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Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms

Fur, S. L., Stunff, C. L., & Bougneres, P. F. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s304 · Cited by 32 · see citing works

Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings

Sánchez‐Corona, J., Flores-Martí­nez, S. E., Machorro-Lazo, M.-V., Galavíz-Hernández, C., Morán-Moguel, M. C., Perea, F. J., Mújica‐López, K. I., Vargas-Ancona, L., Laviada‐Molina, H., Fernández, V., et al. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.08.004 · Cited by 31 · see citing works

Insulin Gene Variable Number of Tandem Repeats (INS VNTR) Genotype and Metabolic Syndrome in Childhood Obesity

Santoro, N., Cirillo, G., Amato, A., Luongo, C., Raimondo, P., D’Aniello, A., Perrone, L., & del Giudice, E. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2705 · Cited by 29 · see citing works

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

Say, Y.-H. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-017-0142-x · Cited by 27 · see citing works

Prospects for predicting and stopping the development of type 1 of diabetes

Gorus, F., PIPELEERS, D. G., & Belgian Diabetes Registry (2001) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2001.0152 · Cited by 26 · see citing works

Insulin gene VNTR genotype is associated with insulin sensitivity and secretion in infancy

Bazaes, R. A., Petry, C. J., Ong, K. K., Avila, A., Dunger, D. B., & Verónica Mericq, G. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01890.x · Cited by 27 · see citing works

Relation between Disease Phenotype and HLA-DQ Genotype in Diabetic Patients Diagnosed in Early Adulthood

Weets, I., Siraux, V., Daubresse, J., Leeuw, I. H. D., Féry, F., Keymeulen, B., Krzentowski, G., Letiexhe, M. R., Mathieu, C., Nobels, F. R. E., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.6.2597 · Cited by 27 · see citing works

INSULIN AND INSULIN RECEPTOR GENE POLYMORPHISMS AND SUSCEPTIBILITY TO NONALCOHOLIC FATTY LIVER DISEASE

Nobakht, H., Mahmoudi, T., Sabzikarian, M., Tabaeian, S. P., Rezamand, G., Asadi, A., Farahani, H., Dabiri, R., Mansour‐Ghanaei, F., Maleki, I., et al. (2020) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202000000-39 · Cited by 25 · see citing works

Insulin Resistance-Related Genes and Advanced Left-Sided Colorectal Adenoma

Gunter, M. J., Hayes, R. B., Chatterjee, N., Yeager, M., Welch, R., Schoen, R. E., Yakochi, L., Schatzkin, A. G., & Peters, U. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0849 · Cited by 25 · see citing works

Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents

Frelut, M., Nicolas, J., Guilland, J.-C., & de Courcy, G. P. (2010) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2010.486835 · Cited by 24 · see citing works

Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes

Rodrı́guez, S., Gaunt, T. R., Dennison, E. M., Chen, X., Syddall, H. E., Phillips, D. I. W., Cooper, C. C., & Day, I. N. M. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201505 · Cited by 23 · see citing works

Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children

Stunff, C. L., Dechartres, A., Mariot, V., Lotton, C., Trainor, C. D., del Giudice, E. M., Meyre, D., Bièche, I., Laurendeau, I., Froguel, P., et al. (2007) · Diabetes · doi:10.2337/db07-1273 · Cited by 24 · see citing works

Development of Obesity: The Driver and the Passenger

Kopp, W. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s280146 · Cited by 24 · see citing works

A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

Santos, C. D., Bougneres, P. F., & Fradin, D. D. (2008) · Diabetes · doi:10.2337/db08-0587 · Cited by 23 · see citing works

Positional Candidate Gene Analysis of Lim Domain Homeobox Gene (Isl-1) on Chromosome 5q11-q13 in a French Morbidly Obese Population Suggests Indication for Association With Type 2 Diabetes

Barat‐Houari, M., Clément, K., Vatin, V., Christian Dina, C., Bonhomme, G., Vasseur, F., Guy-grand, B., & Froguel, P. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1640 · Cited by 22 · see citing works

INS VNTR is a QTL for the insulin response to oral glucose in obese children

Santos, C. D., Fallin, M. D., Stunff, C. L., Fur, S. L., & Bougneres, P. F. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2003 · Cited by 22 · see citing works

Stimulated Insulin Secretion Predicts Changes in Body Composition Following Weight Loss in Adults with High BMI

Wong, J. M., Yu, S., Ma, C., Mehta, T. S., Dickinson, S., Allison, D. B., Heymsfield, S. B., Ebbeling, C. B., & Ludwig, D. S. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab315 · Cited by 21 · see citing works

VNTR Polymorphism of the Insulin Gene and Childhood Overweight in a General Population

Heude, B., Dubois, S. G., Charles, M.-A. A., Deweirder, M., Christian Dina, C., Borys, J.-M., Ducimetière, P., Froguel, P., & Fleurbaix Laventie Ville Santé Study Group (2004) · Obesity Research · doi:10.1038/oby.2004.56 · Cited by 21 · see citing works

The Insulin Gene Variable Number of Tandem Repeat: Associations and Interactions with Childhood Body Fat Mass and Insulin Secretion in Normal Children

Heude, B., Petry, C. J., Pembrey, M. E., Dunger, D. B., & Ong, K. K. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2055 · Cited by 21 · see citing works

Proinsulin 2 Knockout NOD Mice

Dubois‐Laforgue, D., Mogenet, L., Thébault, K., Jami, J., Krief, P., & Boîtard, C. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s489 · Cited by 21 · see citing works

Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children

Fur, S. L., Auffray, C., Letourneur, F., Cruaud, C., Stunff, C. L., & Bougneres, P. F. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00311.2005 · Cited by 20 · see citing works

No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort

Bennett, A. J., Sovio, U., Ruokonen, A., Martikainen, H. K., Pouta, A. M., Taponen, S., Hartikainen, A. L., Franks, P. W., Peltonen, L., Elliott, P., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1737-z · Cited by 20 · see citing works

Detection of single nucleotide polymorphisms by the specific interaction between transition metal ions and mismatched base pairs in duplex DNA

Torigoe, H., Ono, A. M., & Kozasa, T. (2010) · Transition Metal Chemistry · doi:10.1007/s11243-010-9445-z · Cited by 19 · see citing works

Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: A pilot study

Krechler, T., Jáchymová, M., Pavlı́ková, M., Vecka, M., Zeman, M., Krška, Z., Švestka, T., & Žák, A. (2009) · Neoplasma · doi:10.4149/neo_2009_01_26 · Cited by 18 · see citing works

Association between small for gestational age and paternally inherited 5′ insulin haplotypes

Adkins, R. M., Krushkal, J., Klauser, C. K., Magann, E. F., Morrison, J. C., & Somes, G. W. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803700 · Cited by 17 · see citing works

Developmental aspects in the pathogenesis of type 2 diabetes

Ong, K. K., & Dunger, D. B. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00625-6 · Cited by 17 · see citing works

Genetic analysis of candidate genes for the polycystic ovary syndrome

Urbanek, M., & Spielman, R. S. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200212000-00009 · Cited by 17 · see citing works

Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial

Ziegler, A., Achenbach, P., Weiß, A., Berner, R., Casteels, K., Larsson, H. E., Haupt, F., Hommel, A., Jacobs, A., Kordonouri, O., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01726-x · Cited by 21 · see citing works

The Pivotal Role of the Western Diet, Hyperinsulinemia, Ectopic Fat, and Diacylglycerol-Mediated Insulin Resistance in Type 2 Diabetes

Janssen, J. A. M. J. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189191 · Cited by 16 · see citing works

The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer.

Rezaei–Tavirani, M., Safaei, A., & Zali, M. R. (2013) · Europe PMC (PubMed Central) · Cited by 15 · see citing works

The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study

Majores, M., Kölsch, H., Bagli, M., Ptok, U., Kockler, M., Becker, K., Rao, M. L., Maier, W., & Heun, R. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200086 · Cited by 15 · see citing works

Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study

Mook‐Kanamori, D. O., Geelhoed, J. J. M., Steegers, E. A. P., Witteman, J. C. M., Albert Hofman, D., Moll, H. A., van Duijn, C. M., Hokken-Koelega, A., & Jaddoe, V. W. V. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0378 · Cited by 15 · see citing works

Gene–Diet Interactions in Childhood Obesity: Paucity of Evidence as the Epidemic of Childhood Obesity Continues to Rise

Papoutsakis, C., & Dedoussis, G. V. (2007) · Personalized Medicine · doi:10.2217/17410541.4.2.133 · Cited by 14 · see citing works

Increased prevalence of VNTR III of the insulin gene in women with gestational diabetes mellitus (GDM)

Litou, H., Anastasiou, E., Thalassinou, L., Sarika, H.-L., Philippou, G., & Alevizaki, M. K. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.08.016 · Cited by 14 · see citing works

INS VNTR Class Genotype and Indexes of Body Size and Obesity

Sandhu, M. S., Heude, B., Young, E. H., Luben, R., Luan, J., Khaw, K., Todd, J. A., & Wareham, N. J. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2812 · Cited by 14 · see citing works

A Pilot Study of Discontinuous, Insulin-Like Growth Factor 1–Dosing Growth Hormone Treatment in Young Children with FGFR3 N540K-Mutated Hypochondroplasia

Rothenbühler, A., Linglart, A., Piquard, C., & Bougneres, P. F. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.10.023 · Cited by 13 · see citing works

Fetal growth is associated with CpG methylation in the P2 promoter of the IGF1 gene

Stunff, C. L., Castell, A., Todd, N., Mille, C., Belot, M., Frament, N., Brailly‐Tabard, S., Benachi, A., Fradin, D. D., & Bougneres, P. F. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0489-9 · Cited by 13 · see citing works

Running Head: INS VNTR is associated with insulin response to glucose in young obese.

Santos, C. D., Fallin, D., Stunff, C. L., & Fur, S. L. (2015)

Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children

Fur, S. L., Auffray, C., Letourneur, F., Cruaud, C., Stunff, C. L., & Bougneres, P. F. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00311.2005 · Cited by 20 · see citing works

ROLE OF INSULIN VARIABLE NUMBER TANDEM REPEAT POLYMORPHISM IN CHILDHOOD OBESITY

Dubern, B., Tounian, A., Bouglé, D. L., Frelut, M., Herçberg, S., Girardet, J.-P., Clément, K., & Tounian, P. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2006.tb01763.x

Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity

Stunff, C. L., Fallin, M. D., & Bougneres, P. F. (2001) · Nature Genetics · doi:10.1038/ng707 · Cited by 110 · see citing works

INS VNTR is a QTL for the insulin response to oral glucose in obese children

Santos, C. D., Fallin, M. D., Stunff, C. L., Fur, S. L., & Bougneres, P. F. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2003 · Cited by 22 · see citing works