p73 is a human p53-related protein that can induce apoptosis

Jost, Christine A., Marin, Maria C., Jr, William G. Kaelin·1997·Nature
DOI 10.1038/38298

Cited by (943)

Items 301–400 of 943

  1. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51
    Makoto Senoo, Izumi Tsuchiya, Y Matsumura, Takahiro Mori, Yuki Saito, Hiroyuki Kato, Takashi Okamoto, Sonoko Habu · 2001 · British Journal of Cancer
  2. p53 Activates the Mitochondrial Death Pathway and Apoptosis of Ventricular Myocytes Independent of de novo Gene Transcription
    Kelly M. Regula, Lorrie A. Kirshenbaum · 2001 · Journal of Molecular and Cellular Cardiology
  3. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes
    Norbert E. Fusenig, Petra Boukamp · 1998 · Molecular Carcinogenesis
  4. Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway
    Zhong Sun, Zhenyu Cheng, Catherine A. Taylor, Brendan J. McConkey, John E. Thompson · 2010 · Journal of Cellular Physiology
  5. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition
    Xiang Yu Zhou, Q Hao, Qiongdan Zhang, Liao Jm, Ke Jw, P Liao, Beibei Cao, Hang Lu · 2014 · Cell Death and Differentiation
  6. DNp73 a matter of cancer: Mechanisms and clinical implications
    Sven Buhlmann, Brigitte M. Pützer · 2008 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  7. Mdm2 and MdmX as Regulators of Gene Expression
    Lynn Biderman, James L. Manley, Carol L. Prives · 2012 · Genes & Cancer
  8. Nuclear Import and Export Signals in Control of the p53-related Protein p73
    Tomomi Matsui Inoue, Jeremy Stuart, Richard Leno, Carl G. Maki · 2002 · Journal of Biological Chemistry
  9. Of Mice and Genes: Evolution of Vertebrate Brain Development
    Bernd Fritzsch · 1998 · Brain Behavior and Evolution
  10. Physical Interaction between Wilms Tumor 1 and p73 Proteins Modulates Their Functions
    Volkher Scharnhorst, Patrick Dekker, Alex J. van der Eb, Aart G. Jochemsen · 2000 · Journal of Biological Chemistry
  11. Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis
    Jonathan A. Hickson, S. Diane Yamada, Jonathan Berger, John C. Alverdy, James O’Keefe, Bonnie L. Bassler, Carrie W Rinker-Schaeffer · 2008 · Clinical & Experimental Metastasis
  12. Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese
    Yoshimitsu Niwa, Nobuyuki Hamajima, Yoshiko Atsuta, Kazuhito Yamamoto, Akiko Tamakoshi, Toshiko Saito, Kaoru Hirose, Toru Nakanishi, Akihiro Nawa, Kazuo Kuzuya et al. · 2004 · Cancer Letters
  13. UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination
    Mitsuchika Hosoda, Toshinori Ozaki, Kou Miyazaki, Syunji Hayashi, Kazushige Furuya, Kenichi Watanabe, Takahito Nakagawa, Takayuki Hanamoto, Satoru Todo, Akira Nakagawara · 2005 · Oncogene
  14. p73 tumor-suppressor activity is impaired in human thyroid cancer.
    Francesco Frasca, Veronica Vella, Alessandra Aloisi, Angelo Mandarino, Emanuela Mazzon, Riccardo Vigneri, Paolo Giovanni Vigneri · 2003 · PubMed
  15. Expression of the Cell Cycle Phosphatase cdc25C Is Down-Regulated by the Tumor Suppressor Protein p53 but Not by p73
    Karen Krause, Ulrike Haugwitz, Mark Wasner, Marcus W. Wiedmann, Joachim Mössner, Kurt Engeland · 2001 · Biochemical and Biophysical Research Communications
  16. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
    Fumihiro Higashino, James M. Pipas, Thomas E. Shenk · 1998 · Proceedings of the National Academy of Sciences
  17. Human telomerase expression regulation
    Marta Machnik, Aneta Wojtyla, Błażej Rubiś · 2011 · Biochemistry and Cell Biology
  18. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology
    Ying Mao, Xigui Chen, Min Xu, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura et al. · 2016 · Human Molecular Genetics
  19. Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells
    Jianli Liu, Shuai Wang, Siqi Tian, Yin He, Hong Xiang Lou, Zhijun Yang, Yuchi Kong, Xiangyu Cao · 2018 · Food & Nutrition Research
  20. Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells
    Qianjing Zhang, Cuixia Di, Junfang Yan, Fang Wang, Tao Qu, Yupei Wang, Yuhong Chen, Xuetian Zhang, Yang Liu, Hongying Yang et al. · 2019 · Artificial Cells Nanomedicine and Biotechnology
  21. Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism
    Bruno Galy, Laurent Créancier, Catherine Zanibellato, Anne‐Catherine Prats, Hervé Prats · 2001 · Oncogene
  22. p73 and p63 protein stability: the way to regulate function?
    Carine Maisse, Pietro Guerrieri, Gerry Melino · 2003 · Biochemical Pharmacology
  23. YY1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription
    Tatiana Yakovleva, Larissa Kolesnikova, Vladana B. Vukojević, Гилева Ирина Павловна, Koichi Tan–No, Matthias Austen, Bernhard Lüscher, Tomas J. Ekström, Lars Y. Terenius, Georgy Ya. Bakalkin · 2004 · Biochemical and Biophysical Research Communications
  24. Human T-cell Leukemia Virus Type I Tax Repression of p73β Is Mediated through Competition for the C/H1 Domain of CBP
    Isabelle Lemasson, Jennifer K. Nyborg · 2001 · Journal of Biological Chemistry
  25. Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression
    Michimasa Nozaki, Mitsuhiro Tada, Hiroyuki Kobayashi, Chang-Liang Zhang, Yutaka Sawamura, Hiroshi Abe, Nobuaki Ishii, Erwin G. Van Meir · 1999 · Neuro-Oncology
  26. Telomerase as a useful target in cancer fighting—the breast cancer case
    Hanna Hołysz, Natalia Lipińska, Anna Paszel-Jaworska, Błażej Rubiś · 2013 · Tumor Biology
  27. Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression
    Giulia Bon, Selene E. Di Carlo, Valentina Folgiero, Paolo Avetrani, Chiara Lazzari, Gabriella D’Orazi, Maria Felice Brizzi, Ada Sacchi, Silvia Soddu, Giovanni Blandino et al. · 2009 · Cancer Research
  28. Evaluation of 1p Losses in Primary Carcinomas, Local Recurrences and Peripheral Metastases from Colorectal Cancer Patients
    Lin Thorstensen, Hanne Qvist, Sverre Heim, Gerrit‐Jan Liefers, Jahn M. Nesland, Karl-Erik Giercksky, Ragnhild A. Lothe · 2000 · Neoplasia
  29. The Role of P53 in Human Cancer
    David M. Malkin · 2001 · Journal of Neuro-Oncology
  30. p73 competes with p53 and attenuates its response in a human ovarian cancer cell line
    Faina Vikhanskaya · 2000 · Nucleic Acids Research
  31. The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells
    Irit Nahor, Shirley Abramovitch, Kurt Engeland, Haim Werner · 2005 · Growth Hormone & IGF Research
  32. p53 and p73 display common and distinct requirements for sequence specific binding to DNA
    Maria Lokshin, Yingchun Li, Christian Gaiddon, Carol L. Prives · 2006 · Nucleic Acids Research
  33. The C-terminal Sterile α Motif and the Extreme C Terminus Regulate the Transcriptional Activity of the α Isoform of p73
    Gang Liu, Xinbin Chen · 2005 · Journal of Biological Chemistry
  34. Multiple Stress Signals Induce p73β Accumulation
    Kai Wei Lin, Shin Yuen Nam, Wen Hong Toh, Iqbal Dulloo, Kanaga Sabapathy · 2004 · Neoplasia
  35. Folate deficiency, mismatch repair-dependent apoptosis, and human disease
    Guo‐Min Li, Steven R. Presnell, Liya Gu · 2003 · The Journal of Nutritional Biochemistry
  36. Ligand-dependent activation of transcription in vitro by retinoic acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo
    Francis Jeffrey Dilworth, Catherine Fromental-Ramain, Eumorphia Remboutsika, Arndt Benecke, Pierre Chambon · 1999 · Proceedings of the National Academy of Sciences
  37. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population
    Zhibin Hu, Xiaoping Miao, Hongxia Ma, Wen Tan, Xinru Wang, Jin Li, Qingyi Wei, Dongxin Lin, Hongbing Shen · 2004 · International Journal of Cancer
  38. Polymorphisms of p16, p27, p73, and MDM2 Modulate Response and Survival of Pancreatic Cancer Patients Treated with Preoperative Chemoradiation
    Jinyun Chen, Donghui Li, Ann McNeill Killary, Subrata Sen, Christopher I. Amos, Douglas B. Evans, James L. Abbruzzese, Marsha L. Frazier · 2008 · Annals of Surgical Oncology
  39. The changing face of p53 in head and neck cancer
    Maxine Partridge, Daniela Elena Costea, X. Huang · 2007 · International Journal of Oral and Maxillofacial Surgery
  40. Regulation of Fertility by the p53 Family Members
    Wenwei Hu, T. Zheng, Jun Wang · 2011 · Genes & Cancer
  41. p73 isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis
    Raquel Díaz, Cristina Peña, Javier Silva, Yolanda Lorenzo, Vanesa García‐Barberán, José M. García, Antonio Sánchez, Pablo Espinosa Lara, R. Sánchez Yuste, Félix Bonilla et al. · 2008 · International Journal of Cancer
  42. Regulation of telomerase activity by the p53 family member p73
    Michaela Beitzinger, Claudia Oswald, Rasa Beinoravičiūtė-Kellner, Thorsten Stiewe · 2005 · Oncogene
  43. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
    Β. Michael Ghadimi, Dan L. Sackett, Michael J. Difilippantonio, Evelin Schr�ck, Thomas Neumann, Annukka Jauho, Gert Auer, Thomas Ried · 2000 · Genes Chromosomes and Cancer
  44. Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: Prevalence of alterations in inflammatory breast cancers
    J.C. Ahomadegbe, Sophie Tourpin, Mourad Kaghad, Laurent H. Zelek, Muriel Vayssade, Marie Christine Mathieu, France Rochard, M. Spielmann, Thomas Tursz, Daniel Caput et al. · 2000 · Oncogene
  45. Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73
    Andrea Tannapfel, K John, Nathan Mise, Antje Schmidt, Sven Buhlmann, Saleh Mohamed Ibrahim, Brigitte M. Pützer · 2007 · Carcinogenesis
  46. Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects
    Yoshimitsu Niwa, Kaoru Hirose, Keitaro Matsuo, Kazuo Tajima, Yoko Ikoma, Toru Nakanishi, Akihiro Nawa, Kazuo Kuzuya, Akiko Tamakoshi, Nobuyuki Hamajima · 2004 · Cancer Letters
  47. Tumor Suppressor p53 and Its Homologue p73α Affect Cell Migration
    Anna A. Sablina, Peter M. Chumakov, Boris P. Kopnin · 2003 · Journal of Biological Chemistry
  48. Epigenetic Up-Regulation of Leukemia Inhibitory Factor (LIF) Gene During the Progression to Breast Cancer
    Jung Eun Shin, Su Hyung Park, Yeun Kyu Jang · 2010 · Molecules and Cells
  49. The Human p73 Promoter: Characterization and Identification of Functional E2F Binding Sites
    Ratnam S. Seelan, Meredith S. Irwin, Petra P.M. van der Stoop, Chiping Qian, William G. Kaelin, Wanguo Liu · 2002 · Neoplasia
  50. Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers
    Xi Chen, Erich M. Sturgis, Adel K. El‐Naggar, Q. Wei, Guoqiang Li · 2008 · Carcinogenesis
  51. CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53
    Frank Dicker, Arnon Philip Kater, Carlos Enrique Prada, Tetsuya Fukuda, Januario E. Castro, Guizhen Sun, Jean Y. Wang, Thomas J. Kipps · 2006 · Blood
  52. p73 is over-expressed in vulval cancer principally as the Δ2 isoform
    Jenny O’Nions, L. Brooks, Angela Sullivan, A Bell, B Dunne, M. Rozycka, A Reddy, JOHN A. TIDY, D Evans, Paul J. Farrell et al. · 2001 · British Journal of Cancer
  53. Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence
    Stefanie A. Kane, Catherine Fleener, Yun Zhang, Lenora J. Davis, Amy Musselman, Pearl S. Huang · 2000 · Analytical Biochemistry
  54. Bispecific antibody-mediated lysis of primary cultures of ovarian carcinoma cells using multiple target antigens
    Karine A. Smans, Magdalena B. Ingvarsson, Peter Lindgren, Silvana Canevari, Heinrich Walt, Torgny I. Stigbrand, Torbj rn B ckstr m, Jos� Luis Mill�n · 1999 · International Journal of Cancer
  55. Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB
    Toshinori Ozaki, Kenichi Watanabe, Takahito Nakagawa, Kou Miyazaki, Masato Takahashi, Akira Nakagawara · 2003 · Oncogene
  56. c-Abl Tyrosine Kinase Selectively Regulates p73 Nuclear Matrix Association
    Merav Ben‐Yehoyada, Israel Ben‐Dor, Yosef Shaul · 2003 · Journal of Biological Chemistry
  57. Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia
    Urban Novak, Tobias J. Grob, Gökben Baskaynak, U.R. Peters, Stefan Paul Aebi, Daniel R. Zwahlen, Mario P. Tschan, Karl‐Anton Kreuzer, Elisabeth Oppliger Leibundgut, Jean‐François Cajot et al. · 2001 · Annals of Oncology
  58. Negative control elements of the cell cycle in human tumors
    Peter D. Adams, William G. Kaelin · 1998 · Current Opinion in Cell Biology
  59. Transcription factors Tp73, Cebpd Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury
    Lipponen, Anssi, El-Osta, Assam, Kaspi, Antony, Ziemann, Mark, Khurana, Ishant, KN, Harikrishnan, Navarro-Ferrandis, Vicente, Puhakka, Noora, Paananen, Jussi, Pitkänen, Asla · 2018 · Acta Neuropathologica Communications
  60. Tumor Suppressors and Cell-Cycle Proteins in Lung Cancer
    Alfonso Baldi, Antonio De Luca, Vincenzo Esposito, Mara Campioni, Enrico Pierluigi Spugnini, Gennaro Citro · 2011 · Pathology Research International
  61. p73β-Mediated Apoptosis Requires p57kip2 Induction and IEX-1 Inhibition
    Susana González, Manuel M. Pérez‐Pérez, Eva Hernando, Manuel Serrano, Carlos Cordon‐Cardo · 2005 · Cancer Research
  62. TP73 G4C14-A4T14polymorphism and cancer susceptibility: evidence from 36 case–control studies
    Jialin Meng, Shuo Wang, Meng Zhang, Song Fan, Li Zhang, Chang Yin Liang · 2018 · Bioscience Reports
  63. iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes
    Yun Cai, Shi Qiu, Xing Gao, Shou-Zhi Gu, Ze-Jun Liu · 2012 · APOPTOSIS
  64. Amplification and Overexpression of mdm2 Gene in Ependymomas
    Satoshi O. Suzuki, Toru Iwaki · 2000 · Modern Pathology
  65. The role of p73 in hematological malignancies
    Agnieszka Pluta, Ulrika Nyman, Bertrand Joseph, Tadeusz Robak, Boris Zhivotovsky, Piotr Smolewski · 2006 · Leukemia
  66. δEF1 repressor controls selectively p53 family members during differentiation
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  68. The jury is in: p73 is a tumor suppressor after all: Figure 1.
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  69. Combined p53‐related genetic variants together with HPV infection increase oral cancer risk
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  74. Excessive Apoptosis in Low Risk Myelodysplastic Syndromes (MDS)
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  75. P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?
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  76. Regulation of p53 Family Member Isoform ΔNp63α by the Nuclear Factor-κB Targeting Kinase IκB Kinase β
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  77. Molecular mechanisms of apoptosis and cell selectivity of zinc dithiocarbamates functionalized with hydroxyethyl substituents
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  79. MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis
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  80. α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73
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  81. p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function
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  82. Distinct expression patterns of the p53-homologue p73 in malignant and normal hematopoiesis assessed by a novel real-time reverse transcription-polymerase chain reaction assay and protein analysis.
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  83. Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model
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  84. Resurrecting a p53 peptide activator - An enabling nanoengineering strategy for peptide therapeutics
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  85. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation
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  86. The p53-homologue p63 may promote thyroid cancer progression
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  87. Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53
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  88. U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of ΔNp63α
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  89. Identification of Flotillin-2, a Major Protein on Lipid Rafts, as a Novel Target of p53 Family Members
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  90. p73-induced apoptosis: A question of compartments and cooperation
    Matthias Dobbelstein, Sabrina Strano, Judith C. Roth, Giovanni Blandino · 2005 · Biochemical and Biophysical Research Communications
  91. p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner
    Jianhui Zhu, Susan E. Nozell, Jian Wang, Jieyuan Jiang, Wenjing Zhou, Xinbin Chen · 2001 · Oncogene
  92. p73 Is up-regulated in a subset of hepatocellular carcinomas
    Nirmitha I. Herath, Michael Charles Kew, Vicki Whitehall, Michael D. Walsh, Jeremy R. Jass, Kum Kum Khanna, Joanne P Young, Lawrie W. Powell, Barbara Leggett, Graeme A. Macdonald · 2000 · Hepatology
  93. Retinoblastoma Protein-mediated Apoptosis After γ-Irradiation
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  94. Rapp-Hodgkin and AEC syndromes due to a new frameshift mutation in the TP63 gene
    Irma Dianzani, E Garelli, P Gustavsson, A Carando, B Gustafsson, Niklas Dahl, G Annerén · 2003 · Journal of Medical Genetics
  95. Different vulnerability among chromosomes to numerical instability in gastric carcinogenesis: stage-dependent analysis by FISH with the use of microwave irradiation.
    Yasuhiko Kitayama, Hisaki Igarashi, Haruhiko Sugimura · 2000 · PubMed
  96. TAp73 promotes anabolism
    Ivano Amelio, Alexey A. Antonov, Maria Valeria Catani, Renato Massoud, Francesca Bernassola, Richard A. Knight, Gerry Melino, Alessandro Rufini · 2014 · Oncotarget
  97. An essential role for p73 in regulating mitotic cell death
    Wen Hong Toh, Shin Yuen Nam, Kanaga Sabapathy · 2009 · Cell Death and Differentiation
  98. Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy
    María Cristina Estañ, Elisa Fernández-Núñez, Maha Saad Zaki, María Isabel Esteban, Sandra C. Donkervoort, Cynthia E Hawkins, Jose Antonio Caparros-Martin, Dimah N. Saade, Ying Hu, Véronique Bolduc et al. · 2019 · Nature Communications
  99. Targeting p73 in cancer
    Anna-Maria Maas, Anne Catherine Bretz, Elisabeth Mack, Thorsten Stiewe · 2011 · Cancer Letters
  100. Cisplatin-induced apoptosis in Hep3B cells: mitochondria-dependent and -independent pathways
    Ji Su Kim, Jae Myun Lee, Yong‐Joon Chwae, Yeon Hyang Kim, Jung Hwan Lee, Kunhong Kim, Tae Ho Lee, Se‐Jong Kim, Jeon Han Park · 2004 · Biochemical Pharmacology