Identification of 9- cis -retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion
Open accessAbstract
The all-trans-retinoic acid (atRA) isomer, 9-cis-retinoic acid (9cRA), activates retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in vitro. RARs control multiple genes, whereas RXRs serve as partners for RARs and other nuclear receptors that regulate metabolism. Physiological function has not been determined for 9cRA, because it has not been detected in serum or multiple tissues with analytically validated assays. Here, we identify 9cRA in mouse pancreas by liquid chromatography/tandem mass spectrometry (LC/MS/MS), and show that 9cRA decreases with feeding and after glucose dosing and varies inversely with serum insulin. 9cRA reduces glucose-stimulated insulin secretion (GSIS) in mouse islets and in the rat β-cell line 832/13 within 15 min by reducing glucose transporter type 2 (Glut2) and glucokinase (GK) activities. 9cRA also reduces Pdx-1 and HNF4α mRNA expression, ∼8- and 80-fold, respectively: defects in Pdx-1 or HNF4α cause maturity onset diabetes of the young (MODY4 and 1, respectively), as does a defective GK gene (MODY2). Pancreas β-cells generate 9cRA, and mouse models of reduced β-cell number, heterozygous Akita mice, and streptozotocin-treated mice have reduced 9cRA. 9cRA is abnormally high in glucose-intolerant mice, which have β-cell hypertropy, including mice with diet-induced obesity (DIO) and ob/ob and db/db mice. These data establish 9cRA as a pancreas-specific autacoid with multiple mechanisms of action and provide unique insight into GSIS.
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9cRA has been detected recently in pancreatic cells and found to have a function in regulating glucose-stimulated insulin secretion.
“Note, however, that 9cRA has been detected recently in pancreatic cells and found to have a function in regulating glucose-stimulated insulin secretion ( 15 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [15]
Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
The mechanisms of alloxan- and streptozotocin-induced diabetes
Lenzen, S. (2007) · Diabetologia · doi:10.1007/s00125-007-0886-7 · Cited by 2,292 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Components of the AIN-93 Diets as Improvements in the AIN-76A Diet
Reeves, P. G. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.838s · Cited by 1,363 · see citing works
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177 · see citing works
Hohmeier, H. E., Mulder, H., Chen, G., Henkel-Rieger, R., Prentki, M., & Newgard, C. B. (2000) · Diabetes · doi:10.2337/diabetes.49.3.424 · Cited by 922 · see citing works
Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint
Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works
DNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673 · see citing works
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
Mukherjee, R., Davies, P. J., Crombie, D. L., Bischoff, E. D., Cesario, R. M., Jow, L., Hamann, L. G., Boehm, M. F., Mondon, C. E., Nadzan, A. M., et al. (1997) · Nature · doi:10.1038/386407a0 · Cited by 598 · see citing works
Genomic and nongenomic effects of glucocorticoids
Stahn, C., & Buttgereit, F. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0898 · Cited by 594 · see citing works
Yoshioka, M., Kayo, T., Ikeda, T., & Koizuni, A. (1997) · Diabetes · doi:10.2337/diab.46.5.887 · Cited by 536 · see citing works
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496 · see citing works
Diabetes mellitus and genetically programmed defects in β-cell function
Bell, G. I., & Polonsky, K. S. (2001) · Nature · doi:10.1038/414788a · Cited by 475 · see citing works
The unfolding stories of GPR30, a new membrane-bound estrogen receptor
Maggiolini, M., & Picard, D. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0242 · Cited by 360 · see citing works
The Physiology of Obese-Hyperglycemic Mice [ob/obMice]
Lindström, P. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.117 · Cited by 353 · see citing works
Berry, D. C., & Noy, N. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01742-08 · Cited by 345 · see citing works
Boehm, M. F., Zhang, L., Zhi, L., McClurg, M. R., Berger, E. M., WAGONER, M., Mais, D. E., Suto, C. M., Davies, P. J. A., Heyman, R. A., et al. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00016a018 · Cited by 342 · see citing works
Metabolic cycling in control of glucose-stimulated insulin secretion.
Jensen, M., Joseph, J., Ronnebaum, S., Burgess, S. C., Sherry, A., & Newgard, C. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.90604.2008 · Cited by 282 · see citing works
The Molecular Genetics of Rodent Single Gene Obesities
Leibel, R. L., Chung, W. K., & Chua, S. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31937 · Cited by 277 · see citing works
Quantitative Profiling of Endogenous Retinoic Acid in Vivo and in Vitro by Tandem Mass Spectrometry
Kane, M. A., Folias, A. E., Wang, C., & Napoli, J. L. (2008) · Analytical Chemistry · doi:10.1021/ac702030f · Cited by 230 · see citing works
Self-citationQuantification of endogenous retinoic acid in limited biological samples by LC/MS/MS
Kane, M. A., Chen, N., Sparks, S. E., & Napoli, J. L. (2005) · Biochemical Journal · doi:10.1042/bj20041867 · Cited by 204 · see citing works
Self-citationRapid Estrogen Signaling in the Brain
Raz, L., Khan, M. M., Mahesh, V. B., Vadlamudi, R. K., & Brann, D. W. (2008) · Neurosignals · doi:10.1159/000111559 · Cited by 201 · see citing works
Wang, H.-Y., Maechler, P., Antinozzi, P., Hagenfeldt, K., & Wollheim, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006612200 · Cited by 200 · see citing works
Retinoic Acid: Its Biosynthesis and Metabolism
Napoli, J. L. (1999) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60722-9 · Cited by 187 · see citing works
Self-citationHierarchy of the β‐cell signals controlling insulin secretion
Henquin, J. C., Ravier, M. A., Nenquin, M., Jonas, J., & Gilon, P. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01207.x · Cited by 177 · see citing works
Rowe, A. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00101-x · Cited by 175 · see citing works
HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues
Kane, M. A., Folias, A. E., & Napoli, J. L. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.03.038 · Cited by 171 · see citing works
Self-citationMcCarroll, J. A., Phillips, P. A., Santucci, N., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2005) · Gut · doi:10.1136/gut.2005.064543 · Cited by 147 · see citing works
Ahuja, H. S., Szántó, A., Nagy, L., & Davies, P. J. (2003) · PubMed · Cited by 128 · see citing works
New aspects of rapid aldosterone signaling
Großmann, C., & Gekle, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.005 · Cited by 124 · see citing works
Calleja, C., Messaddeq, N., Chapellier, B., Yang, H., Krężel, W., Li, M., METZGER, D., Mascrez, B., Ohta, K., Kagechika, H., et al. (2006) · Genes & Development · doi:10.1101/gad.368706 · Cited by 123 · see citing works
Hattersley, A. T., & Pearson, E. R. (2006) · Endocrinology · doi:10.1210/en.2006-0152 · Cited by 118 · see citing works
Ashizawa, S., Brunicardi, F. C., & Wang, X. (2004) · Pancreas · doi:10.1097/00006676-200403000-00001 · Cited by 107 · see citing works
Babu, D. A., Deering, T. G., & Mirmira, R. G. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.06.008 · Cited by 106 · see citing works
Recovery of Islet β-Cell Function in Streptozotocin- Induced Diabetic Mice
Yin, D., Tao, J., Lee, D. D., Shen, J., Hara, M., Lopez, J. P., Kuznetsov, A., Philipson, L. H., & Chong, A. S. (2006) · Diabetes · doi:10.2337/db05-1275 · Cited by 99 · see citing works
Teruel, T., Hernández, R., Benito, M., & Lorenzo, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207200200 · Cited by 97 · see citing works
Ferber, S., BeltrandelRio, H., Johnson, J. H., Noel, R. J., Cassidy, L., Clark, S., Becker, T. C., Hughes, S., & Newgard, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78155-1 · Cited by 95 · see citing works
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activityPreprint
Wang, J.-C., Shah, N., Pantoja, C., Meijsing, S. H., Ho, J. D., Scanlan, T. S., & Yamamoto, K. R. (2006) · Genes & Development · doi:10.1101/gad.1400506 · Cited by 94 · see citing works
Activation of the Insulin Gene Promoter through a Direct Effect of Hepatocyte Nuclear Factor 4α
Bartoov-Shifman, R., Hertz, R., Wang, H., Wollheim, C. B., Bar‐Tana, J., & WALKER, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201582200 · Cited by 92 · see citing works
Altered vitamin A homeostasis and increased size and adiposity in the rdhl‐null mouse
Zhang, M., Hu, P., Krois, C. R., Kane, M. A., & Napoli, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7964com · Cited by 91 · see citing works
Self-citationChen, N., Onisko, B., & Napoli, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802314200 · Cited by 89 · see citing works
Self-citationAlitretinoin: a comprehensive review
Cheng, C., Michaels, J. D., & Scheinfeld, N. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.3.437 · Cited by 85 · see citing works
Matthews, K. A., Rhoten, W. B., Driscoll, H. K., & Chertow, B. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.1958 · Cited by 77 · see citing works
Conformational transition pathway in the allosteric process of human glucokinase
Zhang, J., Li, C., Chen, K., Zhu, W., Shen, X., & Jiang, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605738103 · Cited by 76 · see citing works
Leibowitz, M. D., Ardecky, R., Boehm, M. F., Broderick, C. L., Carfagna, M. A., Crombie, D. L., D’Arrigo, J., Etgen, G. J., Faul, M. M., Grese, T. A., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0690 · Cited by 71 · see citing works
Protein Kinase A-dependent Phosphorylation of GLUT2 in Pancreatic β Cells
Thorens, B., Dériaz, N., Bosco, D., DeVos, A., Pipeleers, D., Schuit, F. C., Meda, P., & Porret, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8075 · Cited by 69 · see citing works
Research Resource: Nuclear Hormone Receptor Expression in the Endocrine Pancreas
Chuang, J.-C., Cha, J.-Y., Garmey, J. C., Mirmira, R. G., & J., J. J. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0568 · Cited by 60 · see citing works
Zapata-Gonzalez, F., Rueda, F., Pétriz, J., Domingo, P., Villarroya, F., de Madariaga, M. A., & Domingo, J. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6130 · Cited by 57 · see citing works
Ligand Specificity of Nuclear Hormone Receptors: Sifting through Promiscuity
Noy, N. (2007) · Biochemistry · doi:10.1021/bi7018699 · Cited by 55 · see citing works
Sidell, N., Feng, Y., Hao, L., Wu, J., Yu, J., Kane, M. A., Napoli, J. L., & Taylor, R. N. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0155 · Cited by 49 · see citing works
Self-citationKobayashi, H., Spilde, T. L., Bhatia, A. M., Buckingham, R. B., Hembree, M. J., Prasadan, K. L., Preuett, B. L., Imamura, M., & Gittes, G. K. (2002) · Gastroenterology · doi:10.1053/gast.2002.35949 · Cited by 47 · see citing works
Pignatello, M. A., Kauffman, F. C., & Levin, A. A. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8047 · Cited by 43 · see citing works
9‐Cis‐retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein
Shen, H., Luo, Y., Kuo, C., Deng, X., Chang, C., Harvey, B. K., Hoffer, B. J., & Wang, Y. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21865 · Cited by 35 · see citing works
Retinoid signaling directs secondary lineage selection in pancreatic organogenesis
Kadison, A. S., Kim, J., Maldonado, T. S., Crisera, C. A., Prasadan, K. L., Manna, P., Preuett, B. L., Hembree, M. J., Longaker, M. T., & Gittes, G. K. (2001) · Journal of Pediatric Surgery · doi:10.1053/jpsu.2001.25734 · Cited by 30 · see citing works
Vitamin A status affects the development of diabetes and insulitis in BB rats
Driscoll, H. K., Chertow, B. S., Jelic, T. M., Baltaro, R. J., Chandor, S. B., Walker, E. M., Dadgari, J. M., & Pofahl, A. B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90062-1 · Cited by 28 · see citing works
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Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408 · see citing works
Physiological insights into all-trans-retinoic acid biosynthesis
Napoli, J. L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.004 · Cited by 326 · see citing works
Self-citationModulation of T Cell and Innate Immune Responses by Retinoic Acid
Raverdeau, M., & Mills, K. H. G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303245 · Cited by 222 · see citing works
Vitamin A Metabolism, Action, and Role in Skeletal Homeostasis
Conaway, H. H., Henning, P., & Lerner, U. H. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1071 · Cited by 189 · see citing works
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von Lintig, J., Moon, J., Lee, J., & Ramkumar, S. (2019) · Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158580 · Cited by 139 · see citing works
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Hiebl, V., Ladurner, A., Latkolik, S. L., & Dirsch, V. M. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.003 · Cited by 135 · see citing works
Arnold, S. L. M., Amory, J. K., Walsh, T. J., & Isoherranen, N. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d019745 · Cited by 119 · see citing works
Biology of pancreatic stellate cells—more than just pancreatic cancer
Ferdek, P. E., & Jakubowska, M. A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1968-0 · Cited by 115 · see citing works
Retinaldehyde Dehydrogenase 1 Coordinates Hepatic Gluconeogenesis and Lipid Metabolism
Kiefer, F. W., Orasanu, G., Nallamshetty, S., Brown, J. D., Wang, H., Luger, P., Qi, N., Burant, C., Duester, G., & Plutzky, J. (2012) · Endocrinology · doi:10.1210/en.2011-2104 · Cited by 111 · see citing works
Analysis, occurrence, and function of 9-cis-retinoic acid
Kane, M. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.012 · Cited by 111 · see citing works
Self-citationSharma, S., Shen, T., Chitranshi, N., Gupta, V., Basavarajappa, D. K., Sarkar, S., Mirzaei, M., You, Y., Krężel, W., Graham, S. L., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02709-y · Cited by 105 · see citing works
Berry, D. C., & Noy, N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.002 · Cited by 100 · see citing works
Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer
Stevison, F., Jing, J., Tripathy, S., & Isoherranen, N. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.006 · Cited by 94 · see citing works
Functions of Intracellular Retinoid Binding-Proteins
Napoli, J. L. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-024-0945-1_2 · Cited by 91 · see citing works
Self-citationVitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass
Trasino, S. E., Benoit, Y. D., & Gudas, L. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616763 · Cited by 93 · see citing works
The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism
Chen, W., & Chen, G. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3020453 · Cited by 93 · see citing works
Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease
Fukasawa, H., Nakagomi, M., Yamagata, N., Katsuki, H., Kawahara, K., Kitaoka, K., Miki, T., & Shudo, K. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00314 · Cited by 91 · see citing works
Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism
Zhang, R., Wang, Y., Li, R., & Chen, G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160614210 · Cited by 89 · see citing works
Alternative retinoid X receptor (RXR) ligands
Krężel, W., Rühl, R., & de Lera, Á. R. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.04.016 · Cited by 90 · see citing works
Cyanobacteria blooms produce teratogenic retinoic acids
Wu, X., Jiang, J., Wan, Y., Giesy, J. P., & Hu, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200062109 · Cited by 87 · see citing works
Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling
Ruiz, F. X., Porté, S., Parés, X., & Farrés, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00058 · Cited by 88 · see citing works
Retinoids: Potent regulators of metabolism
Brun, P., Yang, K. J. Z., Lee, S., Yuen, J. J., & Blaner, W. S. (2012) · BioFactors · doi:10.1002/biof.1056 · Cited by 84 · see citing works
An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!
de Lera, Á. R., Krężel, W., & Rühl, R. (2016) · ChemMedChem · doi:10.1002/cmdc.201600105 · Cited by 83 · see citing works
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Saeed, A., Hoekstra, M., Hoeke, M. O., Heegsma, J., & Faber, K. N. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.01.007 · Cited by 81 · see citing works
Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
Uebi, T., Itoh, Y., Hatano, O., Kumagai, A., Sanosaka, M., Sasaki, T., Sasagawa, S., Doi, J., Tatsumi, K., Mitamura, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037803 · Cited by 78 · see citing works
Retinoid Metabolism and Diabetes Mellitus
Rhee, E., & Plutzky, J. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.3.167 · Cited by 73 · see citing works
Miller, A. P., Coronel, J., & Amengual, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158635 · Cited by 71 · see citing works
Jones, J. W., Pierzchalski, K., Yu, J., & Kane, M. A. (2015) · Analytical Chemistry · doi:10.1021/ac504597q · Cited by 71 · see citing works
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Brun, P., Grijalva, A., Rausch, R. N., Watson, E., Yuen, J. J., Das, B. C., Shudo, K., Kagechika, H., Leibel, R. L., & Blaner, W. S. (2014) · The FASEB Journal · doi:10.1096/fj.14-256743 · Cited by 70 · see citing works
Oh, Y. S., & Jun, H. (2014) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s13589 · Cited by 69 · see citing works
Topletz, A. R., Tripathy, S., Foti, R., Shimshoni, J. A., Nelson, W. L., & Isoherranen, N. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.096784 · Cited by 68 · see citing works
Ketogenic Diet Acts on Body Remodeling and MicroRNAs Expression Profile
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Kane, M. A., Folias, A. E., Pingitore, A., Perri, M., Krois, C. R., Ryu, J. Y., Cione, E., & Napoli, J. L. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05516-11 · Cited by 48 · see citing works
Self-citationTakeuchi, H., Yokota-Nakatsuma, A., Ohoka, Y., Kagechika, H., Kato, C., Song, S., & Iwata, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300032 · Cited by 48 · see citing works
Quercetin/Oleic Acid-Based G-Protein-Coupled Receptor 40 Ligands as New Insulin Secretion Modulators
Badolato, M., Carullo, G., Perri, M., Cione, E., Manetti, F., Gioia, M. L. D., Brizzi, A., Caroleo, M. C., & Aiello, F. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0113 · Cited by 48 · see citing works
Self-citationModulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair
Wang, S., Yu, J., Kane, M. A., & Moise, A. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107415 · Cited by 43 · see citing works
Self-citationCardiac retinoic acid levels decline in heart failure
Yang, N., Parker, L. E., Yu, J., Jones, J. W., Liu, T., Papanicolaou, K. N., Talbot, C. C., Margulies, K. B., O'Rourke, B. P., Kane, M. A., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.137593 · Cited by 42 · see citing works
Self-citationBeta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion
Moore, W. T., Bowser, S. M., Fausnacht, D. W., Staley, L. L., Suh, K., & Liu, D. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0650-1 · Cited by 42 · see citing works
CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment
Pierzchalski, K., Yu, J., Norman, V. A., & Kane, M. A. (2013) · The FASEB Journal · doi:10.1096/fj.12-219410 · Cited by 41 · see citing works
Self-citationVitamin A, endocrine tissues and hormones: interplay and interactions
Brossaud, J., Pallet, V., & Corcuff, J. (2017) · Endocrine Connections · doi:10.1530/ec-17-0101 · Cited by 43 · see citing works
Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation
Parikh, A., Wu, J., Blanton, R. M., & Tzanakakis, E. S. (2015) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0662 · Cited by 39 · see citing works
Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase
Thatcher, J. E., Buttrick, B., Shaffer, S. A., Shimshoni, J. A., Goodlett, D. R., Nelson, W. L., & Isoherranen, N. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.072413 · Cited by 39 · see citing works
Dietary 9-cis-β,β-Carotene Fails to Rescue Vision in Mouse Models of Leber Congenital Amaurosis
Maeda, T., Perusek, L., Amengual, J., Babino, D., Palczewski, K., & von Lintig, J. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.074732 · Cited by 37 · see citing works
Zhou, Y., Sun, B., Li, W., Zhou, J., Gao, F., Wang, X., Cai, M., & Sun, Z. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00218 · Cited by 37 · see citing works
Zhou, Y., Zhou, J., Sun, B., Xu, W. G., Zhong, M., Li, Y., He, C., Chen, Y., Wang, X., Jones, P. M., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.37861 · Cited by 37 · see citing works
Zhong, G. G., Ortiz, D., Zelter, A., Nath, A., & Isoherranen, N. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111039 · Cited by 37 · see citing works
Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily
Ruiz, F. X., Porté, S., Gallego, O., Moro, A., Ardèvol, A., Río-Espínola, A. D., Rovira, C., Farrés, J., & Parés, X. (2011) · Biochemical Journal · doi:10.1042/bj20111286 · Cited by 37 · see citing works
Brun, P., Wongsiriroj, N., & Blaner, W. S. (2016) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.09.03 · Cited by 34 · see citing works
Sanz, M., Albertos, F., Otero, E., Juez, M., Morcillo, E. J., & Piqueras, L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102942 · Cited by 33 · see citing works
Rühl, R., Krężel, W., & de Lera, Á. R. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy057 · Cited by 33 · see citing works
Binding affinities of CRBPI and CRBPII for 9-cis-retinoids
Kane, M. A., Bright, F. V., & Napoli, J. L. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.02.009 · Cited by 32 · see citing works
Self-citationLee, S., Jiang, H., Trent, C. M., Yuen, J. J., Narayanasamy, S., Curley, R. W., Harrison, E. H., Goldberg, I. J., Maurer, M. S., & Blaner, W. S. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00548.2014 · Cited by 30 · see citing works
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes
Esposito, M., Amory, J. K., & Kang, Y. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240519 · Cited by 32 · see citing works
Impacts of vitamin A deficiency on biological rhythms: Insights from the literature
Guo, X., Wang, H., Xu, J., & Hua, H. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.886244 · Cited by 28 · see citing works
Structural, functional, nutritional and clinical aspects of vitamin A: A review
Menezes, M. S. S., & Almeida, C. M. M. (2024) · PharmaNutrition · doi:10.1016/j.phanu.2024.100383 · Cited by 28 · see citing works
Retinol binding protein 4 and its membrane receptors: a metabolic perspective
Fedders, R., Muenzner, M., & Schupp, M. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0013 · Cited by 25 · see citing works
Catalán, Ú., Barrubés, L., Valls, R. M., Solà, R., & Rubió, L. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.12.007 · Cited by 25 · see citing works
Wu, L., Chaudhary, S., Atigadda, V., Belyaeva, O., Harville, S., Elmets, C., Muccio, D., Athar, M., & Kedishvili, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153556 · Cited by 21 · see citing works
Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects
Bandesh, K., Motakis, E., Nargund, S., Kursawe, R., Selvam, V., Ansarullah, Bhuiyan, R. M., Eryilmaz, G. N., Willett, A., White, J. K., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00744-w · Cited by 20 · see citing works
Yu, J., Perri, M., Jones, J. W., Pierzchalski, K., Ceaicovscaia, N., Cione, E., & Kane, M. A. (2022) · Cells · doi:10.3390/cells11050792 · Cited by 21 · see citing works
Self-citationHarari, A., Harats, D., Marko, D., Cohen, H., Barshack, I., Gonen, A., Ben‐Shushan, D., Kamari, Y., Ben‐Amotz, A., & Shaish, A. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9903-4 · Cited by 20 · see citing works
Role of carotenoids and retinoids during heart development
Sîrbu, I. O., Chiş, A. R., & Moise, A. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158636 · Cited by 21 · see citing works
Draut, H., Liebenstein, T., & Begemann, G. (2019) · Biomolecules · doi:10.3390/biom9120860 · Cited by 19 · see citing works
Perri, M., Caroleo, M. C., Liu, N., Gallelli, L., Sarro, G. D., Kagechika, H., & Cione, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.022 · Cited by 18 · see citing works
Self-citationCione, E., Plastina, P., Pingitore, A., Perri, M., Caroleo, M. C., Fazio, A., Witkamp, R. F., & Meijerink, J. (2019) · Nutrients · doi:10.3390/nu11040915 · Cited by 18 · see citing works
Self-citationYoo, H. S., Moss, K. O., Cockrum, M. A., Woo, W., & Napoli, J. L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105255 · Cited by 16 · see citing works
Self-citationLi, Y., Li, R., Chen, W., & Chen, G. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.012 · Cited by 16 · see citing works
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Aguila, E. M. D., Tang, X., & Gudas, L. J. (2022) · Oncology Research and Treatment · doi:10.1159/000522425 · Cited by 16 · see citing works
André, A., Ruivo, R., Capitão, A., Froufe, E., Páscoa, I., Castro, L. F. C., & Santos, M. M. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.05.064 · Cited by 16 · see citing works
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Parker, L. E., Papanicolaou, K. N., Zalesak‐Kravec, S., Weinberger, E. M., Kane, M. A., & Foster, D. B. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00871.2024 · Cited by 15 · see citing works
Self-citationYang, H., Liu, M., Sheng, Y., Zhu, L., Jin, M., Jiang, T., Lu, Y., Liu, P., Liu, X., & Liu, L. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00740-2 · Cited by 15 · see citing works
Retinoic Acid: Sexually Dimorphic, Anti-Insulin and Concentration-Dependent Effects on Energy
Napoli, J. L. (2022) · Nutrients · doi:10.3390/nu14081553 · Cited by 15 · see citing works
Self-citationTopletz, A. R., Tripathy, S., Foti, R., Shimshoni, J. A., Nelson, W. L., & Isoherranen, N. (2015) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)11911-6 · Cited by 15 · see citing works
Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential
Xu, R., Zhang, L.-Y., Pan, H., & Zhang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1464655 · Cited by 14 · see citing works
Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity
Nallamshetty, S., Le, P. T., Wang, H., Issacsohn, M. J., Reeder, D. J., Rhee, E., Kiefer, F. W., Brown, J. D., Rosen, C. J., & Plutzky, J. (2014) · Bone · doi:10.1016/j.bone.2014.07.005 · Cited by 10 · see citing works
Cione, E., Caroleo, M. C., Kagechika, H., & Manetti, F. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1864629 · Cited by 9 · see citing works
Self-citationGong, G.-G., Zheng, J., Li, S., Bai, Y., & Feng, Y. (2022) · Talanta · doi:10.1016/j.talanta.2022.123474 · Cited by 9 · see citing works
Li, P., Xu, J., Guo, Y., Ma, X., Wang, X., Liu, L., Liu, Y., Ren, X., Li, J., Wang, Y., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00402-1 · Cited by 8 · see citing works
Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology
Khalique, A., Mohammed, A. K., Al-khadran, N. M., Gharaibeh, M. F. A., Abu‐Gharbieh, E., El‐Huneidi, W., Sulaiman, N. D., & Taneera, J. (2022) · Biology · doi:10.3390/biology11071072 · Cited by 10 · see citing works
Bohn, T., Hellmann‐Regen, J., de Lera, Á. R., Böhm, V., & Rühl, R. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00750-3 · Cited by 8 · see citing works
Aberrant retinoic acid production in the decidua: Implications for pre‐eclampsia
Rajakumar, A., Kane, M. A., Yu, J., Taylor, R. N., & Sidell, N. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14262 · Cited by 8 · see citing works
Self-citationBánáti, D., Hellmann‐Regen, J., Mack, I., Young, H. A., Benton, D., Eggersdorfer, M. L., Rohn, S., Dulińska-Litewka, J., Krężel, W., & Rühl, R. (2024) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000808 · Cited by 7 · see citing works
Evolution of the Retinoic Acid Signaling Pathway
Laudet, V., Zieger, E., & Schubert, M. (2015) · doi:10.1002/9781118628003.ch4 · Cited by 7 · see citing works
The glucocorticoid receptor represses, whereas C/EBPβ can enhance or repress CYP26A1 transcription
Yoo, H. S., Rodriguez, A., You, D., Lee, R. A., Cockrum, M. A., Grimes, J. A., Wang, J.-C., Kang, S., & Napoli, J. L. (2022) · iScience · doi:10.1016/j.isci.2022.104564 · Cited by 6 · see citing works
Self-citationNon-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers
García‐Padilla, C., Lozano-Velasco, E., López‐Sánchez, C., García‐Martínez, V., Aránega, A. E., & Franco, D. (2021) · Non-Coding RNA · doi:10.3390/ncrna7010013 · Cited by 6 · see citing works
Is There A Role of Vitamin A in Hepatic Glucose and Fatty Acid Metabolism?
Howell, M. L., & Chen, G. (2012) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000e111 · Cited by 6 · see citing works
Immunometabolic effects of β-carotene and vitamin A in atherogenesis
Blanco, A., & Amengual, J. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000051 · Cited by 5 · see citing works
Stereocontrolled synthesis of ( S )-9- cis - and ( S )-11- cis -13,14-dihydroretinoic acid
Vaz, B., Álvarez, R., & de Lera, Á. R. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.05.006 · Cited by 5 · see citing works
Retinoid signaling in pancreas development, islet function, and disease
Bandral, M., Sussel, L., & Lorberbaum, D. S. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.10.007 · Cited by 4 · see citing works
Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice
Wang, Z., Ouyang, Q., Guo, H., Li, H., & Liu, R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150671 · Cited by 4 · see citing works
Adapting Physiology in Functional Human Islet Organogenesis
Yoshihara, E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.854604 · Cited by 4 · see citing works
Physiological effects of carotenoids on hyperglycemia and associated events
Swamy, V., Alugoju, P., & Periyasamy, L. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817903-1.00010-3 · Cited by 4 · see citing works
Vitamin A Metabolism: Challenges and Perspectives
Ziouzenkova, O. (2012) · Vitamins & Minerals · doi:10.4172/2376-1318.1000e106 · Cited by 3 · see citing works
- Authors
- Kane, M. A., Folias, A. E., Pingitore, A., Perri, M., Obrochta, K. M., Krois, C. R., Cione, E., Ryu, J. Y., & Napoli, J. L.
- Affiliations
- University of California, Berkeley (US)
- University of Maryland, Baltimore (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-11-29
- Volume
- 107
- Issue
- 50
- Pages
- 21884-21889
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3003056
- OpenAlex
- W1964543779
- Cited by
- 120
- References
- 55
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 15 · 2013: 7 · 2012: 13
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cornerstone (Minnesota State University, Mankato) (submittedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Funders
- Università della Calabria
- Ministero dell'Università e della Ricerca
- National Institutes of Health (DK061918)
- University of California, San Francisco
- National Institute on Alcohol Abuse and Alcoholism (R01AA017927)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK061918, R01DK047839, R01DK090522, DK 47839, T32DK061918, DK066924, F32DK066924)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- 9-cis-retinoic acid, autacoids, pancreas, glucose-stimulated insulin secretion, pancreatic beta cells, retinoic acid receptor, retinoid X receptor, GLUT2, glucokinase, PDX1, HNF4α, maturity-onset diabetes of the young, Akita mice, diet-induced obesity, ob/ob mice, db/db mice, impaired glucose tolerance, beta-cell hypertrophy, islets
- MeSH terms
- Alitretinoin, Insulin Secretion, Animals, Antineoplastic Agents, Cell Line, Glucose, Insulin, Male, Mice, Inbred C57BL, Pancreas, Autacoids, Tretinoin, Mice, Rats
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