The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma
Open accessAbstract
Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs) are non-coding RNAs involved in the maturation of other RNA molecules and generally located in the introns of host genes. It is now emerging that altered sno/scaRNAs expression may have a pathological role in cancer. This study elucidates the patterns of sno/scaRNAs expression in multiple myeloma (MM) by profiling purified malignant plasma cells from 55 MMs, 8 secondary plasma cell leukemias (sPCLs) and 4 normal controls. Overall, a global sno/scaRNAs downregulation was found in MMs and, even more, in sPCLs compared with normal plasma cells. Whereas SCARNA22 resulted the only sno/scaRNA characterizing the translocation/cyclin D4 (TC4) MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by an imprinting center at 15q11, which, however, resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information to the bio-molecular complexity of plasma cell dyscrasias.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In this study, only SNORD115-32 and SNORD116-29 overlapped with the SNORDs identified by RNA-seq in plasma EV among the list of all SNORDs associated with myeloma reported by Ronchetti et al.
“Within the list of all SNORDs associated with myeloma reported by Ronchetti et al. (Ronchetti et al., 2012), in our study we found only SNORD115–32 and SNORD116–29 overlapping with the SNORDs identified by RNA-seq in plasma EV.”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Ronchetti et al., 2012
Members of SNORD115 and SNORD116 clusters have been reported upregulated in patients with multiple myeloma, chronic lymphocytic leukemia, or acute lymphoblastic leukemia.
“Members of SNORD115 and SNORD116 clusters have been also reported upregulated in patients with multiple myeloma, chronic lymphocytic leukemia (Ronchetti et al., 2013; Ronchetti et al., 2012), or acute lymphoblastic leukemia (Vendramini et al., 2014).”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Ronchetti et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
The International Myeloma Working Group (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04355.x · Cited by 2,367 · see citing works
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,797 · see citing works
Initial genome sequencing and analysis of multiple myeloma
Chapman, M. A., Lawrence, M. S., Keats, J. J., Cibulskis, K., Sougnez, C. L., Schinzel, A. C., Harview, C. L., Brunet, J.-P., Ahmann, G. J., Adli, M., et al. (2011) · Nature · doi:10.1038/nature09837 · Cited by 1,422 · see citing works
Shaughnessy, J. D., Zhan, F., Burington, B. E., Huang, Y., Colla, S., Hanamura, I., Stewart, P., Kordsmeier, B., Randolph, C. E., Williams, D. R., et al. (2006) · Blood · doi:10.1182/blood-2006-07-038430 · Cited by 916 · see citing works
The genetic architecture of multiple myeloma
Morgan, G. J., Walker, B. A., & Davies, F. E. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3257 · Cited by 913 · see citing works
Kiss (2002) · doi:10.1016/s0092-8674(02)00718-3 · Cited by 816 · see citing works
Genetics and Cytogenetics of Multiple Myeloma
Fonseca, R., Barlogie, B., Bataille, R., Bastard, C., Bergsagel, P. L., Chesi, M., Davies, F. E., Drach, J. W., Greipp, P. R., Kirsch, I. R., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2876 · Cited by 685 · see citing works
Advances in biology of multiple myeloma: clinical applications
Hideshima, T., Bergsagel, P. L., Kuehl, W. M., & Anderson, K. C. (2004) · Blood · doi:10.1182/blood-2004-01-0037 · Cited by 582 · see citing works
snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs
Lestrade, L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj002 · Cited by 504 · see citing works
Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly
Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhäuser, N., Marchisio, P. C., & Biffo, S. (2003) · Nature · doi:10.1038/nature02160 · Cited by 437 · see citing works
Runte, M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.23.2687 · Cited by 391 · see citing works
Are snoRNAs and snoRNA host genes new players in cancer?
Williams, G. T., & Farzaneh, F. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3195 · Cited by 363 · see citing works
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs
Brameier, M., Herwig, A., Reinhardt, R., Walter, L., & Gruber, J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq776 · Cited by 300 · see citing works
Schadt, E. E., Cheng, L., Ellis, B., & Wong, W. H. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10073 · Cited by 288 · see citing works
The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing
Kishore, S., Khanna, A., Zhang, Z., Hui, J., Balwierz, P. J., Stefan, M., Beach, C. M., Nicholls, R. D., Zavolan, M., & Stamm, S. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp585 · Cited by 279 · see citing works
Walker, B. A., Wardell, C. P., Chiecchio, L., Smith, E. M., Boyd, K. D., Neri, A., Davies, F. E., Ross, F. M., & Morgan, G. J. (2011) · Blood · doi:10.1182/blood-2010-04-279539 · Cited by 267 · see citing works
Self-citationSmall nucleolar RNA 42 acts as an oncogene in lung tumorigenesis
Mei, Y.-P., Liao, J.-P., Shen, J., Yu, L., Liu, B.-L., Liu, L., Li, R. Y., Ji, L., Dorsey, S. G., Jiang, Z.-R., et al. (2011) · Oncogene · doi:10.1038/onc.2011.449 · Cited by 254 · see citing works
From snoRNA to miRNA: Dual function regulatory non-coding RNAs
Scott, M. S., & Ono, M. (2011) · Biochimie · doi:10.1016/j.biochi.2011.05.026 · Cited by 253 · see citing works
Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress
Michel, C. I., Holley, C. L., Scruggs, B. S., Sidhu, R., Brookheart, R. T., Listenberger, L. L., Behlke, M. A., Ory, D. S., & Schaffer, J. E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.009 · Cited by 243 · see citing works
Lionetti, M., Biasiolo, M., Agnelli, L., Todoerti, K., Mosca, L., Fabris, S., Sales, G., Deliliers, G. L., Bicciato, S., Lombardi, L., et al. (2009) · Blood · doi:10.1182/blood-2009-08-237495 · Cited by 238 · see citing works
Self-citationJády, B. E., & Kiss, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.541 · Cited by 223 · see citing works
Human miRNA Precursors with Box H/ACA snoRNA Features
Scott, M. S., Avolio, F., Ono, M., Lamond, A. I., & Barton, G. J. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000507 · Cited by 193 · see citing works
Agnelli, L., Mosca, L., Fabris, S., Lionetti, M., Andronache, A., Kwee, I., Todoerti, K., Verdelli, D., Battaglia, C., Bertoni, F., et al. (2009) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20668 · Cited by 142 · see citing works
Self-citationIdentification of human miRNA precursors that resemble box C/D snoRNAs
Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J., & Lamond, A. I. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1355 · Cited by 137 · see citing works
Mattioli, M., Agnelli, L., Fabris, S., Baldini, L., Morabito, F., Bicciato, S., Verdelli, D., Intini, D., Nobili, L., Cro, L., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208447 · Cited by 131 · see citing works
Self-citationSpecific small nucleolar RNA expression profiles in acute leukemia
Valleron, W., Laprévotte, E., Gautier, E., Quelen, C., Demur, C., Delabesse, É., Agirre, X., Prósper, F., Kiss, T., & Brousset, P. (2012) · Leukemia · doi:10.1038/leu.2012.111 · Cited by 129 · see citing works
Agnelli, L., Bicciato, S., Mattioli, M., Fabris, S., Intini, D., Verdelli, D., Baldini, L., Morabito, F., Callea, V., Lombardi, L., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.3870 · Cited by 125 · see citing works
Self-citationRonchetti, D., Lionetti, M., Mosca, L., Agnelli, L., Andronache, A., Fabris, S., Deliliers, G. L., & Neri, A. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-37 · Cited by 120 · see citing works
Self-citationDifferential repetitive DNA methylation in multiple myeloma molecular subgroups
Bollati, V., Fabris, S., Pegoraro, V., Ronchetti, D., Mosca, L., Deliliers, G. L., Motta, V., Bertazzi, P. A., Baccarelli, A., & Neri, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp149 · Cited by 119 · see citing works
Self-citationNon-coding RNAs: a key to future personalized molecular therapy?
Galasso, M., Sana, M. E., & Volinia, S. (2010) · Genome Medicine · doi:10.1186/gm133 · Cited by 108 · see citing works
Chu, L., Su, M. Y., Maggi, L. B., Lu, L., Mullins, C. D., Crosby, S., Huang, G.-F., Chng, W., Vij, R., & Tomasson, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63051 · Cited by 98 · see citing works
Human box C/D snoRNA processing conservation across multiple cell types
Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J., & Lamond, A. I. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1233 · Cited by 96 · see citing works
snoTARGET shows that human orphan snoRNA targets locate close to alternative splice junctions
Bazeley, P. S., Shepelev, V., Talebizadeh, Z., Butler, M. G., Fedorova, L. V., Filatov, V., & Fedorov, A. N. (2007) · Gene · doi:10.1016/j.gene.2007.10.037 · Cited by 96 · see citing works
A novel TBP‐associated factor of SL1 functions in RNA polymerase I transcription
Gorski, J. J., Pathak, S., Panov, K. I., Kasciukovic, T., Panova, T., Russell, J., & Zomerdijk, J. C. B. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601601 · Cited by 95 · see citing works
Bortolin-Cavaille, M.-L., & Cavaille, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks321 · Cited by 88 · see citing works
Agnelli, L., Fabris, S., Bicciato, S., Basso, D., Baldini, L., Morabito, F., Verdelli, D., Todoerti, K., Lambertenghi‐Deliliers, G., Lombardi, L., et al. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06467.x · Cited by 66 · see citing works
Self-citationSno/scaRNAbase: a curated database for small nucleolar RNAs and cajal body-specific RNAs
Xie, J., Zhang, M., Zhou, T., Hua, X., Tang, L., & Wu, W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl873 · Cited by 65 · see citing works
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice
Chen, T. H.-P., Kambal, A., Krysiak, K., Walshauser, M. A., Raju, G., Tibbitts, J. F., & Walter, M. J. (2010) · Blood · doi:10.1182/blood-2010-06-293167 · Cited by 54 · see citing works
Genomic analysis of high-risk smoldering multiple myeloma
López‐Corral, L., Mateos, M. V., Corchete, L. A., Sarasquete, M. E., de la Rubia, J., de Arriba, F., Lahuerta, J. J., García‐Sánz, R., Miguel, J. F. S., & Gutierrez, N. C. (2012) · Haematologica · doi:10.3324/haematol.2011.060780 · Cited by 51 · see citing works
Transcriptional features of multiple myeloma patients with chromosome 1q gain
Fabris, S., Ronchetti, D., Agnelli, L., Baldini, L., Morabito, F., Bicciato, S., Basso, D., Todoerti, K., Lombardi, L. T., Lambertenghi‐Deliliers, G., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404616 · Cited by 48 · see citing works
Self-citationFabris, S., Agnelli, L., Mattioli, M., Baldini, L., Ronchetti, D., Morabito, F., Verdelli, D., Nobili, L., Intini, D., Callea, V., et al. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20123 · Cited by 48 · see citing works
Self-citationMicroRNAs in the Pathobiology of Multiple Myeloma
Lionetti, M., Agnelli, L., Lombardi, L., Tassone, P., & Neri, A. (2012) · Current Cancer Drug Targets · doi:10.2174/156800912802429274 · Cited by 47 · see citing works
Self-citationMicroRNAs: New Players in Multiple Myeloma
Pichiorri, F., Luca, L. D., & Aqeilan, R. I. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00022 · Cited by 43 · see citing works
Evidence for a pro-apoptotic function of RACK1 in human breast cancer
Reefy, S. A., Osman, H., Jiang, W. G., & Mokbel, K. (2010) · Oncogene · doi:10.1038/onc.2010.291 · Cited by 12 · see citing works
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Nombela, P., Miguel‐López, B., & Blanco, S. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01263-w · Cited by 494 · see citing works
Jorjani, H., Kehr, S., Jedlinski, D. J., Gumienny, R., Hertel, J., Stadler, P. F., Zavolan, M., & Gruber, A. R. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw386 · Cited by 257 · see citing works
Shi, H., Chai, P., Jia, R., & Fan, X. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01194-6 · Cited by 249 · see citing works
Diverse human extracellular RNAs are widely detected in human plasma
Freedman, J. E., Gerstein, M., Mick, E., Rozowsky, J., Levy, D., Kitchen, R., Das, S., Shah, R., Danielson, K., Beaulieu, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms11106 · Cited by 202 · see citing works
Haruehanroengra, P., Zheng, Y. Y., Zhou, Y., Huang, Y., & Sheng, J. (2020) · RNA Biology · doi:10.1080/15476286.2020.1722449 · Cited by 175 · see citing works
Decoding pseudouridine: an emerging target for therapeutic development
Cerneckis, J., Cui, Q., He, C., Yi, C., & Shi, Y. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.03.008 · Cited by 155 · see citing works
Bellodi, C., McMahon, M. E., Contreras, A., Juliano, D., Kopmar, N. E., Nakamura, T., Maltby, D. A., Burlingame, A. L., Savage, S. A., Shimamura, A., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.030 · Cited by 150 · see citing works
McMahon, M. E., Contreras, A., & Ruggero, D. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1266 · Cited by 144 · see citing works
Rynkeviciene, R., Simiene, J., Strainiene, E., Stankevicius, V., Usinskiene, J., Miseikyte Kaubriene, E., Meskinyte, I., Cicenas, J., & Suziedelis, K. (2018) · Cancers · doi:10.3390/cancers11010017 · Cited by 136 · see citing works
The role of epigenetics in the biology of multiple myeloma
Dimopoulos, K., Gimsing, P., & Grønbæk, K. (2014) · Blood Cancer Journal · doi:10.1038/bcj.2014.29 · Cited by 133 · see citing works
Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma
Ronchetti, D., Agnelli, L., Taìana, E., Galletti, S., Manzoni, M., Todoerti, K., Musto, P., Strozzi, F., & Neri, A. (2016) · Oncotarget · doi:10.18632/oncotarget.7442 · Cited by 96 · see citing works
Self-citationSmall nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia
Ronchetti, D., Mosca, L., Cutrona, G., Tuana, G., Gentile, M., Fabris, S., Agnelli, L., Ciceri, G., Matis, S., Massucco, C., et al. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-27 · Cited by 91 · see citing works
Self-citationRNA Modifications in Cancer: Functions, Mechanisms, and Therapeutic Implications
Huang, H., Weng, H., Deng, X., & Chen, J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033357 · Cited by 90 · see citing works
Martens‐Uzunova, E. S., Hoogstrate, Y., Kalsbeek, A. M. F., Pigmans, B., den Berg, M. S. V., Dits, N. F. J., Nielsen, S. J., Baker, A., Visakorpi, T., Bangma, C. H., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4172 · Cited by 84 · see citing works
Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma
Amodio, N., Martino, M. T. D., Neri, A., Tagliaferri, P., & Tassone, P. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.796356 · Cited by 81 · see citing works
Self-citationNon-coding RNAs: Emerging from the discovery to therapeutic applications
Baptista, B., Riscado, M., Queiroz, J. A., Pichon, C., & de Sousa, F. P. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114469 · Cited by 62 · see citing works
Guide snoRNAs: Drivers or Passengers in Human Disease?
Deogharia, M., & Majumder, M. (2018) · Biology · doi:10.3390/biology8010001 · Cited by 61 · see citing works
Lawrie, C. H., Larrea, E., Larrinaga, G., Goicoechea, I., Arestin, M., Fernández‐Mercado, M., Hes, O., Cáceres, F., Manterola, L., & Lopez, J. I. (2013) · The Journal of Pathology · doi:10.1002/path.4296 · Cited by 59 · see citing works
Expression profiling of snoRNAs in normal hematopoiesis and AML
Warner, W. A., Spencer, D. H., Trissal, M. C., White, B. S., Helton, N., Ley, T. J., & Link, D. C. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017006668 · Cited by 58 · see citing works
Pesenti, C., Navone, S. E., Guarnaccia, L., Terrasi, A., Costanza, J., Silipigni, R., Guarneri, S., Fusco, N., Fontana, L., Locatelli, M., et al. (2019) · Stem Cells International · doi:10.1155/2019/2617030 · Cited by 57 · see citing works
Self-citationNon-coding RNAs and glioblastoma: Insight into their roles in metastasis
Mousavi, S. M., Derakhshan, M., Baharloii, F., Dashti, F., Mirazimi, S. M. A., Mahjoubin‐Tehran, M., Hosseindoost, S., Goleij, P., Rahimian, N., Hamblin, M. R., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.12.015 · Cited by 56 · see citing works
Han, C., Sun, L.-Y., Luo, X., Pan, Q., Sun, Y., Zeng, Z., Chen, T.-Q., Huang, W., Fang, K., Wang, W., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110421 · Cited by 52 · see citing works
snoRNAs are a novel class of biologically relevant Myc targets
Herter, E. K., Stauch, M., Gallant, M., Wolf, E., Raabe, T., & Gallant, P. (2015) · BMC Biology · doi:10.1186/s12915-015-0132-6 · Cited by 50 · see citing works
Fitz, N. F., Wang, J., Kamboh, M. I., Koldamova, R., & Lefterov, I. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105481 · Cited by 49 · see citing works
“Within the list of all SNORDs associated with myeloma reported by Ronchetti et al. (Ronchetti et al., 2012), in our study we found only SNORD115–32 and SNORD116–29 overlapping with the SNORDs identified by RNA-seq in plasma EV.”
InfluentialBiology and clinical relevance of noncoding sno/scaRNAs
Cao, T., Rajasingh, S., Samanta, S., Dawn, B., Bittel, D. C., & Rajasingh, J. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.08.002 · Cited by 49 · see citing works
MMSET is the key molecular target in t(4;14) myeloma
Mirabella, F., Wu, P., Wardell, C. P., Kaiser, M., Walker, B. A., Johnson, D. C., & Morgan, G. J. (2013) · Blood Cancer Journal · doi:10.1038/bcj.2013.9 · Cited by 47 · see citing works
A compendium of long non-coding RNAs transcriptional fingerprint in multiple myeloma
Ronchetti, D., Agnelli, L., Pietrelli, A., Todoerti, K., Manzoni, M., Taìana, E., & Neri, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24701-8 · Cited by 45 · see citing works
Self-citationJha, P., Agrawal, R., Pathak, P., Kumar, A., Purkait, S., Mallik, S., Suri, V., Chand Sharma, M., Gupta, D., Suri, A., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29610 · Cited by 44 · see citing works
Analysis of Expression Pattern of snoRNAs in Different Cancer Types with Machine Learning Algorithms
Pan, X., Chen, L., Feng, K., Hu, X., Zhang, Y., Kong, X., Huang, T., & Cai, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092185 · Cited by 40 · see citing works
Probing the mechanisms underlying human diseases in making ribosomes
Farley‐Barnes, K. I., & Baserga, S. J. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160064 · Cited by 37 · see citing works
The Non-Coding RNA Landscape of Plasma Cell Dyscrasias
Morelli, E., Gullà, A., Rocca, R., Federico, C., Raimondi, L., Malvestiti, S., Agosti, V., Rossi, M., Costa, G., Giavaresi, G., et al. (2020) · Cancers · doi:10.3390/cancers12020320 · Cited by 34 · see citing works
Self-citationAging through an epitranscriptomic lens
McMahon, M. E., Forester, C. M., & Buffenstein, R. (2021) · Nature Aging · doi:10.1038/s43587-021-00058-y · Cited by 34 · see citing works
Beneventi, G., Munita, R., Ngoc, P. C. T., Madej, M., Cieśla, M., Muthukumar, S., Krogh, N., Nielsen, H., Swaminathan, V., & Bellodi, C. (2021) · NAR Cancer · doi:10.1093/narcan/zcab026 · Cited by 30 · see citing works
Long non-coding RNAs in B-cell malignancies: a comprehensive overview
Nobili, L., Ronchetti, D., Taìana, E., & Neri, A. (2017) · Oncotarget · doi:10.18632/oncotarget.17303 · Cited by 29 · see citing works
Self-citationZhang, Y., Xu, C., Gu, D., Wu, M., Yan, B., Xu, Z., Wang, Y., & Liu, H. (2016) · Stem Cells · doi:10.1002/stem.2490 · Cited by 29 · see citing works
Ameloblastoma RNA profiling uncovers a distinct non-coding RNA signature
Davanian, H., Balasiddaiah, A., Heymann, R., Sundström, M., Redenström, P., Silfverberg, M., Brodin, D., Sällberg, M., Lindskog, S. F., Weiner, C. K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13889 · Cited by 27 · see citing works
Tusup, M., Kündig, T. M., & Pascolo, S. (2018) · World Journal of Clinical Oncology · doi:10.5306/wjco.v9.i3.42 · Cited by 27 · see citing works
Lawrie, C. H., Armesto, M., Fernández‐Mercado, M., Arestin, M., Manterola, L., Goicoechea, I., Larrea, E., Caffarel, M. M., Araujo, A. M., Solé, C., et al. (2017) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2017.09.002 · Cited by 26 · see citing works
Vendramini, E., Giordan, M., Giarin, E., Michielotto, B., Fazio, G., Cazzaniga, G., Biondi, A., Silvestri, D., Valsecchi, M. G., Muckenthaler, M. U., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16392 · Cited by 24 · see citing works
The Role of Epigenetics in the Development and Progression of Multiple Myeloma
Ismail, N. H., Mussa, A., Zakaria, N. A., Al-Khreisat, M. J., Zahidin, M. A., Ramli, N. N., Mohammad, S. N. N. A., Hassan, R., Mohd Noor, N. H., Iberahim, S., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10112767 · Cited by 22 · see citing works
Husna, A. A., Rahman, M. M., Chen, H., Hasan, M. N., Nakagawa, T., & Miura, N. (2022) · Veterinary and Comparative Oncology · doi:10.1111/vco.12818 · Cited by 22 · see citing works
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia
Rodriguez, P. D., Paculová, H., Kogut, S., Heath, J. L., Schjerven, H., & Frietze, S. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052683 · Cited by 21 · see citing works
Molecular profiling of multiple myeloma: from gene expression analysis to next-generation sequencing
Agnelli, L., Tassone, P., & Neri, A. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.793305 · Cited by 21 · see citing works
Self-citationJalan, A., Jayaprakash, J. P., Karemore, P., Narayan, K. P., & Khandelia, P. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00792-1 · Cited by 19 · see citing works
Irizar, H., Muñoz‐Culla, M., Sáenz-Cuesta, M., Osorio-Querejeta, I., Sepúlveda, L., Castillo‐Triviño, T., Prada, A. J., de Munaín, A. L., Olascoaga, J., & Otaegui, D. (2015) · BMC Genomics · doi:10.1186/s12864-015-1396-5 · Cited by 19 · see citing works
In Silico Characterization of miRNA and Long Non-Coding RNA Interplay in Multiple Myeloma
Ronchetti, D., Manzoni, M., Todoerti, K., Neri, A., & Agnelli, L. (2016) · Genes · doi:10.3390/genes7120107 · Cited by 19 · see citing works
Self-citationSingle-Cell Non-coding RNA in Embryonic Development
Fu, Q., Liu, C., Zhai, Z., Zhang, X., Qin, T., & Zhang, H. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0502-3_3 · Cited by 18 · see citing works
snoRNAs in hematopoiesis and blood malignancies: A comprehensive review
Challakkara, M. F., & Chhabra, R. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31032 · Cited by 16 · see citing works
Singireddy, S., Alkhateeb, A., Rezaeian, I., Rueda, L. G., Cavallo‐Medved, D., & Porter, L. A. (2015) · IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) · doi:10.1109/cibcb.2015.7300302 · Cited by 16 · see citing works
Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer
Zhang, H., Liu, X., Zhang, W., Deng, J., Lin, C., Qi, Z., Li, Y., Gu, Y., Wang, Q., Shen, L., et al. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00147-x · Cited by 14 · see citing works
Guglas, K., Kozłowska-Masłoń, J., Kolenda, T., Paszkowska, A., Teresiak, A., Bliźniak, R., & Lamperska, K. M. (2022) · Reports of Practical Oncology & Radiotherapy · doi:10.5603/rpor.a2022.0123 · Cited by 14 · see citing works
Mirabella, F., Murison, A. J., Aronson, L. I., Wardell, C. P., Thompson, A., Hanrahan, S. J., Fok, J. H. L., Pawlyn, C., Kaiser, M., Walker, B. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099493 · Cited by 14 · see citing works
Berquet, L., Valleron, W., Grgurević, S., Quelen, C., Zaki, O., Quillet‐Mary, A., Davi, F., Brousset, P., Bousquet, M., & Ysebaert, L. (2015) · British Journal of Haematology · doi:10.1111/bjh.13544 · Cited by 13 · see citing works
Heimdörfer, D., Vorleuter, A., Eschlböck, A., Spathopoulou, A., Cubero, M. S., Farhan, H., Reiterer, V., Spanjaard, M., Schaaf, C. P., Huber, L. A., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.05.023 · Cited by 12 · see citing works
Emerging roles of noncoding RNAs in multiple myeloma: A review
Yang, Q., Shen, X., Su, Z., & Ju, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27547 · Cited by 12 · see citing works
Lu, Q., Tao, Y., Wang, J., Zhong, J., Zhang, Z., Feng, C., Wang, X., Li, T., Wang, Q., He, R., et al. (2024) · Cancers · doi:10.3390/cancers16030483 · Cited by 10 · see citing works
Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
Lin, L., Pan, Q., Sun, Y., & Wang, W. (2021) · Blood Science · doi:10.1097/bs9.0000000000000091 · Cited by 10 · see citing works
Distinct patterns of global promoter methylation in early stage chronic lymphocytic leukemia
Ronchetti, D., Tuana, G., Rinaldi, A., Agnelli, L., Cutrona, G., Mosca, L., Fabris, S., Matis, S., Colombo, M., Gentile, M., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22139 · Cited by 10 · see citing works
Self-citationSmall but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
Dong, J. P., Wang, H., Zhang, Z., Yang, L., Qian, X., Qian, W., Han, Y., Huang, H., & Qian, P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.939465 · Cited by 9 · see citing works
Dysregulation of Small Nucleolar RNAs in B-Cell Malignancies
Verbeek, M. W. C., Erkeland, S. J., & van der Velden, V. H. J. (2022) · Biomedicines · doi:10.3390/biomedicines10061229 · Cited by 9 · see citing works
Campelo, M. M., Reis-das-Mercês, L., Vidal, A. F., da Silva, F. R. P., de Oliveira, A. C. A., Monteiro, J. R. S., Cabral, C. G., Rodrigues, R. C., & Pereira, A. L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1547889 · Cited by 7 · see citing works
Fazi, F., & Fatica, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094755 · Cited by 7 · see citing works
Wang, M., Ali, H., Xu, Y., Xie, J., & Xu, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107140 · Cited by 5 · see citing works
The landscape of lncRNAs in cell granules: Insights into their significance in cancer
Mathias, C., Rodrigues, A. C., Baal, S. C. S., de Azevedo, A. L. K., Kozak, V. N., Alves, L. F., de Oliveira, J. C., Guil, S., & Gradia, D. F. (2024) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1870 · Cited by 5 · see citing works
Epitranscriptomics in Normal and Malignant Hematopoiesis
Minervini, C. F., Parciante, E., Impera, L., Anelli, L., Zagaria, A., Specchia, G., Musto, P., & Albano, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186578 · Cited by 5 · see citing works
Mechanisms and Clinical Applications of RNA Pseudouridylation
Morais, P., Adachi, H., Chen, J. L., & Yu, Y. (2021) · RNA technologies · doi:10.1007/978-3-030-71612-7_19 · Cited by 5 · see citing works
Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies
Sánchez, J. C., & Köhn, M. (2021) · Non-Coding RNA · doi:10.3390/ncrna7040068 · Cited by 3 · see citing works
Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster
Angrisani, A., Tafer, H., Stadler, P. F., & Furia, M. (2015) · Non-Coding RNA · doi:10.3390/ncrna1020139 · Cited by 3 · see citing works
Zhang, S., Ding, Y., Sun, Z., Ge, Y., Li, Y., Han, X., Xu, Q., Zhou, L., Chen, Y., Xu, H., et al. (2021) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00016 · Cited by 3 · see citing works
Introductory Chapter: Gene Regulation, an RNA Network-Dependent Architecture
Behzadi, P., & Issakhanian, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84535 · Cited by 3 · see citing works
Záveský, L., Jandáková, E., Weinberger, V., Minář, L., Turyna, R., Faridová, A., Hanzíková, V., & Slanař, O. (2025) · Non-Coding RNA · doi:10.3390/ncrna11060076 · Cited by 2 · see citing works
Ruhela, V., Gupta, R., Oberoi, R., & Gupta, A. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110619 · Cited by 2 · see citing works
Applications of noncoding ribonucleic acids in multiple myeloma patients
Zocchi, S., David, A., Goodhardt, M., & Garrick, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824550-7.00005-9 · Cited by 1 · see citing works
snoRNA box C/D levels in leukemia cells in chromosomal abnormalities after irradiation
Rastorgueva, E. V., Pogodina, E. S., Iurova, E., Beloborodov, E. A., Sugak, D. E., Tumozov, I. A., Saenko, Y., & Fomin, A. N. (2025) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2024-23-6-97-106
Dissecting the role of long non-coding RNA in multiple myeloma
Zocchi, S. (2024) · theses.fr (ABES) · doi:10.70675/22f35f26z6442z47d6z8cdaz153527b5df6e
Qi, H., Chen, S.-Y., Mi, J.-Q., Fan, W.-H., Hu, F.-J., Li, Q.-D., Chang, H., Li, Z., Lin, X.-D., Wang, X.-X., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01768-9
Haseltine, W. A., & Patarca, R. (2026) · Springer eBooks · doi:10.1007/978-3-032-30270-0_8
- Authors
- Ronchetti, D., Todoerti, K., Tuana, G., Agnelli, L., Mosca, L., Lionetti, M., Fabris, S., Colapietro, P., Miozzo, M., Ferrarini, M., Tassone, P., & Neri, A.
- Affiliations
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Magna Graecia University (IT)
- Corresponding author
- Neri, A
- ORCID
- Venue
- Blood Cancer Journal
- Published
- 2012-11-23
- Volume
- 2
- Issue
- 11
- Pages
- e96-e96
- ISSN
- 2044-5385 (ISSN-L)
- PMC
- PMC3511933
- OpenAlex
- W2045009762
- Cited by
- 79
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 3 · 2013: 7
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Blood Cancer Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (2009PKMYA2)
- Associazione Italiana per la Ricerca sul Cancro (2010/15, 9980, 2010-15, AIRC 5xmille, 5 x mille)
- Fondazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Keywords
- small nucleolar RNA, multiple myeloma, secondary plasma cell leukemia, SNORD116, DNA methylation, molecular subtypes, plasma cell dyscrasia, allelic imbalance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review