Trends in survival for childhood cancer in Britain diagnosed 1971–85
Open accessAbstract
Survival rates were analysed for a population-based series of over 15,000 childhood cancers registered in Great Britain during 1971-85. There were highly significant improvements (P less than 0.001 for trend) in survival for many major diagnostic groups. Between 1971-73 and 1983-85 the actuarial 5-year survival rates increased from 37% to 70% for acute lymphoblastic leukaemia, from 4% to 26% for acute non-lymphoblastic leukaemia, from 76% to 88% for Hodgkin's disease, from 22% to 70% for non-Hodgkin's lymphoma, from 61% to 72% for astrocytoma, from 24% to 42% for medulloblastoma, from 15% to 43% for neuroblastoma, from 58% to 79% for Wilms' tumour, from 17% to 54% for osteosarcoma, from 26% to 61% for rhabdomyosarcoma, from 59% to 94% for malignant testicular germ-cell tumours and from 43% to 77% for malignant ovarian germ-cell tumours. These increases in population-based survival rates reflect the substantial advances in treatment of a wide range of childhood cancers since 1970. The two principal diagnostic groups for which there was no evidence of any trend were retinoblastoma, which already had an excellent prognosis with a 5-year survival rate of over 85%, and Ewing's sarcoma, for which the survival rate remained below 45%.
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For children, survival was estimated for age groups 0-4, 5-9 and 10-14 years, and age-standardised estimates were obtained by assigning equal weights to the three age-specific estimates.
“For children, we estimated survival for the age groups 0–4, 5–9 and 10–14 years; age-standardised estimates were obtained by assigning equal weights to the three age-specific estimates.41,42”
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- Authors
- Stiller, C., & Bunch, K.
- Affiliations
- University of Oxford (GB)
- Venue
- British Journal of Cancer
- Published
- 1990-11
- Volume
- 62
- Issue
- 5
- Pages
- 806-815
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC1971530
- OpenAlex
- W1994083133
- Cited by
- 140
- References
- 47
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2014: 2 · 2012: 1
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- childhood cancer, cancer survival, survival trends, acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin's disease, non-Hodgkin lymphoma, astrocytoma, medulloblastoma, neuroblastoma, Wilms tumor, osteosarcoma, rhabdomyosarcoma, germ cell tumors, retinoblastoma, Ewing sarcoma, cancer treatment advances
- MeSH terms
- Adolescent, Brain Neoplasms, Child, Child, Preschool, Female, United Kingdom, Humans, Infant, Kidney Neoplasms, Leukemia, Lymphoma, Male, Neoplasms, Neoplasms, Germ Cell and Embryonal, Soft Tissue Neoplasms, Time Factors, Survival Rate
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