Cited by 79Multiple Myeloma Research and TreatmentsRNA modifications and cancerChronic Lymphocytic Leukemia Research

The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma

Open access
Ronchetti, D, Todoerti, K, Tuana, G, Agnelli, L, Mosca, L, Lionetti, M, Fabris, S, Colapietro, P +4 more·2012·Blood Cancer Journal

Abstract

Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs) are non-coding RNAs involved in the maturation of other RNA molecules and generally located in the introns of host genes. It is now emerging that altered sno/scaRNAs expression may have a pathological role in cancer. This study elucidates the patterns of sno/scaRNAs expression in multiple myeloma (MM) by profiling purified malignant plasma cells from 55 MMs, 8 secondary plasma cell leukemias (sPCLs) and 4 normal controls. Overall, a global sno/scaRNAs downregulation was found in MMs and, even more, in sPCLs compared with normal plasma cells. Whereas SCARNA22 resulted the only sno/scaRNA characterizing the translocation/cyclin D4 (TC4) MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by an imprinting center at 15q11, which, however, resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information to the bio-molecular complexity of plasma cell dyscrasias.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/bcj.2012.41

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 49 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ronchetti, D., Todoerti, K., Tuana, G., Agnelli, L., Mosca, L., Lionetti, M., Fabris, S., Colapietro, P., Miozzo, M., Ferrarini, M., Tassone, P., & Neri, A.
Affiliations
  • University of Milan (IT)
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • Magna Graecia University (IT)
Corresponding author
Neri, A
Venue
Blood Cancer Journal
Published
2012-11-23
Volume
2
Issue
11
Pages
e96-e96
ISSN
2044-5385 (ISSN-L)
OpenAlex
W2045009762
Cited by
79
References
49
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 3 · 2013: 7
FWCI
3.63
Type
journal article
Language
en
Open access
Locations
  • Blood Cancer Journal (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders
  • Ministero dell’Istruzione, dell’Università e della Ricerca (2009PKMYA2)
  • Associazione Italiana per la Ricerca sul Cancro (2010/15, 9980, 2010-15, AIRC 5xmille, 5 x mille)
  • Fondazione Italiana per la Ricerca sul Cancro
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
Keywords
small nucleolar RNA, multiple myeloma, secondary plasma cell leukemia, SNORD116, DNA methylation, molecular subtypes, plasma cell dyscrasia, allelic imbalance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review