Cited by 495Regulation of Appetite and ObesityIon channel regulation and functionPancreatic function and diabetes

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., Ashford, M. L. J.·2000·Nature Neuroscience

Open this paper in CoChat — free account

Abstract

Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.

Integrity signals

Registry

Crossref · 10.1038/77660

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953
Leptin receptor missense mutation in the fatty Zucker rat
Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822
Insulin in the Brain: A Hormonal Regulator of Energy Balance*
Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628
Self-citation
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604
Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
Ashford, M. L. J., Boden, P., & Treherne, J. M. (1990) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00373626 · Cited by 338
Self-citation
Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats
Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253
Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats
Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230
Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats
Anai, M., Funaki, M., Ogihara, T., Terasaki, J., Inukai, K., Katagiri, H., Fukushima, Y., Yazaki, Y., Kikuchi, M., Oka, Y., et al. (1998) · Diabetes · doi:10.2337/diab.47.1.13 · Cited by 180
Tolbutamide excites rat glucoreceptive ventromedial hypothallamic neurones by indirect inhibition of ATP‐K+ channels
Ashford, M. L. J., Boden, P., & Treherne, J. M. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14116.x · Cited by 139
Self-citation

Flagged first, then by citations

Show all 15 references

Research works printed but not linked: 1

Schwartz, M. W, Figlewicz, D. P., Baskin, D. G., Woods, S. C. & Porte, D. Jr. Endocrine Rev. 13, 387–414 (1992).

Sorted by citations

Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
The Need to Feed
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.004 · Cited by 695
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654
Hypothalamic KATP channels control hepatic glucose production
Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645
The role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586
Key enzyme in leptin-induced anorexia
Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585
The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X., Harrold, J. A., King, P., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 573
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 596
Leptin Signaling in the Central Nervous System and the Periphery
Bjørbæk, C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.305 · Cited by 559
Physiological and pathophysiological roles of ATP-sensitive K+ channels
Seino, S., & Miki, T. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(02)00053-6 · Cited by 509
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489
Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482
Central insulin action in energy and glucose homeostasis
Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29063 · Cited by 444
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435
Self-citation
Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities
Niswender, K. D., & Schwartz, M. W. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00105-x · Cited by 428
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 435
Genetic approaches to studying energy balance: perception and integration
Barsh, G. S., & Schwartz, M. W. (2002) · Nature Reviews Genetics · doi:10.1038/nrg862 · Cited by 438
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
Roh, E., Song, D. K., & Kim, M.-S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.4 · Cited by 407
Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
McNay, E. C., Ong, C. T., McCrimmon, R. J., Cresswell, J. A., Bogan, J. S., & Sherwin, R. S. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.02.002 · Cited by 425
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395
The Neuroanatomical Axis for Control of Energy Balance
Grill, H. J., & Kaplan, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0224 · Cited by 395
A brain-liver circuit regulates glucose homeostasis
Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392
Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control
Zigman, J. M., & Elmquist, J. K. (2003) · Endocrinology · doi:10.1210/en.2003-0241 · Cited by 382
Neuronal Glucosensing
Levin, B. E., Routh, V. H., Kang, L., Sanders, N. M., & Dunn-Meynell, A. A. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2521 · Cited by 377
Self-citation
Attenuation of leptin and insulin signaling by SOCS proteins
Howard, J. K., & Flier, J. S. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.09.007 · Cited by 382
Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATPChannels
Ibrahim, N., Bosch, M. A., Smart, J. L., Qiu, J., Rubinstein, M., Rønnekleiv, O. K., Low, M. J., & Kelly, M. J. (2003) · Endocrinology · doi:10.1210/en.2002-221033 · Cited by 355
Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons
Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., Elias, C. F., & Elmquist, J. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3118-09.2010 · Cited by 352
Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?
Schwartz, M. W., Woods, S. C., Seeley, R. J., Barsh, G. S., Baskin, D. G., & Leibel, R. L. (2003) · Diabetes · doi:10.2337/diabetes.52.2.232 · Cited by 352
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338
“Moreover, these effects of insulin are blocked by infusion of the PI3K inhibitor and also appear to require activation of KATP channels (135, 145).”
Method
Insulin Signaling in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1264 · Cited by 339
Brain Glucose Sensing, Counterregulation, and Energy Homeostasis
Marty, N., Dallaporta, M., & Thorens, B. (2007) · Physiology · doi:10.1152/physiol.00010.2007 · Cited by 344
Nicotinic receptor‐mediated effects on appetite and food intake
Jo, Y., Talmage, D. A., & Role, L. W. (2002) · Journal of Neurobiology · doi:10.1002/neu.10147 · Cited by 323
Hypothalamic nutrient sensing in the control of energy homeostasis
Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 343
Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons
Kang, L., Routh, V. H., Kuzhikandathil, E. V., Gaspers, L. D., & Levin, B. E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.549 · Cited by 312
Self-citation
The Insulin/PI 3-Kinase Pathway Regulates Salt Chemotaxis Learning in Caenorhabditis elegans
Tomioka, M., Adachi, T., Suzuki, H., Kunitomo, H., Schafer, W. R., & Iino, Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.024 · Cited by 309
Convergence of Pre- and Postsynaptic Influences on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus
Song, Z., Levin, B. E., McArdle, J. J., Bakhos, N., & Routh, V. H. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2673 · Cited by 303
Self-citation
β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release
Franklin, I., Gromada, J., Gjinovci, A., Theander, S. S., & Wollheim, C. B. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1808 · Cited by 304
Glucosensing and glucose homeostasis: From fish to mammals
Polakof, S., Mommsen, T. P., & Soengas, J. L. (2011) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2011.07.006 · Cited by 316
Insulin in the Brain: Sources, Localization and Functions
Ghasemi, R., Haeri, A., Dargahi, L., Mohamed, Z., & Ahmadiani, A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8339-9 · Cited by 308
CNS leptin and insulin action in the control of energy homeostasis
Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 287
Neuronal circuits that regulate feeding behavior and metabolism
Sohn, J., Elmquist, J. K., & Williams, K. W. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.003 · Cited by 282
Cognitive effects of insulin in the central nervous system
Park, C. R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00016-1 · Cited by 270
Brain regulation of food intake and appetite: molecules and networks
Broberger, C. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01553.x · Cited by 286
The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides
Wang, R., Liu, X., Hentges, S. T., Dunn-Meynell, A. A., Levin, B. E., Wang, W., & Routh, V. H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1959 · Cited by 267
Self-citation
Reduced central leptin sensitivity in rats with diet-induced obesity
Levin, B. E., & Dunn-Meynell, A. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00245.2002 · Cited by 264
The brain as an insulin-sensitive metabolic organ
Milstein, J. L., & Ferris, H. A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101234 · Cited by 274
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
Niswender, K. D., Baskin, D. G., & Schwartz, M. W. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.07.009 · Cited by 267
Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS
Foo, K. S., Brismar, H., & Broberger, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.054 · Cited by 246
Neuronal control of peripheral insulin sensitivity and glucose metabolism
Ruud, J., Steculorum, S. M., & Brüning, J. C. (2017) · Nature Communications · doi:10.1038/ncomms15259 · Cited by 245
Hormone and glucose signalling in POMC and AgRP neurons
Belgardt, B., Okamura, T., & Brüning, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179192 · Cited by 257
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 247
Glucose-sensing neurons
Routh, V. H. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00761-8 · Cited by 237
Self-citation
Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes
McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.005 · Cited by 233
Leptin and Insulin Action in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2002) · Nutrition Reviews · doi:10.1301/002966402320634797 · Cited by 229
The role of the autonomic nervous liver innervation in the control of energy metabolism
Yi, C., la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.006 · Cited by 240
Monitoring of stored and available fuel by the CNS: implications for obesity
Seeley, R. J., & Woods, S. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1245 · Cited by 233
Hypothalamic control of energy balance: insights into the role of synaptic plasticity
Dietrich, M. O., & Horvath, T. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.005 · Cited by 227
Characterization of Glucosensing Neuron Subpopulations in the Arcuate Nucleus
Fioramonti, X., Contié, S., Song, Z., Routh, V. H., Lorsignol, A., & Pénicaud, L. (2007) · Diabetes · doi:10.2337/db06-0567 · Cited by 225
Self-citation
Altered hypothalamic function in diet-induced obesity
Velloso, L. A., & Schwartz, M. W. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.56 · Cited by 225
Insulin Signaling in the Pancreatic β-Cell
Leibiger, I. B., Leibiger, B., & Berggren, P. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155530 · Cited by 221
Dietary minerals and modification of cardiovascular risk factors
Vaskonen, T. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00074-3 · Cited by 219
Obesity: Genes, brain, gut, and environment
Das, U. N. (2009) · Nutrition · doi:10.1016/j.nut.2009.09.020 · Cited by 212
The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update
Hoyer, S. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200028 · Cited by 207
Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus
Baver, S. B., Hope, K., Guyot, S., Bjørbaek, C., Kaczorowski, C., & O'Connell, K. M. S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4861-12.2014 · Cited by 203
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis
Könner, A. C., Hess, S., Tovar, S., Mesaros, A., Sánchez-Lasheras, C., Evers, N., Verhagen, L. A. W., Brönneke, H. S., Kleinridders, A., Hampel, B., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.021 · Cited by 194
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels
Ainscow, E., Mirshamsi, S., Tang, T., Ashford, M. L. J., & Rutter, G. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022434 · Cited by 203
Self-citation
CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age
Vogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 194
Brain regulation of food intake and appetite: molecules and networks
Roberger, C. B. (2005) · Cited by 191
PI3K integrates the action of insulin and leptin on hypothalamic neurons
Xu, A. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524301 · Cited by 420
Leptin signaling and circuits in puberty and fertility
Elias, C. F., & Purohit, D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1095-1 · Cited by 200
Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin
Rahmouni, K., Morgan, D. A., Morgan, G. M., Liu, X., Sigmund, C. D., Mark, A. L., & Haynes, W. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21737 · Cited by 187
Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus
Yi, C., van der Vliet, J., Dai, J., Guangfu, Y., Li-qiang, R., & Buijs, R. M. (2005) · Endocrinology · doi:10.1210/en.2005-1051 · Cited by 186
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling
Zhang, Z., Dodd, G. T., & Tiganis, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.003 · Cited by 186
Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women
Hallschmid, M., Higgs, S., Thienel, M., Ott, V., & Lehnert, H. (2012) · Diabetes · doi:10.2337/db11-1390 · Cited by 181
The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178
Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
Walker, J. N., Ramracheya, R. D., Zhang, Q., Johnson, P., Braun, M., & Rorsman, P. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01450.x · Cited by 180
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation
Mirshamsi, S., Laidlaw, H. A., Ning, K., Anderson, E., Burgess, L. A., Gray, A., Sutherland, C., & Ashford, M. L. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-54 · Cited by 173
Self-citation
Brain regulation of energy balance and body weight
Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168
Hypothalamic glucose sensing: making ends meet
Routh, V. H., Hao, L., Santiago, A. M., Sheng, Z., & Zhou, C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00236 · Cited by 177
Self-citation
Developing a head for energy sensing: AMP‐activated protein kinase as a multifunctional metabolic sensor in the brain
Ramamurthy, S., & Ronnett, G. V. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110122 · Cited by 161
Molecular physiology of neuronal K-ATP channels
Liss, B. (2001) · Molecular Membrane Biology · doi:10.1080/09687680110047373 · Cited by 163
The selfish brain: competition for energy resources
Fehm, H. L., Kern, W., & Peters, A. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53007-9 · Cited by 168
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing
Le Foll, C., Irani, B. G., Magnan, C., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2009 · Cited by 159
AgRP neurons: Regulators of feeding, energy expenditure, and behavior
Deem, J. D., Faber, C. L., & Morton, G. J. (2021) · FEBS Journal · doi:10.1111/febs.16176 · Cited by 171
Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
Lam, T. K. T., Juárez, R. G., Pocai, A., Bhanot, S., Tso, P., Schwartz, G. J., & Rossetti, L. (2007) · Nature Medicine · doi:10.1038/nm1540 · Cited by 153
Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 162
Brain Glucose-Sensing Mechanism and Energy Homeostasis
López-Gambero, A. J., Martínez, F., Salazar, K., Cifuentes, M., & Nualart, F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1099-4 · Cited by 158
Roles of KATP channels as metabolic sensors in acute metabolic changes
Miki, T., & Seino, S. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.019 · Cited by 153
Insulin as a physiological modulator of glucagon secretion
Bansal, P., & Wang, Q. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90295.2008 · Cited by 152
Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway
Khan, F. A., Goforth, P. B., Zhang, M., & Satin, L. S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2192 · Cited by 148

Authors: Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J.
Affiliations: University of Aberdeen (GB)
Corresponding author: Ashford, M. L. J.
ORCID: Spanswick, D.
Routh, V. H.
Ashford, M. L. J.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-08
Volume: 3
Issue: 8
Pages: 757-758
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/77660
OpenAlex: W1866620858
Cited by: 495
References: 15
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 13 · 2022: 3 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 21 · 2012: 22
FWCI: 8.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: insulin, ATP-sensitive potassium channels, hypothalamic neurons, leptin, food intake regulation, body weight regulation, energy homeostasis, obesity, Zucker rats, neuronal hyperpolarization
MeSH terms: Adenosine Triphosphate, Animals, Arcuate Nucleus of Hypothalamus, Glucose, Hypothalamus, Insulin, Membrane Potentials, Neurons, Obesity, Rats, Zucker, Thinness, Tolbutamide, Potassium Channels, Patch-Clamp Techniques, Phosphatidylinositol 3-Kinases, Leptin, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks