A putative pheromone receptor gene expressed in human olfactory mucosa
Abstract
Pheromones elicit specific behavioural responses and physiological alterations in recipients of the same species. In mammals, these chemical signals are recognized within the nasal cavity by sensory neurons that express pheromone receptors. In rodents, these receptors are thought to be represented by two large multigene families, comprising the V1r and V2r genes, which encode seven-transmembrane proteins. Although pheromonal effects have been demonstrated in humans, V1R or V2R counterparts of the rodent genes have yet to be characterized.
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Rodriguez et al. reported the discovery of a previously undetected human gene closely related to the V1R family in rodents, and it is expressed in the main olfactory epithelium.
“In a recent paper Rodriguez et al. reported the discovery of a previously undetected human gene closely related to the V1R family in rodents (Rodriguez et al., 2000).Whether it is expressed in human vomeronasal epithelium was not reported, but it is expressed in the main olfactory epithelium.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Rodriguez et al., 2000
Cites
‘Pheromones’: a New Term for a Class of Biologically Active Substances
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A novel family of genes encoding putative pheromone receptors in mammals
Dulac, C., & Axel, R. (1995) · Cell · doi:10.1016/0092-8674(95)90161-2 · Cited by 1,001 · see citing works
The development of the olfactory and the accessory olfactory formations in human embryos and fetuses
Humphrey, T. (1940) · Journal of Comparative Neurology · doi:10.1002/cne.900730305 · Cited by 143 · see citing works
Ultrastructure of the human vomeronasal organ
Stensaas, L. J., Lavker, R. M., Monti-Bloch, L., Grosser, B. I., & Berliner, D. L. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90252-z · Cited by 118 · see citing works
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Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases
Meredith, M. (2001) · Chemical Senses · doi:10.1093/chemse/26.4.433 · Cited by 280 · see citing works
Something in the Air? New Insights into Mammalian Pheromones
Brennan, P. A., & Keverne, E. B. (2004) · Current Biology · doi:10.1016/j.cub.2003.12.052 · Cited by 236 · see citing works
Facts, fallacies, fears, and frustrations with human pheromones
Wysocki, C. J., & Preti, G. (2004) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20125 · Cited by 220 · see citing works
Liebowitz, M. R., Hanover, R., Draine, A., Lemming, R., Careri, J., & Monti, L. (2016) · Depression and Anxiety · doi:10.1002/da.22546 · Cited by 21 · see citing works
- Authors
- Rodriguez, I., Greer, C. A., Mok, M. Y., & Mombaerts, P.
- Affiliations
- Yale University (US)
- Rockefeller University (US)
- Corresponding author
- Mombaerts, Peter
- Venue
- Nature Genetics
- Published
- 2000-09
- Volume
- 26
- Issue
- 1
- Pages
- 18-19
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1543159687
- Cited by
- 235
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 6
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- pheromone receptors, seven-transmembrane proteins, olfactory sensory neurons, pheromone signaling, human pheromones, gene expression
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Chemoreceptor Cells, Chemotactic Factors, Cloning, Molecular, Codon, Glycosylation, Humans, Models, Genetic, Molecular Sequence Data, Olfactory Mucosa, Tissue Distribution, Blotting, Southern, Open Reading Frames, Frameshift Mutation, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Mice, Rats
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