First robust genetic links to depression emerge
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SNP rs12413112, one of the first identified genome-wide to be associated with MDD, is located next to SIRT1, which encodes a type III HDAC.
“Indeed, one of the first single-nucleotide polymorphisms (SNPs; rs12413112) identified genome-wide to be associated with MDD is located next to SIRT1 , 39 which encodes a type III HDAC, an epigenetic modifier.”
From Epigenetics and depression (2019) · cites this paper as [39]
SIRT1 is one of the first genes identified using GWAS to be associated with MDD, with SNP rs12413112.
“SIRT1 is also one of the first genes (SNPs; rs12413112) identified using GWAS to be associated with MDD.154,155”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [154]
SIRT1 is one of the first genes to show genome-wide significant association with major depressive disorder.
“SIRT1 is one of the first genes to show genomewide significant association with MDD.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [95]
Cites
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works
Sparse whole-genome sequencing identifies two loci for major depressive disorder
CONVERGE consortium, Cai, N., Bigdeli, T. B., Kretzschmar, W., Li, Y., Liang, J., Song, L., Hu, J., Li, Q., Jin, W., et al. (2015) · Nature · doi:10.1038/nature14659 · Cited by 864 · see citing works
Molecular Signatures of Major Depression
Cai, N., Chang, S., Li, Y., Li, Q., Hu, J., Liang, J., Song, L., Kretzschmar, W. W., Gan, X., Nicod, J., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.008 · Cited by 264 · see citing works
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1 of the 4 references couldn’t be matched to a known paper.
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Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“The FTO variant rs9939609 in human trials was associated with a lower risk of developing MDD. 358 A correlation is reported between FTO variants and the severity of MDD. 359 Lack of the FTO gene impacts anxiety-depression-like behavior in mice.”
BackgroundInfluentialEpigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
“Additional studies will be needed to elucidate the epigenetic mechanisms responsible for sex-based differences in MDD.”
BackgroundInfluentialEpigenetics in depression and gut-brain axis: A molecular crosstalk
Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 99 · see citing works
“…act as cofactor and substrate for various enzyme reactions; for example, cofactors for the activity of enzyme acetylases and methylases, which regulate histone modification and DNA methylation; comes from the gut microbiome (Figure 2)(Cai et al., 2015; Ledford, 2015; Abe-Higuchi et al., 2016).”
BackgroundInfluentialAusió, J. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0214-5 · Cited by 48 · see citing works
The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder
Aly, J. S., & Engmann, O. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.582853 · Cited by 32 · see citing works
“Accordingly, changes in histone deacetylase enzymes HDAC2 and SIRT1 have been detected in postmortem brain tissues of MDD patients (Covington et al., 2009; Kishi et al., 2010; Ledford, 2015).”
BackgroundThe molecular basis of depression: implications of sex-related differences in epigenetic regulation
Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23 · see citing works
“One of the first SNPs identified as related to depression by GWAS was located in the SIRT1 gene (Ledford, 2015), which encodes a type III HDAC.”
BackgroundChild Labor Hazard on Mental Health: Evidence from Brazil.
Aransiola, T. J., & Justus, M. (2018) · PubMed · Cited by 13 · see citing works
O’Loinsigh, E., & Bose, A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-803161-2.00019-9 · Cited by 5 · see citing works
The Adapting Mind in the Genomic Era
Fieder, M., & Huber, S. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00078 · Cited by 5 · see citing works
O’Mahony, C., & de Paor, A. (2017) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2017.07.002 · Cited by 6 · see citing works
Gopalakrishnan, M., & Gobburu, J. V. S. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-803161-2.00018-7 · Cited by 3 · see citing works
Prevalence of depression among medical students: A Cross-Sectional Study.
Sajjad, W., Samreen, A., Shah, S. A. Y., Batool, A., Umair, M., Ahmad, T., & Abideen, Z. (2021) · The Professional Medical Journal · doi:10.29309/tpmj/2021.28.12.6164 · Cited by 2 · see citing works
Neurobiologic correlates of depression: illustration of challenges in bench-to-bedside translation
Jones, B. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820007-0.00037-4 · Cited by 1 · see citing works
Nutrition and Behavioral Health/Mental Health/Neurological Health
Wallace, R. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-30730-1_29 · Cited by 2 · see citing works
Determinants, dynamic and consequence of child labor in Brazil
Aransiola, T. J. (2017) · doi:10.47749/t/unicamp.2017.983503
- Authors
- Ledford, H.
- Corresponding author
- Ledford, Heidi
- Venue
- Nature
- Published
- 2015-07-15
- Volume
- 523
- Issue
- 7560
- Pages
- 268-269
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1554260177
- Cited by
- 16
- References
- 4
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2
- Type
- other
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, genetic linkage, genetic susceptibility, mental illness, psychiatric genetics
- MeSH terms
- Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Genome-Wide Association Study, Genetic Loci
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