The MDM2 promoter T309G polymorphism was associated with preeclampsia susceptibility

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High-throughput synthetic rescue for exhaustive characterization of suppressor mutations in human genes

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Clinical utility of the imunohistochemical co-expression of p53 and MDM2 in thyroid follicular lesions

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The retinoblastoma binding protein 6 is a potential target for therapeutic drugs

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Targeting p53 as a Promising Therapeutic Option for Cancer By Re-Activating the Wt Or Mutant p53’s Tumor Suppression

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VX-680 induces p53-mediated apoptosis in human cholangiocarcinoma cells

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What Are the Prospects for Treating TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia?

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Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1)

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A Functional SNP in the MDM2 Promoter Mediates E2F1 Affinity to Modulate Cyclin D1 Expression in Tumor Cell Proliferation

Yang, Z.-H., Zhou, C., Zhu, H., Li, J., & He, C. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.8.3817 · Cited by 7

MDM2/P53 Inhibitors as Sensitizing Agents for Cancer Chemotherapy

Zhu, Y. Y., Wang, H., & Thuraisamy, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816435-8.00015-8 · Cited by 7

Control of the Cell Cycle

Malumbres, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00004-9 · Cited by 10

MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail

Sanford, J. D., Yang, J., Han, J., Tollini, L. A., Jin, A., & Zhang, Y. (2021) · BMC Molecular and Cell Biology · doi:10.1186/s12860-021-00385-3 · Cited by 7

The subcellular distribution of the p53 tumour suppressor, and organismal ageing.

Węsierska‐Gądek, J., & Schmid, G. (2005) · PubMed · Cited by 7

Rational design, synthesis, and biophysical characterization of a peptidic MDM2-MDM4 interaction inhibitor

Ballarotto, M., Bianconi, E., Valentini, S., Temperini, A., Moretti, F., & Macchiarulo, A. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117937 · Cited by 6

Rescuing Lethal Phenotypes Induced by Disruption of Genes in Mice: a Review of Novel Strategies

Lipták, N., Gál, Z., Biró, B., Hiripi, L., & Hoffmann, O. I. (2021) · Physiological Research · doi:10.33549/physiolres.934543 · Cited by 6

Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana

Opoku, F., Bedu-Addo, K., Titiloye, N. A., Manu, E. A., Ameh-Mensah, C., & Duduyemi, B. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258543 · Cited by 6

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Pant, V., Aryal, N. K., Xiong, S., Chau, G. P., Fowlkes, N. W., & Lozano, G. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2381 · Cited by 6

Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism

Calderón-González, K. G., Medina‐Medina, I., Hároníková, L., Hernychová, L., Bonczek, O., Uhrík, L., Hrabal, V., Vojtěšek, B., Fåhræus, R., Hernández‐Monge, J., et al. (2022) · Bioscience Reports · doi:10.1042/bsr20220186 · Cited by 6

Inactivation of tumor suppressor TAp63 by hepatitis B virus X protein in hepatocellular carcinoma

Xie, B., Hao, Q., Zhou, X. Y., & Chen, D. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002283 · Cited by 6

FAM193A is a positive regulator of p53 activity

Szwarc, M. M., Guarnieri, A. L., Joshi, M., Duc, H. N., Laird, M. C., Pandey, A., Khanal, S., Dohm, E., Bui, A. K., Sullivan, K. D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112230 · Cited by 6

Cellular senescence and cancer

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Loss of one but not twomdm2 null alleles alters the tumour spectrum inp53 null mice

McDonnell, T. J., Montes de Oca Luna, R., Cho, S., Amelse, L. L., Chavez-Reyes, A., & Lozano, G. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199907)188:3

Rescue of embryonic lethality in mdmx null mice by loss of p53 suggests a non-overlapping pathway with MDM2 to regulate p53

Parant, J. M. (2001) · Digital Commons-TMC (Texas Medical Center)

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development

Steinman, H. A., Hoover, K. L., Keeler, M. L., Sands, A., & Jones, S. N. (2005) · Oncogene · doi:10.1038/sj.onc.1208930 · Cited by 52

A conditional Mdm2 allele shows the importance of Mdm2 in heart development

Grier, J. D. (2005) · Digital Commons-TMC (Texas Medical Center)

Functional activation of p53 induces apoptosis in the absence of MDM2

de Rozìeres, S. (2001) · Digital Commons-TMC (Texas Medical Center)