Physical Activity Decreases Diverticular Complications
Open accessAbstract
OBJECTIVES: Little is known about the effect of physical activity on diverticular complications. This study prospectively examined the associations between physical activity and diverticular bleeding and diverticulitis. METHODS: We studied 47,228 US males in the Health Professionals Follow-up Study cohort who were aged 40-75 years and free of diverticular disease, gastrointestinal cancer, and inflammatory bowel disease at baseline in 1986. Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires outlining details of diagnosis and treatment. Physical activity was assessed every 2 years. Men recorded the average time per week spent in eight recreational activities, and flights of stairs climbed per day. Cox proportional hazards regression was used to calculate relative risks (RRs). RESULTS: During 18 years of follow-up, 800 cases of diverticulitis and 383 cases of diverticular bleeding were identified. Total cumulative physical activity was associated with a decreased risk of diverticulitis and diverticular bleeding. After adjustment for potential confounders, the RR for men in the highest quintile of total activity (> or = 57.4 metabolic equivalent hours per week (MET-h/week) was 0.75 (95% confidence interval, CI, 0.58-0.95) for diverticulitis and 0.54 (95% CI, 0.38-0.77) for bleeding, as compared with men in the lowest quintile (< or = 8.2 MET-h/week). Vigorous activity was inversely related to diverticulitis in a high vs. low comparison (multivariable RR, 0.66; 95% CI, 0.51-0.86) and bleeding (multivariable RR, 0.61; 95% CI, 0.41-0.90), whereas nonvigorous activity was not. These results were similar for recent (simple updated) and baseline activity. CONCLUSIONS: Data from this large prospective cohort suggest that physical activity lowers the risk of diverticulitis and diverticular bleeding. Vigorous activity appears to account for this association.
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Physical activity lowered the risk of diverticulitis and diverticular bleeding during an 18-year follow-up of 47,228 US males in the Health Professionals Study.
“Physical activity lowered the risk of diverticulitis and diverticular bleeding during an 18-yr of follow-up of 47,228 US males in the Health Professionals Study (492).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [492]
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
ter Steege, R. W. F., & Kolkman, J. J. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04980.x · Cited by 145 · see citing works
- Authors
- Strate, L. L., Liu, Y. L., Aldoori, W. H., & Giovannucci, E. L.
- Affiliations
- University of Washington (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Strate, Lisa L
- Venue
- The American Journal of Gastroenterology
- Published
- 2009-04-14
- Volume
- 104
- Issue
- 5
- Pages
- 1221-1230
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- PMC
- PMC3144158
- OpenAlex
- W2050352562
- Cited by
- 185
- References
- 45
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 18 · 2020: 15 · 2019: 9 · 2018: 21 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 11 · 2013: 7 · 2012: 13
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Agency for Healthcare Research and Quality (K08 HS14062, K08HS014062)
- National Heart, Lung, and Blood Institute (R01HL035464)
- National Cancer Institute (P01CA055075)
- Topics
- Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
- Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- physical activity, diverticulitis, diverticular bleeding, diverticular disease, vigorous activity, recreational activities, stair climbing, metabolic equivalent hours, Health Professionals Follow-up Study, men
- MeSH terms
- Adult, Aged, Diverticulitis, Colonic, Diverticulum, Colon, Follow-Up Studies, Gastrointestinal Hemorrhage, Humans, Life Style, Male, Middle Aged, Motor Activity, Physical Fitness, Reference Values, Severity of Illness Index, Cohort Studies, Exercise, Incidence, Multivariate Analysis, Proportional Hazards Models, Risk Assessment
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