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Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

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Findlay, David M, Kuliwaba, Julia S·2016·Bone Research

DOI 10.1038/boneres.2016.28

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Abstract

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction (crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.

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Shirai, T., Kobayashi, M., Nishitani, K., Satake, T., Kuroki, H., Nakagawa, Y., Tanaka, C., & Nakamura, T. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.02.037 · Cited by 22
An update on primary hip osteoarthritis including altered Wnt and TGF- associated gene expression from the bony component of the disease
Kumarasinghe, D. D., Hopwood, B., Kuliwaba, J. S., Atkins, G. J., & Fazzalari, N. L. (2011) · Rheumatology · doi:10.1093/rheumatology/ker291 · Cited by 21
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Abnormal perfusion in patellofemoral subchondral bone marrow in the rat anterior cruciate ligament transection model of post-traumatic osteoarthritis: a dynamic contrast-enhanced magnetic resonance imaging study
Tsai, P.-H., Lee, H.-S., Siow, T. Y., Wang, C., Chang, Y., Lin, M.-H., Hsu, Y.-C., Lee, C.-H., Chung, H., & Huang, G. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.07.015 · Cited by 19
Bone marrow lesions can be subtyped into groups with different clinical outcomes using two magnetic resonance imaging (MRI) sequences
Wluka, A. E., Teichtahl, A. J., Maulana, R., Liu, B. M., Wang, Y., Giles, G. G., O’Sullivan, R., Findlay, D. M., & Cicuttini, F. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0780-5 · Cited by 17
Self-citation

Molecular mechanosensors in osteocytes
Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484
Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes
Zhou, F., Mei, J., Han, X., Li, H., Yang, S., Wang, M., Chu, L., Qiao, H., & Tang, T. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.015 · Cited by 400

See all 283

Authors: Findlay, D. M., & Kuliwaba, J. S.
Venue: Bone Research
Publisher: Springer Science and Business Media LLC
Published: 2016-09-20
Volume: 4
Issue: 1
Pages: 16028-16028
ISSN: 2095-4700 (ISSN-L)
2095-6231
DOI: 10.1038/boneres.2016.28
OpenAlex: W2522849079
Cited by: 283
References: 87
FWCI: 19.86
Type: journal article
Language: en
Open access: gold

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

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