The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis
Open accessAbstract
BACKGROUND: Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial. METHODS: We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity. RESULTS: A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated. CONCLUSIONS: Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The increase in the risk of developing cancer (stratified by cancer site) for increasing average daily amounts of alcohol consumed (measured in grams of pure alcohol consumed per day) has been observed to be linear on an exponentiated scale; however, the magnitude of these risk increases varies by cancer site 169, 170, 171.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [169]
In the citing paper
“However, no association was found between excess alcohol consumption and the dementias,11 CHD,91 lung76 or liver cancer.99”
From Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction (2019) · cites this paper as [76]
In the citing paper
“Excess alcohol consumption was associated with an increased risk of stroke, bowel and breast cancer (between 20% and 50%).11,76,97”
From Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction (2019) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,876
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353
QUANTITATIVE METHODS IN THE REVIEW OF EPIDEMIOLOGIC LITERATURE1
GREENLAND, S. (1987) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036298 · Cited by 1,644 · cited 1×
“Measures of association and the corresponding CIs were translated into log(RR)s and their variances (Greenland, 1987).”
Method
Research works printed but not linked: 2
- IARC Working Group (2010) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: A Review of Human Carcinogens: Personal Habits and Indoor Combustions. International Agency for Research on Cancer: Lyon.
- Lamy L (1910) Étude clinique et statistique de 134 cas de cancer de l’oesophage et du cardia. Arch Mal App Dig 4: 451–475.
Cited by
Sorted by citations
Items 701–800 of 1,000
Kokole, D., Mercken, L. A. G., Jané‐Llopis, E., Rey, G. N., Arroyo, M., Medina, P., Pérez‐Gómez, A., Mejía‐Trujillo, J., Piazza, M., Bustamante, I. V., et al. (2021) · Primary Health Care Research & Development · doi:10.1017/s1463423620000675 · Cited by 6
“, 2015), cancers (Bagnardi et al., 2015), liver disease (Rehm et al.”
BackgroundSims, J., & Coley, R. L. (2022) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2021.11.020 · Cited by 7
C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population
Han, F., Lü, Q., Zhang, Y., Liu, P., Li, R., & Chen, M. (2022) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00827-x · Cited by 7
“Heavy drinkers also had the higher risk of LC (Bagnardi et al. 2015).”
BackgroundRogers, C. J., Petersen, K. H., & Kris‐Etherton, P. M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.06.001 · Cited by 8
Budenz, A., Moser, R. P., Eck, R. H., Agurs‐Collins, T., McNeel, T. S., Klein, W. M. P., & Berrigan, D. A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191911862 · Cited by 7
Pastore, E., Caini, S., Bendinelli, B., Palli, D., Ermini, I., Cavalcabo’, N. D. B., Assedi, M., Ambrogetti, D., Fontana, M., & Masala, G. (2022) · Nutrients · doi:10.3390/nu14245312 · Cited by 8
“Indeed, a recent meta-analysis of 11 studies [11] showed that there was a direct association between MBD and alcohol consumption, which is also an established risk factor for BC [12].”
BackgroundGenerating Counterfactual Explanations For Causal Inference in Breast Cancer Treatment Response
Zhou, S., Pfeiffer, N., Islam, U. J., Banerjee, I., Patel, B., & Iquebal, A. S. (2022) · IEEE International Conference on Automation Science and Engineering (CASE) · doi:10.1109/case49997.2022.9926519 · Cited by 7
“For example, several studies have shown a positive correlation between alcohol consumption and the incidence rate of breast cancer [17], [18].”
BackgroundDai, Z., & Wang, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-27571-x · Cited by 7
Haywood, D., Pantaleo, A. M., Mullan, B. A., Heslop, K., & Baughman, F. D. (2023) · Substance Use & Misuse · doi:10.1080/10826084.2023.2177962 · Cited by 7
Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer
Kumar, K., Goturi, A., Nagaraj, M., & Goud, E. S. S. (2022) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_435_21 · Cited by 7
Luo, J., Liu, X., Zhang, Y., Yin, M., Li, X., Cao, M., Cheng, B., & Yang, S. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03600-z · Cited by 7
“Smoking, chewing betelnut, excessive drinking and other bad habits can cause oral cancer [13]; the incidence of oral cancer remains high especially in South Asia and other regions where chewing betelnut is common.”
BackgroundCha, B. H. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.18.8451 · Cited by 7
“This result is inconsistent to a recent published meta-analysis regarding the various cancer risks from alcohol consumption and suggested that it as a positive predictive factor of GBC (Bagnardi et al., 2015).”
ResultEurópai Rákellenes Kódex: 12 lehetőség, hogy csökkentse a rák kialakulásának kockázatát
Döbrőssy, L., & Cornides, Á. (2016) · Orvosi Hetilap · doi:10.1556/650.2016.30380 · Cited by 7
Sex disparities in cancer incidence in Jiashan County, China, 1995–2014
Jiang, X., Cai, S., Hu, Y., Ye, D., Li, Q., Chen, K., & Jin, M. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2017.07.013 · Cited by 7
Brenner, D. R., Haig, T. R., Poirier, A. E., Akawung, A. K., Friedenreich, C. M., & Robson, P. J. (2017) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.37.12.03 · Cited by 8
Epidemiology beyond its limits
McCullough, L. E., Maliniak, M. L., Amin, A. B., Baker, J. M., Baliashvili, D., Barberio, J., Barrera, C. M., Brown, C., Collin, L. J., Freedman, A. A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn3328 · Cited by 9
Adiamah, A., Ban, L., Hammond, J. S., Jepsen, P., West, J., & Humes, D. J. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa043 · Cited by 7
Shimoshikiryo, I., Ibusuki, R., Shimatani, K., Nishimoto, D., Takezaki, T., Nishida, Y., Shimanoe, C., Hishida, A., Tamura, T., Okada, R., et al. (2020) · Alcohol · doi:10.1016/j.alcohol.2020.09.002 · Cited by 8
Ruwali, M., & Shukla, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-7493-1_10 · Cited by 7
Province-specific alcohol-attributable cancer deaths and years of potential life lost in China
Yang, Z., Cheng, J., Yu, L., Cui, X., & Wang, J. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108431 · Cited by 7
Fusco, S. A. D., Spinelli, A., Castello, L., Marino, G., Maraschi, I., Gulizia, M. M., Gabrielli, D., & Colivicchi, F. (2021) · Circulation Journal · doi:10.1253/circj.cj-21-0459 · Cited by 7
Alcohol Promotes Lipogenesis in Sebocytes—Implications for Acne
Kleemann, J., Cinatl, J. J., Hoffmann, S., Zöller, N. N., Özistanbullu, D., Zouboulis, C. C., Kaufmann, R., & Kippenberger, S. (2024) · Cells · doi:10.3390/cells13040328 · Cited by 6
Maitra, S., Behera, H. C., Bose, A., Chatterjee, D., & Bandyopadhyay, A. R. (2025) · Frontiers in Oral Health · doi:10.3389/froh.2025.1569940 · Cited by 10
Symptom Clusters and Sentinel Symptoms in Patients With Colorectal Cancer: A Network Analysis
Shi, J., Luo, J., Liu, Y., Xu, H., Li, M., Jin, Y., Wu, S., & Jin, T. (2025) · Nursing and Health Sciences · doi:10.1111/nhs.70122 · Cited by 6
“It may be related to specific types of alcohol or to population characteristics (Bagnardi et al. 2015).”
Prediction of Incident Cancers in the Lifelines Population-Based Cohort
Cortés-Ibáñez, F. O., Nagaraj, S. B., Cornelissen, L. J., Navis, G. J., van der Vegt, B., Sidorenkov, G. A., & de Bock, G. H. (2021) · Cancers · doi:10.3390/cancers13092133 · Cited by 6
“Lifestyle risk factors that have an established association with the development of specific primary cancers are smoking [5], alcohol consumption [6], unhealthy diet [7,8], high body mass index (BMI) [9], low level of physical activity [10], and high level of sedentary behavior [11].”
BackgroundAnitha, G. F. S., Kumar, K. V., Deshpande, G., Nagaraj, M., & Kalyani, V. (2022) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_26_22 · Cited by 6
Sugimoto, Y., Koyanagi, Y. N., Kawakatsu, Y., Oze, I., Taniyama, Y., Kasugai, Y., Tanaka, T., Abe, T., Tajika, M., Shimizu, Y., et al. (2023) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyad028 · Cited by 7
Azzi, L., Celesti, F., Chiaravalli, A. M., Shaik, A. K. B., Shallak, M., Gatta, A., Battaglia, P., Rosa, S. L., Tagliabue, A., Accolla, R. S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1387835 · Cited by 6
Card-Gowers, J., Boniface, S., Brown, J., Kock, L. S., Martin, A. M., Retat, L., & Webber, L. (2025) · PLoS ONE · doi:10.1371/journal.pone.0314870 · Cited by 6
Stojanović, M., Rancic, N. K., Apostolovic, M. A., Ignjatović, A., Stojanović, D. R., Mitić-Lakušić, V., & Ilic, M. V. (2022) · Medicina · doi:10.3390/medicina58020306 · Cited by 6
Minichilli, F., Gorini, F., Filippis, G. D., Bustaffa, E., Raho, A. M., Melcarne, A., Quarta, F., Maggiore, G., Idolo, A., Serio, F., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148775 · Cited by 6
“Regarding individual lifestyles, it has been reported that alcohol, classified as a group I carcinogen [20], is associated with a 15% increased risk of LC in heavy drinkers compared to non-drinkers or occasional drinkers [21].”
BackgroundThørrisen, M. M., Sadeghi, T., Bonsaksen, T., Graham, I. D., & Aas, R. W. (2022) · Addiction Science & Clinical Practice · doi:10.1186/s13722-022-00335-0 · Cited by 6
Intake of prebiotic fibers and the risk of laryngeal cancer: the PrebiotiCa study
Turati, F., Concina, F., Bertuccio, P., Fiori, F., Parpinel, M. T., Taborelli, M., Rosato, V., Garavello, W., Negri, E., & Vecchia, C. L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03030-7 · Cited by 6
“Tobacco [3] and alcohol [4] are the most important risk factors for laryngeal cancer, with a multiplicative effect on risk [5].”
BackgroundSelf-citationKim, L. H. C., Bang, A., Sarich, P., Nair‐Shalliker, V., Patel, M. I., & Smith, D. P. (2023) · Annals of Epidemiology · doi:10.1016/j.annepidem.2023.04.014 · Cited by 6
Chen, S., Ding, R., Tang, X., Chen, L., Luo, Q., Xiao, M., Ding, X., & Peng, B. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074697 · Cited by 6
Cancer incidence in Ireland—the possible role of diet, nutrition and lifestyle
McCartney, D. M. A., Byrne, D., Cantwell, M. M., & Turner, M. J. (2016) · Journal of Public Health · doi:10.1007/s10389-016-0769-9 · Cited by 6
“2015), meta-analyses (Bagnardi et al. 2015) and reviews (Scoccianti et al.”
BackgroundAssociation between rs1229984 in ADH1B and cancer prevalence in a Japanese population
Govind, P., Pavethynath, S., Sawabe, M., Arai, T., & Muramatsu, M. (2020) · Molecular and Clinical Oncology · doi:10.3892/mco.2020.2021 · Cited by 6
“Analyses of liver, pancreas and colon cancer were presented due to evidence that these are alcohol-related cancers (21).”
BackgroundLovrečić, M., Lovrečić, B., Simon, M. R., Korošec, A., Rocca, F. D., Maremmani, A. G. I., & Maremmani, I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072122 · Cited by 6
Dashpuntsag, K., Chandaga, U., Tserennadmid, N., Bat-Ochir, U., Mukhtar, Y., Altankhuyag, G.-E., Gombodorj, N., Dulamsuren, O., & Jaalkhorol, M. (2021) · PubMed Central · doi:10.22122/ahj.v13i3.1250 · Cited by 6
Kristina, S. A., Endarti, D., Wiedyaningsih, C., Yuliawati, A. N., & Astyamalia, S. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.7.1845 · Cited by 6
“Relative risk Relative risk (RR) was calculated as per meta-analysis study associated with alcohol use and risk of cancer (Bagnardi et al., 2015).”
MethodInfluentialТhe impact of alcohol abuse on the development of non-communicable diseases (analytical review)
Kaigorodova, T. V., & Kryukova, I. A. (2021) · Public Health · doi:10.21045/2782-1676-2021-1-2-48-61 · Cited by 7
Muntyanu, A., Nechaev, V., Pastukhova, E., Logan, J., Rahme, E., Zubarev, A., Netchiporouk, E., & Litvinov, I. V. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1197287 · Cited by 6
He, R., Shen, Z., Chen, Q., Hu, H., Ding, X., Zheng, Z., Feng, Q., & Li, B. (2025) · BMC Cancer · doi:10.1186/s12885-025-13863-0 · Cited by 5
“There is a significant association between alcohol consumption and pancreatic cancer [34], especially in long-term heavy drinkers [35].”
Raoof, S., Kansal, A. R., Tafazzoli, A., Ye, W., Morris, W., Zou, D., & Fendrick, A. M. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-25-0610 · Cited by 5
“For the heavy alcohol use subpopulation specifically, the primary source was Bagnardi and colleagues (81), which uses a meta-analysis approach to pool data from multiple global studies, ensuring a comprehensive coverage of cancer types associated with alcohol consumption.”
Mirghaed, A. T., Khoshkharam, N., Karimi, F., Abdzadeh, S., Razazan, M., Rahami, Z., & Doustimotlagh, A. H. (2025) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_184_24 · Cited by 5
Smoking and oral and pharyngeal cancer: a meta-analysis
Possenti, I., Miotti, S., Gallus, S., Bagnardi, V., Garavello, W., Specchia, C., Smits, L. J. M., Odone, A., & Lugo, A. (2026) · Oncology Reviews · doi:10.3389/or.2025.1672607 · Cited by 11
Self-citationAccelerating discovery of cancer causes for prevention in the era of rising early-onset cancers
Shi, M., Patti, G. J., Gunter, M. J., Govindan, R., Lansdorp‐Vogelaar, I., Wang, T., Townsend, J. P., Colditz, G. A., Belkaid, Y., & Cao, Y. (2026) · Cell · doi:10.1016/j.cell.2026.03.019 · Cited by 7
Baldaque, P., Coutinho, G., Moreira, J. P. D. L., Luiz, R. R., Fogaça, H. S., de Souza, L. M. P., & de Souza, H. S. P. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08488-5 · Cited by 5
“Different drinking patterns, such as frequency of drinking, usual quantity of daily drinking, and especially heavy drinking, have all been associated with an increased risk [51, 52].”
Williams, M. O., Buekers, J., Castaño‐Vinyals, G., de Cid, R., Delgado‐Ortiz, L., Espinosa, A., García‐Aymerich, J., Koch, S., Kogevinas, M., Viola, M., et al. (2024) · British Journal of Health Psychology · doi:10.1111/bjhp.12746 · Cited by 8
Esfandiari, F., Bakhshi, B., Shahbazi, T., Derakhshan-Nezhad, E., Bahroudi, M., Minaeian, S., Boustanshenas, M., Alborzi, F., Behboudi, B., & Fazeli, M. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0294053 · Cited by 6
Seth, G., Ganesan, V., Kaur, N., Abed, S., Gogineni, K., Swahn, M. H., Martínez, P., & Aneja, R. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03887-w · Cited by 5
“Pooled data from 118 studies show a slight rise in risk (1.04-fold) among light drinkers compared to nondrinkers, with moderate (1.23-fold) and heavy drinkers (1.6-fold) facing higher risks [11, 12].”
InfluentialYang, S. S., Lee, J., Park, Y., Lee, E. K., Hwangbo, Y., Ryu, J., Sung, J., & Kim, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22189-w · Cited by 5
Very-light alcohol consumption suppresses breast tumor progression in a mouse model
Wang, X., Jia, M., Mao, Y., Jia, Z., Liu, H., Yang, G., Wang, S., Sun, B., & Zhang, H. (2022) · Food & Function · doi:10.1039/d1fo02089g · Cited by 5
Palshof, F. K., Mørch, L. S., Køster, B., Engholm, G., Storm, H. H., Andersson, T., & Kroman, N. T. (2024) · Scientific Reports · doi:10.1038/s41598-024-59314-x · Cited by 5
“The RR estimates used were based on findings from Bagnardi et al. 16 , also used in studies by Andersson et al. 17 and Tybjerg et al .”
MethodPrimary Prevention of Coronary and Other Cardiovascular Diseases: A Focused Review
Higashiyama, A., Kohsaka, S., & Fujiyoshi, A. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv22019 · Cited by 6
Cui, H., Du, J., Xue, H., Zhao, Y., & Li, C. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1391542 · Cited by 5
Epidemiology and Site-Specific Risk Factors for Oral Cancer
Johnson, N. W., Gupta, B., Ariyawardana, A., & Amarasinghe, H. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-14911-0_4 · Cited by 7
Influence of lifestyle choices on risks of CYP 1B1 polymorphisms for prostate cancer
Kato, T., Hashimoto, Y., Wong, R., Mitsui, Y., Maekawa, S., Chang, I., Shahryari, V., Yamamura, S., Majid, S., Saini, S., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13696 · Cited by 4
Key problems of the quality of life of patients after total laryngectomy
Slouka, D., Kučera, R., Hošek, P., Gál, B., Trčka, O., Kostlivý, T., & Havel, D. (2018) · Kontakt · doi:10.1016/j.kontakt.2018.08.006 · Cited by 5
“Laryngeal cancer occurs significantly more frequently in men, the highest incidence is in the category between 40 and 70 years of age [6, 7].”
BackgroundLifestyle and Cancer Prevention
Basen‐Engquist, K., Brown, P. H., Coletta, A. M., Savage, M. I., Maresso, K. C., & Hawk, E. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00022-0 · Cited by 5
Yang, C., Liao, C., Zhang, Y., Zhou, H., Diao, X., Han, Q., & Wang, G. (2020) · Gene · doi:10.1016/j.gene.2020.144434 · Cited by 4
Kebede, E. B., Olani, A., Terfa, Y. B., Negash, A., Gelan, M., Abdisa, E., Nigatu, D., & Geleta, B. A. (2021) · Gastrointestinal Nursing · doi:10.12968/gasn.2021.19.2.36 · Cited by 5
The Binary Classification of Protein Kinases
Elkoshi, Z. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s303750 · Cited by 5
Alcohol and Mortality: An Actuarial Issue
Gutterman, S. (2021) · North American Actuarial Journal · doi:10.1080/10920277.2021.1946660 · Cited by 5
“8According to Bagnardi et al. (2015), excess deaths due to cancers of the oral cavity, pharynx, liver, esophagus, (female) breast, and colorectum, with protection against kidney, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma diseases.”
BackgroundNontarak, J., Geater, A. F., Assanangkornchai, S., & Aekplakorn, W. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agab075 · Cited by 5
Bozgeyik, İ., Koparal, M., Eğe, B., Bozgeyi̇k, E., Kurt, M. Y., & Ceylan, O. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153952 · Cited by 5
de Ternay, J., Larrieu, A., Sauvestre, L., Montègue, S., Guénin, M., Icard, C., & Rolland, B. (2022) · Nutrients · doi:10.3390/nu14234958 · Cited by 7
Hirko, K. A., Lucas, D. R., Pathak, D. R., Hamilton, A. S., Post, L. M., Ihenacho, U., Carnegie, N. B., Houang, R. T., Schwartz, K., & Velie, E. M. (2023) · Cancer Causes & Control · doi:10.1007/s10552-023-01801-z · Cited by 5
Clinical Epidemiology of Chronic Liver Disease: Hepatocellular Carcinoma
Suraweera, D., Konyn, P., Vu, T., & Saab, S. (2018) · Clinical Epidemiology of Chronic Liver Diseases · doi:10.1007/978-3-319-94355-8_15 · Cited by 6
Estimates of alcohol-related mortality in Serbia (2016-2018)
Marinković, I. (2020) · Stanovnistvo · doi:10.2298/stnv2001089m · Cited by 5
The association between regular use of aspirin and the prevalence of prostate cancer
Huang, W., Erickson, S. R., Hansen, R. A., & Wu, C. (2016) · Medicine · doi:10.1097/md.0000000000003909 · Cited by 5
Exploring the provision of alcohol advice by clinicians to breast cancer patients
Simapivapan, P., Hodge, A. M., & Boltong, A. G. (2017) · European Journal of Cancer Care · doi:10.1111/ecc.12739 · Cited by 5
Changes in risk habits and influencing factors in the Taiwan oral cancer screening program
Munpolsri, P., Su, C., Yang, H.-F., Hsu, T., Chou, Y.-Y., Lin, L., Wu, C.-C., Chen, S. L., & Yen, A. M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320461 · Cited by 4
Larsson, S. C., Mason, A. M., Cronjé, H. T., Bassett, E., Horta, G., Kar, S., & Burgess, S. (2025) · BMC Medicine · doi:10.1186/s12916-025-04543-8 · Cited by 4
“Alcohol consumption is strongly associated with an increased risk of squamous cell oesophageal cancer but not oesophageal adenocarcinoma [7, 61], the more common type in European descent populations.”
InfluentialLózsa, R., Szikriszt, B., Németh, E., Szeltner, Z., Martinek, R., Póti, Á., Feik, T., Kollarics, S., Márkus, B. G., Kanu, N., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09521-1 · Cited by 6
Bokemeyer, F., Gali, K., Kiefer, P., Bleich, C., Freitag, J., Bokemeyer, C., Abel, B., Schulz, H., & Lebherz, L. (2024) · Journal of Cancer Survivorship · doi:10.1007/s11764-024-01673-5 · Cited by 4
Ma, Z., Haworth, J. L., & Hu, J. (2024) · Addictive Behaviors · doi:10.1016/j.addbeh.2024.108229 · Cited by 4
Aja, P. M., Agu, P. C., Musyoka, A. M., Ngwueche, W., Odo, J. U., Alum, E. U., Fasogbon, I. V., Herbert, M., & Eze, E. D. (2025) · American Journal of Men s Health · doi:10.1177/15579883251344571 · Cited by 4
Miya, T. V., Marima, R. M., Marutha, T., Luvhengo, T. E., Mkhize‐Kwitshana, Z. L., Chauke-Malinga, N., Mazibuko, G., & Dlamini, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1623895 · Cited by 4
Polymorphism of MUC1 Gene in Vietnamese Gastric Cancer Patients: A Multicenter Case–Control Study
Nguyen, N.-L. T., Dang, N.-D. T., Dang, Q.-H., Tran, V.-C., Vo, H.-L., Yamaguchi, M., & Ta, T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.694977 · Cited by 4
Alcohol & cancer: Evidence to action
Mehrotra, R., Kapahtia, S., Kaur, T., Priyanka, K., & Dhaliwal, R. S. (2022) · International Journal of Microbiology Research · doi:10.4103/ijmr.ijmr_4037_20 · Cited by 4
Kanadas Leitlinienempfehlung zu Alkohol und Gesundheit
Maisch, B. (2023) · Herz · doi:10.1007/s00059-023-05226-x · Cited by 4
The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis
Long, J., Yang, M., Pang, Y., Kang, H., Liang, S., & Wang, D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1366958 · Cited by 4
Stullich, A., Hoffmann, L., Stephan, J., Gehrmann, J., & Richter, M. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-078148 · Cited by 4
Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study
Saldivia‐Siracusa, C., Araújo, A., Arboleda, L. P. A., Abrantes, T. C., Ramos, M. B., Mendonça, N., Cordero‐Torres, K., Gilligan, G., Piemonte, E. D., Panico, R., et al. (2024) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.26551 · Cited by 4
Alcohol consumption—none is better than a little
Maisch, B. (2024) · Herz · doi:10.1007/s00059-024-05280-z · Cited by 4
Assessment of the frequency and risk factors for colorectal cancer in acromegaly
Maia, B. L. D. S. A., Madeira, E., Gadelha, M. R., & Kasuki, L. (2024) · Endocrine · doi:10.1007/s12020-024-04099-2 · Cited by 4
Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis
Varshini, M. A., & Devi, A. (2025) · Oral Diseases · doi:10.1111/odi.15293 · Cited by 4
“Several causes, such as alcohol use, cigarette smoking, and HPV infection, have been related to increased incidence rates of oropharyngeal cancer in Australia and New Zealand as well as in Western and Eastern Europe (Bagnardi et al. 2015).”
Forman, D., Yang, M., Chien, R., Nguyen, H., Wong, C., Kim, J. H. J., Ziogas, A., & Park, H. L. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1296 · Cited by 5
Sun, I. O., Lee, H.-S., Lim, C., Bae, E., Hyun, Y. Y., Chung, S., Kwon, S. H., Cho, J., Yoo, K. D., Park, W. Y., et al. (2025) · Nutrients · doi:10.3390/nu17060983 · Cited by 4
“Excessive alcohol consumption is known to have harmful effects, such as increasing the risk of liver cirrhosis, pancreatitis, and cancers at various sites [1,2].”
Zhang, S., Du, D., Li, P., Chen, Y., & Zhang, X. (2025) · BMC Public Health · doi:10.1186/s12889-025-23343-6 · Cited by 4
“Some factors have been extensively studied and identified as definitive risk factors for laryngeal cancer, such as smoking [11, 23], alcohol consumption [24, 25], exposure to air pollution, and occupational exposure [13].”
Do causes of stress differ in their association with problem drinking by sex in Korean adolescents?
Choi, J. W., Park, E., Kim, J., & Park, S. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.08.013 · Cited by 4
Promoting Health and Care Transitions in the Long-Term AYA Survivor
Hudson, M. M., Kinahan, K. E., Sharp, L. K., & Freyer, D. R. (2016) · Pediatric oncology · doi:10.1007/978-3-319-33679-4_29 · Cited by 4
Head and Neck Cancer: Epidemiology and Role of MicroRNAs
Khawar, M. B., Fatima, N., Abbasi, M. H., Mehmood, R., Suqaina, S. K., & Sheikh, N. (2017) · InTech eBooks · doi:10.5772/intechopen.69418 · Cited by 4
“reported a positive relationship in between alcohol drinking and head and neck cancer risk [7].”
Background4. Alcohol as a Risk Factor for Chronic Disease: Raising Awareness and Policy Options
Greenfield, T. K., & Martínez, P. (2017) · American Public Health Association eBooks · doi:10.2105/9780875532929ch04 · Cited by 4
Fisher, J. M., Wolever, T. M. S., Campbell, J. E., Ezatagha, A., Noronha, J. C., & Jenkins, A. L. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0228 · Cited by 5
Economic burden of alcohol-related cancers in the Republic of Korea
Han, M., Tran, B. T., Cho, H., & Oh, J. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108295 · Cited by 4
Xu, C., Wu, J., Zhang, W., Feng, X., Zhao, L., Huang, F., & Jiang, C. Q. (2021) · Bioscience Reports · doi:10.1042/bsr20210124 · Cited by 4
“In previous studies, factors related to the risk of HCC included aging (21), smoking (22-24), and alcohol consumption (22, 25, 26).”
BackgroundHistory of alcohol consumption and cancer burden in Italy
Malvezzi, M., Negri, E., & Vecchia, C. L. (2021) · Journal of Health Inequalities · doi:10.5114/jhi.2021.113168 · Cited by 4
Self-citationAlcohol: the role in nutrition and health
Suter, P. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00025-3 · Cited by 5
Metadata
- Authors
- Bagnardi, V, Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V, Scotti, L., Jenab, M., Turati, F., Pasquali, E., Pelucchi, C., Galeone, C., Bellocco, R., Negri, E., Corrao, G., Boffetta, P., & La Vecchia, C.
- Affiliations
- European Institute of Oncology (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- American Cancer Society (US)
- Emory University (US)
- University of Milano-Bicocca (IT)
- Centre international de recherche sur le cancer (FR)
- Karolinska Institutet (SE)
- Tisch Cancer Institute (US)
- Corresponding author
- Bagnardi, V
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2014-11-25
- Volume
- 112
- Issue
- 3
- Pages
- 580-593
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC4453639
- OpenAlex
- W1965385210
- Cited by
- 1,342
- References
- 70
- Citations by year
- 2026: 130 · 2025: 149 · 2024: 129 · 2023: 139 · 2022: 158 · 2021: 133 · 2020: 123 · 2019: 108 · 2018: 100 · 2017: 86 · 2016: 64 · 2015: 21
- FWCI
- 42.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- World Health Organization
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro (10258)
- Fondazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- alcohol consumption, alcohol and cancer risk, dose-response relationship, heavy drinking, oral and pharyngeal cancer, esophageal squamous cell carcinoma, colorectal cancer, laryngeal cancer, breast cancer, liver cancer, gastric cancer, gallbladder cancer, pancreatic cancer, lung cancer, melanoma, prostate cancer, Hodgkin's disease, non-Hodgkin lymphoma
- MeSH terms
- Esophageal Squamous Cell Carcinoma, Alcohol Drinking, Breast Neoplasms, Carcinoma, Squamous Cell, Dose-Response Relationship, Drug, Esophageal Neoplasms, Female, Humans, Male, Melanoma, Mouth Neoplasms, Neoplasms, Pharyngeal Neoplasms, Prostatic Neoplasms, Risk Factors, Incidence, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
