RIG-1 receptor expression in the pathology of Alzheimer’s disease
Open accessAbstract
BACKGROUND: Neuroinflammation plays a critical role in the pathogenesis of Alzheimer's disease (AD) and involves activation of the innate immune response via recognition of diverse stimuli by pattern recognition receptors (PRRs). The inflammatory inducers and precise innate signaling pathway contributing to AD pathology remain largely undefined. RESULTS: In the present study we analyzed expression levels of innate immune proteins in temporal and occipital cortices from preclinical (no cognitive impairment, NCI, N = 22) to mild cognitive impairment (MCI, N = 20) associated with AD pathology (N = 20) and AD patients (N = 23). We found that retinoic acid-inducible gene-I (RIG-1) is significantly elevated in the temporal cortex and plasma in patients with MCI. In addition, primary human astrocytes stimulated with the RIG-1 ligand 5'ppp RNA showed increased expression of amyloid precursor protein (APP) and amyloid-β (Aβ), supporting the idea that RIG-1 is involved in the pathology of MCI associated with early progression to AD. CONCLUSION: These findings suggest that RIG-1 may play a critical role in incipient AD.
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Previous reports show elevated RIG-I in the brains of patients with mild cognitive impairment.
“Astrocytic dsRNA deposition is conserved in brains of tau transgenic mice and in patients with AD or PSP and occurs alongside elevation of the RIG-I-like dsRNA sensor MDA5 (Ochoa et al. 2023), consistent with previous reports of elevated RIG-I in the brains of patients with mild cognitive impairment (de Rivero Vaccari et al. 2014).”
From The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders (2024) · cites this paper as de Rivero Vaccari et al. 2014
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- Authors
- de Rivero Vaccari, J. P., Brand, F. J., Sedaghat, C., Mash, D. C., Dietrich, W. D., & Keane, R. W.
- Affiliations
- University of Miami (US)
- Venue
- Journal of Neuroinflammation
- Published
- 2014-04-02
- Volume
- 11
- Issue
- 1
- Pages
- 67-67
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3977677
- OpenAlex
- W2151059472
- Cited by
- 43
- References
- 46
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2022: 5 · 2021: 4 · 2020: 2 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Miami
- University of Kentucky
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS042133, NS059836, R01NS059836, NS042133)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- RIG-I, Alzheimer's disease, mild cognitive impairment, neuroinflammation, innate immunity, pattern recognition receptors, amyloid-beta, amyloid precursor protein, astrocytes, temporal cortex, occipital cortex, plasma biomarkers
- MeSH terms
- DEAD Box Protein 58, Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Cells, Cultured, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Occipital Lobe, Peptide Fragments, Receptors, Immunologic, RNA, Viral, Temporal Lobe, Gene Expression, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Interferon Regulatory Factor-3, DEAD-box RNA Helicases, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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