The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Abstract
Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.
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In the citing paper
“leptin and insulin were shown to hyperpolarize a subset of “glucose-responsive” neurons in the ARC via activation of the ATP-sensitive potassium channel (KATP) (176, 177) via a mechanism that was blocked by a PI3K inhibitor (116, 177).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [177]
In the citing paper
“both insulin and leptin activate ATP-sensitive potassium channels and thereby hyperpolarize a subset of “glucose-responsive” neurons via a mechanism that requires PI3K (176, 177).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [177]
Citations
Cites
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
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Leptin receptor missense mutation in the fatty Zucker rat
Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822
Insulin in the Brain: A Hormonal Regulator of Energy Balance*
Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628
Self-citationJiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604
Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
Ashford, M. L. J., Boden, P., & Treherne, J. M. (1990) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00373626 · Cited by 338
Self-citationIntraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats
Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253
Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats
Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230
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Self-citation
Research works printed but not linked: 1
- Schwartz, M. W, Figlewicz, D. P., Baskin, D. G., Woods, S. C. & Porte, D. Jr. Endocrine Rev. 13, 387–414 (1992).
Cited by
Sorted by citations
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Metadata
- Authors
- Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Ashford, M. L. J.
- Venue
- Nature Neuroscience
- Published
- 2000-08
- Volume
- 3
- Issue
- 8
- Pages
- 757-758
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1866620858
- Cited by
- 495
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 13 · 2022: 3 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 21 · 2012: 22
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- insulin, ATP-sensitive potassium channels, hypothalamic neurons, leptin, food intake regulation, body weight regulation, energy homeostasis, obesity, Zucker rats, neuronal hyperpolarization
- MeSH terms
- Adenosine Triphosphate, Animals, Arcuate Nucleus of Hypothalamus, Glucose, Hypothalamus, Insulin, Membrane Potentials, Neurons, Obesity, Rats, Zucker, Thinness, Tolbutamide, Potassium Channels, Patch-Clamp Techniques, Phosphatidylinositol 3-Kinases, Leptin, Rats, In Vitro Techniques
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