Cited by 1,342Alcohol Consumption and Health EffectsHead and Neck Cancer StudiesEsophageal Cancer Research and Treatment

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis

Open access

Bagnardi, V, Rota, M, Botteri, E, Tramacere, I, Islami, F, Fedirko, V, Scotti, L, Jenab, M, Turati, F, Pasquali, E, Pelucchi, C, Galeone, C, Bellocco, R, Negri, E, Corrao, G, Boffetta, P, La Vecchia, C·2015·British Journal of Cancer

DOI 10.1038/bjc.2014.579PMC PMC4453639

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial. METHODS: We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity. RESULTS: A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated. CONCLUSIONS: Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/bjc.2014.579

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,876
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353
QUANTITATIVE METHODS IN THE REVIEW OF EPIDEMIOLOGIC LITERATURE1
GREENLAND, S. (1987) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036298 · Cited by 1,644 · cited 1×
“Measures of association and the corresponding CIs were translated into log(RR)s and their variances (Greenland, 1987).”
Method

Flagged first, then by citations

Show all 70 references

Research works printed but not linked: 2

IARC Working Group (2010) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: A Review of Human Carcinogens: Personal Habits and Indoor Combustions. International Agency for Research on Cancer: Lyon.
Lamy L (1910) Étude clinique et statistique de 134 cas de cancer de l’oesophage et du cardia. Arch Mal App Dig 4: 451–475.

Sorted by citations

Items 501–600 of 1,000

Joint association of alcohol consumption and adiposity with alcohol- and obesity-related cancer in a population sample of 399,575 UK adults
Eroglu, E. I., Huang, B., Sarich, P., Nassar, N., & Stamatakis, E. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522003464 · Cited by 14
“Alcohol is classified as a Group 1 carcinogen (highest level) by the International Agency for Research on Cancer (IARC) (5) and has been strongly linked to many common cancer incidence and mortality (6 – 8) .”
Influential
Mediterranean Alcohol-Drinking Patterns and All-Cause Mortality in Women More Than 55 Years Old and Men More Than 50 Years Old in the “Seguimiento Universidad de Navarra” (SUN) Cohort
Barbería-Latasa, M., Bes‐Rastrollo, M., Pérez-Araluce, R., Martínez‐González, M. Á., & Gea, A. (2022) · Nutrients · doi:10.3390/nu14245310 · Cited by 14
Psychological distance intervention reminders reduce alcohol consumption frequency in daily life
Jovanova, M., Cosme, D., Doré, B., Kang, Y., Stanoi, O. A., Cooper, N., Helion, C., Lomax, S., McGowan, A. L., Boyd, Z. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38478-y · Cited by 14
Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy
Floud, S., Hermon, C., Simpson, R. F., & REEVES, G. K. (2023) · BMC Cancer · doi:10.1186/s12885-023-11184-8 · Cited by 15
“Includes only women who answered no to bilateral oophorectomy at recruitment significant difference in risk by sex, except for one cancer [48].”
Background
Association between wine consumption and cancer: a systematic review and meta-analysis
Lucerón‐Lucas‐Torres, M., Cavero‐Redondo, I., Martínez‐Vizcaíno, V., Bizzozero‐Peroni, B., Pascual‐Morena, C., & Álvarez‐Bueno, C. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1197745 · Cited by 15
The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors
Kranjčević, J.-K., Čonkaš, J., & Ozretić, P. (2024) · Cancers · doi:10.3390/cancers16081575 · Cited by 22
“These include tumors of the upper aerodigestive tract, and the main risk factors include consumption of tobacco in all forms [3] and alcohol [4], as well as infections with human papillomaviruses [5] or the Epstein–Barr virus [6].”
Background
Pharmacokinetic studies, molecular docking, and molecular dynamics simulations of phytochemicals from Morus alba: a multi receptor approach for potential therapeutic agents in colorectal cancer
Stany, B. K., Mishra, S., & Rao, K. V. B. (2024) · Medical Oncology · doi:10.1007/s12032-024-02406-5 · Cited by 14
“Primary prevention strategies emphasize lifestyle modifications, including reducing smoking [6], limiting alcohol [7], maintaining a healthy weight [8], and adopting a balanced diet [9].”
National Cancer Societies and their public statements on alcohol consumption and cancer risk
Amin, G., Siegel, M., & Naimi, T. S. (2018) · Addiction · doi:10.1111/add.14254 · Cited by 14
Assessing Campus Alcohol Policies: Measuring Accessibility, Clarity, and Effectiveness
Jernigan, D. H., Shields, K., Mitchell, M., & Arria, A. M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14017 · Cited by 14
“mation processing deficits), cancer, and liver disease (Bagnardi et al., 2015; Hingson et al., 2009; Yoon et al., 2014; Zeigler et al., 2005).”
The role of lifestyle characteristics on prostate cancer progression in two active surveillance cohorts
Vandersluis, A. D., Guy, D., Klotz, L. H., Fleshner, N. E., Kiss, A., Parker, C. C., & Venkateswaran, V. K. (2016) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2016.22 · Cited by 14
Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men – a genotypic approach
Vaidyanathan, V., Naidu, V., Kao, C., Karunasinghe, N., Bishop, K. S., Wang, A., Pallati, R., Shepherd, P., Masters, J., Zhu, S., et al. (2017) · Molecular BioSystems · doi:10.1039/c6mb00873a · Cited by 14
Effect of alcohol and its metabolites in lung cancer: CAPUA study
Álvarez-Avellón, S. M., Fernández‐Somoano, A., Navarrete‐Muñoz, E. M., Vioqué, J., & Tardón, A. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.12.072 · Cited by 14
Fluid Intake and Beverage Consumption Description and Their Association with Dietary Vitamins and Antioxidant Compounds in Italian Adults from the Mediterranean Healthy Eating, Aging and Lifestyles (MEAL) Study
Platania, A., Castiglione, D., Sinatra, D., Urso, M., & Marranzano, M. (2018) · Antioxidants · doi:10.3390/antiox7040056 · Cited by 14
“Moreover, there is plenty of scientific literature regarding the investigation of the role of specific beverages on health conditions, for instance, the adverse impact of sugar-sweetened soft drinks on metabolic disorders [6–8], the potential beneficial effects of milk on cardiovascular diseases [9,10], the positive i…”
Background
Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study
Choi, C. K., Yang, J.-H., Kweon, S., Cho, S., Kim, H., Myung, E., & Shin, M. (2021) · BMC Cancer · doi:10.1186/s12885-021-07993-4 · Cited by 14
“Second, we did not assess the role of alcohol dehydrogenase 1B (ADH1B) rs1229984 polymorphisms, which are common in East Asians.”
ResultInfluential
Efecto del alcohol y sus metabolitos en el cáncer de pulmón: estudio CAPUA
Álvarez-Avellón, S. M., Fernández‐Somoano, A., Navarrete‐Muñoz, E. M., Vioqué, J., & Tardón, A. (2017) · Medicina Clínica · doi:10.1016/j.medcli.2016.12.033 · Cited by 14
“D/D 691 (81,9) 645 (81,8) 1,00 1,00 D/C 141 (16,7) 135 (17,1) 0,97 (0,75-1,26) 0,97 (0,68-1,38) C/C 12 (1,4) 9 (1,1) 1,24 (0,52-2,97) 1,83 (0,58-5,74) C carriersb 153 (18,1) 144 (18,2) 0,99 (0,77-1,28) 1,02 (0,72-1,43)”
Social, Behavioral, and Clinical Risk Factors Are Associated with Clonal Hematopoiesis
Young, C. D., Hubbard, A. K., Saint‐Maurice, P. F., Chan, I. C. C., Cao, Y., Tran, D., Bolton, K. L., Chanock, S. J., Matthews, C. E., Moore, S. C., et al. (2024) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-0620 · Cited by 13
Malignancies in Prader-Willi Syndrome: Results From a Large International Cohort and Literature Review
Pellikaan, K., Nguyen, N., Rosenberg, A. G. W., Coupaye, M., Goldstone, A. P., Höybye, C., Markovic, T., Grugni, G., Crinò, A., Caixàs, A., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad312 · Cited by 12
A Comparative Study of Healthy Dietary Patterns for Incident and Fatal Digestive System Cancer
Kim, J., Zhang, Y., Kim, H., Zhang, Y., Zhang, X., & Giovannucci, E. L. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002448 · Cited by 13
Associations between depression and cancer risk among patients with diabetes mellitus: A population‐based cohort study
Shi‐Heng, W., Hsu, L., Lin, M., & Wu, C. (2023) · Cancer Medicine · doi:10.1002/cam4.6539 · Cited by 14
“44,45 The linkage be-tween depression and hematological malignancy remains less elucidated.”
Background
Impact of Smoking and Alcohol Consumption on Early-Onset Gastric Cancer Development in Young Koreans: A Population-Based Study
Kang, S. J., Shin, C. M., Han, K., Jung, J., Jin, E. H., Lim, J. H., Choi, Y. J., Yoon, H., Park, Y. S., Kim, N., et al. (2023) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2024.24.e2 · Cited by 13
“Apart from H. pylori , smoking and alcohol consumption are significant risk factors for GC [4].”
Evaluating county-level lung cancer incidence from environmental radiation exposure, PM2.5, and other exposures with regression and machine learning models
Lee, H., Hanson, H. A., Logan, J. S., Maguire, D., Kapadia, A., Dewji, S. A., & Agasthya, G. A. (2024) · Environmental Geochemistry and Health · doi:10.1007/s10653-023-01820-4 · Cited by 13
Tacrolimus Drug Exposure Level and Smoking Are Modifiable Risk Factors for Early De Novo Malignancy After Liver Transplantation for Alcohol-Related Liver Disease
Vanlerberghe, B. T. K., van Malenstein, H., Sainz‐Barriga, M., Jochmans, I., Cassiman, D. M., Monbaliu, D. R. L., der Merwe, V., Pirenne, J., Nevens, F., & Verbeek, J. (2024) · Transplant International · doi:10.3389/ti.2024.12055 · Cited by 13
Greenspace and risk of obesity-related cancer in the UK Biobank cohort: An analysis of private residential gardens and other greenspace types
Odebeatu, C. C., Darssan, D., Roscoe, C., Ahmed, M. B., Reid, S. A., & Osborne, N. J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173833 · Cited by 13
Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal
Doodmani, S. M., Rahimzadeh, P., Farahani, N., Mirilavasani, S., Alimohammadi, M., Nabavi, N., Alaei, E., Taheriazam, A., Abedi, M., Shafiee, N., et al. (2025) · Results in Chemistry · doi:10.1016/j.rechem.2025.102059 · Cited by 13
Comparison of health behaviours between cancer survivors and the general population: a cross-sectional analysis of the Lifelines cohort
Cortés-Ibáñez, F. O., Jaramillo‐Calle, D. A., Vinke, P. C., Byambasukh, O., Corpeleijn, E., Sijtsma, A., zu Eulenburg, C., Vonk, J. M., & de Bock, G. H. (2020) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00854-2 · Cited by 13
Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas
Lifšics, A., Groma, V., Čistjakovs, M., Skuja, S., Deksnis, R., & Murovska, M. (2021) · Viruses · doi:10.3390/v13061008 · Cited by 13
Is there an association between trends in alcohol consumption and cancer mortality? Findings from a multicountry analysis
Schwartz, N. S., Nishri, D., Cheong, S. C., Giesbrecht, N., & Klein-Geltink, J. (2017) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000403 · Cited by 13
Avoiding the ingestion of cytotoxic concentrations of ethanol may reduce the risk of cancer associated with alcohol consumption
Guillén-Mancina, E., Calderón‐Montaño, J. M., & López‐Lázaro, M. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.11.013 · Cited by 12
Characteristics of non‐melanoma skin cancers of the cutaneous perioral and vermilion lip treated by Mohs micrographic surgery
Queen, D., Knackstedt, T., Polacco, M. A., Collins, L. K., Lee, K., & Samie, F. H. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15263 · Cited by 13
Population insight of the relationship between lifestyle and cancer: A population-based survey
Alshammari, F. D., Ahmed, H. G., Alshammari, D., Alharbi, A. M., Alsaedi, A. S., & Elasbaly, A. (2019) · AIMS Public Health · doi:10.3934/publichealth.2019.1.34 · Cited by 13
Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM
Hudson, S. V., Miller, H. A., Mahlbacher, G. E., Saforo, D., Beverly, L. J., Arteel, G. E., & Frieboes, H. B. (2019) · Scientific Reports · doi:10.1038/s41598-019-51249-y · Cited by 13
Extended healthy lifestyle index and colorectal cancer risk in the Moroccan population
Hatime, Z., Kinany, K. E., Huybrechts, I., Gunter, M. J., Khalis, M., Deoula, M. M. S., Boudouaya, H. A., Benslimane, A., Nejjari, C., Benider, A., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02311-3 · Cited by 14
Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff
Sundkvist, A., Myte, R., Bodén, S., Enroth, S., Gyllensten, U., Harlid, S., & Guelpen, B. R. V. (2018) · Scientific Reports · doi:10.1038/s41598-018-20794-3 · Cited by 13
Oral Cancer Disparities in Low‑ and Middle‑Income Countries: A Global Health Equity Perspective on Prevention, Early Detection, and Treatment Access
Francis, D. L., & Reddy, S. S. P. (2025) · Annals of Global Health · doi:10.5334/aogh.5003 · Cited by 12
Incidence rates of digestive cancers among U.S. military servicemen: Comparison with the rates in the general U.S. population
Bytnar, J. A., Shriver, C. D., & Zhu, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257087 · Cited by 12
Predictors and prevalence of hazardous alcohol use in middle-late to late adulthood in Europe
Tschorn, M., Schulze, S., Förstner, B. R., Holmberg, C., Spallek, J., Heinz, A., & Rapp, M. A. (2022) · Aging & Mental Health · doi:10.1080/13607863.2022.2076208 · Cited by 12
Engaging with the Private Sector for Noncommunicable Disease Prevention and Control: Is it Possible to Create “Shared Value?”
Collins, T. E., Akselrod, S., Mahy, L., Poznyak, V. B., Berlina, D., Hatefi, A., & Allen, L. N. (2023) · Annals of Global Health · doi:10.5334/aogh.4136 · Cited by 16
Causal association between dietary factors and esophageal diseases: A Mendelian randomization study
Zou, M., Liang, Q., Zhang, W., Zhu, Y., & Xu, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292113 · Cited by 13
Cardiovascular health of patients with cancer: Challenges abound
Chan, J. S. K., Chan, R. N. C., Lee, Y. H. A., Satti, D. I., Dee, E. C., Ng, K., Achim, A., Ng, C., Liu, T., Matthews, G. D. K., et al. (2024) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2024.04.004 · Cited by 12
Alcohol rehabilitation and cancer risk: a nationwide hospital cohort study in France
Schwarzinger, M., Ferreira‐Borges, C., Neufeld, M., Alla, F., & Rehm, J. T. (2024) · The Lancet Public Health · doi:10.1016/s2468-2667(24)00107-5 · Cited by 12
Consumption of Red Versus White Wine and Cancer Risk: A Meta-Analysis of Observational Studies
Lim, R. K., Rhee, J., Hoang, M., Qureshi, A. A., & Cho, E. (2025) · Nutrients · doi:10.3390/nu17030534 · Cited by 12
The Link between Alcohol Consumption and Kidney Injury
Yokus, B., Maccioni, L., Fu, L., Haskó, G., Nagy, L. E., Gao, B., & Pacher, P. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.05.011 · Cited by 15
Alcohol and Cancer Risk
Morford, K. L., Tetrault, J. M., & O’Connor, P. G. (2025) · JAMA · doi:10.1001/jama.2025.11229 · Cited by 12
Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case–control study
Papa, N. P., MacInnis, R. J., Jayasekara, H., English, D. R., Bolton, D. M., Davis, I. D., Lawrentschuk, N., Millar, J. L., Pedersen, J., Severi, G., et al. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.12 · Cited by 12
Alcohol, stem cells and cancer
Gu, S., Nguyen, B.-N. H., Rao, S., Li, S., Shetty, K., Rashid, A., Shukla, V., Deng, C., Mishra, L., & Mishra, B. (2017) · Genes & Cancer · doi:10.18632/genesandcancer.156 · Cited by 11
“com/Genes&Cancer drinkers also had a significantly higher risk of cancer of the stomach, gallbladder, pancreas and lung [17].”
Background
Association of depression, anxiety, and stress with myocardial infarction: A case–control study
Manoj, M., Joseph, K., & Vijayaraghavan, G. (2018) · Journal of Clinical and Preventive Cardiology · doi:10.4103/jcpc.jcpc_39_17 · Cited by 12
Australia’s Oral Health Tracker: Technical Paper
Manton, D. J., Foley, M., Gikas, A., Ivanoski, S., McCullough, M. J., Peres, M. A., Roberts-Thomson, K. F., Skinner, J. C., Irving, E., Seselja, A., et al. (2018) · Victoria University Research Repository (Victoria University) · Cited by 12
Alcohol, health and cardiovascular disease
Masip, J., & Lluch, J. (2019) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2019.07.001 · Cited by 16
Modelling the number of avoidable new cancer cases in France attributable to alcohol consumption by following official recommendations: a simulation study
Ren, Y., Chase, E., d’Almeida, T. C., Allègre, J., Latino‐Martel, P., Deschamps, V., Arwidson, P., Étilé, F., Herçberg, S., Touvier, M., et al. (2021) · Addiction · doi:10.1111/add.15426 · Cited by 12
Prevention of hepatocellular carcinoma and surveillance of high risk patients
Kaya, E., Mazzolini, G. D., Yilmaz, Y. N., & Canbay, A. E. (2021) · Hepatology forum/Hepatology forum (Online) · doi:10.14744/hf.2021.2021.0033 · Cited by 14
“[56] Heavy alcohol consumption has been established to be significantly associated with increased HCC risk.[57,58] A synergistic relationship between obesity and alcohol use has been reported.”
Background
Role of cell-free network communication in alcohol-associated disorders and liver metastasis
Kuracha, M. R., Thomas, P., Tobi, M., & McVicker, B. L. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i41.7080 · Cited by 11
Sociodemographic factors associated with daily tobacco smoking and binge drinking among Zambians: evidence from the 2017 STEPS survey
Silumbwe, A., Sabastian, M. S., Michelo, C., Zulu, J. M., & Johansson, K. (2022) · BMC Public Health · doi:10.1186/s12889-022-12594-2 · Cited by 15
The association of healthy lifestyle index score and the risk of renal cell cancer in the Netherlands cohort study
Meer, R., van de Pol, J. A. A., van den Brandt, P. A., & Schouten, L. J. (2023) · BMC Cancer · doi:10.1186/s12885-023-10627-6 · Cited by 12
Alcohol Consumption and a Decline in Glomerular Filtration Rate: The Japan Specific Health Checkups Study
Kimura, Y., Yamamoto, R., Shinzawa, M., Aoki, K., Tomi, R., Ozaki, S., Yoshimura, R., Shimomura, A., Iwatani, H., Isaka, Y., et al. (2023) · Nutrients · doi:10.3390/nu15061540 · Cited by 12
“Alcohol consumption causes various health problems [6]: a J-shaped association has been reported with stroke [7,8], especially ischemic stroke [9,10]; a U-shaped association with type 2 diabetes [11–14]; a positive dose-dependent association with atrial fibrillation [15,16], heart failure [7], hemorrhagic stroke [9,10…”
Background
Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders
Pakzad, R., Nedjat, S., Salehiniya, H., Mansournia, N., Etminan, M., Nazemipour, M., Pakzad, I., & Mansournia, M. A. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-01978-6 · Cited by 12
Trends in Gastric and Esophageal Cancer Incidence in Northern Portugal (1994-2009) by Subsite and Histology, and Predictions for 2015
Castro, C., Peleteiro, B., Bento, M. J., & Lunet, N. (2016) · Tumori Journal · doi:10.5301/tj.5000542 · Cited by 12
“This study aimed to describe subtype-specific incidence trends in stomach (cardia and noncardia) and esophageal cancers (ESCC and EAC) in northern Portugal between 1994 and 2009, and to estimate the number of incident cases and age-standardized rates for 2015.”
ResultInfluential
Temporal Trends in Fecal Occult Blood Test: Associated Factors (2009–2017)
Cobo‐Cuenca, A. I., Laredo‐Aguilera, J. A., Rodríguez-Borrego, M.-A., Santacruz‐Salas, E., & Carmona‐Torres, J. M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16122120 · Cited by 12
Global Epidemiology of Gastrointestinal Cancers
Dızdar, Ö., & Kılıçkap, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_1 · Cited by 14
EPIDEMIOLOGY OF COLORECTAL CANCER
Осомбаев, М. Ш., Dzhekshenov, M. D., Сатыбалдиев, О. А., Абдрасулов, К. Д., Макимбетов, Э. К., & Анатольевич, К. М. (2021) · Научное обозрение Медицинские науки (Scientific Review Medical Sciences) · doi:10.17513/srms.1169 · Cited by 12
Exploring the potential of citizen science for public health through an alcohol advertising case study
Thomas, J. A., Trigg, J. L., Morris, J. N., Miller, E. R., & Ward, P. (2021) · Health Promotion International · doi:10.1093/heapro/daab139 · Cited by 12
Oxidative Stress and the Intersection of Oncogenic Signaling and Metabolism in Squamous Cell Carcinomas
Choe, J. H., Mazambani, S., Kim, T. H., & Kim, J. (2021) · Cells · doi:10.3390/cells10030606 · Cited by 14
“of alcohol consumption and cancer risk demonstrates the highest relative risk of ESCC development whereas the relative risk of esophageal adenocarcinoma (ADC) remains nearly unchanged, suggesting that oncogenic insults implicating ROS may preferentially drive SCC development [56].”
Background
Development of mental health first aid guidelines for problem drinking: a Delphi expert consensus study in Argentina and Chile
Agrest, M., Tapia‐Muñoz, T., Encina, E. P., Wright, J., Ardila-Gómez, S. E., Alvarado, R., Leiderman, E. A., & Reavley, N. J. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03749-x · Cited by 11
“Alcohol has many health-related effects since it increases risk of infectious diseases, major non-communicable diseases including cancer [3] and coronary artery disease [4], liver cirrhosis [5], mental health problems including suicide [6] and external causes of harm including injuries, violence, and homicide [7, 8].”
Background
Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma
Yamauchi, T., Shangraw, S., Zhai, Z., Menon, D. R., Batta, N., Dellavalle, R. P., & Fujita, M. (2022) · Cancers · doi:10.3390/cancers14205010 · Cited by 12
“Ethanol is associated with the tumor development of various cancers, such as liver and esophagus [76,90].”
Background
Combinations of lifestyle behaviors and cancer risk among Korean adults
Luu, N. M., Bui, T. T., Tran, T. P. T., Nguyen, T. H. T., & Oh, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-40819-w · Cited by 11
“Similarly, heavy drinkers have a greater risk of some cancers than have non-drinkers and occasional drinkers, and the dose-risk association is evident 18 .”
Background
Is There a Safe Alcohol Consumption Limit for the General Population and in Patients with Liver Disease?
Romero‐Gómez, M., Arab, J. P., de Oliveira, C. P. M. S., Hernández, M., Arrese, M. A., Cortez‐Pinto, H., & Bataller, R. A. (2024) · Seminars in Liver Disease · doi:10.1055/s-0044-1785228 · Cited by 10
Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
Wei, X., Yang, C., Lin, Q., Qiu, M., Wen, Q., Zhou, Z., Jiang, Y., Chen, P., Liang, X., Cao, J., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-12525-x · Cited by 11
“…studies have reported many potential modifiable factors for HCC, including lifestyle factors (e.g., cigarette smoking, alcohol drinking) [4, 5], serum biomarkers (e.g., C-reactive protein, serum iron) [6, 7], and liver and metabolism-related factors (e.g., viral hepatitis, MASLD) [8, 9].”
Background
Exploring the gut microbiome and immunological landscape in kidney cancer: a Mendelian randomization analysis
Lv, S., Guo, Q., He, Y., Yu, Z., Zhan, X., Li, H., & Pan, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1459967 · Cited by 11
Factors associated with alcohol drinking behavior of cancer survivors: The Korean National Health and Nutrition Examination Survey
Ko, H., Song, Y., & Shin, J. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.11.024 · Cited by 11
Alcohol Use and Cancers of the Gastrointestinal Tract. Epidemiology and Preventive Implications
Rehm, J. T., & Shield, K. D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00403 · Cited by 12
Factors associated with different forms of alcohol use behaviors among college students in Bhutan: a cross-sectional study
Dorji, T., Srichan, P., Apidechkul, T., Sunsern, R., & Suttana, W. (2020) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-020-00315-0 · Cited by 11
Alcohol and Breast Cancer
Balaam, S., Bailey, T. G., Anderson, D. J., Retell, J. D., & McCarthy, A. L. (2021) · Cancer Nursing · doi:10.1097/ncc.0000000000000956 · Cited by 11
“A meta-analysis on the association between alcohol consumption and site-specific cancers indicated a dose-response relationship.(21) Pooled relative (RR) estimates of data obtained from more than 118 separate breast cancer studies categorised drinkers (light, moderate or heavy drinkers) and compared them with nondrink…”
Background
Current Developments in European Alcohol Policy: An Analysis of Possible Impacts on the German Wine Industry
Schulz, F. N., Richter, B., & Hanf, J. H. (2022) · Beverages · doi:10.3390/beverages8040075 · Cited by 11
Dietary Inflammatory Nutrients and Esophageal Squamous Cell Carcinoma Risk: A Case-Control Study
Li, S., Ye, J., Lin, Z., Lin, Z., Tang, X., Rao, W., & Hu, Z. (2022) · Nutrients · doi:10.3390/nu14235179 · Cited by 11
“5–50 referred to “moderate drinking” and >50 referred to “heavy drinking” [23].”
Palaeolithic diet score and risk of breast cancer among postmenopausal women overall and by hormone receptor and histologic subtypes
Shah, S., Mahamat‐Saleh, Y., Hajji-Louati, M., Correia, E., Oulhote, Y., Boutron‐Ruault, M., & Laouali, N. (2023) · European Journal of Clinical Nutrition · doi:10.1038/s41430-023-01267-x · Cited by 11
‘Toxic Masculinity’: What Is Known about the Role of Androgen Receptors in Head and Neck Squamous Cell Carcinoma
Čonkaš, J., Sabol, M., & Ozretić, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043766 · Cited by 11
“HNSCC develops from the mucosal epithelial cells of the oral cavity, larynx, nasopharynx, oropharynx, hypopharynx, and sinonasal tract, and its development directly correlates with several risk factors that include alcohol [4] and/or tobacco consumption [5], long-term exposure to environmental pollutants [6], and infe…”
Bovine meat and milk factor protein expression in tumor‐free mucosa of colorectal cancer patients coincides with macrophages and might interfere with patient survival
Nikitina, E., Burk‐Körner, A., Wiesenfarth, M., Alwers, E., Heide, D., Tessmer, C., Ernst, C., Krunic, D., Schrotz‐King, P., Chang-Claude, J. C., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13390 · Cited by 11
Evaluating an alcohol harm-reduction campaign advising drinkers of the alcohol-cancer link
Booth, L., McCausland, T., Keric, D., Kennington, K., Stevens‐Cutler, J., Scott, L., & Pettigrew, S. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107760 · Cited by 11
The effects of alcohol pricing policies on consumption, health, social and economic outcomes, and health inequality in Australia: a protocol of an epidemiological modelling study
Jiang, H., Room, R., Livingston, M., Callinan, S., Brennan, A., Doran, C. M., & Thorn, M. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029918 · Cited by 11
Alkoholkonsum und Krebsrisiko
Scherübl, H. (2019) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-0928-0586 · Cited by 11
“Lancet 2019; 393: 1831–1842 [4] Bagnardi V, Rota M, Botteri E et al.”
Background
Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis
Jia, Y., Jiang, J., Zhao, K., Zhang, T., Sun, P., Peng, J., Yang, Q., & Qian, Y. (2019) · Aging · doi:10.18632/aging.102279 · Cited by 11
Effect of alcohol label designs with different pictorial representations of alcohol content and health warnings on knowledge and understanding of low‐risk drinking guidelines: a randomized controlled trial
Gold, N., Egan, M., Londáková, K., Mottershaw, A. L., Harper, H., Burton, R., Henn, C., Smolar, M., Walmsley, M., Arambepola, R., et al. (2020) · Addiction · doi:10.1111/add.15327 · Cited by 11
“For some conditions, such as liver disease, this relationship is exponential [3], whereas for other conditions, such as some cancers, it is linear [4].”
Background
Estimation of Breast Cancer Incident Cases and Medical Care Costs Attributable to Alcohol Consumption Among Insured Women Aged <45 Years in the U.S.
Ekwueme, D. U., Allaire, B. T., Parish, W. J., Thomas, C. C., Poehler, D. C., Guy, G. P., Aldridge, A., Lahoti, S. R., Fairley, T. L., & Trogdon, J. G. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2017.05.023 · Cited by 11
Can a gastric cancer risk survey identify high-risk patients for endoscopic screening? A pilot study
In, H., Langdon-Embry, M., Gordon, L., Schechter, C. B., Wylie‐Rosett, J., Castle, P. E., Kemeny, M. M., & Rapkin, B. D. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.02.053 · Cited by 11
Awareness of and practice toward cancer prevention recommendations: results of the Korean National Cancer Prevention Awareness and Practice Survey in 2021
Oh, J., Park, E., Kim, B., Choi, Y., Yun, E. H., Lim, M. K., Im, J.-S., & Park, E. Y. (2022) · Epidemiology and Health · doi:10.4178/epih.e2022068 · Cited by 11
“Even though several studies have suggested the classic J-shaped curve regarding the protective effect of light alcohol consumption for ischemic heart disease and all-cause mortality [20,21], it is well established that there is no safe limit of alcohol consumption for causing cancer [22,23].”
Background
Triple Primary Malignancies: Tumor Associations, Survival, and Clinicopathological Analysis: A 25-Year Single-Institution Experience
Almasan, I., & Piciu, D. (2023) · Healthcare · doi:10.3390/healthcare11050738 · Cited by 10
“In regard to alcohol consumption, heavy drinkers present an increased risk of oral/pharyngeal, esophageal (squamous cell carcinoma), colorectal, laryngeal, and female breast cancer when compared with non-drinkers [15].”
Background
Current Status of Korean Alcohol Drinking in Accordance with the Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing
Lee, S., Kim, J., & Kim, J. S. (2023) · Korean Journal of Family Medicine · doi:10.4082/kjfm.23.0024 · Cited by 10
“” Those who selected (2) “no” regarding past alcohol flushing, and then selected (1) “no” regarding current alcohol flushing were classified as “nonflushers.”
Influential
Chemoprevention and Lifestyle Modifications for Risk Reduction in Sporadic and Hereditary Breast Cancer
Manna, E. D. F., Serrano, D., Aurilio, G., Bonanni, B., & Lazzeroni, M. (2023) · Healthcare · doi:10.3390/healthcare11162360 · Cited by 14
“94) for heavy drinking (>50 g/day) [86].”
Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
Yu, S., Tu, R., Chen, Z., Song, J., Li, P., Hu, F., Yuan, G., Zhang, R., & Li, Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01645-1 · Cited by 10
“Among a large number of cancer patients, the mortality rate is significantly higher in smokers compared to non-smokers, such as in lung cancer [35, 36].”
Background
Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients
Muñoz-Bello, J. O., Romero-Cordoba, S. L., García-Chávez, J. N., González‐Espinosa, C., Langley, E., & Lizano, M. (2024) · Cells · doi:10.3390/cells13131107 · Cited by 10
“Several risk factors proposed to be associated with the development of HNSCC include alcohol [5,6] and tobacco [7] consumption.”
Background
An Assessment of Behavioral Risk Factors in Oncology Patients
Mititelu, M., Licu, M., Neacșu, S. M., Călin, M. F., Matei, R. S., Scafa‐Udriște, A., Stanciu, T. I., Busnatu, Ș., Olteanu, G., Măru, N., et al. (2024) · Nutrients · doi:10.3390/nu16152527 · Cited by 11
Alcohol and mortality in Mexico: prospective study of 150 000 adults
Trichia, E., Alegre-Díaz, J., Aguilar-Ramirez, D. J., Ramírez-Reyes, R., Garcilazo‐Ávila, A., González-Carballo, C., Bragg, F., Gnatiuc, L., Herrington, W. G., Holland, L., et al. (2024) · The Lancet Public Health · doi:10.1016/s2468-2667(24)00228-7 · Cited by 11
Alcohol consumption and risk of early onset colorectal cancer: A systematic review and meta‐analysis
Huang, S., Yu, L., Xiong, F., Zhang, B., & Ruan, S. (2025) · Colorectal Disease · doi:10.1111/codi.70046 · Cited by 10
Risk factors for pancreatic cancer in electronic health records: an umbrella review of systematic reviews and meta-analyses
Moore, S. F., Price, S., Konya, J., Blummers, S., Walter, F. M., Neal, R. D., & Abel, G. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103297 · Cited by 12
Global trends in lung cancer incidence and mortality by age, gender and morphology and forecast: A bootstrap-based analysis
George, J. E., George, P. S., Krishna, J. K. M., & Mathew, A. (2025) · Lung Cancer · doi:10.1016/j.lungcan.2025.108626 · Cited by 13
PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α
Fan, S., Li, W., Qi, Y., Li, Z., He, Y., Luo, X., Nie, X., Wang, J., Ji, J., Tian, H., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01575-8 · Cited by 10
Racial and Ethnic Disparities in Alcohol Consumption and Mortality in the U.S.
Naimi, T. S., Sherk, A., Lawrence, K. W., Reece, J., & Esser, M. B. (2025) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2025.107968 · Cited by 10
Alcohol, salud y enfermedad cardiovascular
Masip, J., & Lluch, J. (2019) · Revista Clínica Española · doi:10.1016/j.rce.2019.05.013 · Cited by 13
Implications of Cardioprotective Assumptions for National Drinking Guidelines and Alcohol Harm Monitoring Systems
Sherk, A., Gilmore, W., Churchill, S., Lensvelt, E., Stockwell, T. R., & Chikritzhs, T. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244956 · Cited by 10
“These deaths are termed alcohol-related, as they accrue to a health condition whose incident and mortality risk is increased by exposure to alcohol [2,25,26].”
Background
Celastrol-mediated autophagy regulation in cancer
Haroon, M., & Kang, S. C. (2020) · Applied Biological Chemistry · doi:10.1186/s13765-020-00565-3 · Cited by 11
Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population
Muhimpundu, S., Conway, R. B. N., Andersen, S. W., Lipworth, L. P., Steinwandel, M. D., Blot, W. J., Shu, X., & Sudenga, S. L. (2021) · Cancers · doi:10.3390/cancers13153710 · Cited by 10
“Alcohol [29,30] and cigarette smoking [11,31] are well established risk factors for HCC.”
Background

Authors: Bagnardi, V, Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V, Scotti, L., Jenab, M., Turati, F., Pasquali, E., Pelucchi, C., Galeone, C., Bellocco, R., Negri, E., Corrao, G., Boffetta, P., & La Vecchia, C.
Affiliations: European Institute of Oncology (IT)
Mario Negri Institute for Pharmacological Research (IT)
Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
American Cancer Society (US)
Emory University (US)
University of Milano-Bicocca (IT)
Centre international de recherche sur le cancer (FR)
Karolinska Institutet (SE)
Tisch Cancer Institute (US)
Corresponding author: Bagnardi, V
ORCID: Bagnardi, V
Rota, M
Botteri, E
Tramacere, I
Islami, F
Fedirko, V
Scotti, L
Jenab, M
Turati, F
Pelucchi, C
Galeone, C
Bellocco, R
Negri, E
Corrao, G
Boffetta, P
Venue: British Journal of Cancer
Publisher: Springer Science and Business Media LLC
Published: 2014-11-25
Volume: 112
Issue: 3
Pages: 580-593
ISSN: 0007-0920 (ISSN-L)
1532-1827
DOI: 10.1038/bjc.2014.579
PMC: PMC4453639
OpenAlex: W1965385210
Cited by: 1,342
References: 70
Citations by year: 2026: 130 · 2025: 149 · 2024: 129 · 2023: 139 · 2022: 158 · 2021: 133 · 2020: 123 · 2019: 108 · 2018: 100 · 2017: 86 · 2016: 64 · 2015: 21
FWCI: 42.39
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.springer.com/tdm (unspecified)
Locations: British Journal of Cancer (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Funders: World Health Organization
Fondazione Umberto Veronesi
Associazione Italiana per la Ricerca sul Cancro (10258)
Fondazione Italiana per la Ricerca sul Cancro
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords: alcohol consumption, alcohol and cancer risk, dose-response relationship, heavy drinking, oral and pharyngeal cancer, esophageal squamous cell carcinoma, colorectal cancer, laryngeal cancer, breast cancer, liver cancer, gastric cancer, gallbladder cancer, pancreatic cancer, lung cancer, melanoma, prostate cancer, Hodgkin's disease, non-Hodgkin lymphoma
MeSH terms: Esophageal Squamous Cell Carcinoma, Alcohol Drinking, Breast Neoplasms, Carcinoma, Squamous Cell, Dose-Response Relationship, Drug, Esophageal Neoplasms, Female, Humans, Male, Melanoma, Mouth Neoplasms, Neoplasms, Pharyngeal Neoplasms, Prostatic Neoplasms, Risk Factors, Incidence, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks