Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Jones, Stephen N., Roe, Amy E., Donehower, Lawrence A., Bradley, Allan·1995·Nature

DOI 10.1038/378206a0

Cited by (1,000)

Items 601–700 of 1,000

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Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria
Yingxiao Chen, Yue-Gang Wang, Yuhuang Li, Xiao‐Xin Sun, Mu‐Shui Dai · 2016 · Oncotarget
Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
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Full-length hdmX transcripts decrease following genotoxic stress
Markey, M, Berberich, S J · 2008 · Oncogene
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Jean‐Christophe Marine · 2011 · Current topics in developmental biology/Current Topics in Developmental Biology
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p53 activation by knockdown technologies
Mara E. Robu, Jon D. Larson, Aidas Nasevicius, Soraya Beiraghi, Charles Brenner, Steven Arthur Farber, Stephen Carl Ekker · 2005 · PLoS Genetics
Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop
Riddhita Chakraborty, Ying Li, Lei Ji Zhou, Kent G. Golic · 2015 · PLoS Genetics
High-Resolution Array-Based Comparative Genomic Hybridization of Bladder Cancers Identifies Mouse Double Minute 4 ( MDM4 ) as an Amplification Target Exclusive of MDM2 and TP53
Abhi Veerakumarasivam, Helen E. Scott, Suet‐Feung Chin, Anne Yvonne Warren, Matthew J. Wallard, Donna Grimmer, Koichi Ichimura, Carlos Caldas, Vincent Peter Collins, David Edgar Neal et al. · 2008 · Clinical Cancer Research
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Geoffrey M. Wahl · 2006 · Cell Death and Differentiation
p53 from pathway to therapy
David Philip Lane · 2004 · Carcinogenesis
p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
Kazuo Kurokawa, Toshiaki Tanaka, Jun‐ya Kato · 1999 · Oncogene
Gene disruption in mice: Models of development and disease
Barkur S. Shastry · 1998 · Molecular and Cellular Biochemistry
A repressor function for telomerase activity in telomerase-negative immortal cells
Motonobu Katoh, M Katoh, Michihiro Kameyama, Hiroyuki Kugoh, Motoyuki Shimizu, Mitsuo Oshimura · 1998 · Molecular Carcinogenesis
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
Zhiwei Peter Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi Wei · 2012 · Oncotarget
Negative auto-regulators trap p53 in their web
Xiang Yu Zhou, Bo Cao, Hua Lu · 2017 · Journal of Molecular Cell Biology
Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX
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Dai-Chi Liu, Daphne E. Eagleman, Nien‐Pei Tsai · 2019 · PLoS Genetics
Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer
Wen Li, Xinhao Peng, Jinyi Lang, Chuan Shan Xu · 2020 · Frontiers in Pharmacology
Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching
Sylvia A. Hilliard, Karam Aboudehen, Xiao Yao, Samir Sayem El-Dahr · 2011 · Developmental Biology
Induction of Cullin 7 by DNA damage attenuates p53 function
Peter Jung, Berlinda Verdoodt, Aaron Oakley Bailey, John R. Yates, Antje Menssen, Heiko Hermeking · 2007 · Proceedings of the National Academy of Sciences
Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos
Vashe Chandrakanthan, Aiqing Li, Omar Chami, C. O’Neill · 2006 · Reproductive Biology and Endocrinology
Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells.
Hai Liang Yang, Yan Dong, Mary Jane Elliott, Ta Jen Liu, Cesar A. Atienza, Ariel Stilwell, Kelly M. McMasters · 1999 · PubMed
Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo
De Clercq, Sarah, Gembarska, Agnieszka, Denecker, Geertrui, Maetens, Marion, Naessens, Michael, Haigh, Katharina, Haigh, Jody J., Marine, Jean-Christophe · 2010 · Molecular and Cellular Biology
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Qian Hao, William Cho · 2014 · International Journal of Molecular Sciences
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Ishita Gupta, Nishant Kumar Varshney, Sameena M. Khan · 2018 · Frontiers in Genetics
Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
Heather A. Steinman, Hayla K. Sluss, Arthur Sands, German Albert Pihan, Stephen N. Jones · 2004 · Oncogene
Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity
Toshiaki Tanaka, Masashi Okada, Yasukazu Hozumi, Ken Tachibana, Chifumi Kitanaka, Yoshioki Hamamoto, Alberto Maria Martelli, Matthew K. Topham, Mitsuyoshi Iino, Kaoru Goto · 2013 · Journal of Cell Science
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Karen H. Vousden · 2009 · Biochemical Society Transactions
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Yan Jiang, Weilin Yang, Yuqing Zhou, Lan Ma · 2003 · Neuroscience Letters
Regulation of the Retinoblastoma-Dependent Mdm2 and E2F-1 Signaling Pathways during Neuronal Apoptosis
Emmanuelle Trinh, Anne‐Laurence Boutillier, Jean‐Philippe Loeffler · 2001 · Molecular and Cellular Neuroscience
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Józefa Węsierska‐Gądek, Jacek Wojciechowski, Gerald Schmid · 2003 · Journal of Cellular Biochemistry
The contribution of the RING finger domain of MDM2 to cell cycle progression
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MdmX regulates transformation and chromosomal stability in p53-deficient cells
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Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis
Michael I. Carr, Justine E. Roderick, Hugh Gannon, Michelle A. Kelliher, Stephen N. Jones · 2016 · Cell Reports
SMG7 is a critical regulator of p53 stability and function in DNA damage stress response
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Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility
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p53mRNA and p53 Protein Structures Have Evolved Independently to Interact with MDM2
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A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
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Nucleo-cytoplasmic shuttling of the HDM2 oncoprotein regulates the levels of P53 protein VIA a pathway USED by the human immunodeficiency virus REV protein
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Evidence that the Human Cytomegalovirus IE2-86 Protein Binds mdm2 and Facilitates mdm2 Degradation
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Alan Richard Clarke · 2000 · Carcinogenesis
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