p73 is a human p53-related protein that can induce apoptosis

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Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

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Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

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Clinical studies of p53 in treatment and benefit of breast cancer patients.

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EGF-r gene copy number changes in renal cell carcinoma detected by fluorescencein situ hybridization

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Mutation analysis of the p73 gene in nonastrocytic brain tumours

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p73 G4C14‐to‐A4T14 polymorphism and risk of human papillomavirus‐associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers

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Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway

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Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer

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New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

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p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition

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Role of SHP-2 Tyrosine Phosphatase in the DNA Damage-induced Cell Death Response

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Prognostic Impact of ΔTAp73 Isoform Levels and Their Target Genes in Colon Cancer Patients

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Tumor suppressor genes in breast cancer.

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p53 compound heterozygosity in a severely affected child with Li-Fraumeni Syndrome

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Cytotoxic sensitivity to tumor necrosis factor-? in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin)

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Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

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p53-Dependent apoptosis induced in human bronchial epithelial (16-HBE) cells by PM2.5sampled from air in Guangzhou, China

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p73 as a Pharmaceutical Target for Cancer Therapy

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Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

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Killer in search of a motive?

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TAp73β and DNp73β activate the expression of the pro-survival caspase-2 S

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Overexpression of phosphorylated‐ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma

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Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice

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Inactivation of Retinoblastoma (RB) Tumor Suppressor by Oncogenic Isoforms of the p53 Family Member p73

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Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas.

Takada, N., Ozaki, T., Ichimiya, S., Todo, S., & Nakagawara, A. (1999) · PubMed · Cited by 37

The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain

Wilson, C., Henry, S. E., Smith, M. A., & Bowser, R. P. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00496.x · Cited by 37

Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at Exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's Lymphoma in Japanese

Hishida, A., Matsuo, K., Tajima, K., Ogura, M., Kagami, Y., Taji, H., Morishima, Y., Emi, N., Naoe, T., & Hamajima, N. (2004) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190310001638878 · Cited by 37

Programmed cell death: a missing link is found

Jacobson, M. D. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01182-3 · Cited by 37

Molecular Cloning and Functional Characterization of the Upstream Promoter Region of the Human p73 Gene

Ding, Y. (1999) · DNA Research · doi:10.1093/dnares/6.5.347 · Cited by 37

Gene therapy for thyroid cancer

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Exclusion of c-Abl from the Nucleus Restrains the p73 Tumor Suppression Function

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Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target

Imyanitov, E. N., Birrell, G. W., Filippovich, I. V., Sorokina, N., Arnold, J. M., Mould, M. A., Wright, K., Walsh, M. D., Mok, S. C., Lavin, M. F., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202863 · Cited by 37

Expression of the β4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells

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Gros1, a potential growth suppressor on chromosome 1: its identity to basement membrane-associated proteoglycan, leprecan

Kaul, S. C., Sugihara, T., Yoshida, A., Nomura, H., & Wadhwa, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203696 · Cited by 37

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

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p73 is not Mutated in Meningiomas as Determined with a Functional Yeast Assay but p73 Expression Increases with Tumor Grade

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p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P., & Ryan, K. M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1191714 · Cited by 31

IκB Kinase β Promotes Cell Survival by Antagonizing p53 Functions through ΔNp73α Phosphorylation and Stabilization

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Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome‐specific probes

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p73 Isoforms Can Induce T-Cell Factor–Dependent Transcription in Gastrointestinal Cells

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Differential Effect of ik3-1/Cables on p53- and p73-induced Cell Death

Tsuji, K., Mizumoto, K., Yamochi, T., Nishimoto, I., & Matsuoka, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108535200 · Cited by 36

Aberrant expression of ΔNp73 in benign and malignant tumours of the prostate: correlation with Gleason score

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High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

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Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women

Valladares, A., García-Hernández, N., Gómez, F. S., Curiel‐Quesada, E., Madrigal‐Bujaidar, E., Vergara, M. D., Martínez, M. S., & Arenas-Aranda, D. J. (2006) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2006.06.002 · Cited by 36

Thioredoxin‐Related Regulation of NO/NOS Activities

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ΔNp73 can modulate the expression of various genes in a p53-independent fashion

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Failure of viral oncoproteins to target the p53-homologue p51A

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Genetics and Genodermatoses

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Mammary Epithelial Cell Polarity Is Regulated Differentially by p73 Isoforms via Epithelial-to-mesenchymal Transition

Zhang, Y., Yan, W., Jung, Y.-S., & Chen, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.358143 · Cited by 35

Noble metals in oncology

Markowska, A., Kasprzak, B., Jaszczyńska-Nowinka, K., Lubin, J., & Markowska, J. (2015) · Współczesna Onkologia · doi:10.5114/wo.2015.54386 · Cited by 35

Predicting clinical outcomes of cancer patients with a p53 deficiency gene signature

Schaafsma, E., Takacs, E. M., Kaur, S., Cheng, C., & Kurokawa, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-05243-6 · Cited by 34

Full-length p73α Represses Drug-induced Apoptosis in Small Cell Lung Carcinoma Cells

Nyman, U., Pluta, A., Engskog‐Vlachos, P., Perlmann, T., Zhivotovsky, B., & Joseph, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500394200 · Cited by 36

p73 Overexpression and Angiogenesis in Human Colorectal Carcinoma

Guan, M. (2003) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyg045 · Cited by 35

Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B

Martín, Á. G., Trama, J. P., Crighton, D., Ryan, K. M., & Fearnhead, H. O. (2009) · Aging · doi:10.18632/aging.100026 · Cited by 35

Association of p73 and MDM2 Polymorphisms With the Risk of Epithelial Ovarian Cancer in Chinese Women

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Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line

Goldschneider, D., Blanc, É., Raguénez, G., Barrois, M., Legrand, A., Roux, G. L., Haddada, H., Bénard, J., & Douc‐Rasy, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00834 · Cited by 34

Progress in the Molecular Biology of Ewing Tumors

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Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein

Kaida, A., Ariumi, Y., Ueda, Y., Lin, J.-Y., Hijikata, M., Ikawa, S., & Shimotohno, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203387 · Cited by 35

Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels

Nakano, H., Kohara, M., & Shinohara, K. (2001) · Cell and Tissue Research · doi:10.1007/s004410100438 · Cited by 35

Regulatory feedback loop between TP73 and TRIM32

González-Cano, L., Hillje, A., Fuertes-Álvarez, S., Marqués, M. M., Blanch, A., Ian, R. W., Irwin, M. S., Schwamborn, J. C., & Marín, M. C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.224 · Cited by 34

Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs

Bunjobpol, W., Dulloo, I., Igarashi, K., Concin, N., Matsuo, K., & Sabapathy, K. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.41 · Cited by 34

Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma

Kawano, S. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1151 · Cited by 34

Cutaneous fibrosis induced by docetaxel

Cleveland, M. G., Ajaikumar, B. S., & Reganti, R. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000301)88:5 · Cited by 48

p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53

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p73 gene transcripts in human brain tumors: overexpression and altered splicing in ependymomas

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Regulation of p73 by Hck through kinase-dependent and independent mechanisms

Paliwal, P., Radha, V., & Swarup, G. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-45 · Cited by 34

The effect of radioiodine treatment on the diseased thyroid gland

Riley, A., McKenzie, G. A. G., Green, V., Schettino, G., England, R. J., & Greenman, J. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1665206 · Cited by 34

Multilevel regulation and molecular mechanism of poly (rC)‐binding protein 1 in cancer

Zhang, X., Di, C., Chen, Y., Wang, J., Su, R., Huang, G., Xu, C., Chen, X., Long, F., Yang, H., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000911r · Cited by 33

Identification of the interleukin 4 receptor alpha gene as a direct target for p73.

Sasaki, Y., Mita, H., Toyota, M., Ishida, S., Morimoto, I., Yamashita, T., Tanaka, T., Imai, K., Nakamura, Y., & Tokino, T. (2003) · PubMed · Cited by 33

iASPP Inhibition: Increased Options in Targeting the p53 Family for Cancer Therapy

Bell, H. S., & Ryan, K. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0182 · Cited by 33

WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and ΔNp73 Levels

Chaudhary, N., & Maddika, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00101-14 · Cited by 33

Role of Activating Transcription Factor 3 on TAp73 Stability and Apoptosis in Paclitaxel-Treated Cervical Cancer Cells

Oh, Y. K., Lee, H. J., Jeong, M.-H., Rhee, M., Mo, J., Song, E. H., Lim, J.-Y., Choi, K., Jo, I., Park, S. I., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0297 · Cited by 34

Role of Functional Polymorphisms of P53 and P73 Genes with the Risk of Prostate Cancer in a Case-Control Study from Northern India

Mittal, R. D., George, G. P., Mishra, J., Mittal, T., & Kapoor, R. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.03.001 · Cited by 33

Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene

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p19 Interacts with and Activates p73 by Involving the MDM2 Protein

Jeong, M.-H., Bae, J., Kim, W., Yoo, S.-M., Kim, J.-W., Song, P. I., & Choi, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513853200 · Cited by 33

Molecular Genetics in the Diagnosis and Prognosis of Solid Pediatric Tumors

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Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer

Jung, O., Baek, M.-J., Wooldrik, C., Johnson, K. R., Fisher, K. W., Lou, J., Ricks, T. J., Wen, T., Best, M. D., Cryns, V. L., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00085-6 · Cited by 34

Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2

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Interaction of TAp73 and Breast Cancer–Associated Gene 3 Enhances the Sensitivity of Cervical Cancer Cells in Response to Irradiation-Induced Apoptosis

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c-Jun NH2-Terminal Kinase Activating Kinase 1/Mitogen-Activated Protein Kinase Kinase 4–Mediated Inhibition of SKOV3ip.1 Ovarian Cancer Metastasis Involves Growth Arrest and p21 Up-regulation

Lotan, T. L., Hickson, J. A., Souris, J. S., Huo, D., Taylor, J., Li, T., Otto, K. B., Yamada, S. D., Macleod, K. F., & Rinker-Schaeffer, C. W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-1568 · Cited by 32

Characterization of p73 functional domains necessary for transactivation and growth suppression

Nozell, S. E., Wu, Y., McNaughton, K., Liu, G., Willis, A. C., Paik, J. C., & Chen, X. (2003) · Oncogene · doi:10.1038/sj.onc.1206470 · Cited by 32

Analysis of p73 and p53 gene deletions in multiple myeloma

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Immunohistochemical demonstration of p63 in DMBA‐induced hamster buccal pouch squamous cell carcinogenesis

Yk, C., Ss, H., & Lin, L. (2003) · Oral Diseases · doi:10.1034/j.1601-0825.2003.02920.x · Cited by 32

Proteomics Identification of Azaspiracid Toxin Biomarkers in Blue Mussels, Mytilus edulis

Nzoughet, J. K., Hamilton, J. T. G., Botting, C. H., Douglas, A., Devine, L., Nelson, J., & Elliott, C. T. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800561-mcp200 · Cited by 31

p73: From the p53 shadow to a major pharmacological target in anticancer therapy

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Deacetylation of Transcription Factors in Carcinogenesis

Hałasa, M., Adamczuk, K., Adamczuk, G., Afshan, S., Stepulak, A., Cybulski, M., & Wawruszak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111810 · Cited by 32

Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR‐345‐3p‐FAF1/TP73 axis in intervertebral disc degeneration

Li, Y., Wu, X., Li, J., Du, L., Wang, X., Cao, J., Li, H., Huo, Z., Li, G., Pan, D., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2776440 · Cited by 31

SHP-2 Phosphatase Regulates DNA Damage-induced Apoptosis and G2/M Arrest in Catalytically Dependent and Independent Manners, Respectively

Yuan, L., Yu, W., Xu, M., & Qu, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506768200 · Cited by 31

p53 Family Members Regulate the Expression of the Apolipoprotein D Gene

Sasaki, Y., Negishi, H., Koyama, R., Anbo, N., Ohori, K., Idogawa, M., Mita, H., Toyota, M., Imai, K., Shinomura, Y., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807185200 · Cited by 31

Transcription Factor KLLN Inhibits Tumor Growth byARSuppression, Induces Apoptosis byTP53/TP73Stimulation in Prostate Carcinomas, and Correlates With Cellular Differentiation

Wang, Y., Radhakrishnan, D., He, X., Peehl, D. M., & Eng, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3490 · Cited by 31

Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia

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Specific and conserved roles of TAp73 during zebrafish development

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Loss of heterozygosity on hromosome 1 in sporadic colorectal carcinoma

Zhou, C. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i10.1431 · Cited by 31

Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas.

Herranz, M., Santos, J., SALIDO, E. C., Fernández‐Piqueras, J., & Serrano, M. (1999) · PubMed · Cited by 31

Structure of the C-terminal sterile α-motif (SAM) domain of human p73α

Wang, W. K., Bycroft, M., Foster, N. W., Buckle, A. M., Fersht, A. R., & Chen, Y. W. (2001) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444901002529 · Cited by 31

E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia

Brooks, L., Sullivan, A., O’Nions, J., Bell, A., Dunne, B., TIDY, J. A., Evans, D. J., Osin, P., Vousden, K. H., Gusterson, B. A., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600033 · Cited by 31

Transcriptional activities of p73 splicing variants are regulated by inter-variant association

Ueda, Y., Hijikata, M., Takagi, S., Chiba, T., & Shimotohno, K. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560859 · Cited by 31

Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood

Hernandez-Acosta, N. C., Cabrera‐Socorro, A., Morlans, M. P., Delgado, F. J. G., Suárez-Solá, M. L., Sottocornola, R., Lü, X., González‐Gómez, M., & Meyer, G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.041 · Cited by 30

Germline mutations in the p73 gene do not predispose to familial prostate‐brain cancer

Peters, M. A., Janer, M., Kolb, S., Jarvik, G. P., Ostrander, E. A., & Stanford, J. L. (2001) · The Prostate · doi:10.1002/pros.1109 · Cited by 30

The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways

Yeo, C. I., Ooi, K. K., Akim, A. M., Ang, K. P., Fairuz, Z. A., Halim, S. N. A., Ng, S. W., Seng, H., & Tiekink, E. R. T. (2013) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.05.011 · Cited by 30

Differential regulation of transcription and induction of programmed cell death by human p53‐family members p63 and p73

Dietz, S., Rother, K., Bamberger, C., Schmale, H., Mössner, J., & Engeland, K. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03093-4 · Cited by 59

New Monoclonal Antibodies Recognizing the p53 Tumour Suppressor Protein Homologue p73

Češková, P., Nenutil, R., Bray, S. E., Svitáková, M., Babcanová, S., Uldrijan, S., & Vojtěšek, B. (2001) · Folia Biologica · doi:10.14712/fb2001047060211

p73, a sophisticated p53 family member in the cancer world

Ozaki, T., & Nakagawara, A. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00116.x · Cited by 141

p73 can suppress the proliferation of cells that express mutant p53

Willis, A. C., Pipes, T., Zhu, J., & Chen, X. (2003) · Oncogene · doi:10.1038/sj.onc.1206505 · Cited by 25

The Emerging p53 Gene Family

Kaelin, W. G. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.594 · Cited by 143