Cited by 495Regulation of Appetite and ObesityIon channel regulation and functionPancreatic function and diabetes

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., Ashford, M. L. J.·2000·Nature Neuroscience

Abstract

Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.

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Crossref · 10.1038/77660

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  1. Schwartz, M. W, Figlewicz, D. P., Baskin, D. G., Woods, S. C. & Porte, D. Jr. Endocrine Rev. 13, 387–414 (1992).

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Items 401–493 of 493

Metadata

Authors
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J.
Affiliations
University of Aberdeen (GB)
Corresponding author
Ashford, M. L. J.
Venue
Nature Neuroscience
Published
2000-08
Volume
3
Issue
8
Pages
757-758
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1866620858
Cited by
495
References
15
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 13 · 2022: 3 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 21 · 2012: 22
FWCI
8.86
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
insulin, ATP-sensitive potassium channels, hypothalamic neurons, leptin, food intake regulation, body weight regulation, energy homeostasis, obesity, Zucker rats, neuronal hyperpolarization
MeSH terms
Adenosine Triphosphate, Animals, Arcuate Nucleus of Hypothalamus, Glucose, Hypothalamus, Insulin, Membrane Potentials, Neurons, Obesity, Rats, Zucker, Thinness, Tolbutamide, Potassium Channels, Patch-Clamp Techniques, Phosphatidylinositol 3-Kinases, Leptin, Rats, In Vitro Techniques

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