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Functional neurogenesis in the adult hippocampus
Open accessAbstract
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.
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“doublecortin (DCX), a protein expressed in developing immature neurons, but silenced as those neurons mature37”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [37]
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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationKuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Self-citationParent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03727.1997 · Cited by 1,872
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,511
Induction of neurogenesis in the neocortex of adult mice
Magavi, S. S. P., Leavitt, B. R., & Macklis, J. D. (2000) · Nature · doi:10.1038/35016083 · Cited by 1,217
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044
Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils
Liu, J., Solway, K., Messing, R. O., & Sharp, F. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07768.1998 · Cited by 1,028
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08487.1999 · Cited by 909
Self-citationLewis, P. F., & Emerman, M. (1994) · Journal of Virology · doi:10.1128/jvi.68.1.510-516.1994 · Cited by 797
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Kornack, D. R., & RAKIC, P. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5768 · Cited by 792
Adrenal hormones suppress cell division in the adult rat dentate gyrus
Gould, E., Cameron, H. A., Daniels, D., Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03642.1992 · Cited by 652
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
Roy, N. S., Wang, S., Jiang, L., Kang, J., Benraiss, A., Harrison‐Restelli, C., Fraser, R. A. R., Couldwell, W. T., Kawaguchi, A., Okano, H., et al. (2000) · Nature Medicine · doi:10.1038/73119 · Cited by 559
Biebl, M., Cooper, C., Winkler, J., & Kuhn, H. G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01368-9 · Cited by 523
Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees.
Barnea, A., & Nottebohm, F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11217 · Cited by 495
A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat
Crain, B. J., Cotman, C. W., Taylor, D. A., & LYNCH, G. S. (1973) · Brain Research · doi:10.1016/0006-8993(73)90088-7 · Cited by 349
Staley, K. J., Otis, T. S., & Módy, I. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1346 · Cited by 329
Edwards, F. A. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.759 · Cited by 180
Lübke, J. H. R., Frotscher, M., & Spruston, N. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.3.1518 · Cited by 139
Factors affecting long-term stability of Moloney murine leukemia virus-based vectors
Xu, L., Yee, J. K., Wolff, J. A., & Friedmann, T. (1989) · Virology · doi:10.1016/0042-6822(89)90600-4 · Cited by 128
Coleman, P. A., & Miller, R. F. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.1.218 · Cited by 111
Hippocampal stem cells differentiate into excitatory and inhibitory neurons
Vicario‐Abejón, C., Collin, C., Tsoulfas, P., & McKay, R. D. G. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00953.x · Cited by 93
Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cellsin vitro
Sah, D. W. Y., Ray, J., & Gage, F. H. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199701)32:1 · Cited by 89
Self-citationSuzuki, F., Makiura, Y., Guilhem, D., Sørensen, J. C. H., & Onteniente, B. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6469 · Cited by 68
Johnson, F. A., Dawson, A. J., & Meyer, R. L. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990419)406:4 · Cited by 23
Intracellular injections of permanent tracers in the fixed slice: a comparison of HRP and biocytin
Coleman, L. ‐., & Friedlander, M. J. (1992) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(92)90009-3 · Cited by 15
Spatial and temporal expression of short, long/medium or both opsins in human fetal cones
Xiao (2000) · doi:10.1002/1096-9861(20001002)425:4
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Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268
Metadata
- Authors
- van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- van Praag, Henriette
- ORCID
- Venue
- Nature
- Published
- 2002-02
- Volume
- 415
- Issue
- 6875
- Pages
- 1030-1034
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC9284568
- OpenAlex
- W1963940970
- Cited by
- 2,853
- References
- 31
- Citations by year
- 2026: 28 · 2025: 52 · 2024: 48 · 2023: 45 · 2022: 55 · 2021: 84 · 2020: 105 · 2019: 90 · 2018: 79 · 2017: 126 · 2016: 130 · 2015: 120 · 2014: 144 · 2013: 142 · 2012: 151
- FWCI
- 35.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH090258)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, hippocampus, dentate gyrus granule cells, neuronal maturation, retroviral labeling, live imaging, neuronal morphology, action potential, synaptic input, passive membrane properties
- MeSH terms
- Aging, Animals, Cell Differentiation, Cell Division, Female, Genetic Vectors, Luminescent Proteins, Membrane Potentials, Mice, Inbred C57BL, Neural Pathways, Neurons, Synapses, Dentate Gyrus, Green Fluorescent Proteins, Mice
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