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Cited by 104Gastrointestinal motility and disordersPelvic floor disorders treatmentsInfant Health and Development

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Bloating and Distension in Irritable Bowel Syndrome: The Role of Gastrointestinal Transit

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Agrawal, Anurag, Houghton, Lesley A, Reilly, Brian, Morris, Julie, Whorwell, Peter J·2009·The American Journal of Gastroenterology
DOI 10.1038/ajg.2009.251
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Abstract

OBJECTIVES: Patients with irritable bowel syndrome and constipation (IBS-C) show more abdominal distension than do those with diarrhea. Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating than do those with normal transit. METHODS: Abdominal girth was recorded for 24 h using abdominal inductance plethysmography (AIP) in 30 IBS-C (Rome II criteria) patients (aged 18-68 years; 27 women) and in 30 healthy volunteers (21-58 years of age; 26 women). Within 2 weeks of this recording, orocecal and colonic transits were assessed. Orocecal transit was determined from the increase in breath hydrogen after a standard meal, and colonic transit from the number of radio-opaque markers identified on a plain abdominal X-ray. Bloating severity was assessed hourly during AIP recording using a 0-5 scale. RESULTS: IBS-C patients showed more bloating and distension than did healthy volunteers (P<0.001). They also had prolonged colonic (P<0.001) and orocecal (P=0.05) transits than did healthy volunteers, such that 47 and 17%, respectively, had colonic and orocecal transit times greater than the normal reference range. Those with delayed colonic (P=0.025) and orocecal (P=0.13) transits had greater distension but not bloating (P=0.63 and P=0.48, respectively) compared with those with normal transit. Moreover, distension directly correlated with orocecal (r=0.40; P=0.03) and colonic (r=0.51; P=0.004) transit times and inversely with stool consistency (r=-0.43; P=0.07). CONCLUSIONS: IBS-C patients with delayed transit show greater abdominal distension than do those with normal transit. Therefore, drugs that accelerate transit may be expected to alleviate this troublesome problem.

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  1. Lewis MJV, 2001, Gut, 49, 3088
  2. Thompson WG, 1999, Gut, 45, 1143

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Metadata

Authors
Agrawal, A., Houghton, L. A., Reilly, B., Morris, J., & Whorwell, P. J.
Affiliations
  • University of Manchester (GB)
  • Wythenshawe Hospital (GB)
  • Manchester University NHS Foundation Trust (GB)
Corresponding author
Houghton, Lesley A
ORCID
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-06-02
Volume
104
Issue
8
Pages
1998-2004
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1038/ajg.2009.251
OpenAlex
W2102691923
Cited by
104
References
29
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 11 · 2013: 5 · 2012: 12
FWCI
9.92
Type
journal article
Language
en
Open access
Licence
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords
irritable bowel syndrome with constipation, bloating, abdominal distension, gastrointestinal transit, colonic transit, orocecal transit, breath hydrogen, stool consistency
MeSH terms
Adolescent, Adult, Aged, Female, Gastrointestinal Transit, Humans, Male, Middle Aged, Plethysmography, Time Factors, Irritable Bowel Syndrome, Young Adult

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