Sparse whole-genome sequencing identifies two loci for major depressive disorder
Open accessAbstract
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10−10), the other in an intron of the LHPP gene (P = 6.45 × 10−12). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SIRT1 is one of the first genes identified using GWAS to be associated with MDD, with SNP rs12413112.
“SIRT1 is also one of the first genes (SNPs; rs12413112) identified using GWAS to be associated with MDD.154,155”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [155]
The paper’s main results report a genome-wide significant MDD association at a locus near SIRT1. They identify the associated SNP as rs12415800, not rs12413112; the latter identifier is not supported by the passages in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThe first study reporting replicable depression variants found two loci for severe, recurrent MDD enriched for melancholia in Han Chinese women (n = 10,640).
“The first study to report replicable genetic variants for depression found two significant loci associated with severe, recurrent MDD (85% enriched for melancholia) in a sample of Han Chinese women (total n = 10,640; 5,303 cases and 5,337 controls) 7.”
From Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions (2019) · cites this paper as [7]
SIRT1 is one of the first genes to show genome-wide significant association with major depressive disorder.
“SIRT1 is one of the first genes to show genomewide significant association with MDD.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [94]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895 · see citing works
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Self-citationBrowning, S. R., & Browning, B. L. (2007) · The American Journal of Human Genetics · doi:10.1086/521987 · Cited by 3,138 · see citing works
LocusZoom: regional visualization of genome-wide association scan results
Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works
The Epidemiology of Depression Across Cultures
Kessler, R. C., & Bromet, E. J. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031912-114409 · Cited by 2,657 · see citing works
Power and predictive accuracy of polygenic risk scores
Dudbridge, F. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003348 · Cited by 1,509 · see citing works
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works
FaST linear mixed models for genome-wide association studies
Lippert, C., Listgarten, J., Liu, Y., Kadie, C. M., Davidson, R. I., & Heckerman, D. (2011) · Nature Methods · doi:10.1038/nmeth.1681 · Cited by 1,209 · see citing works
Self-citationA mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works
Self-citationStampy: A statistical algorithm for sensitive and fast mapping of Illumina sequence reads
Lunter, G., & Goodson, M. (2011) · Genome Research · doi:10.1101/gr.111120.110 · Cited by 1,016 · see citing works
The Genetics of Major Depression
Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724 · see citing works
Self-citationImproved linear mixed models for genome-wide association studies
Listgarten, J., Lippert, C., Kadie, C. M., Davidson, R. I., Eskin, E., & Heckerman, D. E. (2012) · Nature Methods · doi:10.1038/nmeth.2037 · Cited by 403 · see citing works
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies
Pasaniuc, B., Rohland, N., McLaren, P. J., Garimella, K., Zaitlen, N., Li, H., Gupta, N., Neale, B. M., Daly, M. J., Sklar, P., et al. (2012) · Nature Genetics · doi:10.1038/ng.2283 · Cited by 299 · see citing works
Low-coverage sequencing: Implications for design of complex trait association studiesPreprint
Li, Y., Sidore, C., Kang, H. M., Boehnke, M., & Abecasis, G. R. (2011) · Genome Research · doi:10.1101/gr.117259.110 · Cited by 296 · see citing works
Self-citationMolecular Signatures of Major Depression
Cai, N., Chang, S., Li, Y., Li, Q., Hu, J., Liang, J., Song, L., Kretzschmar, W. W., Gan, X., Nicod, J., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.008 · Cited by 264 · see citing works
Self-citationThe epidemiology of depression in metropolitan China
Lee, S., Tsang, A., Huang, Y., He, Y., Liu, Z., Zhang, M. Y., Shen, Y.-C., & Kessler, R. C. (2008) · Psychological Medicine · doi:10.1017/s0033291708004091 · Cited by 146 · see citing works
Self-citationLiao, S., Chen, W. J., Lee, M., Lung, F., Lai, T., Liu, C.-Y., Lin, C., Yang, M., & Chen, C.-C. (2011) · Psychological Medicine · doi:10.1017/s0033291711002364 · Cited by 116 · see citing works
The Diagnostic Validity of Melancholic Major Depression in a Population-Based Sample of Female Twins
Kendler, K. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160013002 · Cited by 105 · see citing works
Self-citationAngst, J., Gamma, A., Benazzi, F., Ajdacic‐Gross, V., & Wulf Rössler, A. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00965.x · Cited by 105 · see citing works
Wang, Y., Lu, J. T., Yu, J., Gibbs, R. A., & Yu, F. (2013) · Genome Research · doi:10.1101/gr.146084.112 · Cited by 90 · see citing works
Self-citationFurther Improvements to Linear Mixed Models for Genome-Wide Association Studies
Widmer, C., Lippert, C., Weissbrod, O., Fusi, N., Kadie, C. M., Davidson, R. I., Listgarten, J., & Heckerman, D. E. (2014) · Scientific Reports · doi:10.1038/srep06874 · Cited by 71 · see citing works
Clinical indices of familial depression in the Swedish Twin Registry
Kendler, K. S., Gatz, M., Gardner, C., & Pedersen, N. L. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00863.x · Cited by 45 · see citing works
Self-citationFoley, D. L., Neale, M. C., & Kendler, K. S. (2001) · Psychological Medicine · doi:10.1017/s0033291701004755 · Cited by 38 · see citing works
Self-citationA COMPARISON OF MELANCHOLIC AND NONMELANCHOLIC RECURRENT MAJOR DEPRESSION IN HAN CHINESE WOMEN
Sun, N., Li, Y., Cai, Y., Chen, J., Shen, Y., Sun, J., Zhang, Z., Zhang, J., Wang, L., Guo, L., et al. (2011) · Depression and Anxiety · doi:10.1002/da.20875 · Cited by 32 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [23]23. CTSU, Richard Doll Building, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK. 6 Anhui Mental Health Center, No.316
Cited by
Sorted by citations
Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099 · see citing works
eQTLGen, Wray, N. R., 23andMe, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0090-3 · Cited by 3,005 · see citing works
Self-citationA reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836 · see citing works
Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0326-7 · Cited by 2,565 · see citing works
Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269 · see citing works
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., Schork, A. J., Appadurai, V., Buil, A., Werge, T. M., et al. (2018) · Science · doi:10.1126/science.aad6469 · Cited by 1,095 · see citing works
Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works
Analysis of polygenic risk score usage and performance in diverse human populations
Duncan, L., Shen, H., Gelaye, B., Meijsen, J., Ressler, K., Feldman, M., Peterson, R., & Domingue, B. (2019) · Nature Communications · doi:10.1038/s41467-019-11112-0 · Cited by 1,038 · see citing works
Self-citationHyde, C. L., Nagle, M. W., Tian, C., Chen, X., Paciga, S. A., Wendland, J. R., Tung, J. Y., Hinds, D. A., Perlis, R. H., & Winslow, A. R. (2016) · Nature Genetics · doi:10.1038/ng.3623 · Cited by 784 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Self-citationHoward, D. M., Adams, M. J., Shirali, M., Clarke, T.-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03819-3 · Cited by 612 · see citing works
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lam, M., Indonesia Schizophrenia Consortium, Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), Chen, C.-Y., Li, Z., Martin, A. R., Bryois, J., Ma, X., Gaspar, H., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0512-x · Cited by 655 · see citing works
Beck, A. T., & Bredemeier, K. (2016) · Clinical Psychological Science · doi:10.1177/2167702616628523 · Cited by 510 · see citing works
Arioz, B. I., Tastan, B., Tarakcioglu, E., Tufekci, K. U., Olcum, M., Ersoy, N., Bagriyanik, A., Genc, K., & Genc, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01511 · Cited by 516 · see citing works
Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
Sullivan, P. F., & Geschwind, D. H. (2019) · Cell · doi:10.1016/j.cell.2019.01.015 · Cited by 452 · see citing works
Genetics and genomics of psychiatric disease
Geschwind, D. H., & Flint, J. (2015) · Science · doi:10.1126/science.aaa8954 · Cited by 424 · see citing works
Self-citationFast and accurate long-range phasing in a UK Biobank cohort
Loh, P.-R., Palamara, P. F., & Price, A. L. (2016) · Nature Genetics · doi:10.1038/ng.3571 · Cited by 342 · see citing works
Gender Differences in Depression: Biological, Affective, Cognitive, and Sociocultural Factors
Hyde, J. S., & Mezulis, A. H. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000230 · Cited by 385 · see citing works
Minimal phenotyping yields genome-wide association signals of low specificity for major depression
MDD Working Group of the Psychiatric Genomics Consortium, Cai, N., Revez, J. A., Adams, M. J., Andlauer, T. F. M., Breen, G., Byrne, E. M., Clarke, T.-K., Forstner, A. J., Grabe, H. J., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0594-5 · Cited by 344 · see citing works
Self-citationHu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y., & Hinds, D. A. (2016) · Nature Communications · doi:10.1038/ncomms10448 · Cited by 321 · see citing works
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Smith, D. J., Escott-Price, V, Davies, G., Bailey, M. E. S., Colodro-Conde, L., Ward, J., Vedernikov, A., Marioni, R., Cullen, B., Lyall, D., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.49 · Cited by 259 · see citing works
Hippocampal Sirtuin 1 signaling mediates depression-like behavior
Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works
Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Arango, V, & Mann, J. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.130 · Cited by 229 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Moving forward: how depression heterogeneity hinders progress in treatment and research
Fried, E. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1307737 · Cited by 220 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“151 SIRT1 is also one of the fi rst genes (SNPs; rs12413112) identi fi ed using GWAS to be associated with MDD. 154,155 Furthermore, lower SIRT expression levels in peripheral blood samples of MDD patients 156 Fig.”
BackgroundSelf-citationThe stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
Luo, Y., de Lange, K. M., Jostins, L., Moutsianas, L., Randall, J., Kennedy, N. A., Lamb, C. A., McCarthy, S., Ahmad, T., Edwards, C., et al. (2017) · Nature Genetics · doi:10.1038/ng.3761 · Cited by 162 · see citing works
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
Statistical methods to detect pleiotropy in human complex traits
Hackinger, S., & Zeggini, E. (2017) · Open Biology · doi:10.1098/rsob.170125 · Cited by 143 · see citing works
Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M., & Lu, X.-Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0352-1 · Cited by 131 · see citing works
Self-citationMaul, S., Giegling, I., Fabbri, C., Corponi, F., Serretti, A., & Rujescu, D. (2020) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32763 · Cited by 125 · see citing works
Khandaker, G. M., Zammit, S., Burgess, S., Lewis, G., & Jones, P. B. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.11.020 · Cited by 118 · see citing works
The molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works
Self-citationLiu, S., Xiu, J., Zhu, C., Meng, K., Li, C., Han, R., Du, T., Li, L., Xu, L., Liu, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27044-7 · Cited by 118 · see citing works
Self-citationRole and possible mechanisms of Sirt1 in depression
Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works
Using GWAS to identify genetic predisposition in hepatic autoimmunity
Webb, G. J., & Hirschfield, G. M. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.016 · Cited by 108 · see citing works
Polimanti, R., Peterson, R. E., Ong, J.-S., MacGregor, S., Edwards, A. C., Clarke, T.-K., Frank, J., Gerring, Z., Gillespie, N. A., Lind, P. A., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719000667 · Cited by 108 · see citing works
Self-citationMusliner, K. L., Mortensen, P. B., McGrath, J. J., Suppli, N. P., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Andreassen, O., Pedersen, C. B., Pedersen, M. G., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.4166 · Cited by 108 · see citing works
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression
Zhou, H., Polimanti, R., Yang, B.-Z., Wang, Q., Han, S., Sherva, R., Nuñez, Y. Z., Zhao, H., Farrer, L. A., Kranzler, H. R., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3275 · Cited by 94 · see citing works
Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders
Merikangas, A. K., & Almasy, L. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12660 · Cited by 82 · see citing works
Aberg, K. A., Dean, B., Shabalin, A. A., Chan, R. F., Han, L. K. M., Zhao, M., van Grootheest, G., Xie, L. Y., Milaneschi, Y., Clark, S. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0247-6 · Cited by 73 · see citing works
Grabe, H. J., Wittfeld, K., Van der Auwera, S., Janowitz, D., Hegenscheid, K., Habes, M., Homuth, G., Barnow, S., John, U., Nauck, M., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23123 · Cited by 67 · see citing works
Down-Regulation of <i>SIRT1</i> Gene Expression in Major Depressive Disorder
Luo, X.-J., & Zhang, C. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16040394 · Cited by 66 · see citing works
Genetical genomics of behavior: a novel chicken genomic model for anxiety behavior
Johnsson, M., Williams, M. J., Jensen, P., & Wright, D. (2016) · Genetics · doi:10.1534/genetics.115.179010 · Cited by 62 · see citing works
Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders
Adzic, M., Brkic, Z., Bulajic, S., Mitic, M., & Radojcic, M. B. (2016) · Drug Development Research · doi:10.1002/ddr.21332 · Cited by 60 · see citing works
Zheng, Y., He, J., Guo, L., Yao, L., Zheng, X., Yang, Z., Xia, Y., Wu, X., Su, Y., Xu, N., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00314 · Cited by 52 · see citing works
Self-citationPeyrot, W. J., Boomsma, D. I., Penninx, B. W. J. H., & Wray, N. R. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.12.017 · Cited by 42 · see citing works
Polimanti, R., Wang, Q., Meda, S. A., Patel, K. T., Pearlson, G. D., Zhao, H., Farrer, L. A., Kranzler, H. R., & Gelernter, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.153 · Cited by 43 · see citing works
Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders
Alageel, A., Tomasi, J., Tersigni, C., Brietzke, E., Zuckerman, H., Subramaniapillai, M., Lee, Y., Iacobucci, M., Rosenblat, J. D., Mansur, R. B., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.017 · Cited by 45 · see citing works
Genomic prediction of depression risk and resilience under stress
Fang, Y., Scott, L., Song, P., Burmeister, M., & Sen, S. (2019) · Nature Human Behaviour · doi:10.1038/s41562-019-0759-3 · Cited by 43 · see citing works
Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder
Team7, T. 2. R., Li, X., Luo, Z., Gu, C., Hall, L. S., McIntosh, A. M., Zeng, Y., Porteous, D. J., Hayward, C., Li, M., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0078-9 · Cited by 41 · see citing works
Mingardi, J., La Via, L., Tornese, P., Carini, G., Trontti, K., Seguini, M., Tardito, D., Bono, F., Fiorentini, C., Elia, L., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100381 · Cited by 36 · see citing works
Leeman, R. F., Rowland, B. H. P., Gebru, N. M., & Potenza, M. N. (2019) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2018.0129 · Cited by 35 · see citing works
First robust genetic links to depression emerge
Ledford, H. (2015) · Nature · doi:10.1038/523268a · Cited by 16 · see citing works
Lee, K. W., Ching, S. M., Ramachandran, V., Tusimin, M., Mohd Nordin, N., Chong, S. C., & Hoo, F. K. (2019) · Genes · doi:10.3390/genes10120988 · Cited by 14 · see citing works
Polimanti, R., Peterson, R. E., Ong, J.-S., MacGregor, S., Edwards, A. C., Clarke, T.-K., Frank, J., Gerring, Z., Gillespie, N. A., Lind, P. A., et al. (2018) · doi:10.1101/412098 · Cited by 108 · see citing works
Self-citation
- Authors
- CONVERGE consortium, Cai, N., Bigdeli, T. B., Kretzschmar, W., Li, Y., Liang, J., Song, L., Hu, J., Li, Q., Jin, W., Hu, Z., Wang, G., Wang, L., Qian, P., Liu, Y., Jiang, T., Lu, Y., Zhang, X., Yin, Y., Li, Y., Xu, X., Gao, J., Reimers, M., Webb, T., Riley, B., Bacanu, S., Peterson, R. E., Chen, Y., Zhong, H., Liu, Z., Wang, G., Sun, J., Sang, H., Jiang, G., Zhou, X., Li, Y., Li, Y., Zhang, W., Wang, X., Fang, X., Pan, R., Miao, G., Zhang, Q., Hu, J., Yu, F., Du, B., Sang, W., Li, K., Chen, G., Cai, M., Yang, L., Yang, D., Ha, B., Hong, X., Deng, H., Li, G., Li, K., Song, Y., Gao, S., Zhang, J., Gan, Z., Meng, H., Pan, J., Gao, C., Zhang, K., Sun, N., Li, Y., Niu, Q., Zhang, Y., Liu, T., Hu, C., Zhang, Z., Lv, L., Dong, J., Wang, X., Tao, M., Wang, X., Xia, J., Rong, H., He, Q., Liu, T., Huang, G., Mei, Q., Shen, Z., Liu, Y., Shen, J., Tian, T., Liu, X., Wu, W., Gu, D., Fu, G., Shi, J., Chen, Y., Gan, X., Liu, L., Wang, L., Yang, F., Cong, E., Marchini, J., Yang, H., Wang, J., Shi, S., Mott, R., Xu, Q., Wang, J., Kendler, K. S., & Flint, J.
- Affiliations
- Centre for Human Genetics (GB)
- Virginia Commonwealth University (US)
- BGI Group (China) (CN)
- University of Oxford (GB)
- Anhui Mental Health Center (CN)
- Nanjing Brain Hospital (CN)
- Sixth Hospital of Changchun City (CN)
- Chongqing City Mental Health Center (CN)
- Hebei Medical University (CN)
- Fuzhou Neuro Psychiatric Hospital (CN)
- Guangxi Zhuang Autonomous Region Brain Hospital (CN)
- Guangzhou Psychiatric Hospital (CN)
- Hebei Mental Health Center (CN)
- Jiangxi Mental Health Center (CN)
- Third People's Hospital of Huzhou (CN)
- Brain Hospital of Jilin (CN)
- Fourth People's Hospital of Liaocheng (CN)
- West China Medical Center of Sichuan University (CN)
- Jining Medical University (CN)
- Ningbo Kangning Hospital (CN)
- Sun Yat-sen University (CN)
- Chongqing Medical University (CN)
- Jinan University (CN)
- Xi'an Jiaotong University (CN)
- Shanxi Medical University (CN)
- Zhengzhou University (CN)
- Lanzhou University (CN)
- Shenzhen KangNing Hospital (CN)
- Jiangsu University (CN)
- Henan Psychiatric Hospital (CN)
- Qingdao Mental Health Center (CN)
- Zhejiang Chinese Medical University (CN)
- Sheng Jing Hospital (CN)
- Kanazawa Medical University (JP)
- Suzhou Guangji Hospital (CN)
- Tianjin Anding Hospital (CN)
- Tianjin First Center Hospital (CN)
- Tongji University (CN)
- Weihai City Mental Health Center (CN)
- Xian Mental Health Center (CN)
- Max Planck Institute for Plant Breeding Research (DE)
- Shandong Mental Health Center (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Wang, Jian
- Xu, Qi
- Wang, Jun
- Kendler, Kenneth S.
- Flint, Jonathan
- ORCID
- Cai, Na
- Bigdeli, Tim B.
- Kretzschmar, Warren
- Li, Yihan
- Song, Li
- Hu, Jingchu
- Li, Qibin
- Hu, Zhenfei
- Wang, Guangbiao
- Liu, Yuan
- Lu, Yao
- Zhang, Xiuqing
- Yin, Ye
- Li, Yingrui
- Xu, Xun
- Gao, Jingfang
- Riley, Brien
- Bacanu, Silviu
- Peterson, Roseann E.
- Zhong, Hui
- Wang, Gang
- Sun, Jing
- Zhang, Wei
- Wang, Xueyi
- Fang, Xiang
- Zhang, Qiwen
- Hu, Jian
- Yu, Fengyu
- Du, Bo
- Chen, Guibing
- Cai, Min
- Yang, Lijun
- Yang, Donglin
- Deng, Hong
- Li, Gongying
- Li, Kan
- Song, Yan
- Zhang, Jinbei
- Gan, Zhaoyu
- Pan, Jiyang
- Zhang, Kerang
- Sun, Ning
- Niu, Qihui
- Liu, Tieqiao
- Hu, Chunmei
- Zhang, Zhen
- Lv, Luxian
- Dong, Jicheng
- Wang, Xiaoping
- Tao, Ming
- Wang, Xumei
- He, Qiang
- Shen, Jianhua
- Tian, Tian
- Wu, Wenyuan
- Gu, Danhua
- Chen, Yunchun
- Gan, Xiangchao
- Liu, Lanfen
- Wang, Lina
- Yang, Fuzhong
- Marchini, Jonathan
- Yang, Huanming
- Wang, Jian
- Kendler, Kenneth S.
- Venue
- Nature
- Published
- 2015-07-15
- Volume
- 523
- Issue
- 7562
- Pages
- 588-591
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4522619
- OpenAlex
- W1627352250
- Semantic Scholar
- f8335fc9064404f6224b2d9149b1f6ed4c1a9f81
- Cited by
- 864
- References
- 30
- Citations by year
- 2026: 25 · 2025: 46 · 2024: 40 · 2023: 57 · 2022: 68 · 2021: 76 · 2020: 62 · 2019: 134 · 2018: 98 · 2017: 121 · 2016: 106 · 2015: 31
- FWCI
- 81.09
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-08-11)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Lanzhou University Institutional Repository (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Brain and Behavior Research Foundation
- Wellcome Trust (WT083573/Z/07 /Z, WT089269/Z/09/Z, 083240, WT090532/Z/09/Z, WT097307)
- National Natural Science Foundation of China (973 Program, 31222031, 31430048)
- National Institutes of Health (WT089269/Z/09/Z, WT083573/Z/07/Z)
- National Key Research and Development Program of China (2013CB531301)
- Graduiertenakademie, Technische Universität Dresden
- National Institute of Mental Health (MH100549, R01MH100549)
- FP7 Ideas: European Research Council (617306)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- major depressive disorder, recurrent depression, genetic susceptibility loci, chromosome 10, SIRT1, LHPP, sirtuins, mitochondrial dysfunction, melancholia, Chinese women, low-pass sequencing, genetic association
- MeSH terms
- Adolescent, Adult, China, Chromosomes, Human, Pair 10, Major Depressive Disorder, Depressive Disorder, Female, Humans, Introns, Middle Aged, Cohort Studies, Genome, Human, Sequence Analysis, DNA, Inorganic Pyrophosphatase, Asian People, Genome-Wide Association Study, Young Adult, Genetic Loci, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
