The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Open accessAbstract
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.
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Cites
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Cited by
Subchondral bone microenvironment in osteoarthritis and pain
Hu, Y., Chen, X., Wang, S., Jing, Y., & Su, J. (2021) · Bone Research · doi:10.1038/s41413-021-00147-z · Cited by 577
Current understanding of osteoarthritis pathogenesis and relevant new approaches
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Self-citationCartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
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Metadata
- Authors
- Chen, D., Shen, J., Zhao, W., Wang, T., Han, L., Hamilton, J. L., & Im, H.-J.
- Venue
- Bone Research
- Published
- 2017-01-17
- Volume
- 5
- Issue
- 1
- Pages
- 16044-16044
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- OpenAlex
- W2574647359
- Cited by
- 1,187
- References
- 10
- FWCI
- 61.07
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
