The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089

Hedgehog: functions and mechanisms

Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217

Patched acts catalytically to suppress the activity of Smoothened

Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature · doi:10.1038/nature00989 · Cited by 794

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

Sasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1999) · Development · doi:10.1242/dev.126.17.3915 · Cited by 715

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., & Joyner, A. L. (2002) · Development · doi:10.1242/dev.129.20.4753 · Cited by 692

The Smith-Lemli-Opitz syndrome

Kelley, R. I., & Hennekam, R. C. M. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.5.321 · Cited by 480

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M., & Ishii, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8143 · Cited by 466

Oxysterols are allosteric activators of the oncoprotein Smoothened

Nachtergaele, S., Mydock, L. K., Krishnan, K., Rammohan, J., Schlesinger, P. H., Covey, D. F., & Rohatgi, R. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.765 · Cited by 284

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

Zhang, Y., Bulkley, D. P., Xin, Y., Roberts, K. J., Asarnow, D. E., Sharma, A., Myers, B. R., Cho, W., Cheng, Y., & Beachy, P. A. (2018) · Cell · doi:10.1016/j.cell.2018.10.026 · Cited by 239

Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

Sato, N., Leopold, P. L., & Crystal, R. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7691 · Cited by 253

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

Chen, Y., Sasai, N., Ma, G., Yue, T., Jia, J., Briscoe, J., & Jiang, J. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001083 · Cited by 225

Structural basis for the recognition of Sonic Hedgehog by human Patched1

Gong, X., Qian, H., Cao, P., Zhao, X., Zhou, Q., Lei, J., & Yan, N. (2018) · Science · doi:10.1126/science.aas8935 · Cited by 216

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

Dessaud, E., Ribes, V., Balaskas, N., Yang, L. L., Pierani, A., Kicheva, A., Novitch, B. G., Briscoe, J., & Sasai, N. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000382 · Cited by 203

Involvement of the Sonic Hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays

Laforest, L., Brown, C. W., Poleo, G., Géraudie, J., Tada, M., Ekker, M., & Akimenko, M.-A. (1998) · Development · doi:10.1242/dev.125.21.4175 · Cited by 179

Dependence receptors: a new paradigm in cell signaling and cancer therapy

Goldschneider, D., & Mehlen, P. (2010) · Oncogene · doi:10.1038/onc.2010.13 · Cited by 169

Role of cholesterol in embryonic development

Roux, C., Wolf, C., Mulliez, N., Gaoua, W., Cormier, V., Chevy, F., & Citadelle, D. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1270s · Cited by 152

Similarities between the Hedgehog and Wnt signaling pathways

Kalderon, D. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02388-7 · Cited by 141

Adrenocortical zonation, renewal, and remodeling

Pihlajoki, M., Dörner, J., Cochran, R. S., Heikinheimo, M., & Wilson, D. B. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00027 · Cited by 114

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

Yue, S., Tang, L.-Y., Tang, Y., Tang, Y., Shen, Q.-H., Ding, J., Chen, Y., Zhang, Z., Yu, T.-T., Zhang, Y. E., et al. (2014) · eLife · doi:10.7554/elife.02555 · Cited by 94

The Smith-Lemli-Opitz syndrome: a novel metabolic way of understanding developmental biology, embryogenesis, and dysmorphology

Nowaczyk, M., & Waye, J. (2001) · Clinical Genetics · doi:10.1034/j.1399-0004.2001.590601.x · Cited by 61

Multipotent Mesenchymal Stromal Cells Increase tPA Expression and Concomitantly Decrease PAI-1 Expression in Astrocytes through the Sonic Hedgehog Signaling Pathway after Stroke ( in vitro Study)

Xin, H., Li, Y., Shen, L. H., Liu, X., Hozeska-Solgot, A., Zhang, R. L., Zhang, Z. G., & Chopp, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.116 · Cited by 40

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast

Joubert, O., Nehmé, R., Fleury, D., De Rivoyre, M., Bidet, M., Polidori, A., Ruat, M., Pucci, B., Mollat, P., & Mus-Veteau, I. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.05.009 · Cited by 17